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Alexander Disease

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Review Articles from PubMed

Review articles summarize what is currently known about a disease. They discuss research previously published by others. The terms "Alexander Disease" returned 7 free, full-text review articles. First few results:
[Clinical characteristics and diagnostic criteria on Alexander disease].
Last Updated: Oct 13, 2020

Alexander disease (ALXDRD) is a primary astrocyte disease caused by glial fibrillary acidic protein (GFAP) gene mutation. ALXDRD had been clinically regarded as a cerebral white matter disease that affects only children for about 50 years since the initial report in 1949; however, ...

Severe worsening of adult-onset Alexander disease after minor head trauma: Report of two patients and review of the literature.
Last Updated: Sep 29, 2020

Alexander disease (ALXDRD) is a rare astrocytic leukodystrophy caused by GFAP mutations. The adult-onset (AO) variant is usually characterized by gradual onset of spastic ataxia and bulbar symptoms with slowly progressive course. We report two AO-ALXDRD cases with rapid worsening ...

Refining the concept of GFAP toxicity in Alexander disease.
Last Updated: Jul 07, 2020

Alexander disease is caused by dominantly acting mutations in glial fibrillary acidic protein (GFAP), the major intermediate filament of astrocytes in the central nervous system.

Full PubMed Review articles matches at NCBI:
7 Free Review Articles 27 Review Articles

Editorials from PubMed

Editorial articles describe the outcome of a single study. They are the published results of original research. The terms "Alexander Disease" returned 0 free, full-text editorial articles. First 0 results:
Full PubMed Editorials matches at NCBI:
0 Free Editorials 2 Editorials

Research Articles from PubMed

Research articles describe the outcome of a single study. They are the published results of original research. The terms "Alexander Disease" returned 61 free, full-text research articles. First few results:
[A case of Alexander disease presented with dystonia of lower limb and decreased dopaminergic uptake in dopamine transporter scintigraphy].
Last Updated: Nov 23, 2020

A 50-year-old woman developed gait disturbances and dysarthria since the past 2 years. She also presented with dystonia and hypokinesia of her left lower limb, and orthostatic hypotension. The dopamine transporter SPECT with I ioflupane showed abnormal scans in bilateral striatum. ...

[A case of Alexander disease with repeated loss of consciousness and with rapid aggravation of dysbasia by falling].
Last Updated: Aug 20, 2020

A 41-year-old woman presented with short-stepped gait from 20 years old and with repeated loss of consciousness from 21 years old. She had a deep cerebral white matter lesion on brain MRI at 34 years of age, but she did not reach a definitive diagnosis. At the age of 41, the gait ...

A case report of adult-onset Alexander disease clinically presenting as Parkinson's disease: is the comorbidity associated with genetic susceptibility?
Last Updated: Apr 08, 2020

Alexander disease is a rare neurological disease characterized by progressive spastic quadriparesis and bulbar palsy. Moreover, certain patients with adult-onset Alexander disease were often misdiagnosed as other neurodegenerative disorders.

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61 Free Research Articles 191 Research Articles