Bronchiolitis Obliterans

Common Name(s)

Bronchiolitis Obliterans

Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. The bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. This leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. While there is no way to reverse the disease, treatments are available to stabilize or slow the progression.  

Another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiolitis Obliterans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiolitis Obliterans" returned 252 free, full-text research articles on human participants. First 3 results:

LPS-Responsive Beige-Like Anchor Gene Mutation Associated With Possible Bronchiolitis Obliterans Organizing Pneumonia Associated With Hypogammaglobulinemia and Normal IgM Phenotype and Low Number of B Cells.
 

Author(s): Sima Shokri, Mohammad Nabavi, Tatjana Hirschmugl, Asghar Aghamohammadi, Saba Arshi, Mohamad Hassan Bemanian, Morteza Fallahpour, Rasool Molatefi, Mahsa Rekabi, Narges Eslami, Javad Ahmadian, Kian Darabi, Gholam Reza Sedighi, Maryam Monajemzadeh, Mohammadreza Modaresi, Nima Parvaneh, Kaan Boztug, Nima Rezaei

Journal: Acta Med Iran. 2016 Oct;54(10):620-623.

 

LPS-Responsive Beige-like Anchor (LRBA) deficiency is a disease which has recently been described in a group of patients with common variable immunodeficiency (CVID) in association with autoimmunity and/or inflammatory bowel disease (IBD)-like phenotype. We here describe a 10-year-old ...

Last Updated: 26 Nov 2016

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Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment.
 

Author(s): Hamidreza Abtahi, Soheil Peiman, Morteza Foroumandi, Enayat Safavi

Journal: Acta Med Iran. 2016 Sep;54(9):605-609.

 

Bronchiolitis obliterans (BO) is the most remarkable pulmonary sequels of war-related sulfur mustard inhalation. There is little if any data about long-term efficacy of associated BO treatment. Five years spirometric records of three groups of patients with obstructive pulmonary diseases ...

Last Updated: 11 Nov 2016

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Impaired Capacity of Fibroblasts to Support Airway Epithelial Progenitors in Bronchiolitis Obliterans Syndrome.
 

Author(s): Su-Bei Zhang, Xin Sun, Qi Wu, Jun-Ping Wu, Huai-Yong Chen

Journal: Chin. Med. J.. 2016 09;129(17):2040-4.

 

Bronchiolitis obliterans syndrome (BOS) often develops in transplant patients and results in injury to the respiratory and terminal airway epithelium. Owing to its rising incidence, the pathogenesis of BOS is currently an area of intensive research. Studies have shown that injury ...

Last Updated: 29 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiolitis Obliterans" returned 30 free, full-text review articles on human participants. First 3 results:

Systematic review of postradiotherapy bronchiolitis obliterans organizing pneumonia in women with breast cancer.
 

Author(s): Gary R Epler, Eileen M Kelly

Journal: Oncologist. 2014 Dec;19(12):1216-26.

 

Radiation therapy for breast cancer has been implicated in the development of bronchiolitis obliterans organizing pneumonia (BOOP). This inflammatory lung disorder was first noted in 1983, and there have been numerous reports of BOOP occurring in women who have had radiation therapy ...

Last Updated: 6 Dec 2014

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Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation.
 

Author(s): S Samuel Weigt, Ariss DerHovanessian, W Dean Wallace, Joseph P Lynch, John A Belperio

Journal: Semin Respir Crit Care Med. 2013 Jun;34(3):336-51.

 

Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders. Unfortunately, chronic lung allograft dysfunction (CLAD), most commonly manifest as bronchiolitis obliterans syndrome (BOS), continues to be highly prevalent and is the major limitation to ...

Last Updated: 3 Jul 2013

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Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome.
 

Author(s): V E Kennedy, J L Todd, S M Palmer

Journal: Am. J. Transplant.. 2013 Mar;13(3):552-61.

 

Bronchiolitis obliterans syndrome (BOS), a condition of irreversible small airway fibrosis, is the principal factor limiting long-term survival after lung transplantation. Bronchoscopy and bronchoalveolar lavage (BAL), techniques central to lung transplant clinical practice, provide ...

Last Updated: 26 Feb 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Microparticles and Bronchiolitis Obliterans Syndrome
 

Status: Recruiting

Condition Summary: Bronchiolitis Obliterans

 

Last Updated: 27 May 2015

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Last Updated: 2 Mar 2017

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Last Updated: 24 Jan 2017

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