HIV

Common Name(s)

HIV

Human immunodeficiency virus or HIV is a viral infection of the immune system. Acquired immune deficiency disease (AIDS) is the umbrella term used to describe the final stage of an HIV infection. HIV is a sexually transmitted infection, but HIV can also be transmitted by contaminated hypodermic needles and blood transfusions, as well as from mother to child during pregnancy, delivery, and breastfeeding. Early symptoms of an HIV infection include fever, rash, night sweats, headaches, sore throat, fatigue, and a general feeling of having the flu, but many individuals who are HIV positive do not have any symptoms. This is because the virus has a latency stage, also known as the chronic phase. The virus can lay dormant inside your cells for years. HIV is a human retrovirus. The term retrovirus means that the virus can replicate inside a human cell. The retrovirus is an RNA virus; it converts itself into DNA and inserts itself into the cell’s genome. Once it is part of the cell’s genetic code, the virus is then produced by the cell’s replication machinery. Once enough of the virus has been produced within the cell, the cell dies and releases the virus into the body. HIV attacks the cells of your immune system, specifically the CD4 cells. CD4 cells include T helper cells, monocytes, macrophages, and dendritic cells. The virus decreases the number CD4 cells in the body, therefore diminishing the body’s ability to fight infection. Once your number of CD4 cells has fallen below 200 per cubic millimeter of blood, you will be diagnosed with AIDS. There is no cure for an HIV infection or AIDS. There are treatments that can suppress the HIV virus and help to slow the progression of the disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HIV" for support, advocacy or research.

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The Well Project

The Well Project is a non-profit organization whose mission is to change the course of the HIV/AIDS pandemic through a unique and comprehensive focus on women and girls. The Well Project advocates that every woman and girl should have access to quality, up-to-date information about HIV/AIDS.

Last Updated: 20 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HIV" for support, advocacy or research.

Logo
The Well Project

The Well Project is a non-profit organization whose mission is to change the course of the HIV/AIDS pandemic through a unique and comprehensive focus on women and girls. The Well Project advocates that every woman and girl should have access to quality, up-to-date information about HIV/AIDS.

http://www.thewellproject.org/

Last Updated: 20 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "HIV" returned 31312 free, full-text research articles on human participants. First 3 results:

Single-pill regimens for HIV-1 infection.
 

Author(s): Monica Gandhi, Rajesh T Gandhi

Journal: N. Engl. J. Med.. 2014 Nov;371(19):1845-6.

 

Last Updated: 6 Nov 2014

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American ginseng (Panax quinquefolius) administration does not affect performance of the Roche COBAS Ampliprep/Taqman HIV-1 RNA assay.
 

Author(s): Rahul P Bakshi, Todd T Brown, Antoine Simmons, Chun-Su Yuan, Brent A Bauer, Jeff A Sloan, Adriana Andrade

Journal:

 

Previous data indicate that purified components of ginseng can inhibit HIV reverse transcriptase in vitro, suggesting that ginseng components in plasma may interfere with HIV-1 RNA detection assays.

Last Updated: 11 Nov 2014

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Neurodevelopmental benefits of antiretroviral therapy in Ugandan children aged 0-6 years with HIV.
 

Author(s): Heena Brahmbhatt, Michael Boivin, Victor Ssempijja, Godfrey Kigozi, Joseph Kagaayi, David Serwadda, Ronald H Gray

Journal: J. Acquir. Immune Defic. Syndr.. 2014 Nov;67(3):316-22.

 

Insufficient data on neurodevelopmental benefits of antiretroviral therapy (ART) in children.

Last Updated: 15 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "HIV" returned 3028 free, full-text review articles on human participants. First 3 results:

Antiretroviral therapy response among HIV-2 infected patients: a systematic review.
 

Author(s): Didier K Ekouevi, Boris K Tchounga, Patrick A Coffie, Joseph Tegbe, Alexandra M Anderson, Geoffrey S Gottlieb, Marco Vitoria, François Dabis, Serge P Eholie

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Few data are available on antiretroviral therapy (ART) response among HIV-2 infected patients. We conducted a systematic review on treatment outcomes among HIV-2 infected patients on ART, focusing on the immunological and virological responses in adults.

Last Updated: 3 Sep 2014

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Ocular infections in sub-Saharan Africa in the context of high HIV prevalence.
 

Author(s): Erik Schaftenaar, Eric C M van Gorp, Christina Meenken, Albert D M E Osterhaus, Lies Remeijer, Helen E Struthers, James A McIntyre, G Seerp Baarsma, Georges M G M Verjans, Remco P H Peters

Journal: Trop. Med. Int. Health. 2014 Sep;19(9):1003-14.

 

Healthy eyes and good vision are important determinants of populations' health across the globe. Sub-Saharan Africa is affected by simultaneous epidemics of ocular infections and human immunodeficiency virus (HIV). Ocular infection and its complications, along with cataract and ocular ...

Last Updated: 8 Aug 2014

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Do HIV-1 non-B subtypes differentially impact resistance mutations and clinical disease progression in treated populations? Evidence from a systematic review.
 

Author(s): Madhavi Bhargava, Jorge Martinez Cajas, Mark A Wainberg, Marina B Klein, Nitika Pant Pai

Journal:

 

There are 31 million adults living with HIV-1 non-B subtypes globally, and about 10 million are on antiretroviral therapy (ART). Global evidence to guide clinical practice on ART response in HIV-1 non-B subtypes remains limited. We systematically searched 11 databases for the period ...

Last Updated: 7 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of People With HIV Infection Who Have High Viral Loads Despite Combination Antiretroviral Therapy
 

Status: Recruiting

Condition Summary: Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; AIDS Virus; Human Immunodeficiency Virus; Human Immunodeficiency Viruses

 

Last Updated: 13 Sep 2014

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DVD-based HIV/HCV Prevention Intervention for Drug-Involved Latino Criminal Justice Clients
 

Status: Not yet recruiting

Condition Summary: Human Immunodeficiency Virus; Acquired Immunodeficiency Syndrome; Hepatitis C

 

Last Updated: 15 Apr 2014

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