Rhabdomyolysis

Common Name(s)

Rhabdomyolysis

Rhabdomyolysis is the breakdown of muscle and the release of muscle cell contents into the bloodstream. Rhabdomyolysis can be caused by genetic or environmental factors. Environmental factors that may cause rhabdomyolysis include crushing trauma, long surgeries, extreme temperatures, or severe muscle strain such as after a marathon or other athletic event. Other causes include severe dehydration, infection, drug use, and seizures. Genetic disorders such as those causing a reduction in muscle enzymes may also lead to rhabdomyolysis. The risk of rhabdomyolysis may be reduced by proper hydration after workout or injury.

Affected individuals may notice dark red or brown urine due to the excretion of muscle breakdown products. Other symptoms of rhabdomyolysis include vomiting, confusion, muscle aches, weakness, low blood pressure, and a rapid heart rate. In severe cases, complications such as permanent kidney damage may occur.

While some individuals may experience the symptoms described above, milder cases are often asymptomatic and later discovered on blood tests. Medications may be used to regulate urine output, and fluid may be given to restore electrolyte levels and prevent shock and kidney damage. Dialysis may be required to remove muscle breakdown products from the blood in individuals with poor kidney function. If you or your child has been diagnosed with rhabdomyolysis, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rhabdomyolysis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rhabdomyolysis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rhabdomyolysis" returned 517 free, full-text research articles on human participants. First 3 results:

Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.
 

Author(s): E F Diekman, G Visser, J P J Schmitz, R A J Nievelstein, M de Sain-van der Velden, M Wardrop, W L Van der Pol, S M Houten, N A W van Riel, T Takken, J A L Jeneson

Journal:

 

Rhabdomyolysis is common in very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) and other metabolic myopathies, but its pathogenic basis is poorly understood. Here, we show that prolonged bicycling exercise against a standardized moderate workload in VLCADD patients is associated ...

Last Updated: 17 Feb 2016

Go To URL
[Clinical characteristics of children with acute rhabdomyolysis].
 

Author(s): Zhu-Feng Liu, Bi-Li Zhang, Wen-Hong Wang, Xuan Zhang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Nov;17(11):1253-6.

 

Last Updated: 20 Nov 2015

Go To URL
Hypokalemic rhabdomyolysis: a rare manifestation of primary aldosteronism.
 

Author(s): A Zavatto, A Concistrè, C Marinelli, V Zingaretti, I Umbro, F Fiacco, F Tinti, L Petramala, A P Mitterhofer, C Letizia

Journal: Eur Rev Med Pharmacol Sci. 2015 Oct;19(20):3910-6.

 

Rhabdomyolysis is a rare presentation of hypokalemia, although muscle weakness is a well-known manifestation of hypokalemia. Primary aldosteronism is characterized by hypertension, suppressed plasma renin activity, increased aldosterone excretion and hypokalemia with metabolic alkalosis. ...

Last Updated: 4 Nov 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rhabdomyolysis" returned 44 free, full-text review articles on human participants. First 3 results:

Rhabdomyolysis after tourniquet use in proximal tibial osteotomy: a case report and review of the literature.
 

Author(s): İsmail Türkmen, İrfan Esenkaya, Koray Unay, Mehmet Akif Akçal

Journal: Acta Orthop Traumatol Turc. 2015 ;49(3):338-41.

 

Rhabdomyolysis following pneumotic tourniquet use is an extremely rare complication. In this case report, we aimed to present an unusual tourniquet complication following proximal tibial osteotomy. A 55-year-old female patient was operated on for genu varum in our clinic. Postoperatively, ...

Last Updated: 23 Jul 2015

Go To URL
Rhabdomyolysis: a genetic perspective.
 

Author(s): Renata Siciliani Scalco, Alice R Gardiner, Robert Ds Pitceathly, Edmar Zanoteli, Jefferson Becker, Janice L Holton, Henry Houlden, Heinz Jungbluth, Ros Quinlivan

Journal:

 

Rhabdomyolysis (RM) is a clinical emergency characterized by fulminant skeletal muscle damage and release of intracellular muscle components into the blood stream leading to myoglobinuria and, in severe cases, acute renal failure. Apart from trauma, a wide range of causes have been ...

Last Updated: 3 Aug 2015

Go To URL
Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review.
 

Author(s): Nadezda Petejova, Arnost Martinek

Journal:

 

Rhabdomyolysis, a clinical syndrome caused by damage to skeletal muscle and release of its breakdown products into the circulation, can be followed by acute kidney injury (AKI) as a severe complication. The belief that the AKI is triggered by myoglobin as the toxin responsible appears ...

Last Updated: 30 Aug 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty
 

Status: Not yet recruiting

Condition Summary: Rhabdomyolysis

 

Last Updated: 14 Jul 2015

Go to URL
The Effect of Remote Ischemic Preconditioning on Physical Performance and Exertional Rhabdomyolysis
 

Status: Not yet recruiting

Condition Summary: Physical Performance; Rhabdomyolysis

 

Last Updated: 23 Dec 2015

Go to URL
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
 

Status: Recruiting

Condition Summary: Rhabdomyolysis; Myopathy; Acute Renal Failure; Neuroleptic Malignant Syndrome

 

Last Updated: 30 Nov 2009

Go to URL