Chronic Graft versus Host Disease

Common Name(s)

Chronic Graft versus Host Disease

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Graft versus Host Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Graft versus Host Disease" returned 410 free, full-text research articles on human participants. First 3 results:

Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.
 

Author(s): Nicolaus Kröger, Carlos Solano, Christine Wolschke, Giuseppe Bandini, Francesca Patriarca, Massimo Pini, Arnon Nagler, Carmine Selleri, Antonio Risitano, Giuseppe Messina, Wolfgang Bethge, Jaime Pérez de Oteiza, Rafael Duarte, Angelo Michele Carella, Michele Cimminiello, Stefano Guidi, Jürgen Finke, Nicola Mordini, Christelle Ferra, Jorge Sierra, Domenico Russo, Mario Petrini, Giuseppe Milone, Fabio Benedetti, Marion Heinzelmann, Domenico Pastore, Manuel Jurado, Elisabetta Terruzzi, Franco Narni, Andreas Völp, Francis Ayuk, Tapani Ruutu, Francesca Bonifazi

Journal: N. Engl. J. Med.. 2016 Jan;374(1):43-53.

 

Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that the inclusion of antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients ...

Last Updated: 7 Jan 2016

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Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice.
 

Author(s): Steven D Schutt, Jianing Fu, Hung Nguyen, David Bastian, Jessica Heinrichs, Yongxia Wu, Chen Liu, Daniel G McDonald, Joseph Pidala, Xue-Zhong Yu

Journal:

 

Bruton's Tyrosine Kinase (BTK) and IL-2 Inducible T-cell Kinase (ITK) are enzymes responsible for the phosphorylation and activation of downstream effectors in the B-cell receptor (BCR) signaling and T cell receptor (TCR) signaling pathways, respectively. Ibrutinib is an FDA-approved ...

Last Updated: 9 Sep 2015

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Modulation and Apoptosis of Neutrophil Granulocytes by Extracorporeal Photopheresis in the Treatment of Chronic Graft-Versus-Host Disease.
 

Author(s): Cindy Franklin, Elvir Cesko, Uwe Hillen, Bastian Schilling, Sven Brandau

Journal:

 

Chronic graft-versus-host disease (cGVHD) is a common side effect of allogeneic stem cell transplantation and a major cause of morbidity and mortality in affected patients. Especially skin, eyes and oral mucosa are affected. This can lead to pain and functional impairment. Extracorporeal ...

Last Updated: 5 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Graft versus Host Disease" returned 47 free, full-text review articles on human participants. First 3 results:

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: III. The 2014 Biomarker Working Group Report.
 

Author(s): Sophie Paczesny, Frances T Hakim, Joseph Pidala, Kenneth R Cooke, Julia Lathrop, Linda M Griffith, John Hansen, Madan Jagasia, David Miklos, Steven Pavletic, Robertson Parkman, Estelle Russek-Cohen, Mary E D Flowers, Stephanie Lee, Paul Martin, Georgia Vogelsang, Marc Walton, Kirk R Schultz

Journal: Biol. Blood Marrow Transplant.. 2015 May;21(5):780-92.

 

Biology-based markers to confirm or aid in the diagnosis or prognosis of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation or monitor its progression are critically needed to facilitate evaluation of new therapies. Biomarkers have been defined ...

Last Updated: 23 Apr 2015

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NIH Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report.
 

Author(s): Howard M Shulman, Diana M Cardona, Joel K Greenson, Sangeeta Hingorani, Thomas Horn, Elisabeth Huber, Andreas Kreft, Thomas Longerich, Thomas Morton, David Myerson, Victor G Prieto, Avi Rosenberg, Nathaniel Treister, Kay Washington, Mirjana Ziemer, Steven Z Pavletic, Stephanie J Lee, Mary E D Flowers, Kirk R Schultz, Madan Jagasia, Paul J Martin, Georgia B Vogelsang, David E Kleiner

Journal: Biol. Blood Marrow Transplant.. 2015 Apr;21(4):589-603.

 

The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information ...

Last Updated: 13 Mar 2015

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B cells in chronic graft-versus-host disease.
 

Author(s): Stefanie Sarantopoulos, Bruce R Blazar, Corey Cutler, Jerome Ritz

Journal: Biol. Blood Marrow Transplant.. 2015 Jan;21(1):16-23.

 

Chronic graft-versus-host disease (cGVHD) continues to be a common complication of allogeneic hematopoietic stem cell transplantation. Unlike acute graft-versus-host disease, which is mediated almost entirely by donor T cells, the immune pathology of cGVHD is more complex and donor ...

Last Updated: 20 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
 

Status: Recruiting

Condition Summary: Chronic Graft Versus Host Disease; Chronic GVHD; Complications of Organ Transplant Stem Cells

 

Last Updated: 28 Jan 2016

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An Open Label Phase II Trial of Topical Sirolimus for the Treatment of Refractory Oral Chronic Graft-versus-Host-Disease
 

Status: Recruiting

Condition Summary: Chronic Graft-versus-Host-Disease; Oral Mucosal Disease Due to Graft-versus-host Disease

 

Last Updated: 14 Oct 2014

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Ofatumumab as Primary Therapy of Chronic Graft Versus Host Disease
 

Status: Recruiting

Condition Summary: Chronic Graft Versus Host Disease

 

Last Updated: 5 Apr 2016

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