Brown Syndrome

Common Name(s)

Brown Syndrome

Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. Specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. The condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. Some cases are constant while other are intermittent. Treatment depends upon the cause and severity of the movement disorder. Options include close observation, nonsteroidal anti-inflammatory agents like Ibuprofen, corticosteroids, and surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brown Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brown Syndrome" returned 76 free, full-text research articles on human participants. First 3 results:

Lateral medullary infarction with similar features of Brown Sequard syndrome caused by vertebrobasilar dysplasia and Klippel-Feil syndrome: A case report.
 

Author(s): Jingzhe Han, Duanhua Cao, Guomei Ma, Tingting Wang, Ye Ji, Zhilei Kang

Journal: Medicine (Baltimore). 2017 Nov;96(45):e8647.

 

Patients with Klippel-Feil syndrome (KFS) are always anomaly associated with vertebrobasilar dysplasia. That may present commonly as infarction of brainstem, medulla, and cerebellum. In this article, we reported a rare case of lateral medullary infarction (LMI) with similar features ...

Last Updated: 31 Dec 1969

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Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report.
 

Author(s): Hee Kyung Yang, Jae Hyoung Kim, Ji-Soo Kim, Jeong-Min Hwang

Journal:

 

Congenital Brown syndrome is characterized by limited elevation particularly during adduction. The pathogenesis of congenital Brown syndrome is still controversial.

Last Updated: 31 Dec 1969

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SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters.
 

Author(s): Tamilarasan Udhayabanu, Veedamali S Subramanian, Trevor Teafatiller, Vykuntaraju K Gowda, Varun S Raghavan, Perumal Varalakshmi, Hamid M Said, Balasubramaniem Ashokkumar

Journal: Clin. Chim. Acta. 2016 Nov;462():210-214.

 

Brown-Vialetto-Van Laere Syndrome (BVVLS), a rare neurological disorder characterized by bulbar palsies and sensorineural deafness, is mainly associated with defective riboflavin transporters encoded by the SLC52A2 and SLC52A3 genes.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brown Syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

Brown bowel syndrome: a rare complication in diseases associated with long-standing malabsorption.
 

Author(s): Heinz Albrecht, Alexander Hagel, Thomas de Rossi, Tilman T Rau, Thomas Kirchner, Markus F Neurath, Martin Raithel

Journal: Digestion. 2014 ;89(2):105-9.

 

Longtime chronic malabsorption may among other things cause a lack of liposoluble vitamins. Vitamin E deficiency can lead to formation of lipofuscin aggregates. Its deficiency is also associated with an increased lipofuscinosis of the bowel, i.e. brown bowel syndrome.

Last Updated: 31 Dec 1969

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Brown bowel syndrome (intestinal lipofuscinosis) - a case report and review of the literature.
 

Author(s): Magdalena Białas, Sergiusz Demczuk, Grzegorz Dyduch, Grażyna Drabik, Małgorzata Chrupek, Krzysztof Okoń

Journal: Pol J Pathol. 2013 Oct;64(3):228-31.

 

Brown bowel syndrome (BBS) is a very rare condition occurring in association with malabsorption syndromes. It is characterised by deposition of granular, brown pigment (lipofuscin or ceroid) in intestinal smooth muscles. Rarely BBS can be complicated by distention of any segment of ...

Last Updated: 31 Dec 1969

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The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited: natural history, genetics, treatment and future perspectives.
 

Author(s): Annet M Bosch, Kevin Stroek, Nico G Abeling, Hans R Waterham, Lodewijk Ijlst, Ronald J A Wanders

Journal:

 

The Brown-Vialetto-Van Laere syndrome is a rare neurological disorder which may present at all ages with sensorineural deafness, bulbar palsy and respiratory compromise. Fazio-Londe syndrome is considered to be the same disease entity. Recently it was demonstrated that in some patients ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
 

Status: Recruiting

Condition Summary: Congenital Fibrosis of Extraocular Muscles; Duane Retraction Syndrome; Duane Radial Ray Syndrome; Mobius Syndrome; Brown Syndrome; Marcus Gunn Syndrome; Strabismus Congenital; Horizontal Gaze Palsy; Horizontal Gaze Palsy With Progressive Scoliosis; Facial Palsy; Facial Paresis, Hereditary, Congenital; Third Nerve Palsy; Fourth Nerve Palsy; Sixth Nerve Palsy; Synkinesis; Ocular Motility Disorders; Levator-Medial Rectus Synkinesis; Athabaskan Brainstem Dysgenesis; Tongue Paralysis; Ninth Nerve Disorder; Fifth Nerve Palsy; Seventh Nerve Palsy; Eleventh Nerve Disorder; Twelfth Nerve Disorder; Vagus Nerve Paralysis; Moebius Sequence

 

Last Updated: 16 Feb 2017

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Brown Fat Activation Study
 

Status: Recruiting

Condition Summary: Obese; Metabolic Syndrome

 

Last Updated: 24 May 2017

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