Emphysema

Common Name(s)

Emphysema

Emphysema is a chronic (long term) lung condition. It is a form of COPD (chronic obstructive pulmonary disease). The air you breathe goes into your lungs through airways. At the end of our airways in our lungs are tiny air sacs (alveoli). It is the air sacs that become damaged over time in emphysema. As the air sacs are damaged, their inner walls break down causing the sac to become larger. Larger sacs absorb less oxygen than those of normal size. The damage also causes difficulty breathing or shortness of breath. The damaged air sacs cannot be replaced.

Symptoms of emphysema may not occur until years after the damage to the air sacs begins. Symptoms may include shortness of breath, decreased mental alertness, and blue or gray fingertips or lips. Risk of developing emphysema is increased if there has been long-term exposure to airborne irritants including tobacco smoke, marijuana smoke, air pollution, and manufacturing fumes. A less common form of emphysema is caused by the lack of a special type of protein (alpha-1-antitrypsin). This type of emphysema is usually caused by a mutation or change in your genes and therefore will run in families.

To diagnosis emphysema, a physician may perform a variety of tests, which may include a chest x-ray to rule out other causes, lab tests to examine oxygen in the blood stream, and lung function tests to measure air flow in and out of the lungs. Treatment to relieve symptoms and slow the progression of the disease may include medications, therapy, or surgery. See a doctor if you have had unexplained shortness of breath for several months, particularly if it is getting worse or interfering with your daily activities. If you have been diagnosed with emphysema, talk with your doctor or specialist about the most current treatment options. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Emphysema" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Emphysema" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Emphysema" returned 1038 free, full-text research articles on human participants. First 3 results:

The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.
 

Author(s): Wen Lu, Ran You, Xiaoyi Yuan, Tianshu Yang, Errol L G Samuel, Daniela C Marcano, William K A Sikkema, James M Tour, Antony Rodriguez, Farrah Kheradmand, David B Corry

Journal: Nat. Immunol.. 2015 Nov;16(11):1185-94.

 

Smoking-related emphysema is a chronic inflammatory disease driven by the T(H)17 subset of helper T cells through molecular mechanisms that remain obscure. Here we explored the role of the microRNA miR-22 in emphysema. We found that miR-22 was upregulated in lung myeloid dendritic ...

Last Updated: 20 Oct 2015

Go To URL
Subcutaneous emphysema and pneumomediastinum following cocaine inhalation: a case report.
 

Author(s): Deanne S Soares, Anna Ferdman, Rozanna Alli

Journal:

 

Subcutaneous emphysema or pneumomediastinum can occur as a complication of illicit drug use although this is rare. When occurring without a pneumothorax and spontaneously, it is usually treated conservatively, but can have serious consequences.

Last Updated: 14 Sep 2015

Go To URL
[Rheumatoid arthritis and combined pulmonary fibrosis and emphysema].
 

Author(s): Marcelo Fernández Casares, Mariano Fielli, Laura Cristaldo, Lucía Zárate, María Nieves Capozzi

Journal: Medicina (B Aires). 2015 ;75(4):225-8.

 

The combination of pulmonary fibrosis and emphysema is a syndrome described in the last years, which has its own characteristics and it is not only the casual association between the two entities. The idiopathic pulmonary fibrosis is the most common type of pulmonary fibrosis. However ...

Last Updated: 5 Sep 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Emphysema" returned 94 free, full-text review articles on human participants. First 3 results:

Emphysema: Imaging for Endoscopic Lung Volume Reduction.
 

Author(s): B Storbeck, T H Schröder, M Oldigs, K F Rabe, C Weber

Journal: Rofo. 2015 Jul;187(7):543-54.

 

Chronic obstructive pulmonary disease (COPD) is characterized by two entities, the more airway-predominant type ("bronchitis") on the one hand, and emphysema-predominant type on the other. Imaging via high-resolution computed tomography plays an important role in phenotyping COPD. ...

Last Updated: 20 Jun 2015

Go To URL
[A newly-defined entity: combined pulmonary fibrosis and emphysema syndrome].
 

Author(s): Neslihan Özçelik, Savaş Özsu

Journal: Tuberk Toraks. 2015 ;63(1):48-52.

 

Combined pulmonary fibrosis and emphysema (CPFE) syndrome is a rare disease characterized with shortness of breath, upper lobe emphysema, lower lobe fibrosis and impairment of gas exchange. This syndrome is a disease usually seen in male smokers. Pulmonary hypertension is associated ...

Last Updated: 8 Apr 2015

Go To URL
Segmental approach to lung volume reduction therapy for emphysema patients.
 

Author(s): Sourish Bandyopadhyay, Erik Henne, Avina Gupta, Robert Barry, Greg Snell, Charlie Strange, Felix J F Herth

Journal: Respiration. 2015 ;89(1):76-81.

 

Emphysema is often distributed heterogeneously throughout the lungs, even at the segmental level. It is important for interventional lung volume reduction therapies to target and treat the most diseased regions of the lung while preserving the less diseased functional regions. Identification ...

Last Updated: 9 Feb 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of the Combined Pulmonary Fibrosis and Emphysema Syndrome
 

Status: Recruiting

Condition Summary: Combined Pulmonary Fibrosis and Emphysema Syndrome; Pulmonary Fibrosis; Emphysema; Healthy Subjects

 

Last Updated: 7 May 2015

Go to URL
Endoscopic Lung Volume Reduction in Patients With Advanced Emphysema Due to alpha1 Antitrypsin Deficiency
 

Status: Recruiting

Condition Summary: Hereditary Emphysema (Alpha 1-antitrypsin Deficiency)

 

Last Updated: 19 May 2011

Go to URL