Autosomal dominant polycystic kidney disease (ADPKD)
is a genetic disorder characterized by the growth of numerous cysts in the kidneys. It is the most common inherited disorder of the kidneys. Symptoms usually develop between the ages of 30 and 40, but they can begin earlier, even in childhood. The most common symptoms are pain in the back and the sides and headaches. Other symptoms include liver and pancreatic cysts, urinary tract infections, abnormal heart valves, high blood pressure, kidney stones, brain aneurysms, and diverticulosis. About 90 percent of all cases of polycystic kidney disease (PKD) are inherited in an autosomal dominant fashion. Although there is no cure for ADPKD, treatment can ease symptoms and prolong life. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.