Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 390 free, full-text research articles on human participants. First 3 results:

POSTFUNDOPLICATION DYSPHAGIA CAUSES SIMILAR WATER INGESTION DYNAMICS AS ACHALASIA.
 

Author(s): Roberto Oliveira Dantas, Carla Manfredi Santos, Rachel Aguiar Cassiani, Leda Maria Tavares Alves, Weslania Viviane Nascimento

Journal: Arq Gastroenterol. ;53(2):98-102.

 

- After surgical treatment of gastroesophageal reflux disease dysphagia is a symptom in the majority of patients, with decrease in intensity over time. However, some patients may have persistent dysphagia.

Last Updated: 16 Jun 2016

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"Stray" achalasia: From gastroenterologist to pulmonologist and back.
 

Author(s): Dusanka Obradović, Biljana Joves Sević, Milos Stojanović, Miroslav Ilić, Igor Ivanov

Journal: Srp Arh Celok Lek. ;144(1-2):85-9.

 

Achalasia is a rare esophageal disorder which, due to frequent presence of both respiratory and gastrointestinal symptoms, can initially be referred either to pulmonologist or gastroenterologist.

Last Updated: 9 Jun 2016

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Socio-economic status and lifestyle factors are associated with achalasia risk: A population-based case-control study.
 

Author(s): Helen G Coleman, Ronan T Gray, Kar W Lau, Conall McCaughey, Peter V Coyle, Liam J Murray, Brian T Johnston

Journal: World J. Gastroenterol.. 2016 Apr;22(15):4002-8.

 

To evaluate the association between various lifestyle factors and achalasia risk.

Last Updated: 21 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 55 free, full-text review articles on human participants. First 3 results:

Diagnosis and Treatment Strategy of Achalasia Subtypes and Esophagogastric Junction Outflow Obstruction Based on High-Resolution Manometry.
 

Author(s): Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Kazuhiko Nakamura

Journal: Digestion. 2017 ;95(1):29-35.

 

Based on Chicago Classification version 3.0, the disorders of esophagogastric junction outflow obstruction (EGJOO) include achalasia (types I, II and III) and EGJOO. Although no curative treatments are currently available for the treatment of the disorders of EGJOO, medical treatments, ...

Last Updated: 4 Jan 2017

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Incidence of Esophageal Carcinomas After Surgery for Achalasia: Usefulness of Long-Term and Periodic Follow-up.
 

Author(s): Masaho Ota, Kosuke Narumiya, Kenji Kudo, Yohsuke Yagawa, Shinsuke Maeda, Harushi Osugi, Masakazu Yamamoto

Journal:

 

BACKGROUND Patients with esophageal achalasia are considered to be a high-risk group for esophageal carcinoma, and it has been reported that this cancer often arises at a long interval after surgery for achalasia. However, it is unclear whether esophageal carcinoma is frequent when ...

Last Updated: 14 Nov 2016

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Surgery or Peroral Esophageal Myotomy for Achalasia: A Systematic Review and Meta-Analysis.
 

Author(s): Luigi Marano, Giovanni Pallabazzer, Biagio Solito, Stefano Santi, Alessio Pigazzi, Raffaele De Luca, Francesco Giuseppe Biondo, Alessandro Spaziani, Maurizio Longaroni, Natale Di Martino, Virginia Boccardi, Alberto Patriti

Journal: Medicine (Baltimore). 2016 Mar;95(10):e3001.

 

To date very few studies with small sample size have compared peroral esophageal myotomy (POEM) with the current surgical standard of care, laparoscopic Heller myotomy (LHM), in terms of efficacy and safety, and no recommendations have been proposed.To investigate the efficacy and ...

Last Updated: 11 Mar 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sensorimotor Dysfunction in Achalasia
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 12 Sep 2016

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Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Registry
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 16 Feb 2017

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Last Updated: 18 Oct 2016

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