Renal cell carcinoma

Common Name(s)

Renal cell carcinoma

Renal cell carcinoma (RCC) is one of the most common types of kidney cancers seen in adults. RCC occurs more often in men between the ages of 50 to 70. The kidneys help get rid of waste in the body. There are small tubes in the kidneys that help filter waste from the blood and help make urine. RCC occurs when cells start growing uncontrollably in the lining of these small tubes. Symptoms may not appear in the early stages of renal cell carcinoma, which is why renal cell carcinoma is normally advanced when found. Later symptoms may include blood in urine, a lump in the abdomen, weight loss, anemia, and loss of appetite. If untreated, it may spread to the lymph nodes, lungs, liver, adrenal glands, brain, or bones.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Renal cell carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Renal cell carcinoma" returned 4592 free, full-text research articles on human participants. First 3 results:

Outcome of papillary versus clear cell renal cell carcinoma varies significantly in non-metastatic disease.
 

Author(s): Nina Wagener, Dominic Edelmann, Axel Benner, Richard Zigeuner, Hendrik Borgmann, Ingmar Wolff, Laura M Krabbe, Mireia Musquera, Paolo Dell'Oglio, Umberto Capitanio, Tobias Klatte, Luca Cindolo, Matthias May, Sabine D Brookman-May,

Journal:

 

Renal cell carcinoma (RCC) comprises a heterogenous group of tumors. Traditionally, papillary RCC (pRCC) is associated with a favorable outcome compared to clear cell RCC (ccRCC), while other series report equivalent or worse prognosis. In this paper we comparatively evaluate outcome ...

Last Updated: 21 Sep 2017

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Cabozantinib versus everolimus, nivolumab, axitinib, sorafenib and best supportive care: A network meta-analysis of progression-free survival and overall survival in second line treatment of advanced renal cell carcinoma.
 

Author(s): Billy Amzal, Shuai Fu, Jie Meng, Johanna Lister, Helene Karcher

Journal:

 

Relative effect of therapies indicated for the treatment of advanced renal cell carcinoma (aRCC) after failure of first line treatment is currently not known. The objective of the present study is to evaluate progression-free survival (PFS) and overall survival (OS) of cabozantinib ...

Last Updated: 8 Sep 2017

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Secondary Adrenal Insufficiency Following Nivolumab Therapy in a Patient with Metastatic Renal Cell Carcinoma.
 

Author(s): Toshiro Seki, Atsushi Yasuda, Masayuki Oki, Natsumi Kitajima, Atsushi Takagi, Nobuyuki Nakajima, Akira Miyajima, Masafumi Fukagawa

Journal:

 

Currently, nivolumab (an anti-programmed cell death-1 receptor monoclonal antibody) is available for many types of advanced cancers in Japan. However, there have been few detailed case reports about endocrine-related adverse events of this therapy. Here, we report a patient with metastatic ...

Last Updated: 5 Sep 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Renal cell carcinoma" returned 542 free, full-text review articles on human participants. First 3 results:

Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis.
 

Author(s): Lu Tang, Xintao Li, Yu Gao, Luyao Chen, Liangyou Gu, Jianwen Chen, Xiangjun Lyu, Yu Zhang, Xu Zhang

Journal:

 

The phosphatase and tensin homolog (PTEN) gene is suggested to be a dormant tumor suppressor. However, the prognostic value of the loss of PTEN expression in renal cell carcinoma (RCC) remains controversial. Therefore, we conducted a meta-analysis to evaluate the association of PTEN ...

Last Updated: 3 Jul 2017

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Cabozantinib: an Active Novel Multikinase Inhibitor in Renal Cell Carcinoma.
 

Author(s): Nizar M Tannir, Gisela Schwab, Viktor Gr├╝nwald

Journal: Curr Oncol Rep. 2017 Feb;19(2):14.

 

Clear cell renal cell carcinoma (RCC) is characterized by inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. VHL loss drives tumor angiogenesis and accounts for the clinical activity of VEGF receptor (VEGFR) tyrosine kinase inhibitors (TKIs), the first-line standard ...

Last Updated: 1 Mar 2017

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Effects and Side Effects of Using Sorafenib and Sunitinib in the Treatment of Metastatic Renal Cell Carcinoma.
 

Author(s): Caroline Randrup Hansen, Daniela Grimm, Johann Bauer, Markus Wehland, Nils E Magnusson

Journal:

 

In recent years, targeted therapies have proven beneficial in terms of progression-free survival (PFS) and overall survival (OS) in the treatment of metastatic renal cell carcinoma (mRCC). The tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib are included in international ...

Last Updated: 23 Feb 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of TAK-228 In Patients With Previously Treated Metastatic Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Renal Cell Carcinoma

 

Last Updated: 10 Oct 2017

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A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Renal Cell Carcinoma

 

Last Updated: 27 Jul 2017

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Molecular Determinants for Therapy Response on Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Renal Cell Carcinoma

 

Last Updated: 31 Jul 2014

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