Rhabdomyolysis

Common Name(s)

Rhabdomyolysis

Rhabdomyolysis is the breakdown of muscle and the release of muscle cell contents into the bloodstream. Rhabdomyolysis can be caused by genetic or environmental factors. Environmental factors that may cause rhabdomyolysis include crushing trauma, long surgeries, extreme temperatures, or severe muscle strain such as after a marathon or other athletic event. Other causes include severe dehydration, infection, drug use, and seizures. Genetic disorders such as those causing a reduction in muscle enzymes may also lead to rhabdomyolysis. The risk of rhabdomyolysis may be reduced by proper hydration after workout or injury.

Affected individuals may notice dark red or brown urine due to the excretion of muscle breakdown products. Other symptoms of rhabdomyolysis include vomiting, confusion, muscle aches, weakness, low blood pressure, and a rapid heart rate. In severe cases, complications such as permanent kidney damage may occur.

While some individuals may experience the symptoms described above, milder cases are often asymptomatic and later discovered on blood tests. Medications may be used to regulate urine output, and fluid may be given to restore electrolyte levels and prevent shock and kidney damage. Dialysis may be required to remove muscle breakdown products from the blood in individuals with poor kidney function. If you or your child has been diagnosed with rhabdomyolysis, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rhabdomyolysis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rhabdomyolysis" returned 497 free, full-text research articles on human participants. First 3 results:

Increased frequency of rhabdomyolysis in familial dysautonomia.
 

Author(s): Jose-Alberto Palma, Ricardo Roda, Lucy Norcliffe-Kaufmann, Horacio Kaufmann

Journal: Muscle Nerve. 2015 Nov;52(5):887-90.

 

Familial dysautonomia (FD; OMIM # 223900) is an autosomal recessive disease with features of impaired pain and temperature perception and lack of functional muscle spindles. After 3 FD patients presented with rhabdomyolysis in a short time span, we aimed to determine the frequency ...

Last Updated: 7 Oct 2015

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A Patient with Dengue Fever Presenting with Rhabdomyolysis.
 

Author(s): Masayuki Nakamura, Shuntaro Ikeda, Hiroyuki Nagahara, Tatsurou Hitsumoto, Shogo Matsui, Hisaki Kadota, Hideaki Shimizu, Kiyotaka Ohshima, Naoki Yakushiji, Mareomi Hamada

Journal: Intern. Med.. 2015 ;54(13):1657-60.

 

A 16-year-old boy stayed in Tokyo near Yoyogi Park for extracurricular high school activities. After returning home, he experienced an episode of fever and visited our emergency outpatient unit. He initially exhibited symptoms of leukopenia, thrombocytopenia and concomitant rhabdomyolysis ...

Last Updated: 3 Jul 2015

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A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis.
 

Author(s): Shin Hisahara, Takashi Matsushita, Hiroyasu Furuyama, Go Tajima, Yosuke Shigematsu, Tomihiro Imai, Shun Shimohama

Journal: Tohoku J. Exp. Med.. 2015 ;235(4):305-10.

 

Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is characterized by impaired mitochondrial β-oxidation of fatty acids. The fatty acid oxidation plays a significant role in energy production especially in skeletal muscle. VLCAD is one of four acyl-CoA dehydrogenases with ...

Last Updated: 6 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rhabdomyolysis" returned 40 free, full-text review articles on human participants. First 3 results:

Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review.
 

Author(s): Nadezda Petejova, Arnost Martinek

Journal:

 

Rhabdomyolysis, a clinical syndrome caused by damage to skeletal muscle and release of its breakdown products into the circulation, can be followed by acute kidney injury (AKI) as a severe complication. The belief that the AKI is triggered by myoglobin as the toxin responsible appears ...

Last Updated: 30 Aug 2014

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Acute kidney injury associated with rhabdomyolysis after coronary artery bypass graft: a case report and review of the literatures.
 

Author(s): Suraj Sudarsanan, Amr S Omar, Rasheed A Pattath, Abdulwahid Al Mulla

Journal:

 

Post-operative rhabdomyolysis is a well-known complication, especially after bariatric and orthopaedic surgeries. There are few published reports of rhabdomyolysis following cardiac surgery. Acute kidney injury had been distinguished as a serious complication of cardiac surgery. We ...

Last Updated: 20 Mar 2014

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Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature.
 

Author(s): Liliany P Repizo, Denise M Malheiros, Luis Yu, Rui T Barros, Emmanuel A Burdmann

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(1):85-8.

 

Renal histology results are very scarce in dengue-associated rhabdomyolysis patients developing acute kidney injury (AKI). We report a case of dengue fever-induced AKI associated to rhabdomyolysis with a renal biopsy showing acute tubular necrosis (ATN) and renal deposition of myoglobin. ...

Last Updated: 20 Feb 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty
 

Status: Not yet recruiting

Condition Summary: Rhabdomyolysis

 

Last Updated: 14 Jul 2015

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The Effect of Remote Ischemic Preconditioning on Physical Performance and Exertional Rhabdomyolysis
 

Status: Not yet recruiting

Condition Summary: Physical Performance; Rhabdomyolysis

 

Last Updated: 23 Dec 2015

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Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
 

Status: Recruiting

Condition Summary: Rhabdomyolysis; Myopathy; Acute Renal Failure; Neuroleptic Malignant Syndrome

 

Last Updated: 30 Nov 2009

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