Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 263 free, full-text research articles on human participants. First 3 results:

Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.
 

Author(s): Dominique Hervé, Anne Philippi, Reda Belbouab, Michel Zerah, Stéphane Chabrier, Sophie Collardeau-Frachon, Francoise Bergametti, Aurore Essongue, Eliane Berrou, Valérie Krivosic, Christian Sainte-Rose, Emmanuel Houdart, Frédéric Adam, Kareen Billiemaz, Marilyne Lebret, Sabine Roman, Sandrine Passemard, Gwenola Boulday, Audrey Delaforge, Stéphanie Guey, Xavier Dray, Hugues Chabriat, Peter Brouckaert, Maryjke Bryckaert, Elisabeth Tournier-Lasserve

Journal: Am. J. Hum. Genet.. 2014 Mar;94(3):385-94.

 

Moyamoya is a cerebrovascular condition characterized by a progressive stenosis of the terminal part of the internal carotid arteries (ICAs) and the compensatory development of abnormal "moyamoya" vessels. The pathophysiological mechanisms of this condition, which leads to ischemic ...

Last Updated: 10 Mar 2014

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Esophageal per oral endoscopic myotomy (POEM) for achalasia: first case reported in Eastern Europe.
 

Author(s): Marcel Tantau, Alina Tantau

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):461-3.

 

Traditional endoscopic treatment of achalasia consists of endoscopic balloon dilatation with the inconvenience of the recurrence of symptoms and the necessity of repeated sessions. Surgical laparoscopic procedure has been advocated to be more efficient especially in young patients ...

Last Updated: 26 Dec 2013

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Achalasia--balloon dilation or surgery?
 

Author(s): Renata Tabola, Krzysztof Grabowski, Andrzej Lewandowski, Katarzyna Augoff, Krystyna Markocka-Maczka

Journal:

 

The optimal therapeutic schedule in patients with achalasia is still under discussion. The aim of this study was to review our institution's experience with myotomy and dilation in patients with achalasia.

Last Updated: 3 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 35 free, full-text review articles on human participants. First 3 results:

Is Dor fundoplication optimum after laparoscopic Heller myotomy for achalasia? A meta-analysis.
 

Author(s): Ming-Tian Wei, Ya-Zhou He, Xiang-Bing Deng, Yuan-Chuan Zhang, Ting-Han Yang, Cheng-Wu Jin, Bing Hu, Zi-Qiang Wang

Journal: World J. Gastroenterol.. 2013 Nov;19(43):7804-12.

 

To compare the outcome of acid reflux prevention by Dor fundoplication after laparoscopic Heller myotomy (LHM) for achalasia.

Last Updated: 27 Nov 2013

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Achalasia: a review of clinical diagnosis, epidemiology, treatment and outcomes.
 

Author(s): Orla M O'Neill, Brian T Johnston, Helen G Coleman

Journal: World J. Gastroenterol.. 2013 Sep;19(35):5806-12.

 

Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function. Historically, annual achalasia incidence rates were believed to be low, approximately 0.5-1.2 per 100000. More recent ...

Last Updated: 14 Oct 2013

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Current status in the treatment options for esophageal achalasia.
 

Author(s): Seng-Kee Chuah, Chien-Hua Chiu, Wei-Chen Tai, Jyong-Hong Lee, Hung-I Lu, Chi-Sin Changchien, Ping-Huei Tseng, Keng-Liang Wu

Journal: World J. Gastroenterol.. 2013 Sep;19(33):5421-9.

 

Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy (POEM). The first multicenter randomized, controlled, 2-year follow-up study conducted by the European Achalasia ...

Last Updated: 11 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Achalasia: Mechanisms Underlying Treatment Failure
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 4 Feb 2014

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Hot Water Drinking Therapy in Achalasia
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 23 May 2013

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Efficacy of Dark Chocolate in Achalasia Patients
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 12 Nov 2008

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