Bronchiolitis Obliterans

Common Name(s)

Bronchiolitis Obliterans

Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. The bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. This leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. While there is no way to reverse the disease, treatments are available to stabilize or slow the progression.  

Another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiolitis Obliterans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiolitis Obliterans" returned 215 free, full-text research articles on human participants. First 3 results:

Post-infectious bronchiolitis obliterans in children: a review of 42 cases.
 

Author(s): Ya-Nan Li, Li Liu, Hong-Mei Qiao, Hang Cheng, Huan-Ji Cheng

Journal:

 

This study aimed to describe the clinical characteristics, radiological features and outcomes of 42 children with post-infectious bronchiolitis obliterans (PIBO).

Last Updated: 29 Sep 2014

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Follow-up on pediatric patients with bronchiolitis obliterans treated with corticosteroid pulse therapy.
 

Author(s): Silvia Onoda Tomikawa, FabĂ­ola Villac Adde, Luiz Vicente Ribeiro Ferreira da Silva Filho, Claudio Leone, Joaquim Carlos Rodrigues

Journal:

 

Bronchiolitis obliterans (BO) is a rare but severe disease in children. Currently, there is no consensus on the treatment for BO with respect to the systemic use of corticosteroids. Here we report on the follow-up of children with a diagnosis of BO who were treated with corticosteroid pulse therapy.

Last Updated: 3 Sep 2014

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Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
 

Author(s): Bo-Qia Xie, Wei Wang, Wen-Qian Zhang, Xin-Hua Guo, Min-Fu Yang, Li Wang, Zuo-Xiang He, Yue-Qin Tian

Journal:

 

Childhood post-infectious bronchiolitis obliterans (BO) is an infrequent lung disease leading to narrowing and/or complete obliteration of small airways. Ventilation and perfusion (V/Q) scan can provide both regional and global pulmonary information. However, only few retrospective ...

Last Updated: 23 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiolitis Obliterans" returned 29 free, full-text review articles on human participants. First 3 results:

[Bilateral lung transplantation for bronchiolitis obliterans after allogeneic bone marrow transplantation: a case report and literature review].
 

Author(s): Fei Gao, Dong Wei, Bo Wu, Min Zhou, Ji Zhang, Jing-yu Chen

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Aug;34(8):669-72.

 

To explore the feasibility and efficiency of lung transplantation in the treatment of bronchiolitis obliterans (BO) after allogeneic bone marrow transplantation (allo-BMT).

Last Updated: 27 Aug 2013

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Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome.
 

Author(s): V E Kennedy, J L Todd, S M Palmer

Journal: Am. J. Transplant.. 2013 Mar;13(3):552-61.

 

Bronchiolitis obliterans syndrome (BOS), a condition of irreversible small airway fibrosis, is the principal factor limiting long-term survival after lung transplantation. Bronchoscopy and bronchoalveolar lavage (BAL), techniques central to lung transplant clinical practice, provide ...

Last Updated: 26 Feb 2013

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Time to explore preventive and novel therapies for bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation.
 

Author(s): Salyka M Sengsayadeth, Shivani Srivastava, Madan Jagasia, Bipin N Savani

Journal: Biol. Blood Marrow Transplant.. 2012 Oct;18(10):1479-87.

 

Although allogeneic hematopoietic stem cell transplant (allo-HSCT) is performed to treat otherwise incurable and fatal diseases, transplantation itself can lead to life-threatening complications due to organ damage. Pulmonary complications remain a significant barrier to the success ...

Last Updated: 14 Sep 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation
 

Status: Recruiting

Condition Summary: Lung Transplantation; Bronchiolitis Obliterans Syndrome

 

Last Updated: 19 Jul 2011

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Dry Powder Inhalation of Cyclosporine A in Lung Transplant Patients With Bronchiolitis Obliterans Syndrome
 

Status: Recruiting

Condition Summary: Lung Transplantation; Bronchiolitis Obliterans

 

Last Updated: 6 Feb 2007

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Last Updated: 8 Nov 2014

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