Rhabdomyolysis

Common Name(s)

Rhabdomyolysis

Rhabdomyolysis is the breakdown of muscle and the release of muscle cell contents into the bloodstream. Rhabdomyolysis can be caused by genetic or environmental factors. Environmental factors that may cause rhabdomyolysis include crushing trauma, long surgeries, extreme temperatures, or severe muscle strain such as after a marathon or other athletic event. Other causes include severe dehydration, infection, drug use, and seizures. Genetic disorders such as those causing a reduction in muscle enzymes may also lead to rhabdomyolysis. The risk of rhabdomyolysis may be reduced by proper hydration after workout or injury.

Affected individuals may notice dark red or brown urine due to the excretion of muscle breakdown products. Other symptoms of rhabdomyolysis include vomiting, confusion, muscle aches, weakness, low blood pressure, and a rapid heart rate. In severe cases, complications such as permanent kidney damage may occur.

While some individuals may experience the symptoms described above, milder cases are often asymptomatic and later discovered on blood tests. Medications may be used to regulate urine output, and fluid may be given to restore electrolyte levels and prevent shock and kidney damage. Dialysis may be required to remove muscle breakdown products from the blood in individuals with poor kidney function. If you or your child has been diagnosed with rhabdomyolysis, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rhabdomyolysis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rhabdomyolysis" returned 476 free, full-text research articles on human participants. First 3 results:

Sickle Cell Trait, Rhabdomyolysis, and Mortality among U.S. Army Soldiers.
 

Author(s): D Alan Nelson, Patricia A Deuster, Robert Carter, Owen T Hill, Vickee L Wolcott, Lianne M Kurina

Journal: N. Engl. J. Med.. 2016 Aug;375(5):435-42.

 

Studies have suggested that sickle cell trait elevates the risks of exertional rhabdomyolysis and death. We conducted a study of sickle cell trait in relation to these outcomes, controlling for known risk factors for exertional rhabdomyolysis, in a large population of active persons ...

Last Updated: 13 Aug 2016

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Rhabdomyolysis associated with single-dose intravenous esomeprazole administration: A case report.
 

Author(s): Dae-Hong Jeon, Yire Kim, Min Jeong Kim, Hyun Seop Cho, Eun Jin Bae, Se-Ho Chang, Dong Jun Park

Journal: Medicine (Baltimore). 2016 Jul;95(29):e4313.

 

Proton pump inhibitors are usually safe, although serious adverse effects can occur. We report the first case of rhabdomyolysis associated with single-dose intravenous esomeprozole administration.

Last Updated: 22 Jul 2016

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Lymphoma in Danon disease with chronic rhabdomyolysis treated with EPOCH-R: A case report.
 

Author(s): Edit Porpaczy, Marius Mayerhoefer, Ulrike Salzer-Muhar, Ulrich Jaeger

Journal: Medicine (Baltimore). 2016 Jul;95(29):e4237.

 

Rare disorders often represent a challenge for clinicians and require close collaboration of an interdisciplinary team.We present the complex case of a 22-year-old male with Danon disease and late-onset of posttransplant lymphoproliferative disorder after heart transplantation. The ...

Last Updated: 22 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rhabdomyolysis" returned 44 free, full-text review articles on human participants. First 3 results:

Fatal endocarditis with methicilin-sensible Staphylococcus aureus and major complications: rhabdomyolysis, pericarditis, and intracerebral hematoma: A case report and review of the literature.
 

Author(s): Anca Meda Georgescu, Leonard Azamfirei, Krisztina Szalman, Edit Szekely

Journal: Medicine (Baltimore). 2016 Oct;95(41):e5125.

 

Over the last decades Staphylococcus aureus (SA) has become the dominant etiology of native valve infective endocarditis, with the community-acquired methicillin-sensible Staphylococcus aureus (CA-MSSA) strains being the prevailing type.

Last Updated: 14 Oct 2016

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Serotonin Syndrome Induced by Combined Use of Mirtazapine and Olanzapine Complicated with Rhabdomyolysis, Acute Renal Failure, and Acute Pulmonary Edema-A Case Report.
 

Author(s): Chi-Shun Wu, Show-Hwa Tong, Cheung-Ter Ong, Sheng-Feng Sung

Journal: Acta Neurol Taiwan. 2015 Dec;24(4):117-21.

 

Serotonin syndrome is a potentially life-threatening complication of serotonergic agents. Although mirtazapine is a relatively safe antidepressant and has a comparatively low incidence of side effects, it still could induce serotonin syndrome.

Last Updated: 23 Jun 2016

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Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury.
 

Author(s): Nayara Panizo, Alfonso Rubio-Navarro, Juan Manuel Amaro-Villalobos, Jesús Egido, Juan Antonio Moreno

Journal: Kidney Blood Press. Res.. 2015 ;40(5):520-32.

 

Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including severe trauma and intense physical exercise. Myoglobin-induced renal toxicity plays a key role in rhabdomyolysis-associated ...

Last Updated: 30 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty
 

Status: Not yet recruiting

Condition Summary: Rhabdomyolysis

 

Last Updated: 14 Jul 2015

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Support for the Rhabdomyolysis in an Emergency Department
 

Status: Not yet recruiting

Condition Summary: Rhabdomyolysis

 

Last Updated: 6 Sep 2016

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The Effect of Remote Ischemic Preconditioning on Physical Performance and Exertional Rhabdomyolysis
 

Status: Not yet recruiting

Condition Summary: Physical Performance; Rhabdomyolysis

 

Last Updated: 23 Dec 2015

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