Triple Negative Breast Cancer

Common Name(s)

Triple Negative Breast Cancer

Triple-negative breast cancer is when the cancerous cells lack estrogen and progesterone receptors, and HER2 protein on cell surfaces. Without these receptors and the HER2 protein, neither hormone therapy nor drug treatments that target the HER2 protein are effective. Also triple-negative breast cancers grow and spread faster than most other breast cancers. For these mentioned reasons, chemotherapy is recommended even at the early onset of the disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Triple Negative Breast Cancer" for support, advocacy or research.

Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Triple Negative Breast Cancer" returned 584 free, full-text research articles on human participants. First 3 results:

Impact of neoadjuvant chemotherapy in stage II-III triple negative breast cancer on eligibility for breast-conserving surgery and breast conservation rates: surgical results from CALGB 40603 (Alliance).
 

Author(s): Mehra Golshan, Constance T Cirrincione, William M Sikov, Donald A Berry, Sara Jasinski, Tracey F Weisberg, George Somlo, Clifford Hudis, Eric Winer, David W Ollila,

Journal: Ann. Surg.. 2015 Sep;262(3):434-9; discussion 438-9.

 

To assess the efficacy of neoadjuvant systemic therapy (NST) at increasing the rate of successful breast-conserving therapy (BCT) in triple negative breast cancer.

Last Updated: 11 Aug 2015

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An Autoimmune Response Signature Associated with the Development of Triple-Negative Breast Cancer Reflects Disease Pathogenesis.
 

Author(s): Hiroyuki Katayama, Clayton Boldt, Jon J Ladd, Melissa M Johnson, Timothy Chao, Michela Capello, Jinfeng Suo, Jianning Mao, JoAnn E Manson, Ross Prentice, Francisco Esteva, Hong Wang, Mary L Disis, Samir Hanash

Journal: Cancer Res.. 2015 Aug;75(16):3246-54.

 

The repertoire of antigens associated with the development of an autoimmune response in breast cancer has relevance to detection and treatment strategies. We have investigated the occurrence of autoantibodies associated with the development of triple-negative breast cancer (TNBC) ...

Last Updated: 15 Aug 2015

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MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.
 

Author(s): Yong-qiang Ren, Fengkui Fu, Jianjun Han

Journal:

 

MiR-27a is significantly overexpressed in triple-negative breast cancer (TNBC). However, the exact biological function of MiR-27a in TNBC is not fully understood. In this study, we verified miR-27a expression in TNBC cells and explored how its overexpression modulates radiosensitivity of the cells.

Last Updated: 6 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Triple Negative Breast Cancer" returned 56 free, full-text review articles on human participants. First 3 results:

Androgen receptor, EGFR, and BRCA1 as biomarkers in triple-negative breast cancer: a meta-analysis.
 

Author(s): Li Zhang, Cheng Fang, Xianqun Xu, Anling Li, Qing Cai, Xinghua Long

Journal: Biomed Res Int. 2015 ;2015():357485.

 

More and more evidences demonstrate that androgen receptor (AR), epidermal growth factor receptor (EGFR), and breast cancer susceptibility gene 1 (BRCA1) have unique clinical implications for targeted therapy or prognosis in triple-negative breast cancer (TNBC). Therefore, we conducted ...

Last Updated: 19 Feb 2015

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Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry.
 

Author(s): Abenaa M Brewster, Mariana Chavez-MacGregor, Powel Brown

Journal: Lancet Oncol.. 2014 Dec;15(13):e625-34.

 

Breast cancer incidence is increasing worldwide, and breast cancer-related mortality is highest in women of African ancestry, who are more likely to have basal-like or triple-negative breast cancer (TNBC) than are women of European ancestry. Identification of cultural, epidemiological, ...

Last Updated: 3 Dec 2014

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Subtyping of triple-negative breast cancer: implications for therapy.
 

Author(s): Vandana G Abramson, Brian D Lehmann, Tarah J Ballinger, Jennifer A Pietenpol

Journal: Cancer. 2015 Jan;121(1):8-16.

 

Triple-negative breast cancer (TNBC) is a heterogeneous disease; gene expression analyses recently identified 6 distinct TNBC subtypes, each of which displays a unique biology. Exploring novel approaches for the treatment of these subtypes is critical, especially because the median ...

Last Updated: 19 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
 

Status: Recruiting

Condition Summary: Triple Negative Breast Cancer; Triple Negative Breast Neoplasms; Triple-Negative Breast Cancer

 

Last Updated: 18 Nov 2015

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Last Updated: 28 Nov 2012

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Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
 

Status: Recruiting

Condition Summary: Triple Negative Breast Cancer

 

Last Updated: 23 Dec 2015

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