Brugada Syndrome

Common Name(s)

Brugada Syndrome

Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm (arrhythmia). Signs and symptoms usually develop in adulthood and include ventricular arrhythmia that can cause fainting, seizures, difficulty breathing, or sudden death. These complications often occur when an affected person is resting or asleep. Brugada syndrome is inherited in an autosomal dominant manner and may be caused by a mutation in any of several genes (most commonly the SCN5A gene). In many cases, the genetic cause is not identified. There have also been reports of acquired Brugada syndrome which have been associated with adverse reactions to certain drugs or other substances. Treatment may include use of an implantable cardioverter defibrillator (ICD) in people with a history of fainting or heart attack.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

Last Updated: 23 Apr 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

http://www.StopSADS.org

Last Updated: 23 Apr 2015

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General Support Organizations

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General Resources

SADS Foundation Website

Information on living with SADS, diagnosis, treatment, prevention, and advocacy/education.

Updated 29 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brugada Syndrome" returned 432 free, full-text research articles on human participants. First 3 results:

Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome.
 

Author(s): Alfonso Bueno-Orovio, Elizabeth M Cherry, Steven J Evans, Flavio H Fenton

Journal: Biomed Res Int. 2015 ;2015():197586.

 

Human action potentials in the Brugada syndrome have been characterized by delayed or even complete loss of dome formation, especially in the right ventricular epicardial layers. Such a repolarization pattern is believed to trigger phase-2 reentry (P2R); however, little is known about ...

Last Updated: 20 Nov 2015

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Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome.
 

Author(s): Koonlawee Nademanee, Hariharan Raju, Sofia V de Noronha, Michael Papadakis, Laurence Robinson, Stephen Rothery, Naomasa Makita, Shinya Kowase, Nakorn Boonmee, Vorapot Vitayakritsirikul, Samrerng Ratanarapee, Sanjay Sharma, Allard C van der Wal, Michael Christiansen, Hanno L Tan, Arthur A Wilde, Akihiko Nogami, Mary N Sheppard, Gumpanart Veerakul, Elijah R Behr

Journal: J. Am. Coll. Cardiol.. 2015 Nov;66(18):1976-86.

 

The right ventricular outflow tract (RVOT) is acknowledged to be responsible for arrhythmogenesis in Brugada syndrome (BrS), but the pathophysiology remains controversial.

Last Updated: 30 Oct 2015

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Incidence and Clinical Significance of Brugada Syndrome Masked by Complete Right Bundle-Branch Block.
 

Author(s): Tadashi Wada, Satoshi Nagase, Hiroshi Morita, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Ito, Kengo F Kusano, Tohru Ohe

Journal: Circ. J.. 2015 ;79(12):2568-75.

 

Brugada syndrome (BrS)-type electrocardiogram (ECG) is concealed by complete right bundle-branch block (CRBBB) in some cases of BrS. Clinical significance of BrS masked by CRBBB is not well known.

Last Updated: 26 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brugada Syndrome" returned 51 free, full-text review articles on human participants. First 3 results:

Update on the Diagnosis and Management of Brugada Syndrome.
 

Author(s): Jitendra Vohra, Sulekha Rajagopalan,

Journal: Heart Lung Circ. 2015 Dec;24(12):1141-8.

 

Brugada Syndrome (BrS) is an autosomal dominant channelopathy with variable penetrance affecting the sodium channel. It reduces the transport of sodium ions essential for proper generation of the cardiac action potential. The resulting inhomogeneous repolarisation in areas of the ...

Last Updated: 21 Nov 2015

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Brugada syndrome and its relevance in the perioperative period.
 

Author(s): Dan Sorajja, Harish Ramakrishna, A Karl Poterack, Win-Kuang Shen, Farouk Mookadam

Journal: Ann Card Anaesth. ;18(3):403-13.

 

Brugada syndrome is an autosomal dominant genetic disorder associated with an increased risk of sudden cardiac death, as well as ventricular tachyarrhythmias.The defective cardiac sodium channels result in usual electrocardiographic findings of a coved-type ST elevation in precordial ...

Last Updated: 3 Jul 2015

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Brugada syndrome, exercise, and exercise testing.
 

Author(s): Shihab Masrur, Sarfaraz Memon, Paul D Thompson

Journal: Clin Cardiol. 2015 May;38(5):323-6.

 

There are few data on the risk of exercise and the role of exercise stress testing in Brugada syndrome. We sought to address this deficiency using a systematic literature review. We identified 98 English-language articles possibly addressing exercise in Brugada syndrome by searching ...

Last Updated: 20 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnostic Value and Safety of Flecainide Infusion Test in Brugada Syndrome
 

Status: Recruiting

Condition Summary: Brugada Syndrome; Arrhythmogenic Right Ventricular Cardiomyopathy

 

Last Updated: 21 Sep 2016

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DAPERB 3,4-DiAminoPyridine and Electrophysiological Response in Brugada Syndrome
 

Status: Not yet recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 1 Jul 2008

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Brugada Syndrome: A New Treatment Approach Driven by Clinical Experience
 

Status: Recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 14 Jul 2016

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