Monkeypox is a virus that is very dangerous to humans. It is similar in symptoms to smallpox, and occurs sporadically in parts of Africa. Human monkepox first appeared in 1970 in the Democratic Republic of Congo, and since then has been reported in rural areas of the Congo Basin and western African. The disease can be spread through direct contact with the blood, bodily fluids, or rashes of infected animals, and also through transmission from human-to-human, through close contact. Signs and symptoms of monkeypox include fever, intense headache, swelling of the lymph node, muscle ache, and an intense lack of energy. Symptoms can then progress to skin eruptions on the palms of the hands and soles of the feet. Symptoms of monkeypox typically last 14 to 21 days, and the disease can be fatal.