Triple Negative Breast Cancer

Common Name(s)

Triple Negative Breast Cancer

Triple-negative breast cancer is when the cancerous cells lack estrogen and progesterone receptors, and HER2 protein on cell surfaces. Without these receptors and the HER2 protein, neither hormone therapy nor drug treatments that target the HER2 protein are effective. Also triple-negative breast cancers grow and spread faster than most other breast cancers. For these mentioned reasons, chemotherapy is recommended even at the early onset of the disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

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Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 22 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

Logo
Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 22 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Triple Negative Breast Cancer" returned 304 free, full-text research articles on human participants. First 3 results:

Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines.
 

Author(s): Mike Tarpley, Temesgen T Abdissa, Gary L Johnson, John E Scott

Journal: Anticancer Res.. 2014 Apr;34(4):1629-35.

 

Triple-negative breast cancer (TNBC) is an aggressive sub-type of breast cancer. Dasatinib and bosutinib are FDA-approved Src/Abl kinase inhibitor drugs. Dasatinib potently inhibits the proliferation of many TNBC cell lines.

Last Updated: 2 Apr 2014

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Single nucleotide polymorphisms (SNPs) of ERCC2, hOGG1, and XRCC1 DNA repair genes and the risk of triple-negative breast cancer in Polish women.
 

Author(s): Beata Smolarz, Marianna Makowska, Dariusz Samulak, Magdalena M Michalska, Ewa Mojs, Maciej Wilczak, Hanna Romanowicz

Journal: Tumour Biol.. 2014 Apr;35(4):3495-502.

 

Triple-negative breast cancer (TNBC) refers to about 15-20% of all breast cancer cases. It is characterized by worse clinical outcome, poor prognosis, and absence of prognostic indicators. Several polymorphisms in the nucleotide excision repair (NER) and base excision repair (BER) ...

Last Updated: 9 Apr 2014

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Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer.
 

Author(s): Ning Qing Liu, Christoph Stingl, Maxime P Look, Marcel Smid, René B H Braakman, Tommaso De Marchi, Anieta M Sieuwerts, Paul N Span, Fred C G J Sweep, Barbro K Linderholm, Anita Mangia, Angelo Paradiso, Luc Y Dirix, Steven J Van Laere, Theo M Luider, John W M Martens, John A Foekens, Arzu Umar

Journal: J. Natl. Cancer Inst.. 2014 Feb;106(2):djt376.

 

Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy.

Last Updated: 31 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Triple Negative Breast Cancer" returned 44 free, full-text review articles on human participants. First 3 results:

MicroRNAs and triple negative breast cancer.
 

Author(s): Elvira D'Ippolito, Marilena V Iorio

Journal:

 

Triple Negative Breast Cancer (TNBC) is a very aggressive tumor subtype, which still lacks specific markers for an effective targeted therapy. Despite the common feature of negativity for the three most relevant receptors (ER, PgR and HER2), TNBC is a very heterogeneous disease where ...

Last Updated: 28 Nov 2013

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Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes.
 

Author(s): Brian D Lehmann, Jennifer A Pietenpol

Journal: J. Pathol.. 2014 Jan;232(2):142-50.

 

Triple-negative breast cancer (TNBC) is a heterogeneous disease with distinct molecular subtypes that respond differentially to chemotherapy and targeted agents. The absence of high-frequency molecular alterations and a limited number of known biomarkers have limited the development ...

Last Updated: 11 Dec 2013

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Triple-negative breast cancer and the need for new therapeutic targets.
 

Author(s): Olav Engebraaten, Hans Kristian Moen Vollan, Anne-Lise Børresen-Dale

Journal: Am. J. Pathol.. 2013 Oct;183(4):1064-74.

 

Triple-negative breast cancers (TNBCs) are a diverse and heterogeneous group of tumors that by definition lack estrogen and progesterone receptors and amplification of the HER2 gene. The majority of the tumors classified as TNBCs are highly malignant, and only a subgroup responds ...

Last Updated: 27 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison Study of Adjuvant Chemotherapy for Chinese Triple Negative Breast Cancer
 

Status: Available

Condition Summary: Triple Negative Breast Cancer

 

Last Updated: 6 Oct 2010

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Last Updated: 28 Nov 2012

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