Burkitt's Lymphoma

Common Name(s)

Burkitt's Lymphoma

Burkitt lymphoma is a rare, aggressive B-cell lymphoma that accounts for 30 to 50% of lymphomas in children but only 1 to 2% of lymphomas in adults ({10:Harris and Horning, 2006}). It results from chromosomal translocations that involve the MYC gene ({190080}) and either the lambda or the kappa light chain immunoglobulin genes ({147220}, {147200}). Burkitt lymphoma is causally related to the Epstein-Barr virus (EBV), although the pathogenetic mechanisms are not clear.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Burkitt's Lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Burkitt's Lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Burkitt's Lymphoma" returned 445 free, full-text research articles on human participants. First 3 results:

Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival.
 

Author(s): Jasmin Corso, Kuan-Ting Pan, Roland Walter, Carmen Doebele, Sebastian Mohr, Hanibal Bohnenberger, Philipp Ströbel, Christof Lenz, Mikolaj Slabicki, Jennifer Hüllein, Federico Comoglio, Michael A Rieger, Thorsten Zenz, Jürgen Wienands, Michael Engelke, Hubert Serve, Henning Urlaub, Thomas Oellerich

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2016 May;113(20):5688-93.

 

Burkitt's lymphoma (BL) is a highly proliferative B-cell neoplasm and is treated with intensive chemotherapy that, because of its toxicity, is often not suitable for the elderly or for patients with endemic BL in developing countries. BL cell survival relies on signals transduced ...

Last Updated: 18 May 2016

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Burkitt's lymphoma of the humerus.
 

Author(s): N Geetha, K P Sreelesh, Rekha A Nair, Priya Mary Jacob

Journal: J Cancer Res Ther. ;11(4):1025.

 

Burkitt's lymphoma is an uncommon form of non-Hodgkin's lymphoma (NHL) in adults and represents < 5% of NHL adults. Burkitt's lymphoma involving primarily the appendicular skeleton is rarely described. We present the case of a young man with primary Burkitt's lymphoma involving the ...

Last Updated: 17 Feb 2016

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Reversible Posterior Leukoencephalopathy Syndrome Sometimes Could be Irreversible: A Case Following Tumor Lysis Syndrome in Childhood Burkitt's Lymphoma.
 

Author(s): Rui Zhang, Ling Jin, Hua Cheng, Jing Yang, Yan-Long Duan, Shuang Huang, Yong-Hong Zhang

Journal: Chin. Med. J.. 2016 Feb;129(4):480-3.

 

Last Updated: 16 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Burkitt's Lymphoma" returned 18 free, full-text review articles on human participants. First 3 results:

The Link between Plasmodium falciparum Malaria and Endemic Burkitt's Lymphoma-New Insight into a 50-Year-Old Enigma.
 

Author(s): David Thorley-Lawson, Kirk W Deitsch, Karen A Duca, Charles Torgbor

Journal:

 

Last Updated: 22 Jan 2016

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Burkitt's lymphoma developing post liver transplantation: posttransplant lymphoproliferative disorders international survey.
 

Author(s): Hossein Khedmat, Mohammad Ebrahim Ghamar-Chehreh, Mohsen Amini, Saeed Taheri

Journal: Saudi J Kidney Dis Transpl. 2014 Nov;25(6):1290-2.

 

Last Updated: 14 Nov 2014

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Burkitt's lymphoma masquerading as appendicitis--two case reports and review of the literature.
 

Author(s): Elroy P Weledji, Marcelin N Ngowe, John S Abba

Journal:

 

Two cases of Burkitt's lymphoma masquerading as appendicitis are reported herein. The diagnoses were made post-operatively from the appendix specimen in one case and from an ileocecal resection specimen for cecal fistula complicating an appendicectomy in the second case. These cases ...

Last Updated: 1 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Dose-Adjusted EPOCH-Rituximab in Adults With Untreated Burkitt Lymphoma and c-MYC+ Diffuse Large B-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Burkitt Lymphoma; Diffuse Large B-cell Lymphoma, c-MYC Positive; Plasmablastic Lymphoma

 

Last Updated: 24 Jan 2017

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The Safety and Efficacy of CART-19 Cells in B-cell Acute Lymphoblastic Leukemia (B-ALL).
 

Status: Recruiting

Condition Summary: B-cell Acute Lymphoblastic Leukemia

 

Last Updated: 4 Oct 2016

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Epidemiology of Burkitt Lymphoma in East Africa Children or Minors (EMBLEM)
 

Status: Recruiting

Condition Summary: Lymphoma, Non-Hodgkin; Malaria; Herpesvirus 4, Human

 

Last Updated: 2 Feb 2017

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