Rhabdomyolysis

Common Name(s)

Rhabdomyolysis

Rhabdomyolysis is the breakdown of muscle and the release of muscle cell contents into the bloodstream. Rhabdomyolysis can be caused by genetic or environmental factors. Environmental factors that may cause rhabdomyolysis include crushing trauma, long surgeries, extreme temperatures, or severe muscle strain such as after a marathon or other athletic event. Other causes include severe dehydration, infection, drug use, and seizures. Genetic disorders such as those causing a reduction in muscle enzymes may also lead to rhabdomyolysis. The risk of rhabdomyolysis may be reduced by proper hydration after workout or injury.

Affected individuals may notice dark red or brown urine due to the excretion of muscle breakdown products. Other symptoms of rhabdomyolysis include vomiting, confusion, muscle aches, weakness, low blood pressure, and a rapid heart rate. In severe cases, complications such as permanent kidney damage may occur.

While some individuals may experience the symptoms described above, milder cases are often asymptomatic and later discovered on blood tests. Medications may be used to regulate urine output, and fluid may be given to restore electrolyte levels and prevent shock and kidney damage. Dialysis may be required to remove muscle breakdown products from the blood in individuals with poor kidney function. If you or your child has been diagnosed with rhabdomyolysis, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rhabdomyolysis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rhabdomyolysis" returned 542 free, full-text research articles on human participants. First 3 results:

Ticagrelor Leads to Statin-Induced Rhabdomyolysis: A Case Report.
 

Author(s): Simone M Mrotzek, Tienush Rassaf, Matthias Totzeck

Journal:

 

BACKGROUND Following acute coronary intervention in cardiology patients, the combined medical therapy with the platelet inhibitory drug ticagrelor and a statin medication (e.g., simvastatin) is recommended according to international guidelines. Yet combined therapeutic regimens have ...

Last Updated: 31 Dec 1969

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Exercise-induced rhabdomyolysis - a patient series.
 

Author(s): Kiarash Tazmini, Christoffer Schreiner, Sidsel Bruserud, Truls Raastad, Erik Ekker Solberg

Journal:

 

No guidelines are available for the treatment and follow up of exercise-induced rhabdomyolysis. The purpose of this study was to describe the treatment, complications and follow-up of patients with exercise-induced rhabdomyolysis at Diakonhjemmet Hospital.

Last Updated: 31 Dec 1969

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Clinical and laboratory findings of rhabdomyolysis in opioid overdose patients in the intensive care unit of a poisoning center in 2014 in Iran.
 

Author(s): Khoshideh Babak, Arefi Mohammad, Ghorbani Mazaher, Akbarpour Samaneh, Taghizadeh Fatemeh

Journal:

 

The aim of this study was to investigate the clinical and demographic characteristics and some laboratory findings of hospitalized patients with acute opioid toxicity and rhabdomyolysis.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rhabdomyolysis" returned 51 free, full-text review articles on human participants. First 3 results:

Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism: A rare case report and literature review.
 

Author(s): Dawei Wang, Yanqiu Wang

Journal: Medicine (Baltimore). 2018 Apr;97(14):e0318.

 

Fenofibrate is a fibric acid derivative indicated for use in hypertriglyceridemia and mixed dyslipidemia treatment among adults. Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle contents into the systemic circulation, which is the ...

Last Updated: 31 Dec 1969

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A Klebsiella pneumoniae liver abscess presenting with myasthenia and tea-colored urine: A case report and review of 77 cases of bacterial rhabdomyolysis.
 

Author(s): Lihua Deng, Rong Jia, Wei Li, Qian Xue, Jie Liu, Yide Miao, Jingtong Wang

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9458.

 

Rhabdomyolysis is a well-known syndrome in clinical practice, although rhabdomyolysis caused by a liver abscess is rarely reported and the patient may lack symptoms that are associated with a primary site of infection. Early recognition of this possibility is needed to avoid diagnostic ...

Last Updated: 31 Dec 1969

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Perspectives on Exertional Rhabdomyolysis.
 

Author(s): Eric S Rawson, Priscilla M Clarkson, Mark A Tarnopolsky

Journal: Sports Med. 2017 Mar;47(Suppl 1):33-49.

 

Exertional (exercise-induced) rhabdomyolysis is a potentially life threatening condition that has been the subject of research, intense discussion, and media attention. The causes of rhabdomyolysis are numerous and can include direct muscle injury, unaccustomed exercise, ischemia, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluate the Muscle Protection Effect of Sevoflurane Sedation in Vascular Surgery
 

Status: Recruiting

Condition Summary: Vascular Surgery

 

Last Updated: 10 Jul 2017

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Fatty Acid Oxidation Defects and Insulin Sensitivity
 

Status: Recruiting

Condition Summary: Very Long-chain Acyl-CoA Dehydrogenase Deficiency; Trifunctional Protein Deficiency; Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency; Medium-chain Acyl-CoA Dehydrogenase Deficiency; Normal Volunteers; Carnitine Palmitoyltransferase II Deficiency, Myopathic

 

Last Updated: 14 May 2018

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Fat and Sugar Metabolism During Exercise in Patients With Metabolic Myopathy
 

Status: Recruiting

Condition Summary: Metabolism, Inborn Errors; Lipid Metabolism, Inborn Errors; Carbohydrate Metabolism, Inborn Errors; Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency; Glycogenin-1 Deficiency (Glycogen Storage Disease Type XV); Carnitine Palmitoyl Transferase 2 Deficiency; VLCAD Deficiency; Medium-chain Acyl-CoA Dehydrogenase Deficiency; Multiple Acyl-CoA Dehydrogenase Deficiency; Carnitine Transporter Deficiency; Neutral Lipid Storage Disease; Glycogen Storage Disease Type II; Glycogen Storage Disease Type III; Glycogen Storage Disease Type IV; Glycogen Storage Disease Type V; Muscle Phosphofructokinase Deficiency; Phosphoglucomutase 1 Deficiency; Phosphoglycerate Mutase Deficiency; Phosphoglycerate Kinase Deficiency; Phosphorylase Kinase Deficiency; Beta Enolase Deficiency; Lactate Dehydrogenase Deficiency; Glycogen Synthase Deficiency

 

Last Updated: 31 Aug 2017

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