Rocky Mountain spotted fever (RMSF) is a disease that primarily affects those in North and South America, transmitted to humans by the bite of infected ticks. RMSF cases have been reported throughout most of the United States, though the states of North Carolina, Oklahoma, Arkansas, Tennessee, and Missouri account for over 60% of cases, with the majority of cases reported have peaked during the summer months in June and July. Children under 10 years old, Native Americans, people with a compromised immune system, and people with delayed treatment are most at risk of a fatal outcome from RMSF. Signs and symptoms of RMSF include fever, headache, abdominal pain, rash, vomiting, and muscle pain. If not treated immediately, RMSF can be a severe or even fatal illness. RMSF and other tick-borne diseases are preventable.