Triple Negative Breast Cancer

Common Name(s)

Triple Negative Breast Cancer

Triple-negative breast cancer is when the cancerous cells lack estrogen and progesterone receptors, and HER2 protein on cell surfaces. Without these receptors and the HER2 protein, neither hormone therapy nor drug treatments that target the HER2 protein are effective. Also triple-negative breast cancers grow and spread faster than most other breast cancers. For these mentioned reasons, chemotherapy is recommended even at the early onset of the disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

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Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 22 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

Logo
Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 22 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Triple Negative Breast Cancer" returned 424 free, full-text research articles on human participants. First 3 results:

Triple negative breast cancer: the role of metabolic pathways.
 

Author(s): S J R Dean, A Rhodes

Journal: Malays J Pathol. 2014 Dec;36(3):155-62.

 

The incidence of breast cancer in Malaysia and other Asian countries is on the increase, reflecting lifestyle changes some of which are known risk factors for the development of breast cancer. Most breast cancers are amenable to adjuvant therapies that target hormone receptors or ...

Last Updated: 16 Dec 2014

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Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer.
 

Author(s): Johanna I Kiiski, Liisa M Pelttari, Sofia Khan, Edda S Freysteinsdottir, Inga Reynisdottir, Steven N Hart, Hermela Shimelis, Sara Vilske, Anne Kallioniemi, Johanna Schleutker, Arto Leminen, Ralf Bützow, Carl Blomqvist, Rosa B Barkardottir, Fergus J Couch, Kristiina Aittomäki, Heli Nevanlinna

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Oct;111(42):15172-7.

 

Inherited predisposition to breast cancer is known to be caused by loss-of-function mutations in BRCA1, BRCA2, PALB2, CHEK2, and other genes involved in DNA repair. However, most families severely affected by breast cancer do not harbor mutations in any of these genes. In Finland, ...

Last Updated: 22 Oct 2014

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ICAM-1 as a molecular target for triple negative breast cancer.
 

Author(s): Peng Guo, Jing Huang, Liya Wang, Di Jia, Jiang Yang, Deborah A Dillon, David Zurakowski, Hui Mao, Marsha A Moses, Debra T Auguste

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Oct;111(41):14710-5.

 

Triple negative breast cancers (TNBCs) have a high mortality rate owing to aggressive proliferation and metastasis and a lack of effective therapeutic options. Herein, we describe the overexpression of intercellular adhesion molecule-1 (ICAM-1) in human TNBC cell lines and tissues, ...

Last Updated: 15 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Triple Negative Breast Cancer" returned 50 free, full-text review articles on human participants. First 3 results:

Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry.
 

Author(s): Abenaa M Brewster, Mariana Chavez-MacGregor, Powel Brown

Journal: Lancet Oncol.. 2014 Dec;15(13):e625-34.

 

Breast cancer incidence is increasing worldwide, and breast cancer-related mortality is highest in women of African ancestry, who are more likely to have basal-like or triple-negative breast cancer (TNBC) than are women of European ancestry. Identification of cultural, epidemiological, ...

Last Updated: 3 Dec 2014

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Rationale for targeting the Ras/MAPK pathway in triple-negative breast cancer.
 

Author(s): Jennifer M Giltnane, Justin M Balko

Journal: Discov Med. 2014 May;17(95):275-83.

 

"Triple negative" breast cancer (TNBC) is the most aggressive and least common clinical subtype of breast cancer. As its nomenclature implies, TNBC lacks specific biomarker expression marking response to an effective targeted therapy. The incidence of TNBC is higher in young minority ...

Last Updated: 2 Jun 2014

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Triple negative breast cancer.
 

Author(s): Idil Cetin, Mehmet Topcul

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(6):2427-31.

 

Triple-negative breast cancers (TNBC), characterized by absence of the estrogen receptor (ER) and progesterone receptor (PR) and lack of overexpression of human epidermal growth factor receptor 2 (HER2), have a poor prognosis. To overcome therapy limitations of TNBC, various new approaches ...

Last Updated: 25 Apr 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
 

Status: Not yet recruiting

Condition Summary: Triple Negative Breast Cancer; Triple Negative Breast Neoplasms; Triple-Negative Breast Cancer

 

Last Updated: 27 Apr 2015

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Last Updated: 28 Nov 2012

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Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
 

Status: Recruiting

Condition Summary: Triple Negative Breast Cancer

 

Last Updated: 19 Sep 2014

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