Rhabdomyolysis

Common Name(s)

Rhabdomyolysis

Rhabdomyolysis is the breakdown of muscle and the release of muscle cell contents into the bloodstream. Rhabdomyolysis can be caused by genetic or environmental factors. Environmental factors that may cause rhabdomyolysis include crushing trauma, long surgeries, extreme temperatures, or severe muscle strain such as after a marathon or other athletic event. Other causes include severe dehydration, infection, drug use, and seizures. Genetic disorders such as those causing a reduction in muscle enzymes may also lead to rhabdomyolysis. The risk of rhabdomyolysis may be reduced by proper hydration after workout or injury.

Affected individuals may notice dark red or brown urine due to the excretion of muscle breakdown products. Other symptoms of rhabdomyolysis include vomiting, confusion, muscle aches, weakness, low blood pressure, and a rapid heart rate. In severe cases, complications such as permanent kidney damage may occur.

While some individuals may experience the symptoms described above, milder cases are often asymptomatic and later discovered on blood tests. Medications may be used to regulate urine output, and fluid may be given to restore electrolyte levels and prevent shock and kidney damage. Dialysis may be required to remove muscle breakdown products from the blood in individuals with poor kidney function. If you or your child has been diagnosed with rhabdomyolysis, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rhabdomyolysis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rhabdomyolysis" returned 527 free, full-text research articles on human participants. First 3 results:

Sickle Cell Trait, Rhabdomyolysis, and Mortality among U.S. Army Soldiers.
 

Author(s): D Alan Nelson, Patricia A Deuster, Robert Carter, Owen T Hill, Vickee L Wolcott, Lianne M Kurina

Journal: N. Engl. J. Med.. 2016 Aug;375(5):435-42.

 

Studies have suggested that sickle cell trait elevates the risks of exertional rhabdomyolysis and death. We conducted a study of sickle cell trait in relation to these outcomes, controlling for known risk factors for exertional rhabdomyolysis, in a large population of active persons ...

Last Updated: 13 Aug 2016

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Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.
 

Author(s): E F Diekman, G Visser, J P J Schmitz, R A J Nievelstein, M de Sain-van der Velden, M Wardrop, W L Van der Pol, S M Houten, N A W van Riel, T Takken, J A L Jeneson

Journal:

 

Rhabdomyolysis is common in very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) and other metabolic myopathies, but its pathogenic basis is poorly understood. Here, we show that prolonged bicycling exercise against a standardized moderate workload in VLCADD patients is associated ...

Last Updated: 17 Feb 2016

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Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations.
 

Author(s): Seema R Lalani, Pengfei Liu, Jill A Rosenfeld, Levi B Watkin, Theodore Chiang, Magalie S Leduc, Wenmiao Zhu, Yan Ding, Shujuan Pan, Francesco Vetrini, Christina Y Miyake, Marwan Shinawi, Tomasz Gambin, Mohammad K Eldomery, Zeynep Hande Coban Akdemir, Lisa Emrick, Yael Wilnai, Susan Schelley, Mary Kay Koenig, Nada Memon, Laura S Farach, Bradley P Coe, Mahshid Azamian, Patricia Hernandez, Gladys Zapata, Shalini N Jhangiani, Donna M Muzny, Timothy Lotze, Gary Clark, Angus Wilfong, Hope Northrup, Adekunle Adesina, Carlos A Bacino, Fernando Scaglia, Penelope E Bonnen, Jane Crosson, Jessica Duis, Gustavo H B Maegawa, David Coman, Anita Inwood, Jim McGill, Eric Boerwinkle, Brett Graham, Art Beaudet, Christine M Eng, Neil A Hanchard, Fan Xia, Jordan S Orange, Richard A Gibbs, James R Lupski, Yaping Yang

Journal: Am. J. Hum. Genet.. 2016 Feb;98(2):347-57.

 

The underlying genetic etiology of rhabdomyolysis remains elusive in a significant fraction of individuals presenting with recurrent metabolic crises and muscle weakness. Using exome sequencing, we identified bi-allelic mutations in TANGO2 encoding transport and Golgi organization ...

Last Updated: 6 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rhabdomyolysis" returned 45 free, full-text review articles on human participants. First 3 results:

Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury.
 

Author(s): Nayara Panizo, Alfonso Rubio-Navarro, Juan Manuel Amaro-Villalobos, Jesús Egido, Juan Antonio Moreno

Journal: Kidney Blood Press. Res.. 2015 ;40(5):520-32.

 

Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including severe trauma and intense physical exercise. Myoglobin-induced renal toxicity plays a key role in rhabdomyolysis-associated ...

Last Updated: 30 Oct 2015

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Rhabdomyolysis after tourniquet use in proximal tibial osteotomy: a case report and review of the literature.
 

Author(s): İsmail Türkmen, İrfan Esenkaya, Koray Unay, Mehmet Akif Akçal

Journal: Acta Orthop Traumatol Turc. 2015 ;49(3):338-41.

 

Rhabdomyolysis following pneumotic tourniquet use is an extremely rare complication. In this case report, we aimed to present an unusual tourniquet complication following proximal tibial osteotomy. A 55-year-old female patient was operated on for genu varum in our clinic. Postoperatively, ...

Last Updated: 23 Jul 2015

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Rhabdomyolysis: a genetic perspective.
 

Author(s): Renata Siciliani Scalco, Alice R Gardiner, Robert Ds Pitceathly, Edmar Zanoteli, Jefferson Becker, Janice L Holton, Henry Houlden, Heinz Jungbluth, Ros Quinlivan

Journal:

 

Rhabdomyolysis (RM) is a clinical emergency characterized by fulminant skeletal muscle damage and release of intracellular muscle components into the blood stream leading to myoglobinuria and, in severe cases, acute renal failure. Apart from trauma, a wide range of causes have been ...

Last Updated: 3 Aug 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty
 

Status: Not yet recruiting

Condition Summary: Rhabdomyolysis

 

Last Updated: 14 Jul 2015

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Support for the Rhabdomyolysis in an Emergency Department
 

Status: Not yet recruiting

Condition Summary: Rhabdomyolysis

 

Last Updated: 6 Sep 2016

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The Effect of Remote Ischemic Preconditioning on Physical Performance and Exertional Rhabdomyolysis
 

Status: Not yet recruiting

Condition Summary: Physical Performance; Rhabdomyolysis

 

Last Updated: 23 Dec 2015

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