Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 324 free, full-text research articles on human participants. First 3 results:

IMAGES IN CLINICAL MEDICINE. Achalasia with Megaesophagus.
 

Author(s): Chinemerem Okwara, David Cangemi

Journal: N. Engl. J. Med.. 2015 Dec;373(25):e30.

 

Last Updated: 17 Dec 2015

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Clinical Effect of Endoscopic Pneumatic Dilation for Achalasia.
 

Author(s): Peng Cheng, Hai Shi, Yanjie Zhang, Huabang Zhou, Jinhua Dong, Yiting Cai, Xing Hu, Qiang Dai, Wenyan Yang

Journal: Medicine (Baltimore). 2015 Jul;94(28):e1193.

 

Although pneumatic dilation is an accepted method for the treatment of achalasia, this therapy has high recurrence and complication rates, and prolonged follow-up studies on the parameters associated with various outcomes are rare. In this prospective 10-year follow-up study, a satisfactory ...

Last Updated: 18 Jul 2015

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Self-medication of achalasia with cannabis, complicated by a cannabis use disorder.
 

Author(s): Amandine Luquiens, Nelson Lourenco, Amine Benyamina, Henri-Jean Aubin

Journal: World J. Gastroenterol.. 2015 May;21(20):6381-3.

 

Achalasia is a rare esophagus motility disorder. Medical, endoscopic and surgical treatments are available, but all endorse high relapse rates. No data has been published to date reporting a therapeutic effect of cannabis use neither in achalasia nor on its influence on manometric ...

Last Updated: 2 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 46 free, full-text review articles on human participants. First 3 results:

Perspective on peroral endoscopic myotomy for achalasia: Zhongshan experience.
 

Author(s): Quan Lin Li, Ping Hong Zhou

Journal: Gut Liver. 2015 Mar;9(2):152-8.

 

Worldwide, peroral endoscopic myotomy (POEM) has achieved remarkable initial outcomes in the treatment of achalasia. In China, POEM has developed very quickly since the first case was performed in our center in August 2010. With ex-perience, we have successfully performed POEM for ...

Last Updated: 27 Feb 2015

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Per-oral endoscopic myotomy: major advance in achalasia treatment and in endoscopic surgery.
 

Author(s): David Friedel, Rani Modayil, Stavros N Stavropoulos

Journal: World J. Gastroenterol.. 2014 Dec;20(47):17746-55.

 

Per-oral endoscopic myotomy (POEM) represents a natural orifice endoscopic surgery (NOTES) approach to laparoscopy Heller myotomy (LHM). POEM is arguably the most successful clinical application of NOTES. The growth of POEM from a single center in 2008 to approximately 60 centers ...

Last Updated: 30 Dec 2014

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Family case of achalasia cardia: case report and review of literature.
 

Author(s): Yulia Viktorovna Evsyutina, Alexander Sergeevich Trukhmanov, Vladimir Trophimovich Ivashkin

Journal: World J. Gastroenterol.. 2014 Jan;20(4):1114-8.

 

Achalasia cardia is an idiopathic disease that occurs as a result of inflammation and degeneration of myenteric plexi leading to the loss of postganglionic inhibitory neurons required for relaxation of the lower esophageal sphincter and peristalsis of the esophagus. The main symptoms ...

Last Updated: 27 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Achalasia: Mechanisms Underlying Treatment Failure
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 4 Feb 2014

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Sensorimotor Dysfunction in Achalasia
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 16 Dec 2015

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Hot Water Drinking Therapy in Achalasia
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 23 May 2013

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