Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 362 free, full-text research articles on human participants. First 3 results:

IMAGES IN CLINICAL MEDICINE. Achalasia with Megaesophagus.
 

Author(s): Chinemerem Okwara, David Cangemi

Journal: N. Engl. J. Med.. 2015 Dec;373(25):e30.

 

Last Updated: 17 Dec 2015

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Early clinical experience with the POEM procedure for achalasia.
 

Author(s): Dennis Hong, Radu Pescarus, Rana Khan, Luciano Ambrosini, Mehran Anvari, Margherita Cadeddu

Journal: Can J Surg. 2015 Dec;58(6):389-93.

 

Per oral endoscopic myotomy (POEM) is a viable alternative to standard Heller myotomy for surgical treatment of achalasia. Outcomes from the United States, Europe and Asia have been reported. We sought to report data after the initiation of POEM in a Canadian centre.

Last Updated: 20 Nov 2015

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Clinical Effect of Endoscopic Pneumatic Dilation for Achalasia.
 

Author(s): Peng Cheng, Hai Shi, Yanjie Zhang, Huabang Zhou, Jinhua Dong, Yiting Cai, Xing Hu, Qiang Dai, Wenyan Yang

Journal: Medicine (Baltimore). 2015 Jul;94(28):e1193.

 

Although pneumatic dilation is an accepted method for the treatment of achalasia, this therapy has high recurrence and complication rates, and prolonged follow-up studies on the parameters associated with various outcomes are rare. In this prospective 10-year follow-up study, a satisfactory ...

Last Updated: 18 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 53 free, full-text review articles on human participants. First 3 results:

Data analyses and perspectives on laparoscopic surgery for esophageal achalasia.
 

Author(s): Kazuto Tsuboi, Nobuo Omura, Fumiaki Yano, Masato Hoshino, Se-Ryung Yamamoto, Shunsuke Akimoto, Takahiro Masuda, Hideyuki Kashiwagi, Katsuhiko Yanaga

Journal: World J. Gastroenterol.. 2015 Oct;21(38):10830-9.

 

In general, the treatment methods for esophageal achalasia are largely classified into four groups, including drug therapy using nitrite or a calcium channel blocker, botulinum toxin injection, endoscopic therapy such as endoscopic balloon dilation, and surgery. Various studies have ...

Last Updated: 19 Oct 2015

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Idiopathic (primary) achalasia: a review.
 

Author(s): Dhyanesh A Patel, Hannah P Kim, Jerry S Zifodya, Michael F Vaezi

Journal:

 

Idiopathic achalasia is a primary esophageal motor disorder characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter relaxation in response to deglutition. Patients with achalasia commonly complain of dysphagia to solids and liquids, bland regurgitation ...

Last Updated: 22 Jul 2015

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The Pathogenesis and Management of Achalasia: Current Status and Future Directions.
 

Author(s): Fehmi Ates, Michael F Vaezi

Journal: Gut Liver. 2015 Jul;9(4):449-63.

 

Achalasia is an esophageal motility disorder that is commonly misdiagnosed initially as gastroesophageal reflux disease. Patients with achalasia often complain of dysphagia with solids and liquids but may focus on regurgitation as the primary symptom, leading to initial misdiagnosis. ...

Last Updated: 19 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Achalasia: Mechanisms Underlying Treatment Failure
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 4 Feb 2014

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Sensorimotor Dysfunction in Achalasia
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 16 Dec 2015

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Hot Water Drinking Therapy in Achalasia
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 23 May 2013

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