Renal cell carcinoma

Common Name(s)

Renal cell carcinoma

Renal cell carcinoma (RCC) is one of the most common types of kidney cancers seen in adults. RCC occurs more often in men between the ages of 50 to 70. The kidneys help get rid of waste in the body. There are small tubes in the kidneys that help filter waste from the blood and help make urine. RCC occurs when cells start growing uncontrollably in the lining of these small tubes. Symptoms may not appear in the early stages of renal cell carcinoma, which is why renal cell carcinoma is normally advanced when found. Later symptoms may include blood in urine, a lump in the abdomen, weight loss, anemia, and loss of appetite. If untreated, it may spread to the lymph nodes, lungs, liver, adrenal glands, brain, or bones.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Renal cell carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Renal cell carcinoma" returned 2526 free, full-text research articles on human participants. First 3 results:

Experience with sunitinib treatment for metastatic renal cell carcinoma in a large cohort of Israeli patients: outcome and associated factors.
 

Author(s): Dana Livne-Segev, Maya Gottfried, Natalie Maimon, Avivit Peer, Avivit Neumann, Henry Hayat, Svetlana Kovel, Avishay Sella, Wilmosh Mermershtain, Keren Rouvinov, Ben Boursi, Rony Weitzen, Raanan Berger, Daniel Keizman

Journal: Isr. Med. Assoc. J.. 2014 Jun;16(6):347-51.

 

The VEGFR/PDGFR inhibitor sunitinib was approved in Israel in 2008 for the treatment of metastatic renal cell carcinoma (mRCC), based on an international trial. However, the efficacy of sunitinib treatment in Israeli mRCC patients has not been previously reported.

Last Updated: 25 Jul 2014

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Validation of housekeeping gene and impact on normalized gene expression in clear cell renal cell carcinoma: critical reassessment of YBX3/ZONAB/CSDA expression.
 

Author(s): S├ębastien Dupasquier, Anne-Sophie Delmarcelle, Etienne Marbaix, Jean-Pierre Cosyns, Pierre J Courtoy, Christophe E Pierreux

Journal:

 

YBX3/ZONAB/CSDA is an epithelial-specific transcription factor acting in the density-based switch between proliferation and differentiation. Our laboratory reported overexpression of YBX3 in clear cell renal cell arcinoma (ccRCC), as part of a wide study of YBX3 regulation in vitro ...

Last Updated: 4 Jun 2014

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Axitinib versus sorafenib in advanced renal cell carcinoma: subanalyses by prior therapy from a randomised phase III trial.
 

Author(s): B Escudier, M D Michaelson, R J Motzer, T E Hutson, J I Clark, H Y Lim, E Porfiri, P Zalewski, G Kannourakis, M Staehler, J Tarazi, B Rosbrook, L Cisar, S Hariharan, S Kim, B I Rini

Journal: Br. J. Cancer. 2014 Jun;110(12):2821-8.

 

In the AXIS trial, axitinib prolonged progression-free survival (PFS) vs sorafenib in patients with advanced renal cell carcinoma (RCC) previously treated with sunitinib or cytokines.

Last Updated: 12 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Renal cell carcinoma" returned 271 free, full-text review articles on human participants. First 3 results:

Tumor necrosis factor receptor 2: its contribution to acute cellular rejection and clear cell renal carcinoma.
 

Author(s): Jun Wang, Rafia S Al-Lamki

Journal: Biomed Res Int. 2013 ;2013():821310.

 

Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF- ╬▒ ). Accumulating experimental evidence suggests that TNFR2 plays an important ...

Last Updated: 18 Dec 2013

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Renal mucinous tubular and spindle cell carcinoma: a report of 8 cases and review of the literature.
 

Author(s): Xiao-rong Wu, Yong-hui Chen, Jian-jun Sha, Ling Zhao, Ji-wei Huang, Juan-Jie Bo, Dong-ming Liu, Yi-ran Huang

Journal:

 

Mucinous tubular and spindle cell carcinoma of kidney (MTSCC-K) is a rare variant of renal tumor. The current data show most of MTSCCs are of low malignant potential and rare cases metastatic to lymph nodes have been reported; however, the recorded computed tomography (CT) and follow ...

Last Updated: 28 Feb 2014

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Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature.
 

Author(s): Ke Sun, Qihan You, Ming Zhao, Hongtian Yao, Hua Xiang, Lijun Wang

Journal:

 

Primary carcinoid tumor arising in a mature teratoma of the horseshoe kidney is exceptionally rare and only 4 such cases have been reported in the world literature to date. The simultaneous occurrence of different subtypes of renal cell carcinoma (RCC) or RCC coexistence with non-RCC ...

Last Updated: 14 Nov 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunotherapy Study for Metastatic Renal Cell Cancer
 

Status: Not yet recruiting

Condition Summary: Metastatic Renal Cell Carcinoma; Metastatic Clear-cell Renal Cancer; Recurrent Renal Cell Carcinoma; Refractory Renal Cell Carcinoma; Metastatic Kidney Cancer

 

Last Updated: 28 Aug 2014

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AMG 172 First in Human Study in Patients With Kidney Cancer
 

Status: Recruiting

Condition Summary: Renal Cell Adenocarcinoma; Clear Cell Renal Carcinoma; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 17 Oct 2014

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Phase 3 Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma (RCC)
 

Status: Recruiting

Condition Summary: Advanced Renal Cell Carcinoma; Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma

 

Last Updated: 11 Sep 2014

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