Bronchiolitis Obliterans

Common Name(s)

Bronchiolitis Obliterans

Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. The bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. This leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. While there is no way to reverse the disease, treatments are available to stabilize or slow the progression.  

Another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiolitis Obliterans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiolitis Obliterans" returned 274 free, full-text research articles on human participants. First 3 results:

Double lung, unlike single lung transplantation might provide a protective effect on mortality and bronchiolitis obliterans syndrome.
 

Author(s): Mohammed Fakhro, Ellen Broberg, Lars Algotsson, Lennart Hansson, Bansi Koul, Ronny Gustafsson, Per Wierup, Richard Ingemansson, Sandra Lindstedt

Journal:

 

Survival after lung transplantation (LTx) is often limited by bronchiolitis obliterans syndrome (BOS).

Last Updated: 31 Dec 1969

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Impact of Forced Expiratory Volume in 1 Second (FEV1) and 6-Minute Walking Distance at 3, 6, and 12 Months and Annually on Survival and Occurrence of Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation.
 

Author(s): Mohammed Fakhro, Richard Ingemansson, Lars Algotsson, Sandra Lindstedt

Journal:

 

BACKGROUND Development of bronchiolitis obliterans syndrome (BOS) is a great limitation for patient survival in lung transplantation (LTx). A curative treatment for BOS is still missing, and in terminal stages re-transplantation (Re-LTx) is the only salvation. It is possible to slow ...

Last Updated: 31 Dec 1969

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Serum miRNAs as potential biomarkers for the bronchiolitis obliterans syndrome after lung transplantation.
 

Author(s): K Budding, M Rossato, E A van de Graaf, J M Kwakkel-van Erp, T R D J Radstake, H G Otten

Journal: Transpl. Immunol.. 2017 06;42():1-4.

 

Lung transplantation (LTx) is the last treatment for patients suffering from end-stage lung diseases. Survival post-LTx is hampered by the development of the bronchiolitis obliterans syndrome (BOS) and diagnosis is often late. Given the urgent clinical need to recognize BOS patients ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiolitis Obliterans" returned 31 free, full-text review articles on human participants. First 3 results:

How I treat bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.
 

Author(s): Kirsten M Williams

Journal: Blood. 2017 01;129(4):448-455.

 

In past years, a diagnosis of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplant (HCT) conferred nearly universal mortality secondary to lack of consensus for diagnostic criteria, poorly understood disease pathogenesis, and very few studies of therapeutic ...

Last Updated: 31 Dec 1969

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Systematic review of postradiotherapy bronchiolitis obliterans organizing pneumonia in women with breast cancer.
 

Author(s): Gary R Epler, Eileen M Kelly

Journal: Oncologist. 2014 Dec;19(12):1216-26.

 

Radiation therapy for breast cancer has been implicated in the development of bronchiolitis obliterans organizing pneumonia (BOOP). This inflammatory lung disorder was first noted in 1983, and there have been numerous reports of BOOP occurring in women who have had radiation therapy ...

Last Updated: 31 Dec 1969

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Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation.
 

Author(s): S Samuel Weigt, Ariss DerHovanessian, W Dean Wallace, Joseph P Lynch, John A Belperio

Journal: Semin Respir Crit Care Med. 2013 Jun;34(3):336-51.

 

Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders. Unfortunately, chronic lung allograft dysfunction (CLAD), most commonly manifest as bronchiolitis obliterans syndrome (BOS), continues to be highly prevalent and is the major limitation to ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Microparticles and Bronchiolitis Obliterans Syndrome
 

Status: Recruiting

Condition Summary: Bronchiolitis Obliterans

 

Last Updated: 27 May 2015

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Last Updated: 2 Mar 2017

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The Safety and Tolerability of Pirfenidone for BOS After HCT
 

Status: Recruiting

Condition Summary: Bronchiolitis Obliterans; Graft Vs Host Disease

 

Last Updated: 16 Mar 2018

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