Brugada Syndrome

Common Name(s)

Brugada Syndrome

Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm (arrhythmia). Signs and symptoms usually develop in adulthood and include ventricular arrhythmia that can cause fainting, seizures, difficulty breathing, or sudden death. These complications often occur when an affected person is resting or asleep. Brugada syndrome is inherited in an autosomal dominant manner and may be caused by a mutation in any of several genes (most commonly the SCN5A gene). In many cases, the genetic cause is not identified. There have also been reports of acquired Brugada syndrome which have been associated with adverse reactions to certain drugs or other substances. Treatment may include use of an implantable cardioverter defibrillator (ICD) in people with a history of fainting or heart attack.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

Last Updated: 23 Apr 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

http://www.StopSADS.org

Last Updated: 23 Apr 2015

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General Support Organizations

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General Resources

SADS Foundation Website

Information on living with SADS, diagnosis, treatment, prevention, and advocacy/education.

Updated 29 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brugada Syndrome" returned 416 free, full-text research articles on human participants. First 3 results:

Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome.
 

Author(s): Koonlawee Nademanee, Hariharan Raju, Sofia V de Noronha, Michael Papadakis, Laurence Robinson, Stephen Rothery, Naomasa Makita, Shinya Kowase, Nakorn Boonmee, Vorapot Vitayakritsirikul, Samrerng Ratanarapee, Sanjay Sharma, Allard C van der Wal, Michael Christiansen, Hanno L Tan, Arthur A Wilde, Akihiko Nogami, Mary N Sheppard, Gumpanart Veerakul, Elijah R Behr

Journal: J. Am. Coll. Cardiol.. 2015 Nov;66(18):1976-86.

 

The right ventricular outflow tract (RVOT) is acknowledged to be responsible for arrhythmogenesis in Brugada syndrome (BrS), but the pathophysiology remains controversial.

Last Updated: 30 Oct 2015

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Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate.
 

Author(s): David Calvo, Felipe Atienza, Javier Saiz, Laura Martínez, Pablo Ávila, José Rubín, Benito Herreros, Ángel Arenal, Javier García-Fernández, Ana Ferrer, Rafael Sebastián, Pablo Martínez-Camblor, José Jalife, Omer Berenfeld

Journal: Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1133-43.

 

Ventricular fibrillation (VF) has been proposed to be maintained by localized high-frequency sources. We tested whether spectral-phase analysis of the precordial ECG enabled identification of periodic activation patterns generated by such sources.

Last Updated: 21 Oct 2015

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Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome.
 

Author(s): Catarina Allegue, Mònica Coll, Jesus Mates, Oscar Campuzano, Anna Iglesias, Beatriz Sobrino, Maria Brion, Jorge Amigo, Angel Carracedo, Pedro Brugada, Josep Brugada, Ramon Brugada

Journal:

 

The use of next-generation sequencing enables a rapid analysis of many genes associated with sudden cardiac death in diseases like Brugada Syndrome. Genetic variation is identified and associated with 30-35% of cases of Brugada Syndrome, with nearly 20-25% attributable to variants ...

Last Updated: 3 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brugada Syndrome" returned 49 free, full-text review articles on human participants. First 3 results:

Brugada syndrome and its relevance in the perioperative period.
 

Author(s): Dan Sorajja, Harish Ramakrishna, A Karl Poterack, Win-Kuang Shen, Farouk Mookadam

Journal: Ann Card Anaesth. ;18(3):403-13.

 

Brugada syndrome is an autosomal dominant genetic disorder associated with an increased risk of sudden cardiac death, as well as ventricular tachyarrhythmias.The defective cardiac sodium channels result in usual electrocardiographic findings of a coved-type ST elevation in precordial ...

Last Updated: 3 Jul 2015

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Brugada syndrome, exercise, and exercise testing.
 

Author(s): Shihab Masrur, Sarfaraz Memon, Paul D Thompson

Journal: Clin Cardiol. 2015 May;38(5):323-6.

 

There are few data on the risk of exercise and the role of exercise stress testing in Brugada syndrome. We sought to address this deficiency using a systematic literature review. We identified 98 English-language articles possibly addressing exercise in Brugada syndrome by searching ...

Last Updated: 20 May 2015

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Brugada syndrome.
 

Author(s): Ramon Brugada, Oscar Campuzano, Georgia Sarquella-Brugada, Josep Brugada, Pedro Brugada

Journal: Methodist Debakey Cardiovasc J. ;10(1):25-8.

 

Brugada syndrome is a rare cardiac arrhythmia characterized by electrocardiographic right bundle branch block and persistent ST-segment elevation in the right precordial leads. It is associated with ventricular fibrillation and a high risk for sudden cardiac death, predominantly in ...

Last Updated: 16 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnostic Value and Safety of Flecainide Infusion Test in Brugada Syndrome
 

Status: Recruiting

Condition Summary: Brugada Syndrome; Arrhythmogenic Right Ventricular Cardiomyopathy

 

Last Updated: 8 Mar 2016

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DAPERB 3,4-DiAminoPyridine and Electrophysiological Response in Brugada Syndrome
 

Status: Not yet recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 1 Jul 2008

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Brugada Syndrome: A New Treatment Approach Driven by Clinical Experience
 

Status: Recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 28 Dec 2015

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