Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 382 free, full-text research articles on human participants. First 3 results:

"Stray" achalasia: From gastroenterologist to pulmonologist and back.
 

Author(s): Dusanka Obradović, Biljana Joves Sević, Milos Stojanović, Miroslav Ilić, Igor Ivanov

Journal: Srp Arh Celok Lek. ;144(1-2):85-9.

 

Achalasia is a rare esophageal disorder which, due to frequent presence of both respiratory and gastrointestinal symptoms, can initially be referred either to pulmonologist or gastroenterologist.

Last Updated: 9 Jun 2016

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[Efficacy and safety of peroral endoscopic myotomy in the treatment of achalasia cardia].
 

Author(s): Yunxiang Yuan, Anliu Tang, Shourong Shen, Xiangqi Liao, Xiaoyan Wang

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Feb;41(2):158-62.

 

To evaluate the efficacy and safety of peroral endoscopic myotomy (POEM) for achalasia cardia (AC).


Last Updated: 2 Mar 2016

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Per-Oral Endoscopic Myotomy Versus Laparoscopic Heller Myotomy for Achalasia: A Meta-Analysis of Nonrandomized Comparative Studies.
 

Author(s): Yuan Zhang, Hongjuan Wang, Xingdong Chen, Lan Liu, Hongbo Wang, Bin Liu, Jianqiang Guo, Hongying Jia

Journal: Medicine (Baltimore). 2016 Feb;95(6):e2736.

 

We aimed to assess the short-term outcomes of per-oral endoscopic myotomy (POEM) compared with laparoscopic Heller myotomy (LHM) for achalasia through a meta-analysis of nonrandomized comparative studies.We searched PubMed, Embase, Medline, Cochrane Library, and Google Scholar for ...

Last Updated: 13 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 54 free, full-text review articles on human participants. First 3 results:

Surgery or Peroral Esophageal Myotomy for Achalasia: A Systematic Review and Meta-Analysis.
 

Author(s): Luigi Marano, Giovanni Pallabazzer, Biagio Solito, Stefano Santi, Alessio Pigazzi, Raffaele De Luca, Francesco Giuseppe Biondo, Alessandro Spaziani, Maurizio Longaroni, Natale Di Martino, Virginia Boccardi, Alberto Patriti

Journal: Medicine (Baltimore). 2016 Mar;95(10):e3001.

 

To date very few studies with small sample size have compared peroral esophageal myotomy (POEM) with the current surgical standard of care, laparoscopic Heller myotomy (LHM), in terms of efficacy and safety, and no recommendations have been proposed.To investigate the efficacy and ...

Last Updated: 11 Mar 2016

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Data analyses and perspectives on laparoscopic surgery for esophageal achalasia.
 

Author(s): Kazuto Tsuboi, Nobuo Omura, Fumiaki Yano, Masato Hoshino, Se-Ryung Yamamoto, Shunsuke Akimoto, Takahiro Masuda, Hideyuki Kashiwagi, Katsuhiko Yanaga

Journal: World J. Gastroenterol.. 2015 Oct;21(38):10830-9.

 

In general, the treatment methods for esophageal achalasia are largely classified into four groups, including drug therapy using nitrite or a calcium channel blocker, botulinum toxin injection, endoscopic therapy such as endoscopic balloon dilation, and surgery. Various studies have ...

Last Updated: 19 Oct 2015

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Idiopathic (primary) achalasia: a review.
 

Author(s): Dhyanesh A Patel, Hannah P Kim, Jerry S Zifodya, Michael F Vaezi

Journal:

 

Idiopathic achalasia is a primary esophageal motor disorder characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter relaxation in response to deglutition. Patients with achalasia commonly complain of dysphagia to solids and liquids, bland regurgitation ...

Last Updated: 22 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sensorimotor Dysfunction in Achalasia
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 12 Sep 2016

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Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Registry
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 1 Jun 2015

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Last Updated: 18 Oct 2016

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