Brittle diabetes

Common Name(s)

Brittle diabetes, Brittle diabetes mellitus, Brittle type 1 diabetes, Labile diabetes

Brittle diabetes is characterized by severe instability of blood glucose levels with frequent and unpredictable episodes of hypoglycemia and/or ketoacidosis that disrupt quality of life, often requiring frequent or prolonged hospitalizations. These unpredictable episodes are due to an absolute insulin dependency, affecting type 1 diabetics almost exclusively. Brittle diabetes is most common in women in their twenties or thirties, but can occur at any age and in either gender. The condition may be caused by stress and hormonal inbalance, neglect of self-care (noncompliance), or underlying medical conditions such as malabsorption, delayed gastric emptying due to autonomic neuropathy, drug or alcohol use or abnormal insulin absorption or degradation. Treatment is difficult and dependent upon the underlying cause.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brittle diabetes" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brittle diabetes" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brittle diabetes" returned 29 free, full-text research articles on human participants. First 3 results:

Characterization of insulin antibodies by Surface Plasmon Resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome.
 

Author(s): Aldana Trabucchi, Ruben F Iacono, Luciano L Guerra, Natalia I Faccinetti, Andrea G Krochik, MarĂ­a C Arriazu, Edgardo Poskus, Silvina N Valdez

Journal:

 

In this study, the characterization of insulin (auto)antibodies has been described, mainly in terms of concentration (q), affinity (Ka) and Ig (sub)isotypes by Surface Plasmon Resonance (SPR) in two particular clinical cases of individuals with severe episodes of impaired glycemia. ...

Last Updated: 3 Jan 2014

Go To URL
Successful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report.
 

Author(s): Angela Koh, Sharleen Imes, Andrew Mark James Shapiro, Peter A Senior

Journal:

 

Allotransplantation of islets can successfully treat subjects with type 1 diabetes complicated by severe hypoglycemia and erratic glycemic control. Insulin independence is often lost over time due to several factors, including recurrent autoimmunity. Brittle diabetes (frequent hypoglycemia ...

Last Updated: 12 Jul 2013

Go To URL
Challenges for diabetic care: rural Africa & type 1 brittle diabetes.
 

Author(s): Michael Bannon

Journal: QJM. 2011 Jul;104(7):559-60.

 

Last Updated: 17 Jun 2011

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brittle diabetes" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Islet Transplant for Type 1 or Surgical Diabetes
 

Status: Available

Condition Summary: Type 1 Diabetes Mellitus; Hypoglycemia; Labile Diabetes; End-stage Renal Disease

 

Last Updated: 24 Jun 2013

Go to URL
Islet Transplantation in Patients With "Brittle" Type I Diabetes
 

Status: Recruiting

Condition Summary: Diabetes Mellitus, Type 1

 

Last Updated: 2 Jul 2014

Go to URL