Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 261 free, full-text research articles on human participants. First 3 results:

Esophageal per oral endoscopic myotomy (POEM) for achalasia: first case reported in Eastern Europe.
 

Author(s): Marcel Tantau, Alina Tantau

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):461-3.

 

Traditional endoscopic treatment of achalasia consists of endoscopic balloon dilatation with the inconvenience of the recurrence of symptoms and the necessity of repeated sessions. Surgical laparoscopic procedure has been advocated to be more efficient especially in young patients ...

Last Updated: 26 Dec 2013

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Laparoscopic treatment for esophageal achalasia: experience at a single center.
 

Author(s): A Agrusa, G Romano, S Bonventre, G Salamone, G Cocorullo, G Gulotta

Journal: G Chir. ;34(7-8):220-3.

 

Achalasia is a not frequent esophageal disorder characterized by the absence of esophageal peristalsis and incomplete relaxation of the lower esophageal sphincter (LES). Its cause is unknown. The aim of treatment is to improve the symptoms. We report the results of the treatment of ...

Last Updated: 4 Oct 2013

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Cricopharyngeal achalasia in children: surgical and medical treatment.
 

Author(s): Michael Drendel, Eldar Carmel, Panayiotis Kerimis, Michael Wolf, Yehuda Finkelstein

Journal: Isr. Med. Assoc. J.. 2013 Aug;15(8):430-3.

 

Cricopharyngeal achalasia (CA) is a rare cause of dysphagia in children presenting with non-specific symptoms such as choking, food regurgitation, nasal reflux, coughing, recurrent pneumonia, cyanosis, and failure to thrive. It results from failure of relaxation of the upper esophageal ...

Last Updated: 1 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 35 free, full-text review articles on human participants. First 3 results:

Is Dor fundoplication optimum after laparoscopic Heller myotomy for achalasia? A meta-analysis.
 

Author(s): Ming-Tian Wei, Ya-Zhou He, Xiang-Bing Deng, Yuan-Chuan Zhang, Ting-Han Yang, Cheng-Wu Jin, Bing Hu, Zi-Qiang Wang

Journal: World J. Gastroenterol.. 2013 Nov;19(43):7804-12.

 

To compare the outcome of acid reflux prevention by Dor fundoplication after laparoscopic Heller myotomy (LHM) for achalasia.

Last Updated: 27 Nov 2013

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Achalasia: a review of clinical diagnosis, epidemiology, treatment and outcomes.
 

Author(s): Orla M O'Neill, Brian T Johnston, Helen G Coleman

Journal: World J. Gastroenterol.. 2013 Sep;19(35):5806-12.

 

Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function. Historically, annual achalasia incidence rates were believed to be low, approximately 0.5-1.2 per 100000. More recent ...

Last Updated: 14 Oct 2013

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Current status in the treatment options for esophageal achalasia.
 

Author(s): Seng-Kee Chuah, Chien-Hua Chiu, Wei-Chen Tai, Jyong-Hong Lee, Hung-I Lu, Chi-Sin Changchien, Ping-Huei Tseng, Keng-Liang Wu

Journal: World J. Gastroenterol.. 2013 Sep;19(33):5421-9.

 

Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy (POEM). The first multicenter randomized, controlled, 2-year follow-up study conducted by the European Achalasia ...

Last Updated: 11 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endoscopic Esophageal Myotomy for the Treatment of Achalasia
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 25 Jul 2011

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Achalasia: Mechanisms Underlying Treatment Failure
 

Status: Not yet recruiting

Condition Summary: Achalasia

 

Last Updated: 4 Feb 2014

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Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 12 Apr 2012

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