Triple negative breast cancer

Common Name(s)

Triple negative breast cancer

Triple negative breast cancer (TNBC) describes any type of breast cancer that lacks three types of receptors that are often used for targeted treatments. These three types of receptors are estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2/neu). These receptors are involved in cell signaling and are found on affected cells in breast cancer that is not TNBC. There are different forms of TNBC, and about 10-20 percent of women who are diagnosed with breast cancer have a TNBC form.

Women who are younger in age, African American or Hispanic, and/or have mutations in the BRCA1 gene are more likely to have TNBC. TNBC often spreads more quickly than other types of breast cancer and presents a higher risk of coming back or recurring, especially in the first few years after treatment. After the first 3-5 years following treatment, the risk of recurrence of TNBC matches that of non-TNBC.

TNBC is diagnosed by taking a biopsy, or tissue sample, of the cancer. TNBC is less likely to respond to hormonal treatments but often does respond well to chemotherapy, radiation therapy, and surgery. If you have been diagnosed with TNBC, talk to your doctor about the most current treatment options. In addition, a genetic counselor can help discuss inheritance and risks to other family members. Support groups are a good source of information and can connect you with others who have been affected by breast cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple negative breast cancer" for support, advocacy or research.

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple negative breast cancer" for support, advocacy or research.

Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Triple negative breast cancer" returned 760 free, full-text research articles on human participants. First 3 results:

[Construction of Nude Mouse Model of Triple Negative Breast Cancer and Value of Thermal Tomography].
 

Author(s): Hui-ping Huo, Jian-bin Huo, Wen-bo Wan, Jun-lai Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Apr;38(2):198-204.

 

To explore the early detection of breast cancer by ultrasonic imaging and thermal tomography of luciferase or green fluorescent protein (GFP)-labeled MDA-MB-231 breast cancer cell line-xenografts in nude mice.

Last Updated: 16 May 2016

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Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer.
 

Author(s): Aruna Korlimarla, Jyothi S Prabhu, Jose Remacle, Savitha Rajarajan, Uma Raja, Anupama C E, B S Srinath, Suraj Manjunath, Gopinath K S, Marjorrie Correa, Prasad M S N, T S Sridhar

Journal:

 

Apart from germ-line BRCA1-mutated breast cancers, a significant proportion of women with sporadic triple negative breast cancer (TNBC) sub-type are known to harbour varying levels of BRCA1-dysfuction. There is currently no established diagnostic method to identify these patients.

Last Updated: 15 Apr 2016

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miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.
 

Author(s): Sonia G Das, Mathilde Romagnoli, Nora D Mineva, Sophie Barillé-Nion, Pascal Jézéquel, Mario Campone, Gail E Sonenshein

Journal:

 

ADAM8 (a disintegrin and metalloproteinase 8) protein promotes the invasive and metastatic phenotype of triple-negative breast cancer (TNBC) cells. High ADAM8 expression in breast cancer patients is an independent predictor of poor prognosis. Here, we investigated whether ADAM8 regulates ...

Last Updated: 4 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Triple negative breast cancer" returned 66 free, full-text review articles on human participants. First 3 results:

MiRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer.
 

Author(s): Andrea Mathe, Rodney J Scott, Kelly A Avery-Kiejda

Journal:

 

Triple negative breast cancer (TNBC) is characterised by the lack of receptors for estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER2). Since it cannot be treated by current endocrine therapies which target these receptors and due to its aggressive nature, ...

Last Updated: 4 Dec 2015

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Liver Metastasis of a Triple-Negative Breast Cancer and Complete Remission for 5 Years After Treatment With Combined Bevacizumab/Paclitaxel/Carboplatin: Case Report and Review of the Literature.
 

Author(s): Hideaki Ogata, Yoshihiro Kikuchi, Kazuhiko Natori, Nobuyuki Shiraga, Masahiro Kobayashi, Shunsuke Magoshi, Fumi Saito, Tadatoshi Osaku, Shinsaku Kanazawa, Yorichika Kubota, Yoshie Murakami, Hironori Kaneko

Journal: Medicine (Baltimore). 2015 Oct;94(42):e1756.

 

Triple-negative breast cancer (TNBC) is aggressive, with high risk of visceral metastasis and death. A substantial proportion of patients with TNBC is associated with BRCA mutations, implying that these tumors are sensitive to DNA-damaging agents. We report successful treatment of ...

Last Updated: 27 Oct 2015

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Triple negative breast cancer: looking for the missing link between biology and treatments.
 

Author(s): Giuseppe Palma, Giuseppe Frasci, Andrea Chirico, Emanuela Esposito, Claudio Siani, Carmela Saturnino, Claudio Arra, Gennaro Ciliberto, Antonio Giordano, Massimiliano D'Aiuto

Journal: Oncotarget. 2015 Sep;6(29):26560-74.

 

The so called "Triple Negative Breast Cancer" (TNBC) represents approximately 15-20% of breast cancers. This acronym simply means that the tumour does not express oestrogen receptor (ER) and progesterone receptor (PR) and does not exhibit amplification of the human epidermal growth ...

Last Updated: 9 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
 

Status: Recruiting

Condition Summary: Triple Negative Breast Cancer

 

Last Updated: 6 Sep 2016

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Phase II Study of IMMU-132 Alone or in Combination With Carboplatin in Patients With Triple-Negative Breast Cancer
 

Status: Not yet recruiting

Condition Summary: Triple-negative Breast Cancer

 

Last Updated: 9 Oct 2015

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Neoadjuvant Study of Two Platinum Regimens in Triple Negative Breast Cancer
 

Status: Recruiting

Condition Summary: Triple-negative Breast Cancer

 

Last Updated: 22 Jun 2016

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