Invasive lobular carcinoma

Common Name(s)

Invasive lobular carcinoma, Invasive lobular carcinoma, breast cancer

Invasive lobular carcinoma (ILC) is a type of breast cancer that originates in the milk producing tissues (lobules) of the breast and spreads to other tissue. Cancers form when a mutation in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis. Many of the risk factors for breast cancer are related to estrogen exposure, such as older age, having children later in life, having few or no children, taking estrogen-containing medications, early menarche (first period), and late menopause. Other risk factors include older age, obesity, and family and individual history of certain types of cancer.

Signs of ILC include swelling or hardened areas of the breast, nipple or breast pain, nipple discharge, and skin irritation (redness, thickening, scaling), and skin puckering. Unlike invasive ductal carcinoma, ILC will almost never present with a lump or mass in the breast. Instead, ILC is often diagnosed by mammogram or imaging of the breast. Diagnosis is then confirmed by taking a biopsy, or sample, of the affected tissue. In one third of affected individuals, ILC is found bilaterally, or in both breasts.

Treatment options for ILC depend on the stage of disease. The stage of cancer will be determined based on the tumor size and whether it has spread to nearby lymph nodes or to other organs by metastasis. Treatment options may include surgery for tumor removal, radiation therapy, chemotherapy, hormone therapy, and other methods. If you have been diagnosed with invasive lobular carcinoma, talk to your doctor about the best treatment options. In addition, a genetic counselor can help discuss inheritance and risks to other family members. Support groups are a good source of information and can help connect you with others in the breast cancer community.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Invasive lobular carcinoma" for support, advocacy or research.

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

Last Updated: 7 Jan 2016

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Invasive lobular carcinoma" for support, advocacy or research.

Logo
Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

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No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

http://www.nostomachforcancer.org

Last Updated: 7 Jan 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Invasive lobular carcinoma" returned 88 free, full-text research articles on human participants. First 3 results:

Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma.
 

Author(s): Zheling Chen, Jiao Yang, Shuting Li, Meng Lv, Yanwei Shen, Biyuan Wang, Pan Li, Min Yi, Xiao'ai Zhao, Lingxiao Zhang, Le Wang, Jin Yang

Journal:

 

The clinical outcomes and therapeutic strategies for infiltrating ductal carcinoma (IDC) and infiltrating lobular carcinoma (ILC) are not uniform. The primary objectives of this study were to identify the differences in the clinical characteristics and prognoses between ILC and IDC, ...

Last Updated: 1 Sep 2017

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The pattern of invasive lobular carcinoma in the patients diagnosed with breast cancer from Balochistan.
 

Author(s): A H Baloch, A N Khosa, N Bangulzai, H Sadia, M Ahmed, F Khan, M Jan, M Tareen, M H Kakar, J Shuja, H K Naseeb, J Ahmad

Journal: Indian J Cancer. ;53(3):363-365.

 

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer accounting for 5%-15% of all the breast cancer cases. The present study was performed on 171 breast cancer patients from Balochistan registered in CENAR (Center for Nuclear Medicine and Radiotherapy), Quetta.

Last Updated: 28 Feb 2017

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Expression of Lipid Metabolism-Related Proteins Differs between Invasive Lobular Carcinoma and Invasive Ductal Carcinoma.
 

Author(s): Yoon Jin Cha, Hye Min Kim, Ja Seung Koo

Journal:

 

We comparatively investigated the expression and clinical implications of lipid metabolism-related proteins in invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) of the breast. A total of 584 breast cancers (108 ILC and 476 IDC) were subjected to tissue microarray ...

Last Updated: 26 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Invasive lobular carcinoma" returned 6 free, full-text review articles on human participants. First 3 results:

Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics.
 

Author(s): Amy E McCart Reed, Jamie R Kutasovic, Sunil R Lakhani, Peter T Simpson

Journal:

 

Invasive lobular carcinoma of the breast is the most common 'special' morphological subtype of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good prognostic phenotype, being low histological grade and low mitotic index, hormone receptor positive and ...

Last Updated: 8 Apr 2015

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Relapse of invasive lobular carcinoma.
 

Author(s): Elizabeth Mallon, Zsuzsanna Varga

Journal: Breast Dis. ;30():53-6.

 

Last Updated: 22 Mar 2012

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MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature.
 

Author(s): Ritse M Mann, Yvonne L Hoogeveen, Johan G Blickman, Carla Boetes

Journal: Breast Cancer Res. Treat.. 2008 Jan;107(1):1-14.

 

The clinical diagnosis and management of invasive lobular carcinoma (ILC) of the breast presents difficulties. Magnetic resonance imaging (MRI) has been proposed as the imaging modality of choice for the evaluation of ILC. Small studies addressing different aspects of MRI in ILC have ...

Last Updated: 28 Nov 2007

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS)
 

Status: Recruiting

Condition Summary: Breast Cancer

 

Last Updated: 25 Jul 2017

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Intraoperative Imaging of Breast Cancer With Indocyanine Green
 

Status: Recruiting

Condition Summary: Invasive Ductal Carcinoma; Invasive Lobular Carcinoma; Ductal Carcinoma

 

Last Updated: 11 Jun 2017

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Single Fraction Intraoperative Radiotherapy
 

Status: Recruiting

Condition Summary: Invasive Ductal and Invasive Lobular Breast Carcinoma; Stage 0 Breast Carcinoma; Stage I Breast Carcinoma; Stage II Breast Carcinoma

 

Last Updated: 14 Oct 2014

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