Brugada Syndrome

Common Name(s)

Brugada Syndrome

Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm (arrhythmia). Signs and symptoms usually develop in adulthood and include ventricular arrhythmia that can cause fainting, seizures, difficulty breathing, or sudden death. These complications often occur when an affected person is resting or asleep. Brugada syndrome is inherited in an autosomal dominant manner and may be caused by a mutation in any of several genes (most commonly the SCN5A gene). In many cases, the genetic cause is not identified. There have also been reports of acquired Brugada syndrome which have been associated with adverse reactions to certain drugs or other substances. Treatment may include use of an implantable cardioverter defibrillator (ICD) in people with a history of fainting or heart attack.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

Last Updated: 23 Apr 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

http://www.StopSADS.org

Last Updated: 23 Apr 2015

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General Support Organizations

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General Resources

SADS Foundation Website

Information on living with SADS, diagnosis, treatment, prevention, and advocacy/education.

Updated 29 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brugada Syndrome" returned 349 free, full-text research articles on human participants. First 3 results:

Prevalence and Clinical Impact of Early Repolarization Pattern and QRS-Fragmentation in High-Risk Patients With Brugada Syndrome.
 

Author(s): Giulio Conte, Carlo de Asmundis, Juan Sieira, Giuseppe Ciconte, Giacomo Di Giovanni, Gian-Battista Chierchia, Ruben Casado-Arroyo, Giannis Baltogiannis, Erwin Ströker, Ghazala Irfan, Gudrun Pappaert, Angelo Auricchio, Pedro Brugada

Journal: Circ. J.. 2016 Sep;80(10):2109-16.

 

The phenotypic heterogeneity of Brugada syndrome (BrS) can lead some patients to show an additional inferolateral early repolarization pattern (ERP), or fragmented QRS (f-QRS). The aim of the study was to investigate the prevalence and clinical impact of f-QRS, ERP or combined f-QRS/ERP ...

Last Updated: 26 Sep 2016

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Activation Pattern of the Polymorphic Ventricular Tachycardia and Ventricular Fibrillation on Body Surface Mapping in Patients With Brugada Syndrome.
 

Author(s): Akira Ueoka, Hiroshi Morita, Atsuyuki Watanabe, Koji Nakagawa, Nobuhiro Nishii, Satoshi Nagase, Tohru Ohe, Hiroshi Ito

Journal: Circ. J.. 2016 Jul;80(8):1734-43.

 

Clinical and experimental studies have shown the existence of an arrhythmogenic substrate in the right ventricular outflow tract (RVOT) in patients with Brugada syndrome (BrS). To evaluate the importance of the RVOT, we evaluated the activation pattern of induced ventricular tachyarrhythmias ...

Last Updated: 25 Jul 2016

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Next Generation Sequencing and Linkage Analysis for the Molecular Diagnosis of a Novel Overlapping Syndrome Characterized by Hypertrophic Cardiomyopathy and Typical Electrical Instability of Brugada Syndrome.
 

Author(s): Ruggiero Mango, Andrea Luchetti, Raffaele Sangiuolo, Valentina Ferradini, Nicola Briglia, Emiliano Giardina, Fabrizio Ferrè, Manuela Helmer Citterich, Francesco Romeo, Giuseppe Novelli, Federica Sangiuolo

Journal: Circ. J.. 2016 ;80(4):938-49.

 

Familial hypertrophic cardiomyopathy (HCM) is an autosomal dominant inherited disorder; mutations in at least 20 genes have been associated. Brugada syndrome (BrS) is an autosomal dominant inherited disorder caused by mutations mainly in theSCN5Agene. A new clinical entity that consists ...

Last Updated: 29 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brugada Syndrome" returned 49 free, full-text review articles on human participants. First 3 results:

Risk factors for cardiac events in patients with Brugada syndrome: A PRISMA-compliant meta-analysis and systematic review.
 

Author(s): Wenqing Wu, Li Tian, Jinshan Ke, Yi Sun, Ruixia Wu, Jianfang Zhu, Qinmei Ke

Journal: Medicine (Baltimore). 2016 Jul;95(30):e4214.

 

Inconsistent results have been reported about the risk stratification of patients with Brugada syndrome. We have summarized the evidence regarding the strength of association between 6 risk factors (family history of sudden cardiac death [SCD] or syncope, inducible ventricular arrhythmias ...

Last Updated: 30 Jul 2016

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Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis.
 

Author(s): Jakub Sroubek, Vincent Probst, Andrea Mazzanti, Pietro Delise, Jesus Castro Hevia, Kimie Ohkubo, Alessandro Zorzi, Jean Champagne, Anna Kostopoulou, Xiaoyan Yin, Carlo Napolitano, David J Milan, Arthur Wilde, Frederic Sacher, Martin Borggrefe, Patrick T Ellinor, George Theodorakis, Isabelle Nault, Domenico Corrado, Ichiro Watanabe, Charles Antzelevitch, Giuseppe Allocca, Silvia G Priori, Steven A Lubitz

Journal: Circulation. 2016 Feb;133(7):622-30.

 

The role of programmed ventricular stimulation in identifying patients with Brugada syndrome at the highest risk for sudden death is uncertain.

Last Updated: 17 Feb 2016

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A Tale of 2 Diseases: The History of Long-QT Syndrome and Brugada Syndrome.
 

Author(s): Ofer Havakuk, Sami Viskin

Journal: J. Am. Coll. Cardiol.. 2016 Jan;67(1):100-8.

 

The Brugada syndrome (BrS) and long-QT syndrome (LQTS) present as congenital or acquired disorders with diagnostic electrocardiograms (ST-segment elevation and prolonged QT interval, respectively) and increased risk for malignant arrhythmias. Our understanding of the 2 disease forms ...

Last Updated: 14 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ablation in Brugada Syndrome for the Prevention of VF
 

Status: Not yet recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 26 Sep 2016

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Diagnostic Value and Safety of Flecainide Infusion Test in Brugada Syndrome
 

Status: Recruiting

Condition Summary: Brugada Syndrome; Arrhythmogenic Right Ventricular Cardiomyopathy

 

Last Updated: 21 Sep 2016

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Empiric Quinidine for Asymptomatic Brugada Syndrome
 

Status: Recruiting

Condition Summary: Arrhythmia

 

Last Updated: 8 Jan 2017

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