Bronchiolitis Obliterans

Common Name(s)

Bronchiolitis Obliterans

Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. The bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. This leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. While there is no way to reverse the disease, treatments are available to stabilize or slow the progression.  

Another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiolitis Obliterans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiolitis Obliterans" returned 219 free, full-text research articles on human participants. First 3 results:

A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation.
 

Author(s): Paul A Corris, Victoria A Ryan, Therese Small, James Lordan, Andrew J Fisher, Gerard Meachery, Gail Johnson, Chris Ward

Journal: Thorax. 2015 May;70(5):442-50.

 

We conducted a placebo-controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation.

Last Updated: 14 Apr 2015

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Bronchiolitis obliterans associated with Stevens-Johnson syndrome: a case report.
 

Author(s): Hyungchul Park, Young Bo Ko, Hyouk-Soo Kwon, Chae-Man Lim

Journal: Yonsei Med. J.. 2015 Mar;56(2):578-81.

 

We report a case of bronchiolitis obliterans associated with Stevens-Johnson syndrome. A 59-year-old man presented with respiratory distress that gradually worsened over 3 months. He had been diagnosed with Stevens-Johnson syndrome 3 months before admission. He had no history of previous ...

Last Updated: 16 Feb 2015

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Cardiac mass and function decrease in bronchiolitis obliterans syndrome after lung transplantation: relationship to physical activity?
 

Author(s): Jan B Hinrichs, Julius Renne, Christian Schoenfeld, Marcel Gutberlet, Axel Haverich, Gregor Warnecke, Tobias Welte, Frank Wacker, Jens Gottlieb, Jens Vogel-Claussen

Journal:

 

There is a need to expand knowledge on cardio-pulmonary pathophysiology of bronchiolitis obliterans syndrome (BOS) following lung transplantation (LTx).

Last Updated: 6 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiolitis Obliterans" returned 29 free, full-text review articles on human participants. First 3 results:

[Bilateral lung transplantation for bronchiolitis obliterans after allogeneic bone marrow transplantation: a case report and literature review].
 

Author(s): Fei Gao, Dong Wei, Bo Wu, Min Zhou, Ji Zhang, Jing-yu Chen

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Aug;34(8):669-72.

 

To explore the feasibility and efficiency of lung transplantation in the treatment of bronchiolitis obliterans (BO) after allogeneic bone marrow transplantation (allo-BMT).

Last Updated: 27 Aug 2013

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Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome.
 

Author(s): V E Kennedy, J L Todd, S M Palmer

Journal: Am. J. Transplant.. 2013 Mar;13(3):552-61.

 

Bronchiolitis obliterans syndrome (BOS), a condition of irreversible small airway fibrosis, is the principal factor limiting long-term survival after lung transplantation. Bronchoscopy and bronchoalveolar lavage (BAL), techniques central to lung transplant clinical practice, provide ...

Last Updated: 26 Feb 2013

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Time to explore preventive and novel therapies for bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation.
 

Author(s): Salyka M Sengsayadeth, Shivani Srivastava, Madan Jagasia, Bipin N Savani

Journal: Biol. Blood Marrow Transplant.. 2012 Oct;18(10):1479-87.

 

Although allogeneic hematopoietic stem cell transplant (allo-HSCT) is performed to treat otherwise incurable and fatal diseases, transplantation itself can lead to life-threatening complications due to organ damage. Pulmonary complications remain a significant barrier to the success ...

Last Updated: 14 Sep 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation
 

Status: Recruiting

Condition Summary: Lung Transplantation; Bronchiolitis Obliterans Syndrome

 

Last Updated: 19 Jul 2011

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Dry Powder Inhalation of Cyclosporine A in Lung Transplant Patients With Bronchiolitis Obliterans Syndrome
 

Status: Recruiting

Condition Summary: Lung Transplantation; Bronchiolitis Obliterans

 

Last Updated: 6 Feb 2007

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Last Updated: 7 Jul 2015

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