Infertility

Common Name(s)

Infertility

Infertility is defined as the inability to become pregnant, despite having frequent, unprotected sex for at least a year (or six months under certain circumstances). Infertility may also refer to the state of a woman not being able to carry a pregnancy to full term (resulting in miscarriage). About 10-15% of couples are infertile in the United States. Infertility may be due to a single cause in either you or your partner or a combination of factors. About one third of the time the cause of infertility only involves the male. About one third of the time, the cause of infertility only involves the female. In the remaining one third of the time, the cause involves both male and female or no cause can be found. The causes of male infertility include abnormal sperm production or function, problems with the delivery of sperm, overexposure to certain environmental factors, or damage related to cancer. Causes of female infertility include ovulation disorders, uterine or cervical abnormalities, fallopian tube damage or blockage, endometriosis, pelvic adhesions, thyroid problems, cancer treatment, or other conditions or medications. Risk factors for male and female infertility include advanced age (for women over 35, for men over 40), tobacco use, alcohol use, being overweight or underweight, not enough exercise, or too much strenuous, intense exercise (particularly for women). Diagnosis is made through a number of different tests. Testing and trial treatments may extend over several months. The good news is that there are many safe and effective therapies for overcoming infertility. And due to research, treatment options continue to improve the chances a couple will become pregnant. Talk with your obstetrician or midwife if you are having trouble becoming pregnant. He or she will most likely suggest you see an infertility specialist possibly at an infertility center. Support organizations are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 27 Apr 2015

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 27 Apr 2015

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

http://www.resolve.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Infertility" returned 1192 free, full-text research articles on human participants. First 3 results:

Infertility care among OEF/OIF/OND women Veterans in the Department of Veterans Affairs.
 

Author(s): Kristin Mattocks, Aimee Kroll-Desrosiers, Laurie Zephyrin, Jodie Katon, Julie Weitlauf, Lori Bastian, Sally Haskell, Cynthia Brandt

Journal: Med Care. 2015 Apr;53(4 Suppl 1):S68-75.

 

An increasing number of young women Veterans seek reproductive health care through the VA, yet little is known regarding the provision of infertility care for this population. The VA provides a range of infertility services for Veterans including artificial insemination, but does ...

Last Updated: 15 Mar 2015

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Effect of a comprehensive therapy plus gushenyutai plaster administered at guanyuan (CV 4) on male infertility associated with semen non-liquefaction.
 

Author(s): Shaofang Peng, Yanping Zheng, Kangzhuang Zheng, Ke Lin, Juhong Wu, Wenqin Zheng, Yongzhong Li, Yang Li, Chuangjian Lin

Journal: J Tradit Chin Med. 2014 Dec;34(6):666-72.

 

To observe the clinical effect of Gushenyutai plaster administered at the Guanyuan (CV 4) acupoint on male infertility associated with semen non-liquefaction.

Last Updated: 26 Jan 2015

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The presence of multiple gestational sacs confers a higher live birth rate in women with infertility who achieve a positive pregnancy test after fresh and frozen embryo transfer: a retrospective local cohort.
 

Author(s): Erika Balassiano, Shaveta Malik, Praful Vaid, Eric S Knochenhauer, Michael L Traub

Journal:

 

After spontaneous conception, the rate of miscarriage is more common in multiple rather than singleton pregnancies. However, the incidence of miscarriage is lower in in-vitro fertilization twin versus singleton pregnancies. Most patients have little understanding of pregnancy outcomes ...

Last Updated: 27 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Infertility" returned 247 free, full-text review articles on human participants. First 3 results:

Improving the Reporting of Clinical Trials of Infertility Treatments (IMPRINT): modifying the CONSORT statement.
 

Author(s):

Journal: Fertil. Steril.. 2014 Oct;102(4):952-959.e15.

 

Clinical trials testing infertility treatments often do not report on the major outcomes of interest to patients and clinicians and the public (such as live birth) nor on the harms, including maternal risks during pregnancy and fetal anomalies. This is complicated by the multiple ...

Last Updated: 2 Oct 2014

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Infertility care and the introduction of new reproductive technologies in poor resource settings.
 

Author(s): Luis Bahamondes, Maria Y Makuch

Journal:

 

The overall prevalence of infertility was estimated to be 3.5-16.7% in developing countries and 6.9-9.3% in developed countries. Furthermore, according to reports from some regions of sub-Saharan Africa, the prevalence rate is 30-40%. The consequences of infertility and how it affects ...

Last Updated: 26 Sep 2014

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Risk of infertility in patients with celiac disease: a meta-analysis of observational studies.
 

Author(s): Juan Sebastian Lasa, Ignacio Zubiaurre, Luis Oscar Soifer

Journal: Arq Gastroenterol. ;51(2):144-50.

 

Celiac disease is an autoimmune disorder of the small intestine associated with several extra-intestinal features, such as reproductive disorders. The relationship between celiac disease and infertility has been previously assessed, with conflicting results.

Last Updated: 9 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Proposed Research Protocol For Male Infertility
 

Status: Not yet recruiting

Condition Summary: Male Infertility

 

Last Updated: 6 Dec 2010

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Impact of Folates in the Care of the Male Infertility
 

Status: Recruiting

Condition Summary: Male Infertility

 

Last Updated: 7 Oct 2014

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Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility
 

Status: Not yet recruiting

Condition Summary: Primary Infertility Unspecified; Infertility; Ovarian Hyperstimulation; Pregnancy

 

Last Updated: 10 Apr 2015

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