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Pineoblastoma

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Clinical Trials

This information is provided by ClinicalTrials.gov

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Displaying 1-8 of 8 results.
Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma
Status: Recruiting
Last Changed: Oct 22, 2018
First Received: Nov 04, 2015
Disease(s): Pineoblastoma
Intervention(s): Temozolomide, Irinotecan, Dasatinib, Rapamycin
Locations: University Hospital of Regensburg, Regensburg, Germany
International HIT-MED Registry (I-HIT-MED)
Status: Recruiting
Last Changed: Oct 18, 2017
First Received: Apr 15, 2015
Disease(s): Childhood Brain Tumor
Locations: University Hospital Aachen, Aachen, Germany
Klinikum Augsburg, Augsburg, Germany
Helios Klinikum Berlin-Buch, Berlin, Germany
Charite Campus, University of Berlin, Berlin, Germany
Evangelisches Krankenhaus Bielefeld, Bielefeld, Germany
... and 53 other locations.
EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors
Status: Recruiting
Last Changed: Apr 05, 2019
First Received: Aug 20, 2018
Disease(s): Central Nervous System Tumor, Pediatric, Glioma, Ependymoma, Medulloblastoma, Germ Cell Tumor, Atypical Teratoid/Rhabdoid Tumor, Primitive Neuroectodermal Tumor, Choroid Plexus Carcinoma, Pineoblastoma
Intervention(s): EGFR806-specific chimeric antigen receptor (CAR) T cell
Locations: Seattle Children's Hospital, Seattle, Washington, United States
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors
Status: Recruiting
Last Changed: Jun 11, 2019
First Received: Apr 17, 2018
Disease(s): Central Nervous System Tumor, Pediatric, Glioma, Ependymoma, Medulloblastoma, Germ Cell Tumor, Atypical Teratoid/Rhabdoid Tumor, Primitive Neuroectodermal Tumor, Choroid Plexus Carcinoma, Pineoblastoma
Intervention(s): HER2-specific chimeric antigen receptor (CAR) T cell
Locations: Seattle Children's Hospital, Seattle, Washington, United States
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Status: Recruiting
Last Changed: Jan 08, 2019
First Received: Feb 15, 2018
Disease(s): Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma, Anaplastic Oligodendroglioma, Pleomorphic Xanthoastrocytoma, Anaplastic, Atypical Teratoid/Rhabdoid Tumor, Brain Cancer, Brain Tumor, Central Nervous System Neoplasms, Choroid Plexus Carcinoma, CNS Embryonal Tumor With Rhabdoid Features, Ganglioneuroblastoma of Central Nervous System, CNS Tumor, Embryonal Tumor of CNS, Ependymoma, Glioblastoma, Glioma, Glioma, Malignant, Medulloblastoma, Medulloblastoma; Unspecified Site, Medulloepithelioma, Neuroepithelial Tumor, Neoplasms, Neoplasms, Neuroepithelial, Papillary Tumor of the Pineal Region (High-grade Only), Pediatric Brain Tumor, Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only), Pineoblastoma, Primitive Neuroectodermal Tumor, Recurrent Medulloblastoma, Refractory Brain Tumor, Neuroblastoma. CNS, Glioblastoma, IDH-mutant, Glioblastoma, IDH-wildtype, Medulloblastoma, Group 3, Medulloblastoma, Group 4, Glioma, High Grade, Neuroepithelial Tumor, High Grade, Medulloblastoma, SHH-activated and TP53 Mutant, Medulloblastoma, SHH-activated and TP53 Wildtype, Medulloblastoma, Chromosome 9q Loss, Medulloblastoma, Non-WNT Non-SHH, NOS, Medulloblastoma, Non-WNT/Non-SHH, Medulloblastoma, PTCH1 Mutation, Medulloblastoma, WNT-activated, Ependymoma, Recurrent, Glioma, Recurrent High Grade, Glioma, Recurrent Malignant, Embryonal Tumor, NOS, Glioma, Diffuse Midline, H3K27M-mutant, Embryonal Tumor With Multilayered Rosettes (ETMR), Ependymoma, NOS, WHO Grade III, Ependymoma, NOS, WHO Grade II, Medulloblastoma, G3/G4, Ependymoma, RELA Fusion Positive
Intervention(s): Gemcitabine, ribociclib, sonidegib, trametinib, filgrastim
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee, United States
Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Status: Recruiting
Last Changed: Sep 17, 2019
First Received: Mar 24, 2014
Disease(s): Central Nervous System Embryonal Tumor With Rhabdoid Features, Central Nervous System Embryonal Tumor, Not Otherwise Specified, Central Nervous System Ganglioneuroblastoma, Embryonal Tumor With Multilayered Rosettes, C19MC-Altered, Pineoblastoma, Primary Central Nervous System Neoplasm, Recurrent Childhood Central Nervous System Embryonal Neoplasm, Recurrent Malignant Solid Neoplasm, Recurrent Medulloblastoma, Recurrent Neuroblastoma, Recurrent Rhabdomyosarcoma, Refractory Malignant Solid Neoplasm, Refractory Medulloblastoma, Refractory Neuroblastoma, Refractory Rhabdomyosarcoma
Intervention(s): Adavosertib, Irinotecan, Irinotecan Hydrochloride
Locations: Children's Hospital of Alabama, Birmingham, Alabama, United States
Children's Hospital Los Angeles, Los Angeles, California, United States
Children's Hospital of Orange County, Orange, California, United States
UCSF Medical Center-Parnassus, San Francisco, California, United States
UCSF Medical Center-Mission Bay, San Francisco, California, United States
... and 20 other locations.
International PPB/DICER1 Registry
Status: Recruiting
Last Changed: Aug 19, 2019
First Received: Dec 22, 2017
Disease(s): Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma, Wilms Tumor, Pineoblastoma, Renal Sarcoma, Nodular Hyperplasia of Thyroid, Nasal Chondromesenchymal Hamartoma, Ciliary Body Medulloepithelioma, Neuroblastoma, Pituitary Cancer, Embryonal Rhabdomyosarcoma
Locations: Children's Minnesota, Minneapolis, Minnesota, United States
StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord
Status: Not yet recruiting
Last Changed: Jun 19, 2019
First Received: Jun 19, 2019
Disease(s): Central Nervous System Sarcoma, Ependymoma, Glioma, Malignant Intracranial Germ Cell Tumor, Medulloblastoma, Pineoblastoma, Primary Central Nervous System Neoplasm
Intervention(s): Placebo, Questionnaire Administration, Wound Dressing Material
Locations: M D Anderson Cancer Center, Houston, Texas, United States