HIV

Common Name(s)

HIV

Human immunodeficiency virus or HIV is a viral infection of the immune system. Acquired immune deficiency disease (AIDS) is the umbrella term used to describe the final stage of an HIV infection. HIV is a sexually transmitted infection, but HIV can also be transmitted by contaminated hypodermic needles and blood transfusions, as well as from mother to child during pregnancy, delivery, and breastfeeding. Early symptoms of an HIV infection include fever, rash, night sweats, headaches, sore throat, fatigue, and a general feeling of having the flu, but many individuals who are HIV positive do not have any symptoms. This is because the virus has a latency stage, also known as the chronic phase. The virus can lay dormant inside your cells for years. HIV is a human retrovirus. The term retrovirus means that the virus can replicate inside a human cell. The retrovirus is an RNA virus; it converts itself into DNA and inserts itself into the cell’s genome. Once it is part of the cell’s genetic code, the virus is then produced by the cell’s replication machinery. Once enough of the virus has been produced within the cell, the cell dies and releases the virus into the body. HIV attacks the cells of your immune system, specifically the CD4 cells. CD4 cells include T helper cells, monocytes, macrophages, and dendritic cells. The virus decreases the number CD4 cells in the body, therefore diminishing the body’s ability to fight infection. Once your number of CD4 cells has fallen below 200 per cubic millimeter of blood, you will be diagnosed with AIDS. There is no cure for an HIV infection or AIDS. There are treatments that can suppress the HIV virus and help to slow the progression of the disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HIV" for support, advocacy or research.

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The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

Last Updated: 11 Jul 2016

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The Well Project

The Well Project is a non-profit organization whose mission is to change the course of the HIV/AIDS pandemic through a unique and comprehensive focus on women and girls. The Well Project advocates that every woman and girl should have access to quality, up-to-date information about HIV/AIDS.

Last Updated: 20 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "HIV" for support, advocacy or research.

Logo
The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

http://www.thestdproject.com/

Last Updated: 11 Jul 2016

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The Well Project

The Well Project is a non-profit organization whose mission is to change the course of the HIV/AIDS pandemic through a unique and comprehensive focus on women and girls. The Well Project advocates that every woman and girl should have access to quality, up-to-date information about HIV/AIDS.

http://www.thewellproject.org/

Last Updated: 20 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "HIV" returned 39277 free, full-text research articles on human participants. First 3 results:

Dapivirine Vaginal Ring for HIV-1 Prevention.
 

Author(s): Jared M Baeten, Elizabeth R Brown, Sharon L Hillier

Journal: N. Engl. J. Med.. 2017 03;376(10):995-6.

 

Last Updated: 8 Mar 2017

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High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic: A cross-sectional study.
 

Author(s): Christian Diamant Mossoro-Kpinde, Jean-Chrysostome Gody, Ralph-Sydney Mboumba Bouassa, Olivia Mbitikon, Mohammad-Ali Jenabian, Leman Robin, Mathieu Matta, Kamal Zeitouni, Jean De Dieu Longo, Cecilia Costiniuk, Gérard Grésenguet, Ndèye Coumba Touré Kane, Laurent Bélec

Journal: Medicine (Baltimore). 2017 Mar;96(10):e6282.

 

A large cohort of 220 HIV-1-infected children (median [range] age: 12 [4-17] years) was cared and followed up in the Central African Republic, including 198 in 1st-line and 22 in 2nd-line antiretroviral regimens. Patients were monitored clinically and biologically for HIV-1 RNA load ...

Last Updated: 8 Mar 2017

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Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era.
 

Author(s): Laura Iordache, Djaouida Bengoufa, Olivier Taulera, Agathe Rami, Caroline Lascoux-Combe, Nesrine Day, Maguy Parrinello, Pierre-Olivier Sellier, Jean-Michel Molina, Alfred Mahr

Journal: Medicine (Baltimore). 2017 Mar;96(10):e6230.

 

Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs ...

Last Updated: 8 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "HIV" returned 3704 free, full-text review articles on human participants. First 3 results:

Factors Associated with the Size of HIV DNA Reservoir.
 

Author(s): Ni-Dan Wang, Tai-Sheng Li

Journal: Chin. Med. J.. 2017 01;130(2):224-230.

 

To review the recent literatures related to the factors associated with the size of the HIV reservoir and their clinical significance.

Last Updated: 16 Jan 2017

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Oxidative Stress during HIV Infection: Mechanisms and Consequences.
 

Author(s): Alexander V Ivanov, Vladimir T Valuev-Elliston, Olga N Ivanova, Sergey N Kochetkov, Elizaveta S Starodubova, Birke Bartosch, Maria G Isaguliants

Journal: Oxid Med Cell Longev. 2016 ;2016():8910396.

 

It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a variety of natural processes in cells. If increased to levels which cannot be neutralized by the defense mechanisms, they damage biological molecules, alter their functions, and also act as signaling ...

Last Updated: 10 Nov 2016

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Generalized Posttransplant Kaposi Sarcoma without Mucocutaneous Manifestations in the First Liver Transplantation in an HIV-Positive Patient in Poland: A Case Report and Review of Literature.
 

Author(s): Bogna Ziarkiewicz-Wróblewska, Magdalena M Suchacz, Krzysztof Zieniewicz, Michał Ciszek, Urszula Ołdakowska-Jedynak, Krzysztof Dudek, Tadeusz Wróblewski, Michał Mazurkiewicz, Barbara Górnicka, Leszek Pączek, Marek Krawczyk, Alicja Wiercińska-Drapało

Journal:

 

BACKGROUND Kaposi sarcoma (KS) is the most frequent skin cancer in solid organ recipients, and also a typical malignancy in HIV-infected persons. CASE REPORT We describe here a rare case of primary nodal KS without mucocutaneous manifestations, diagnosed in a 20-year-old HIV/HBV co-infected ...

Last Updated: 4 Nov 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 24 Oct 2016

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Community-based Distribution of Oral HIV Self-testing Kits
 

Status: Not yet recruiting

Condition Summary: HIV Seropositivity

 

Last Updated: 14 Dec 2016

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Safety and Immune Response to a Clade C DNA HIV Vaccine
 

Status: Recruiting

Condition Summary: HIV Infections

 

Last Updated: 28 Dec 2016

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