Renal cell carcinoma

Common Name(s)

Renal cell carcinoma

Renal cell carcinoma (RCC) is one of the most common types of kidney cancers seen in adults. RCC occurs more often in men between the ages of 50 to 70. The kidneys help get rid of waste in the body. There are small tubes in the kidneys that help filter waste from the blood and help make urine. RCC occurs when cells start growing uncontrollably in the lining of these small tubes. Symptoms may not appear in the early stages of renal cell carcinoma, which is why renal cell carcinoma is normally advanced when found. Later symptoms may include blood in urine, a lump in the abdomen, weight loss, anemia, and loss of appetite. If untreated, it may spread to the lymph nodes, lungs, liver, adrenal glands, brain, or bones.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Renal cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Renal cell carcinoma" returned 2552 free, full-text research articles on human participants. First 3 results:

Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival.
 

Author(s): Mattias Johansson, Anouar Fanidi, David C Muller, Julie K Bassett, Øivind Midttun, Stein Emil Vollset, Ruth C Travis, Domenico Palli, Amalia Mattiello, Sabina Sieri, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Börje Ljungberg, Göran Hallmans, Elisabete Weiderpass, Guri Skeie, Carlos A González, Miren Dorronsoro, Petra H Peeters, H Bas Bueno-de-Mesquita, Martine M Ros, Marie-Christine Boutron Ruault, Guy Fagherazzi, Françoise Clavel, María-José Sánchez, Aurelio Barricarte Gurrea, Carmen Navarro, J Ramon Quiros, Kim Overvad, Anne Tjønneland, Krassimira Aleksandrova, Paolo Vineis, Marc J Gunter, Rudolf Kaaks, Graham Giles, Caroline Relton, Elio Riboli, Heiner Boeing, Per Magne Ueland, Gianluca Severi, Paul Brennan

Journal:

 

The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.

Last Updated: 7 Nov 2014

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Experience with sunitinib treatment for metastatic renal cell carcinoma in a large cohort of Israeli patients: outcome and associated factors.
 

Author(s): Dana Livne-Segev, Maya Gottfried, Natalie Maimon, Avivit Peer, Avivit Neumann, Henry Hayat, Svetlana Kovel, Avishay Sella, Wilmosh Mermershtain, Keren Rouvinov, Ben Boursi, Rony Weitzen, Raanan Berger, Daniel Keizman

Journal: Isr. Med. Assoc. J.. 2014 Jun;16(6):347-51.

 

The VEGFR/PDGFR inhibitor sunitinib was approved in Israel in 2008 for the treatment of metastatic renal cell carcinoma (mRCC), based on an international trial. However, the efficacy of sunitinib treatment in Israeli mRCC patients has not been previously reported.

Last Updated: 25 Jul 2014

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Serum level and immunohistochemical expression of vascular endothelial growth factor for the prediction of postoperative recurrence in renal cell carcinoma.
 

Author(s): Naoyuki Fujita, Takatsugu Okegawa, Yuichi Terado, Mitsuhiro Tambo, Eiji Higashihara, Kikuo Nutahara

Journal:

 

Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis. One of the functions of VEGF is to regulate neovascularization in clear cell renal cell carcinoma (CCRCC). The objective of our study was to examine whether before nephrectomy serum levels of VEGF or expression ...

Last Updated: 27 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Renal cell carcinoma" returned 270 free, full-text review articles on human participants. First 3 results:

[Prognostic factors and associated models for metastatic renal cell carcinoma treated with targeted therapy].
 

Author(s): Zheng Zheng, Han-zhong Li, Yong-qiang Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2014 Aug;36(4):450-3.

 

Since 2006, tyrosine kinase inhibitors and anti-angiogenic drugs have revolutionized the treatment of metastatic renal cell carcinoma by improving progression-free survival and overall survival. The prognostic factors in metastatic renal cell carcinoma treated by targeted therapy ...

Last Updated: 1 Sep 2014

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Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma.
 

Author(s): Anna M Czarnecka, Anna Kornakiewicz, Wojciech Kukwa, Cezary Szczylik

Journal: Future Oncol. 2014 May;10(6):1095-111.

 

The last few years have brought advances in the understanding of the molecular biology of metastatic clear cell renal cell carcinoma (RCC). Both preclinical research and clinical trials brought together results from the latest advancements in RCC diagnostic and staging. Understanding ...

Last Updated: 19 Jun 2014

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Ampullary tumor caused by metastatic renal cell carcinoma and literature review.
 

Author(s): Wang Haidong, Wang Jianwei, Li Guizhong, Liu Ning, He Feng, Man Libo

Journal:

 

We present a case of a 50-year-old man with a metastasis to the ampulla of vater that led to the discovery of renal cell carcinomas.The man was referred to us because of jaundice.Computed tomography (CT) scan of the abdomen showed irregular masses in the right kidney. Magnetic resonance ...

Last Updated: 8 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunotherapy Study for Metastatic Renal Cell Cancer
 

Status: Not yet recruiting

Condition Summary: Metastatic Renal Cell Carcinoma; Metastatic Clear-cell Renal Cancer; Recurrent Renal Cell Carcinoma; Refractory Renal Cell Carcinoma; Metastatic Kidney Cancer

 

Last Updated: 28 Aug 2014

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AMG 172 First in Human Study in Patients With Kidney Cancer
 

Status: Recruiting

Condition Summary: Renal Cell Adenocarcinoma; Clear Cell Renal Carcinoma; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 17 Oct 2014

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Phase 3 Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma (RCC)
 

Status: Recruiting

Condition Summary: Advanced Renal Cell Carcinoma; Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma

 

Last Updated: 18 Dec 2014

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