Uterine Fibroid

Common Name(s)

Uterine Fibroid, Uterine Leiomyoma

Uterine fibroids, also called leiomyomas or myomas, are growths in the uterus that frequently appear during childbearing years. These growths are noncancerous and develop from the smooth muscular tissue of the uterus. These fibroids are not associated with an increased risk of uterine cancer and almost never develop into cancer. Symptoms are usually not present, but in women who do have symptoms, symptoms include heavy menstrual bleeding, prolonged menstrual periods, pelvic pressure or pain, frequent urination, difficulty emptying the bladder, constipation, or backache or leg pains.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Uterine Fibroid" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Uterine Fibroid" returned 45 free, full-text research articles on human participants. First 3 results:

MRI-guided focused ultrasound surgery for uterine fibroid treatment: a cost-effectiveness analysis.
 

Author(s): Chung Y Kong, Lesley Meng, Zehra B Omer, J Shannon Swan, Serene Srouji, G Scott Gazelle, Fiona M Fennessy

Journal: AJR Am J Roentgenol. 2014 Aug;203(2):361-71.

 

OBJECTIVE. The purpose of this article is to evaluate the cost effectiveness of a treatment strategy for symptomatic uterine fibroids that uses MRI-guided focused ultrasound as a first-line therapy relative to uterine artery embolization (UAE) or hysterectomy. MATERIALS AND METHODS. ...

Last Updated: 24 Jul 2014

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1,25-dihydroxyvitamin d3 reduces extracellular matrix-associated protein expression in human uterine fibroid cells.
 

Author(s): Sunil K Halder, Kevin G Osteen, Ayman Al-Hendy

Journal:

 

Uterine fibroids (leiomyomas) are the most common benign tumors associated with excessive deposition of extracellular matrix (ECM)-associated proteins that increase fibroid tumorigenicity. Herein, we determined the expression levels of vitamin D receptor (VDR) protein in human uterine ...

Last Updated: 27 Dec 2013

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Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells.
 

Author(s): Sunil K Halder, Kevin G Osteen, Ayman Al-Hendy

Journal: Hum. Reprod.. 2013 Sep;28(9):2407-16.

 

Can biologically active vitamin D3 [1,25(OH)₂D3] regulate the expression and activity of matrix metalloproteinases (MMPs) in human uterine fibroid cells?

Last Updated: 22 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Uterine Fibroid" returned 6 free, full-text review articles on human participants. First 3 results:

The health disparities of uterine fibroid tumors for African American women: a public health issue.
 

Author(s): Heba M Eltoukhi, Monica N Modi, Meredith Weston, Alicia Y Armstrong, Elizabeth A Stewart

Journal: Am. J. Obstet. Gynecol.. 2014 Mar;210(3):194-9.

 

Uterine fibroid tumors (leiomyomas) are the most common benign pelvic tumors in women and are the major indication for hysterectomy. Fibroid tumors are more common and more severe among African American women. Although this disease disproportionately affects the African American population, ...

Last Updated: 25 Feb 2014

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Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications.
 

Author(s): Pasquapina Ciarmela, Md Soriful Islam, Fernando M Reis, Peter C Gray, Enrrico Bloise, Felice Petraglia, Wylie Vale, Mario Castellucci

Journal: Hum. Reprod. Update. ;17(6):772-90.

 

Growth factors are proteins secreted by a number of cell types that are capable of modulating cellular growth, proliferation and cellular differentiation. It is well accepted that uterine cellular events such as proliferation and differentiation are regulated by sex steroids and their ...

Last Updated: 13 Oct 2011

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Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop.
 

Author(s): William H Catherino, Estella Parrott, James Segars

Journal: Fertil. Steril.. 2011 Jan;95(1):9-12.

 

The purpose of the National Institutes of Health conference Fibroid Research Workshop in September 2007 was to bring Eunice Kennedy Shriver National Institute of Child Health and Human Development-funded fibroid investigators together to discuss basic science and clinical research ...

Last Updated: 20 Dec 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biologic Predictors of Leiomyoma Treatment Outcomes
 

Status: Recruiting

Condition Summary: Uterine Leiomyomas; Fibroids; Uterine Fibroids; Myomas

 

Last Updated: 24 Nov 2014

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Magnetic Resonance Elastography (MRE) of Uterine Fibroids
 

Status: Recruiting

Condition Summary: Uterine Fibroids

 

Last Updated: 6 Aug 2014

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ExAblate UF V2 System for the Treatment of Symptomatic Uterine Fibroids
 

Status: Recruiting

Condition Summary: Uterine Fibroids

 

Last Updated: 12 Jan 2015

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