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Antitrypsin Deficiency

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Clinical Trials

This information is provided by ClinicalTrials.gov

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Displaying 1-10 of 22 results.
Alpha-1 Antitrypsin Deficiency Adult Liver Study
Status: Recruiting
Last Changed: Dec 17, 2019
First Received: Dec 18, 2013
Disease(s): Alpha-1 Antitrypsin Deficiency
Intervention(s): Liver Biopsy (Biopsy Group Only)
Locations: University of California, San Diego, California, United States
Boston University School of Medicine, Boston, Massachusetts, United States
Saint Louis University, Saint Louis, Missouri, United States
Liver Disease in Patients With alpha1-antitrypsin Deficiency
Status: Recruiting
Last Changed: May 31, 2017
First Received: Oct 11, 2016
Disease(s): alpha1-antitrypsin Deficiency
Intervention(s): No intervention
Locations: RWTH Aachen University, Aachen, North Rhine Westphalia, Germany
Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency
Status: Recruiting
Last Changed: Mar 13, 2020
First Received: Jan 24, 2019
Disease(s): Alpha-1 Antitrypsin Deficiency, AATD
Intervention(s): INBRX-101/rhAAT-Fc
Locations: University of Florida College of Medicine, Gainesville, Florida, United States
University of Miami, Miami, Florida, United States
Indiana University, Indianapolis, Indiana, United States
The University of Texas Health Science Center at Tyler, Tyler, Texas, United States
University of Cambridge, Cambridge, East Of England, United Kingdom
... and 2 other locations.
Effects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency Patients
Status: Recruiting
Last Changed: Jan 16, 2019
First Received: Jan 14, 2019
Disease(s): Chronic Obstructive Pulmonary Disease, Alpha 1-Antitrypsin Deficiency
Intervention(s): Exercise training
Locations: Schoen Klinik Berchtesgadener Land, Schönau Am Königssee, Germany
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD
Status: Recruiting
Last Changed: Jan 06, 2020
First Received: Dec 18, 2019
Disease(s): Alpha 1-Antitrypsin Deficiency
Intervention(s): Alpha 1-Antitrypsin, Placebos
Locations: Leiden University Medical Center (LUMC), Leiden, ZA, Netherlands
Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT
Status: Recruiting
Last Changed: Mar 12, 2020
First Received: May 10, 2019
Disease(s): Alpha 1-Antitrypsin Deficiency
Intervention(s): ARO-AAT Injection
Locations: Medical University of Vienna Division of Gastroenterology and Hepatology, Vienna, Austria
Universitatsklinikum Aachen, Anstalt des offentlich, Aachen, Germany
Queen Elizabeth Hospital,University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Addenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom
Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom
... and 1 other locations.
Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT
Status: Recruiting
Last Changed: Mar 12, 2020
First Received: May 10, 2019
Disease(s): Alpha 1-Antitrypsin Deficiency
Intervention(s): ARO-AAT Injection, Placebo
Locations: University of Alabama at Birmingham Medical Center, Birmingham, Alabama, United States
Mayo Clinic Arizona, Phoenix, Arizona, United States
University of California San Diego Altman Clinical and Translational Research Institute, La Jolla, California, United States
UCLA David Geffen School of Medicine, Center for Health Sciences, Los Angeles, California, United States
University of California Davis Medical Center, Sacramento, California, United States
... and 20 other locations.
Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency
Status: Recruiting
Last Changed: Jun 24, 2019
First Received: Jun 23, 2011
Disease(s): Alpha-1-antitrypsin Deficiency, Liver Cirrhosis
Intervention(s): Drug-Carbamazepine (Tegretol XR), Carbamazepine (Tegretol XR) Placebo
Locations: Washington University in St. Louis School of Medicine, Saint Louis, Missouri, United States
Children's Hospital of Pittsburgh, UPMC, Pittsburgh, Pennsylvania, United States
University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, Pennsylvania, United States
A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease
Status: Recruiting
Last Changed: Nov 22, 2019
First Received: Nov 22, 2019
Disease(s): Alpha 1-Antitrypsin Deficiency
Intervention(s): DCR-A1AT, Placebo
Locations: Clinical Trial Consultants AB, Uppsala, Sweden
Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency
Status: Recruiting
Last Changed: Mar 09, 2020
First Received: Sep 20, 2018
Disease(s): Alpha-1 Antitrypsin Deficiency (AATD), Pi*ZZ, Pi*SZ, or Pi*Null Phenotype, Emphysema or COPD
Intervention(s): Alvelestat (MPH996), Placebo
Locations: The University of Alabama at Birmingham Lung Health Center, Birmingham, Alabama, United States
National Jewish Health, Denver, Colorado, United States
Columbia University, New York, New York, United States
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Cleveland Clinic, Cleveland, Ohio, United States
... and 5 other locations.