infertility

Common Name(s)

infertility

Infertility is defined as the inability to get pregnant, despite having frequent, unprotected sex for at least a year. Infertility can also refer to the state of a woman unable to carry a pregnancy full term. The cause of infertility may involve male infertility, such as abnormal sperm production or function, problems with the delivery of sperm, overexposure to certain environmental factors, or damage related to cancer. Causes of female infertility may include ovulation disorders, uterine or cervical abnormalities, fallopian tube damage or blockage, endometriosis, pelvic adhesions, thyroid problems, cancer treatment, or other conditions or medications. Infertility may involve only the male, female, both male and female, or no known cause.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "infertility" for support, advocacy or research.

FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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RESOLVE, INC.: The National Infertility Association

RESOLVE: The National Infertility Association, established in 1974, is a non-profit organization with the only established, nationwide network mandated to promote reproductive health and to ensure equal access to all family building options for men and women experiencing infertility or other reproductive disorders. RESOLVE improves the lives of women and men living with infertility by providing community to these women and men, connecting them with others who can help, empowering them to find resolution and giving voice to their demands for access to all family building options.

http://www.resolve.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "infertility" returned 1118 free, full-text research articles on human participants. First 3 results:

ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure.
 

Author(s): Diego Davila Paskulin, João Sabino Cunha-Filho, Livia Davila Paskulin, Carlos Augusto Bastos Souza, Patricia Ashton-Prolla

Journal: Dis. Markers. 2013 ;35(6):907-13.

 

Estrogen receptor alpha has a central role in human fertility by regulating estrogen action in all human reproductive tissues. Leukemia inhibitory factor (LIF) expression, a cytokine critical for blastocyst implantation, is mediated by estrogen signaling, so we hypothesized that ESR1 ...

Last Updated: 14 Jan 2014

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A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility.
 

Author(s): Nobuyoshi Takasaki, Kouichi Tachibana, Satoshi Ogasawara, Hideki Matsuzaki, Jun Hagiuda, Hiromichi Ishikawa, Keiji Mochida, Kimiko Inoue, Narumi Ogonuki, Atsuo Ogura, Toshiaki Noce, Chizuru Ito, Kiyotaka Toshimori, Hisashi Narimatsu

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Jan;111(3):1120-5.

 

For normal fertilization in mammals, it is important that functionally mature sperm are motile and have a fully formed acrosome. The glycosyltransferase-like gene, human polypeptide N-acetylgalactosaminyltransferase-like protein 5 (GALNTL5), belongs to the polypeptide N-acetylgalactosamine-transferase ...

Last Updated: 22 Jan 2014

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The invention of infertility in the classical Greek world: medicine, divinity, and gender.
 

Author(s): Rebecca Flemming

Journal: Bull Hist Med. 2013 ;87(4):565-90.

 

The article examines the understandings of, and responses to, reproductive failure in the classical Greek world. It discusses explanations and treatments for non-procreation in a range of ancient Greek medical texts, focusing on the writings of the Hippocratic Corpus, which devote ...

Last Updated: 23 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "infertility" returned 232 free, full-text review articles on human participants. First 3 results:

[The impact of thyroid function in women of reproductive age: infertility, pregnancy and the postpartum period].
 

Author(s): Gábor Speer

Journal: Orv Hetil. 2013 Dec;154(51):2017-23.

 

This article reviews the management and diagnosis of thyroid dysfunction during pregnancy and postpartum, which was published by any of the endocrine societies in 2012. The author presents human data based on these clinical practice guidelines, however, there are also many unresolved ...

Last Updated: 16 Dec 2013

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Infertility and its treatments in association with autism spectrum disorders: a review and results from the CHARGE study.
 

Author(s): Kristen Lyall, Alice Baker, Irva Hertz-Picciotto, Cheryl K Walker

Journal:

 

Previous findings on relationships between infertility, infertility therapies, and autism spectrum disorders (ASD) have been inconsistent. The goals of this study are first, to briefly review this evidence and second, to examine infertility and its treatments in association with having ...

Last Updated: 22 Aug 2013

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Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development.
 

Author(s): R John Aitken, Mark A Baker

Journal: Int. J. Dev. Biol.. 2013 ;57(2-4):265-72.

 

During early development, apoptosis plays a major role in the ontogeny of the germ line as a means of regulating the germ cell:Sertoli cell ratio. In the adult, apoptosis fulfils another function in removing damaged germ cells from the seminiferous epithelium in response to a wide ...

Last Updated: 20 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Assessment of Ovarian Reserve Tests in Unexplained Infertile Women
 

Status: Recruiting

Condition Summary: Infertility; Infertility, Female

 

Last Updated: 28 Apr 2014

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Clinical Study of Y Chromosome Variants and Infertility
 

Status: Recruiting

Condition Summary: Male Factor Infertility; Female Factor Infertility; Turner Syndrome

 

Last Updated: 21 Jun 2014

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Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
 

Status: Not yet recruiting

Condition Summary: Male Infertility With Severe Oligo-terato-asteno-spermia

 

Last Updated: 6 Aug 2013

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