Brown Syndrome

Common Name(s)

Brown Syndrome

Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. Specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. The condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. Some cases are constant while other are intermittent. Treatment depends upon the cause and severity of the movement disorder. Options include close observation, nonsteroidal anti-inflammatory agents like Ibuprofen, corticosteroids, and surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brown Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brown Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brown Syndrome" returned 72 free, full-text research articles on human participants. First 3 results:

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
 

Author(s): Matthew Van De Pette, Simon J Tunster, Grainne I McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M John

Journal:

 

The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for many years due to the myriad of genetic and epigenetic alterations reported in these patients and the lack of suitable animal ...

Last Updated: 11 Mar 2016

Go To URL
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.
 

Author(s): Xiaoxue Yuan, Tao Hu, Han Zhao, Yuanyuan Huang, Rongcai Ye, Jun Lin, Chuanhai Zhang, Hanlin Zhang, Gang Wei, Huiqiao Zhou, Meng Dong, Jun Zhao, Haibin Wang, Qingsong Liu, Hyuek Jong Lee, Wanzhu Jin, Zi-Jiang Chen

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2016 Mar;113(10):2708-13.

 

Polycystic ovary syndrome (PCOS), which is characterized by anovulation, hyperandrogenism, and polycystic ovaries, is a complex endocrinopathy. Because the cause of PCOS at the molecular level is largely unknown, there is no cure or specific treatment for PCOS. Here, we show that ...

Last Updated: 9 Mar 2016

Go To URL
Jejunitis and brown bowel syndrome with multifocal carcinogenesis of the small bowel.
 

Author(s): Martin Raithel, Tilman T Rau, Alexander F Hagel, Heinz Albrecht, Thomas de Rossi, Thomas Kirchner, Eckhart G Hahn

Journal: World J. Gastroenterol.. 2015 Sep;21(36):10461-7.

 

This is the first report describing a case where prolonged, severe malabsorption from brown bowel syndrome progressed to multifocally spread small bowel adenocarcinoma. This case involves a female patient who was initially diagnosed with chronic jejunitis associated with primary diffuse ...

Last Updated: 30 Sep 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brown Syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

Brown bowel syndrome: a rare complication in diseases associated with long-standing malabsorption.
 

Author(s): Heinz Albrecht, Alexander Hagel, Thomas de Rossi, Tilman T Rau, Thomas Kirchner, Markus F Neurath, Martin Raithel

Journal: Digestion. 2014 ;89(2):105-9.

 

Longtime chronic malabsorption may among other things cause a lack of liposoluble vitamins. Vitamin E deficiency can lead to formation of lipofuscin aggregates. Its deficiency is also associated with an increased lipofuscinosis of the bowel, i.e. brown bowel syndrome.

Last Updated: 28 Mar 2014

Go To URL
Brown bowel syndrome (intestinal lipofuscinosis) - a case report and review of the literature.
 

Author(s): Magdalena Białas, Sergiusz Demczuk, Grzegorz Dyduch, Grażyna Drabik, Małgorzata Chrupek, Krzysztof Okoń

Journal: Pol J Pathol. 2013 Oct;64(3):228-31.

 

Brown bowel syndrome (BBS) is a very rare condition occurring in association with malabsorption syndromes. It is characterised by deposition of granular, brown pigment (lipofuscin or ceroid) in intestinal smooth muscles. Rarely BBS can be complicated by distention of any segment of ...

Last Updated: 29 Oct 2013

Go To URL
The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited: natural history, genetics, treatment and future perspectives.
 

Author(s): Annet M Bosch, Kevin Stroek, Nico G Abeling, Hans R Waterham, Lodewijk Ijlst, Ronald J A Wanders

Journal:

 

The Brown-Vialetto-Van Laere syndrome is a rare neurological disorder which may present at all ages with sensorineural deafness, bulbar palsy and respiratory compromise. Fazio-Londe syndrome is considered to be the same disease entity. Recently it was demonstrated that in some patients ...

Last Updated: 11 Dec 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Brown Fat Activation Study
 

Status: Not yet recruiting

Condition Summary: Obese; Metabolic Syndrome

 

Last Updated: 27 Sep 2016

Go to URL
Activating Brown Adipose Tissue Through Exercise
 

Status: Recruiting

Condition Summary: Obesity; Diabetes Mellitus; Metabolic Syndrome X

 

Last Updated: 10 Feb 2015

Go to URL