Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 374 free, full-text research articles on human participants. First 3 results:

Peroral endoscopic myotomy for treatment of Guillain-Barre syndrome-associated achalasia: A rare case.
 

Author(s): Seung Kak Shin, Kyoung Oh Kim, Eui Joo Kim, Su Young Kim, Jung Ho Kim, Yoon Jae Kim, Jun-Won Chung, Kwang An Kwon, Dong Kyun Park

Journal: World J. Gastroenterol.. 2017 Feb;23(5):926-930.

 

Guillain-Barre syndrome (GBS)-associated achalasia is a very rare disease of uncertain cause. We report the case of a patient diagnosed with GBS-associated type I achalasia who was successfully treated with peroral endoscopic myotomy (POEM). A 30-year-old man who was diagnosed with ...

Last Updated: 22 Feb 2017

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Incidence, clinical features and para-clinical findings of achalasia in Algeria: Experience of 25 years.
 

Author(s): Amar Tebaibia, Mohammed Amine Boudjella, Djamel Boutarene, Farouk Benmediouni, Hakim Brahimi, Nadia Oumnia

Journal: World J. Gastroenterol.. 2016 Oct;22(38):8615-8623.

 

To investigate the incidence of achalasia in Algeria and to determine its clinical and para-clinical profile. To evaluate the impact of continuing medical education (CME) on the incidence of this disease.

Last Updated: 27 Oct 2016

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Infantile Achalasia Cardia.
 

Author(s): Rupa Banerjee, Alpana Prasad, Vivek Kumar, Nishant Wadhwa

Journal: Indian Pediatr. 2016 Sep;53(9):831-832.

 

Achalasia is extremely rare in infants.

Last Updated: 23 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 52 free, full-text review articles on human participants. First 3 results:

Laparoscopic Heller myotomy is not superior to pneumatic dilation in the management of primary achalasia: Conclusions of a systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Ji-Wei Cheng, Yin Li, Wen-Qun Xing, Hong-Wei Lv, Hao-Ran Wang

Journal: Medicine (Baltimore). 2017 Feb;96(7):e5525.

 

Achalasia is an esophageal motility disorder, of unknown cause, which results in increased lower esophageal sphincter tone and symptoms of difficulty swallowing. Current major therapeutic options include laparoscopic Heller myotomy (LHM) and pneumatic dilation (PD). We undertake a ...

Last Updated: 16 Feb 2017

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Incidence of Esophageal Carcinomas After Surgery for Achalasia: Usefulness of Long-Term and Periodic Follow-up.
 

Author(s): Masaho Ota, Kosuke Narumiya, Kenji Kudo, Yohsuke Yagawa, Shinsuke Maeda, Harushi Osugi, Masakazu Yamamoto

Journal:

 

BACKGROUND Patients with esophageal achalasia are considered to be a high-risk group for esophageal carcinoma, and it has been reported that this cancer often arises at a long interval after surgery for achalasia. However, it is unclear whether esophageal carcinoma is frequent when ...

Last Updated: 14 Nov 2016

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Update on the endoscopic treatments for achalasia.
 

Author(s): Dushant S Uppal, Andrew Y Wang

Journal: World J. Gastroenterol.. 2016 Oct;22(39):8670-8683.

 

Achalasia is the most common primary motility disorder of the esophagus and presents as dysphagia to solids and liquids. It is characterized by impaired deglutitive relaxation of the lower esophageal sphincter. High-resolution manometry allows for definitive diagnosis and classification ...

Last Updated: 7 Nov 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sensorimotor Dysfunction in Achalasia
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 12 Sep 2016

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Randomized Clinical Trial Comparing Short Versus Long Oesophageal Myotomy in POEM for Achalasia Cardia.
 

Status: Not yet recruiting

Condition Summary: Achalasia Cardia

 

Last Updated: 12 Jun 2017

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Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Registry
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 16 Feb 2017

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