Infertility

Common Name(s)

Infertility

Infertility is defined as the inability to become pregnant, despite having frequent, unprotected sex for at least a year (or six months under certain circumstances). Infertility may also refer to the state of a woman not being able to carry a pregnancy to full term (resulting in miscarriage). About 10-15% of couples are infertile in the United States. Infertility may be due to a single cause in either you or your partner or a combination of factors. About one third of the time the cause of infertility only involves the male. About one third of the time, the cause of infertility only involves the female. In the remaining one third of the time, the cause involves both male and female or no cause can be found. The causes of male infertility include abnormal sperm production or function, problems with the delivery of sperm, overexposure to certain environmental factors, or damage related to cancer. Causes of female infertility include ovulation disorders, uterine or cervical abnormalities, fallopian tube damage or blockage, endometriosis, pelvic adhesions, thyroid problems, cancer treatment, or other conditions or medications. Risk factors for male and female infertility include advanced age (for women over 35, for men over 40), tobacco use, alcohol use, being overweight or underweight, not enough exercise, or too much strenuous, intense exercise (particularly for women). Diagnosis is made through a number of different tests. Testing and trial treatments may extend over several months. The good news is that there are many safe and effective therapies for overcoming infertility. And due to research, treatment options continue to improve the chances a couple will become pregnant. Talk with your obstetrician or midwife if you are having trouble becoming pregnant. He or she will most likely suggest you see an infertility specialist possibly at an infertility center. Support organizations are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

http://www.resolve.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Infertility" returned 1371 free, full-text research articles on human participants. First 3 results:

[Intracytoplasmic injection of morphologically selected spermatozoa from patients with male factor infertility: clinical and embryo development outcomes].
 

Author(s): Yi Gong, Xiang-Qian Meng, Mian Liu, Jing Wang, Fu Xiong, Ying Zhong, Song Quan

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Oct;35(10):1428-33.

 

To test whether intracytoplasmic injection of morphologically selected spermatozoa (IMSI) from patients with male factor infertility can improve the clinical and embryo development outcomes of intracytoplasmic sperm injection-embryo transfer (ICSI-ET).

Last Updated: 9 Nov 2015

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[Anxiety status and influential factors in patients with infertility].
 

Author(s): Fang Wu, Yang Liu, Xiaogang Li

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Sep;40(9):1023-8.

 

To investigate the anxiety status of infertile patients and the influential factors.


Last Updated: 26 Sep 2015

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Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility.
 

Author(s): Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Joel Ager, Hao Huang, Karl R Hansen, Valerie Baker, Rebecca Usadi, Aimee Seungdamrong, G Wright Bates, R Mitchell Rosen, Daniel Haisenleder, Stephen A Krawetz, Kurt Barnhart, J C Trussell, Dana Ohl, Yufeng Jin, Nanette Santoro, Esther Eisenberg, Heping Zhang,

Journal: N. Engl. J. Med.. 2015 Sep;373(13):1230-40.

 

The standard therapy for women with unexplained infertility is gonadotropin or clomiphene citrate. Ovarian stimulation with letrozole has been proposed to reduce multiple gestations while maintaining live birth rates.

Last Updated: 24 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Infertility" returned 286 free, full-text review articles on human participants. First 3 results:

Small Supernumerary Marker Chromosomes in Human Infertility.
 

Author(s): Narjes Armanet, Lucie Tosca, Sophie Brisset, Thomas Liehr, Gérard Tachdjian

Journal: Cytogenet. Genome Res.. 2015 ;146(2):100-8.

 

Small supernumerary marker chromosomes (sSMC) are structurally abnormal chromosomes that cannot be unambiguously identified by banding cytogenetics. The objective of this study was to provide an overview of sSMC frequency and characterization in a context of infertility and to review ...

Last Updated: 24 Sep 2015

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[Successful pregnancy in women with infertility following surgeries for gynecological malignancies: report of 3 cases and literature review].
 

Author(s): Nan Wang, Xin Chen, Desheng Ye, Lijuan Xu, Xiaolong Tian, Ting Tao, Shiling Chen

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jun;35(6):838-43.

 

We report 3 cases of successful pregnancies in women with a history of surgeries for gynecological malignancies and postoperative infertility, achieved by in vitro fertilization-embryo transfer (IVF-ET) with controlled ovarian hyperstimulation. All the 3 patients had clinical pregnancies ...

Last Updated: 26 Jun 2015

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Male reproductive cancers and infertility: a mutual relationship.
 

Author(s): Eva Tvrda, Ashok Agarwal, Nawaf Alkuhaimi

Journal:

 

Reproductive dysfunction and malignancies related to the male gender represent a serious health concern, whose incidence has significantly risen over the past years. Prior to treatment, testicular or prostate cancer patients often display poor semen characteristics similar to subfertile ...

Last Updated: 3 Apr 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Preovulatory Uterine Flushing With Saline as a Treatment for Unexplained Infertility
 

Status: Recruiting

Condition Summary: Unexplained Infertility; Infertility

 

Last Updated: 31 Aug 2015

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Proposed Research Protocol For Male Infertility
 

Status: Not yet recruiting

Condition Summary: Male Infertility

 

Last Updated: 6 Dec 2010

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Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility
 

Status: Not yet recruiting

Condition Summary: Primary Infertility Unspecified; Infertility; Ovarian Hyperstimulation; Pregnancy

 

Last Updated: 10 Apr 2015

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