Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 267 free, full-text research articles on human participants. First 3 results:

Laparoscopic treatment in achalasia of the cardia.
 

Author(s): B Ursut, L Alecu, A Tulin, O Enciu

Journal: Chirurgia (Bucur). ;109(5):604-7.

 

Achalasia, although a rare disease (an incidence of 1 100 000 individuals each year) is one of the common causes of motor dysphagia and is characterized by loss of peristalsis in the esophageal body and lack of relaxation of the lower esophageal sphincter.

Last Updated: 7 Nov 2014

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Gastroplasty for esophageal perforation after endoscopic balloon dilatation for achalasia: two cases.
 

Author(s): Hyunjo Kim

Journal: J. Korean Med. Sci.. 2014 May;29(5):739-42.

 

Esophageal perforation after endoscopic forceful pneumatic dilatation for achalasia is a devastating complication and surgical treatment is necessary. A 65-yr-old man and a 54-yr-old woman referred for esophageal perforation two hours after pneumatic dilatation and during the procedure, ...

Last Updated: 22 May 2014

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Achalasia in Korea: an epidemiologic study using a national healthcare database.
 

Author(s): Eunkyung Kim, Hongsub Lee, Hye-Kyung Jung, Kwang Jae Lee

Journal: J. Korean Med. Sci.. 2014 Apr;29(4):576-80.

 

Owing to the rarity of the disease, epidemiologic information on achalasia is limited. This study aimed to investigate the epidemiology and treatment patterns of achalasia in the population of Korea using a national healthcare database. The diagnostic code K22.0 of the International ...

Last Updated: 22 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 40 free, full-text review articles on human participants. First 3 results:

Family case of achalasia cardia: case report and review of literature.
 

Author(s): Yulia Viktorovna Evsyutina, Alexander Sergeevich Trukhmanov, Vladimir Trophimovich Ivashkin

Journal: World J. Gastroenterol.. 2014 Jan;20(4):1114-8.

 

Achalasia cardia is an idiopathic disease that occurs as a result of inflammation and degeneration of myenteric plexi leading to the loss of postganglionic inhibitory neurons required for relaxation of the lower esophageal sphincter and peristalsis of the esophagus. The main symptoms ...

Last Updated: 27 Feb 2014

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Is Dor fundoplication optimum after laparoscopic Heller myotomy for achalasia? A meta-analysis.
 

Author(s): Ming-Tian Wei, Ya-Zhou He, Xiang-Bing Deng, Yuan-Chuan Zhang, Ting-Han Yang, Cheng-Wu Jin, Bing Hu, Zi-Qiang Wang

Journal: World J. Gastroenterol.. 2013 Nov;19(43):7804-12.

 

To compare the outcome of acid reflux prevention by Dor fundoplication after laparoscopic Heller myotomy (LHM) for achalasia.

Last Updated: 27 Nov 2013

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Achalasia: a review of clinical diagnosis, epidemiology, treatment and outcomes.
 

Author(s): Orla M O'Neill, Brian T Johnston, Helen G Coleman

Journal: World J. Gastroenterol.. 2013 Sep;19(35):5806-12.

 

Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function. Historically, annual achalasia incidence rates were believed to be low, approximately 0.5-1.2 per 100000. More recent ...

Last Updated: 14 Oct 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Achalasia: Mechanisms Underlying Treatment Failure
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 4 Feb 2014

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Hot Water Drinking Therapy in Achalasia
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 23 May 2013

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Efficacy of Dark Chocolate in Achalasia Patients
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 12 Nov 2008

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