Pleomorphic Undifferentiated Sarcoma

Common Name(s)

Pleomorphic Undifferentiated Sarcoma

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pleomorphic Undifferentiated Sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pleomorphic Undifferentiated Sarcoma" returned 17 free, full-text research articles on human participants. First 3 results:

Undifferentiated pleomorphic sarcoma with co-existence of KRAS/PIK3CA mutations.
 

Author(s): Bingcheng Li, Li Li, Xiaoying Li, Yuanyuan Wang, Yuwen Xie, Chunxia Liu, Feng Li

Journal:

 

Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma, comprises a series of high-grade soft tissue sarcomas, which fail to exhibit any specific line of differentiation by using currently available ancillary techniques. Studies on gene mutation ...

Last Updated: 4 Sep 2015

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Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma.
 

Author(s): Jakob Hofvander, Johnbosco Tayebwa, Jenny Nilsson, Linda Magnusson, Otte Brosjö, Olle Larsson, Fredrik Vult von Steyern, Nils Mandahl, Christopher D M Fletcher, Fredrik Mertens

Journal: Clin. Cancer Res.. 2015 Feb;21(4):864-9.

 

Undifferentiated pleomorphic sarcoma (UPS) is defined as a sarcoma with cellular pleomorphism and no identifiable line of differentiation. It is typically a high-grade lesion with a metastatic rate of about one third. No tumor-specific rearrangement has been identified, and genetic ...

Last Updated: 18 Feb 2015

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Life-threatening acute heart failure due to primary cardiac undifferentiated pleomorphic sarcoma.
 

Author(s): Daisuke Abe, Akira Sato, Noriyuki Takeyasu, Chiho Tokunaga, Shinji Akishima, Tatsuo Iijima, Yuzuru Sakakibara, Kazutaka Aonuma

Journal: Intern. Med.. 2014 ;53(16):1775-7.

 

A 41-year-old man was admitted with acute heart failure and shock status. An echocardiogram showed a mobile tumor obstructing blood flow through the mitral valve with a stalk on the posterior left atrium (LA) wall. Emergent open-heart surgery was performed to resect the tumor (77×36×30 ...

Last Updated: 18 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pleomorphic Undifferentiated Sarcoma" returned 2 free, full-text review articles on human participants. First 3 results:

MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st Century.
 

Author(s): Igor Matushansky, Elizabeth Charytonowicz, Joslyn Mills, Sara Siddiqi, Todd Hricik, Carlos Cordon-Cardo

Journal: Expert Rev Anticancer Ther. 2009 Aug;9(8):1135-44.

 

The essence and origin of malignant fibrous histiocytoma (MFH) have been debated for now close to five decades. Originally characterized as a morphologically unique soft-tissue sarcoma subtype of unclear etiology in 1963, with a following 15 years of research only to conclude that ...

Last Updated: 12 Aug 2009

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Primary pleomorphic undifferentiated sarcoma of the kidney: a rare renal tumor.
 

Author(s): Ruchika Gupta, Sampada Gupta, Deepti Aggarwal, Sompal Singh

Journal: Indian J Pathol Microbiol. ;51(4):573-6.

 

Last Updated: 14 Nov 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma
 

Status: Recruiting

Condition Summary: High Grade Sarcoma; Metastatic Leiomyosarcoma; Metastatic Malignant Peripheral Nerve Sheath Tumor; Metastatic Synovial Sarcoma; Metastatic Undifferentiated Pleomorphic Sarcoma; Myxofibrosarcoma; Recurrent Leiomyosarcoma; Recurrent Malignant Peripheral Nerve Sheath Tumor; Recurrent Synovial Sarcoma; Recurrent Undifferentiated Pleomorphic Sarcoma; Uterine Corpus Leiomyosarcoma

 

Last Updated: 1 Jun 2016

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Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Undifferentiated (Embryonal) Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone

 

Last Updated: 29 Jun 2016

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Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Sarcoma, Soft Tissue; Soft Tissue Sarcoma; Undifferentiated Pleomorphic Sarcoma; Leiomyosarcoma; Liposarcoma; Synovial Sarcoma; Myxofibrosarcoma; Angiosarcoma; Fibrosarcoma; Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma

 

Last Updated: 7 Mar 2016

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