Infertility

Common Name(s)

Infertility

Infertility is defined as the inability to become pregnant, despite having frequent, unprotected sex for at least a year (or six months under certain circumstances). Infertility may also refer to the state of a woman not being able to carry a pregnancy to full term (resulting in miscarriage). About 10-15% of couples are infertile in the United States. Infertility may be due to a single cause in either you or your partner or a combination of factors. About one third of the time the cause of infertility only involves the male. About one third of the time, the cause of infertility only involves the female. In the remaining one third of the time, the cause involves both male and female or no cause can be found. The causes of male infertility include abnormal sperm production or function, problems with the delivery of sperm, overexposure to certain environmental factors, or damage related to cancer. Causes of female infertility include ovulation disorders, uterine or cervical abnormalities, fallopian tube damage or blockage, endometriosis, pelvic adhesions, thyroid problems, cancer treatment, or other conditions or medications. Risk factors for male and female infertility include advanced age (for women over 35, for men over 40), tobacco use, alcohol use, being overweight or underweight, not enough exercise, or too much strenuous, intense exercise (particularly for women). Diagnosis is made through a number of different tests. Testing and trial treatments may extend over several months. The good news is that there are many safe and effective therapies for overcoming infertility. And due to research, treatment options continue to improve the chances a couple will become pregnant. Talk with your obstetrician or midwife if you are having trouble becoming pregnant. He or she will most likely suggest you see an infertility specialist possibly at an infertility center. Support organizations are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

http://www.resolve.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Infertility" returned 1166 free, full-text research articles on human participants. First 3 results:

Perspectives of complementary and alternative medicine (CAM) practitioners in the support and treatment of infertility.
 

Author(s): Erin O'Reilly, Marika Sevigny, Kelley-Anne Sabarre, Karen P Phillips

Journal:

 

Infertility patients are increasingly using complementary and alternative medicine (CAM) to supplement or replace conventional fertility treatments. The objective of this study was to determine the roles of CAM practitioners in the support and treatment of infertility.

Last Updated: 16 Oct 2014

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Letrozole or clomiphene for infertility in the polycystic ovary syndrome.
 

Author(s): Richard S Legro, Heping Zhang,

Journal: N. Engl. J. Med.. 2014 Oct;371(15):1463-4.

 

Last Updated: 9 Oct 2014

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Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
 

Author(s): Richard S Legro, Robert G Brzyski, Michael P Diamond, Christos Coutifaris, William D Schlaff, Peter Casson, Gregory M Christman, Hao Huang, Qingshang Yan, Ruben Alvero, Daniel J Haisenleder, Kurt T Barnhart, G Wright Bates, Rebecca Usadi, Scott Lucidi, Valerie Baker, J C Trussell, Stephen A Krawetz, Peter Snyder, Dana Ohl, Nanette Santoro, Esther Eisenberg, Heping Zhang,

Journal: N. Engl. J. Med.. 2014 Jul;371(2):119-29.

 

Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes.

Last Updated: 10 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Infertility" returned 247 free, full-text review articles on human participants. First 3 results:

Improving the Reporting of Clinical Trials of Infertility Treatments (IMPRINT): modifying the CONSORT statement.
 

Author(s):

Journal: Fertil. Steril.. 2014 Oct;102(4):952-959.e15.

 

Clinical trials testing infertility treatments often do not report on the major outcomes of interest to patients and clinicians and the public (such as live birth) nor on the harms, including maternal risks during pregnancy and fetal anomalies. This is complicated by the multiple ...

Last Updated: 2 Oct 2014

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Risk of infertility in patients with celiac disease: a meta-analysis of observational studies.
 

Author(s): Juan Sebastian Lasa, Ignacio Zubiaurre, Luis Oscar Soifer

Journal: Arq Gastroenterol. ;51(2):144-50.

 

Celiac disease is an autoimmune disorder of the small intestine associated with several extra-intestinal features, such as reproductive disorders. The relationship between celiac disease and infertility has been previously assessed, with conflicting results.

Last Updated: 9 Jul 2014

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Power of proteomics in linking oxidative stress and female infertility.
 

Author(s): Sajal Gupta, Jana Ghulmiyyah, Rakesh Sharma, Jacques Halabi, Ashok Agarwal

Journal: Biomed Res Int. 2014 ;2014():916212.

 

Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women infertile worldwide. Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the important mechanistic pathways ...

Last Updated: 6 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Male Infertility Related With Post Infection Inflammatory Syndrome
 

Status: Recruiting

Condition Summary: Male Infertility; Leukopenia; Postinfection Inflammation; Oxidative Stress

 

Last Updated: 25 Aug 2014

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Assessment of Ovarian Reserve Tests in Unexplained Infertile Women
 

Status: Recruiting

Condition Summary: Infertility; Infertility, Female

 

Last Updated: 28 Apr 2014

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Proposed Research Protocol For Male Infertility
 

Status: Not yet recruiting

Condition Summary: Male Infertility

 

Last Updated: 6 Dec 2010

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