Triple Negative Breast Cancer

Common Name(s)

Triple Negative Breast Cancer

Triple-negative breast cancer is when the cancerous cells lack estrogen and progesterone receptors, and HER2 protein on cell surfaces. Without these receptors and the HER2 protein, neither hormone therapy nor drug treatments that target the HER2 protein are effective. Also triple-negative breast cancers grow and spread faster than most other breast cancers. For these mentioned reasons, chemotherapy is recommended even at the early onset of the disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Triple Negative Breast Cancer" returned 669 free, full-text research articles on human participants. First 3 results:

[Construction of Nude Mouse Model of Triple Negative Breast Cancer and Value of Thermal Tomography].
 

Author(s): Hui-ping Huo, Jian-bin Huo, Wen-bo Wan, Jun-lai Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Apr;38(2):198-204.

 

To explore the early detection of breast cancer by ultrasonic imaging and thermal tomography of luciferase or green fluorescent protein (GFP)-labeled MDA-MB-231 breast cancer cell line-xenografts in nude mice.

Last Updated: 16 May 2016

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Metaplastic Breast Carcinoma Versus Triple-Negative Breast Cancer: Survival and Response to Treatment.
 

Author(s): Adnan Aydiner, Fatma Sen, Makbule Tambas, Rumeysa Ciftci, Yesim Eralp, Pinar Saip, Hasan Karanlik, Merdan Fayda, Seden Kucucuk, Semen Onder, Ekrem Yavuz, Mahmut Muslumanoglu, Abdullah Igci

Journal: Medicine (Baltimore). 2015 Dec;94(52):e2341.

 

Metaplastic breast carcinoma (MBC) differs from classic invasive ductal carcinomas regarding incidence, pathogenesis, and prognosis. The purpose of this study was to compare patients with MBC with clinicopathologic and treatment-matched patients with triple-negative breast carcinoma ...

Last Updated: 31 Dec 2015

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Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity.
 

Author(s): Yuan-Yuan Jin, Jade Andrade, Eric Wickstrom

Journal:

 

Conventional wisdom holds that only one of the two strands in a micro ribonucleic acid (miRNA) precursor duplex is selected as the active miRNA guide strand. The complementary miRNA passenger strand, however, is thought to be inactive. High levels of the oncogenic miRNA (oncomiR) ...

Last Updated: 3 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Triple Negative Breast Cancer" returned 61 free, full-text review articles on human participants. First 3 results:

Liver Metastasis of a Triple-Negative Breast Cancer and Complete Remission for 5 Years After Treatment With Combined Bevacizumab/Paclitaxel/Carboplatin: Case Report and Review of the Literature.
 

Author(s): Hideaki Ogata, Yoshihiro Kikuchi, Kazuhiko Natori, Nobuyuki Shiraga, Masahiro Kobayashi, Shunsuke Magoshi, Fumi Saito, Tadatoshi Osaku, Shinsaku Kanazawa, Yorichika Kubota, Yoshie Murakami, Hironori Kaneko

Journal: Medicine (Baltimore). 2015 Oct;94(42):e1756.

 

Triple-negative breast cancer (TNBC) is aggressive, with high risk of visceral metastasis and death. A substantial proportion of patients with TNBC is associated with BRCA mutations, implying that these tumors are sensitive to DNA-damaging agents. We report successful treatment of ...

Last Updated: 27 Oct 2015

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The role of taxanes in triple-negative breast cancer: literature review.
 

Author(s): Giorgio Mustacchi, Michelino De Laurentiis

Journal:

 

Breast cancer (BC) is the most frequent tumor worldwide. Triple-negative BCs are characterized by the negative estrogen and progesterone receptors and negative HER2, and represent 15% of all BCs. In this review, data on the use of taxanes in triple-negative BCs are analyzed, concluding ...

Last Updated: 14 Aug 2015

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Targeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast Cancer.
 

Author(s): Kamila A Marzec, Robert C Baxter, Janet L Martin

Journal: Biomed Res Int. 2015 ;2015():638526.

 

Insulin-like growth factor binding protein-3 (IGFBP-3) is a key regulatory molecule of the IGF axis and can function in a tissue-specific way as both a tumor suppressor and promoter. Triple-negative breast cancer (TNBC) has high tumor expression of IGFBP-3 associated with markers ...

Last Updated: 29 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Neoadjuvant Paclitaxel in Combination With Bavituximab in Early- Stage Triple- Negative Breast Cancer
 

Status: Not yet recruiting

Condition Summary: Breast Cancer; Triple Negative Breast Neoplasms; Triple-Negative Breast Neoplasm; Triple-Negative Breast Cancer; Triple Negative Breast Cancer; ER-Negative PR-Negative HER2-Negative Breast Neoplasms; ER-Negative PR-Negative HER2-Negative Breast Cancer

 

Last Updated: 12 Feb 2016

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Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
 

Status: Recruiting

Condition Summary: Triple Negative Breast Cancer; Triple Negative Breast Neoplasms; Triple-Negative Breast Cancer

 

Last Updated: 23 May 2016

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Last Updated: 28 Nov 2012

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