Triple Negative Breast Cancer

Common Name(s)

Triple Negative Breast Cancer

Triple-negative breast cancer is when the cancerous cells lack estrogen and progesterone receptors, and HER2 protein on cell surfaces. Without these receptors and the HER2 protein, neither hormone therapy nor drug treatments that target the HER2 protein are effective. Also triple-negative breast cancers grow and spread faster than most other breast cancers. For these mentioned reasons, chemotherapy is recommended even at the early onset of the disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

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Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 22 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

Logo
Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 22 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Triple Negative Breast Cancer" returned 361 free, full-text research articles on human participants. First 3 results:

The many faces of triple negative breast cancer.
 

Author(s): T Potecă, M Comănescu, A Potecă, C Cocosila,

Journal: Chirurgia (Bucur). ;109(4):471-9.

 

Triple negative breast tumors are described by the lack of immunohistochemical expression for hormone receptors (ER and PgR) and Her2 neu. The immunophenotype is, in general,associated with young age and high biological aggressiveness,its frequency in the literature ranging from 10 ...

Last Updated: 23 Aug 2014

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Predicting response and survival in chemotherapy-treated triple-negative breast cancer.
 

Author(s): A Prat, A Lluch, J Albanell, W T Barry, C Fan, J I Chacón, J S Parker, L Calvo, A Plazaola, A Arcusa, M A Seguí-Palmer, O Burgues, N Ribelles, A Rodriguez-Lescure, A Guerrero, M Ruiz-Borrego, B Munarriz, J A López, B Adamo, M C U Cheang, Y Li, Z Hu, M L Gulley, M J Vidal, B N Pitcher, M C Liu, M L Citron, M J Ellis, E Mardis, T Vickery, C A Hudis, E P Winer, L A Carey, R Caballero, E Carrasco, M Martín, C M Perou, E Alba

Journal: Br. J. Cancer. 2014 Oct;111(8):1532-41.

 

In this study, we evaluated the ability of gene expression profiles to predict chemotherapy response and survival in triple-negative breast cancer (TNBC).

Last Updated: 15 Oct 2014

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Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling.
 

Author(s): Christof Bernemann, Carolin Hülsewig, Christian Ruckert, Sarah Schäfer, Lena Blümel, Georg Hempel, Martin Götte, Burkhard Greve, Peter J Barth, Ludwig Kiesel, Cornelia Liedtke

Journal:

 

Triple negative breast cancer (TNBC) is characterized by lack of expression of both estrogen and progesterone receptor as well as lack of overexpression or amplification of HER2. Despite an increased probability of response to chemotherapy, many patients resistant to current chemotherapy ...

Last Updated: 25 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Triple Negative Breast Cancer" returned 45 free, full-text review articles on human participants. First 3 results:

Tackling the diversity of triple-negative breast cancer.
 

Author(s): Nicholas C Turner, Jorge S Reis-Filho

Journal: Clin. Cancer Res.. 2013 Dec;19(23):6380-8.

 

Triple-negative breast cancer (TNBC) comprises a highly diverse collection of cancers. Here, we review this diversity both in terms of gene expression subtypes and the repertoire of genetic events. Transcriptomic analyses of TNBC have revealed at least six subtypes, with the luminal ...

Last Updated: 3 Dec 2013

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MicroRNAs and triple negative breast cancer.
 

Author(s): Elvira D'Ippolito, Marilena V Iorio

Journal:

 

Triple Negative Breast Cancer (TNBC) is a very aggressive tumor subtype, which still lacks specific markers for an effective targeted therapy. Despite the common feature of negativity for the three most relevant receptors (ER, PgR and HER2), TNBC is a very heterogeneous disease where ...

Last Updated: 28 Nov 2013

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New targets for triple-negative breast cancer.
 

Author(s): Christina I Herold, Carey K Anders

Journal: Oncology (Williston Park, N.Y.). 2013 Sep;27(9):846-54.

 

Triple-negative breast cancer (TNBC) lacks the three most commonly targeted receptors in human breast cancer--the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)/neu--and it is associated with an aggressive natural history. More ...

Last Updated: 28 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 28 Nov 2012

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Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
 

Status: Recruiting

Condition Summary: Triple Negative Breast Cancer

 

Last Updated: 19 Sep 2014

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Phase II Study of IMMU-132 Alone or in Combination With Carboplatin in Patients With Triple-Negative Breast Cancer
 

Status: Not yet recruiting

Condition Summary: Triple-negative Breast Cancer

 

Last Updated: 11 Jun 2014

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