Triple negative breast cancer

Common Name(s)

Triple negative breast cancer

Triple negative breast cancer (TNBC) describes any type of breast cancer that lacks three types of receptors that are often used for targeted treatments. These three types of receptors are estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2/neu). These receptors are involved in cell signaling and are found on affected cells in breast cancer that is not TNBC. There are different forms of TNBC, and about 10-20 percent of women who are diagnosed with breast cancer have a TNBC form.

Women who are younger in age, African American or Hispanic, and/or have mutations in the BRCA1 gene are more likely to have TNBC. TNBC often spreads more quickly than other types of breast cancer and presents a higher risk of coming back or recurring, especially in the first few years after treatment. After the first 3-5 years following treatment, the risk of recurrence of TNBC matches that of non-TNBC.

TNBC is diagnosed by taking a biopsy, or tissue sample, of the cancer. TNBC is less likely to respond to hormonal treatments but often does respond well to chemotherapy, radiation therapy, and surgery. If you have been diagnosed with TNBC, talk to your doctor about the most current treatment options. In addition, a genetic counselor can help discuss inheritance and risks to other family members. Support groups are a good source of information and can connect you with others who have been affected by breast cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple negative breast cancer" for support, advocacy or research.

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple negative breast cancer" for support, advocacy or research.

Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Triple negative breast cancer" returned 763 free, full-text research articles on human participants. First 3 results:

Trends of triple negative breast cancer research (2007-2015): A bibliometric study.
 

Author(s): Yiran Wang, Xiao Zhai, Chuan Liu, Ning Wang, Yajie Wang

Journal: Medicine (Baltimore). 2016 Nov;95(46):e5427.

 

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. However, there have been limited data to evaluate the trend of TNBC research. This study aims to investigate the trend of TNBC research and compare the contribution of research from different regions, organizations, ...

Last Updated: 18 Nov 2016

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RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy.
 

Author(s): Ning Zhao, Zhangru Yang, Bingxin Li, Jin Meng, Zeliang Shi, Ping Li, Shen Fu

Journal:

 

Multifunctional nanoprobes have great potential as effective radiosensitizers and drug carriers. RGD-modified gold nanorods could increase the uptake of nanoparticles via receptor-mediated endocytosis in integrin alphaV beta3-overexpressing breast cancer cells, which could enhance ...

Last Updated: 8 Nov 2016

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Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2A and prognostic value in triple-negative breast cancer.
 

Author(s): Hongmei Zheng, Xiang Li, Chuang Chen, Jian Chen, Jinzhong Sun, Si Sun, Liting Jin, Juanjuan Li, Shengrong Sun, Xinhong Wu

Journal:

 

Topoisomerase 2 alpha (TOP2A) is a key enzyme in DNA replication and a target of various cytotoxic agents including anthracyclines. Previous studies evaluating the predictive and prognostic values of TOP2A in breast cancer are contradictory, likely secondary to the use of both different ...

Last Updated: 1 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Triple negative breast cancer" returned 57 free, full-text review articles on human participants. First 3 results:

The Evolution of Triple-Negative Breast Cancer: From Biology to Novel Therapeutics.
 

Author(s): Carey K Anders, Vandana Abramson, Tira Tan, Rebecca Dent

Journal: Am Soc Clin Oncol Educ Book. 2016 ;35():34-42.

 

Triple-negative breast cancer (TNBC) is clinically defined as lacking expression of the estrogen receptor (ER), progesterone receptor (ER), and HER2. Historically, TNBC has been characterized by an aggressive natural history and worse disease-specific outcomes compared with other ...

Last Updated: 2 Jun 2016

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Recent Progress in Triple Negative Breast Cancer Research.
 

Author(s): Fatima Zahra Mouh, Mohammed El Mzibri, Meriem Slaoui, Mariam Amrani

Journal: Asian Pac. J. Cancer Prev.. 2016 ;17(4):1595-608.

 

Triple-negative breast cancer (TNBC) is defined as a type of breast carcinoma that is negative for expression of oestrogene and progesterone hormone receptors (ER, PR) and HER2. This form of breast cancer is marked by its aggressiveness, low survival rate and lack of specific therapies. ...

Last Updated: 25 May 2016

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Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
 

Author(s): Maria Cristina Rangel, Daniel Bertolette, Nadia P Castro, Malgorzata Klauzinska, Frank Cuttitta, David S Salomon

Journal: Breast Cancer Res. Treat.. 2016 Apr;156(2):211-26.

 

Cancer has been considered as temporal and spatial aberrations of normal development in tissues. Similarities between mammary embryonic development and cell transformation suggest that the underlying processes required for mammary gland development are also those perturbed during ...

Last Updated: 29 Mar 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison Study of Adjuvant Chemotherapy for Chinese Triple Negative Breast Cancer
 

Status: Available

Condition Summary: Triple Negative Breast Cancer

 

Last Updated: 6 Oct 2010

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Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
 

Status: Recruiting

Condition Summary: Triple Negative Breast Cancer

 

Last Updated: 6 Sep 2016

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Phase II Study of IMMU-132 Alone or in Combination With Carboplatin in Patients With Triple-Negative Breast Cancer
 

Status: Not yet recruiting

Condition Summary: Triple-negative Breast Cancer

 

Last Updated: 9 Oct 2015

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