Bronchiolitis Obliterans

Common Name(s)

Bronchiolitis Obliterans

Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. The bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. This leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. While there is no way to reverse the disease, treatments are available to stabilize or slow the progression.  

Another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiolitis Obliterans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiolitis Obliterans" returned 205 free, full-text research articles on human participants. First 3 results:

Elevated peptides in lung lavage fluid associated with bronchiolitis obliterans syndrome.
 

Author(s): Matthew D Stone, Stephen B Harvey, Gary L Nelsestuen, Cavan Reilly, Marshall I Hertz, Chris H Wendt

Journal:

 

The objective of this discovery-level investigation was to use mass spectrometry to identify low mass compounds in bronchoalveolar lavage fluid from lung transplant recipients that associate with bronchiolitis obliterans syndrome.

Last Updated: 6 Jan 2014

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Propylthiouracil-induced bronchiolitis obliterans organizing pneumonia.
 

Author(s): Jaehee Lee, Sun Ha Choi, Keum Ju Choi, Seung Ick Cha, Tae In Park, Chang Ho Kim

Journal: Intern. Med.. 2013 ;52(23):2657-9.

 

Propylthiouracil (PTU) is commonly used to treat hyperthyroidism. However, it is also associated with a number of adverse events. In particular, pulmonary complications, although rare, can be serious. Therefore, early detection is paramount. We herein describe a first case of PTU-induced ...

Last Updated: 2 Dec 2013

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Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model.
 

Author(s): Yunge Zhao, Jacob R Gillen, David A Harris, Irving L Kron, Michael P Murphy, Christine L Lau

Journal: J. Thorac. Cardiovasc. Surg.. 2014 May;147(5):1668-1677.e5.

 

Bone marrow-derived mesenchymal stem cells (MSCs) have shown therapeutic potential in acute lung injury. Recently, placenta-derived human mesenchymal stem cells (PMSCs) have shown similarities with bone marrow-derived MSCs in terms of regenerative capabilities and immunogenicity. ...

Last Updated: 5 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiolitis Obliterans" returned 27 free, full-text review articles on human participants. First 3 results:

[Bilateral lung transplantation for bronchiolitis obliterans after allogeneic bone marrow transplantation: a case report and literature review].
 

Author(s): Fei Gao, Dong Wei, Bo Wu, Min Zhou, Ji Zhang, Jing-yu Chen

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Aug;34(8):669-72.

 

To explore the feasibility and efficiency of lung transplantation in the treatment of bronchiolitis obliterans (BO) after allogeneic bone marrow transplantation (allo-BMT).

Last Updated: 27 Aug 2013

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Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome.
 

Author(s): V E Kennedy, J L Todd, S M Palmer

Journal: Am. J. Transplant.. 2013 Mar;13(3):552-61.

 

Bronchiolitis obliterans syndrome (BOS), a condition of irreversible small airway fibrosis, is the principal factor limiting long-term survival after lung transplantation. Bronchoscopy and bronchoalveolar lavage (BAL), techniques central to lung transplant clinical practice, provide ...

Last Updated: 26 Feb 2013

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A review of bronchiolitis obliterans syndrome and therapeutic strategies.
 

Author(s): Don Hayes

Journal:

 

Lung transplantation is an important treatment option for patients with advanced lung disease. Survival rates for lung transplant recipients have improved; however, the major obstacle limiting better survival is bronchiolitis obliterans syndrome (BOS). In the last decade, survival ...

Last Updated: 29 Aug 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation
 

Status: Recruiting

Condition Summary: Lung Transplantation; Bronchiolitis Obliterans Syndrome

 

Last Updated: 19 Jul 2011

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Dry Powder Inhalation of Cyclosporine A in Lung Transplant Patients With Bronchiolitis Obliterans Syndrome
 

Status: Recruiting

Condition Summary: Lung Transplantation; Bronchiolitis Obliterans

 

Last Updated: 6 Feb 2007

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Last Updated: 8 Nov 2014

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