Brown Syndrome

Common Name(s)

Brown Syndrome

Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. Specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. The condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. Some cases are constant while other are intermittent. Treatment depends upon the cause and severity of the movement disorder. Options include close observation, nonsteroidal anti-inflammatory agents like Ibuprofen, corticosteroids, and surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brown Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brown Syndrome" returned 75 free, full-text research articles on human participants. First 3 results:

SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters.
 

Author(s): Tamilarasan Udhayabanu, Veedamali S Subramanian, Trevor Teafatiller, Vykuntaraju K Gowda, Varun S Raghavan, Perumal Varalakshmi, Hamid M Said, Balasubramaniem Ashokkumar

Journal: Clin. Chim. Acta. 2016 Nov;462():210-214.

 

Brown-Vialetto-Van Laere Syndrome (BVVLS), a rare neurological disorder characterized by bulbar palsies and sensorineural deafness, is mainly associated with defective riboflavin transporters encoded by the SLC52A2 and SLC52A3 genes.

Last Updated: 5 Oct 2016

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SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation.
 

Author(s): Atsushi Intoh, Naoki Suzuki, Kathryn Koszka, Kevin Eggan

Journal: Hum. Mol. Genet.. 2016 May;25(9):1814-23.

 

Riboflavin, also known as vitamin B2, is essential for cellular reduction-oxidation reactions, but is not readily synthesized by mammalian cells. It has been proposed that riboflavin absorption occurs through solute carrier family 52 members (SLC52) A1, A2 and A3. These transporters ...

Last Updated: 6 Jul 2016

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Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
 

Author(s): Matthew Van De Pette, Simon J Tunster, Grainne I McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M John

Journal:

 

The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for many years due to the myriad of genetic and epigenetic alterations reported in these patients and the lack of suitable animal ...

Last Updated: 11 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brown Syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

Brown bowel syndrome: a rare complication in diseases associated with long-standing malabsorption.
 

Author(s): Heinz Albrecht, Alexander Hagel, Thomas de Rossi, Tilman T Rau, Thomas Kirchner, Markus F Neurath, Martin Raithel

Journal: Digestion. 2014 ;89(2):105-9.

 

Longtime chronic malabsorption may among other things cause a lack of liposoluble vitamins. Vitamin E deficiency can lead to formation of lipofuscin aggregates. Its deficiency is also associated with an increased lipofuscinosis of the bowel, i.e. brown bowel syndrome.

Last Updated: 28 Mar 2014

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Brown bowel syndrome (intestinal lipofuscinosis) - a case report and review of the literature.
 

Author(s): Magdalena Białas, Sergiusz Demczuk, Grzegorz Dyduch, Grażyna Drabik, Małgorzata Chrupek, Krzysztof Okoń

Journal: Pol J Pathol. 2013 Oct;64(3):228-31.

 

Brown bowel syndrome (BBS) is a very rare condition occurring in association with malabsorption syndromes. It is characterised by deposition of granular, brown pigment (lipofuscin or ceroid) in intestinal smooth muscles. Rarely BBS can be complicated by distention of any segment of ...

Last Updated: 29 Oct 2013

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The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited: natural history, genetics, treatment and future perspectives.
 

Author(s): Annet M Bosch, Kevin Stroek, Nico G Abeling, Hans R Waterham, Lodewijk Ijlst, Ronald J A Wanders

Journal:

 

The Brown-Vialetto-Van Laere syndrome is a rare neurological disorder which may present at all ages with sensorineural deafness, bulbar palsy and respiratory compromise. Fazio-Londe syndrome is considered to be the same disease entity. Recently it was demonstrated that in some patients ...

Last Updated: 11 Dec 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
 

Status: Recruiting

Condition Summary: Congenital Fibrosis of Extraocular Muscles; Duane Retraction Syndrome; Duane Radial Ray Syndrome; Mobius Syndrome; Brown Syndrome; Marcus Gunn Syndrome; Strabismus Congenital; Horizontal Gaze Palsy; Horizontal Gaze Palsy With Progressive Scoliosis; Facial Palsy; Facial Paresis, Hereditary, Congenital; Third Nerve Palsy; Fourth Nerve Palsy; Sixth Nerve Palsy; Synkinesis; Ocular Motility Disorders; Levator-Medial Rectus Synkinesis; Athabaskan Brainstem Dysgenesis; Tongue Paralysis; Ninth Nerve Disorder; Fifth Nerve Palsy; Seventh Nerve Palsy; Eleventh Nerve Disorder; Twelfth Nerve Disorder; Vagus Nerve Paralysis; Moebius Sequence

 

Last Updated: 16 Feb 2017

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Brown Fat Activation Study
 

Status: Recruiting

Condition Summary: Obese; Metabolic Syndrome

 

Last Updated: 24 May 2017

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