Serotonin syndrome

Common Name(s)

Serotonin syndrome

Serotonin syndrome is a condition in which there is too much serotonin present in the body. Serotonin is a natural chemical that helps regulate mood, attention, emotions, and causes muscle contraction in the intestines. The body normally absorbs serotonin and stores it until it is needed, at which point it is released into the blood.

Decreased levels of serotonin are found in many patients with depression and anxiety, and these patients are often treated with medications that increase the amount of serotonin in the blood. Thus, a common cause of serotonin syndrome is from taking large doses of antidepressants or taking multiple different antidepressants at the same time. Serotonin syndrome may also be caused by other medications, herbal supplements, or illegal drugs that work by increasing serotonin levels in the blood. Individuals at the highest risk of developing serotonin syndrome include those who are taking new medications or new doses of their medications.

Symptoms of serotonin syndrome typically occur within hours of taking a drug. Individuals often experience an increased heart rate, restlessness, and confusion. The individual may experience heavy sweating, muscle twitching or rigidity, dilation of the pupils, shivering, headaches, and diarrhea. Symptoms often last for 1 to 3 days before they resolve. More severe cases of serotonin syndrome may involve high fever, irregular heartbeats, seizures, and loss of consciousness.

If you believe that you or someone around you may be experiencing serotonin syndrome, it is important to seek medical attention. Doctors will check drug levels, look for signs of infection, and monitor vital signs. Treatment depends on the severity and type of symptoms. While some individuals will not require treatment, others may require hospitalization. If you or your child is experiencing serotonin syndrome, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Serotonin syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Serotonin syndrome" returned 141 free, full-text research articles on human participants. First 3 results:

Metoclopramide-induced Serotonin Syndrome.
 

Author(s): Taku Harada, Takanobu Hirosawa, Kouhei Morinaga, Taro Shimizu

Journal: Intern. Med.. 2017 ;56(6):737-739.

 

A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide. Her medical history, which included the use of serotonergic agents, and the presence of symptoms including ...

Last Updated: 21 Mar 2017

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Tramadol-Induced Hypomania and Serotonin Syndrome.
 

Author(s): Verinder Sharma

Journal:

 

Last Updated: 21 Dec 2016

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Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran.
 

Author(s): Toru Koshiishi, Kiyoshi Okuyama

Journal: Yakugaku Zasshi. 2016 ;136(12):1675-1679.

 

 A 70-year-old woman, residing in a nursing home, was admitted to our hospital because of cerebral hemorrhage. She had excessive sweating, a temperature above 37°C, and intermittent muscle spasm such as myoclonus, since the time of admission. We suspected that these symptoms were ...

Last Updated: 1 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Serotonin syndrome" returned 29 free, full-text review articles on human participants. First 3 results:

Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome.
 

Author(s): Duo-Chen Jin, Hai-Long Cao, Meng-Que Xu, Si-Nan Wang, Yu-Ming Wang, Fang Yan, Bang-Mao Wang

Journal: World J. Gastroenterol.. 2016 Sep;22(36):8137-48.

 

Serotonin (5-HT) and the serotonin transporter (SERT) have earned a tremendous amount of attention regarding the pathogenesis of irritable bowel syndrome (IBS). Considering that enteric 5-HT is responsible for the secretion, motility and perception of the bowel, the involvement of ...

Last Updated: 30 Sep 2016

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Serotonin Syndrome Induced by Combined Use of Mirtazapine and Olanzapine Complicated with Rhabdomyolysis, Acute Renal Failure, and Acute Pulmonary Edema-A Case Report.
 

Author(s): Chi-Shun Wu, Show-Hwa Tong, Cheung-Ter Ong, Sheng-Feng Sung

Journal: Acta Neurol Taiwan. 2015 Dec;24(4):117-21.

 

Serotonin syndrome is a potentially life-threatening complication of serotonergic agents. Although mirtazapine is a relatively safe antidepressant and has a comparatively low incidence of side effects, it still could induce serotonin syndrome.

Last Updated: 23 Jun 2016

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Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review.
 

Author(s): Burton D Beakley, Adam M Kaye, Alan D Kaye

Journal: Pain Physician. ;18(4):395-400.

 

Serotonin syndrome is a mild to potentially life-threatening syndrome associated with excessive serotonergic activity within the central nervous system. Serotonin syndrome is associated with medication use, drug interactions, and overdose. While serotonin syndrome is often associated ...

Last Updated: 29 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Regorafenib in Treating Patients With Advanced or Metastatic Neuroendocrine Tumors
 

Status: Recruiting

Condition Summary: Gastrinoma; Glucagonoma; Insulinoma; Metastatic Gastrointestinal Carcinoid Tumor; Pancreatic Polypeptide Tumor; Pulmonary Carcinoid Tumor; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Somatostatinoma

 

Last Updated: 18 Apr 2017

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Clinical Trial Assessing 5-HT3 Receptor Antagonist (Ramosetron) for the Treatment of Anterior Resection Syndrome
 

Status: Not yet recruiting

Condition Summary: Anterior Resection Syndrome

 

Last Updated: 12 Aug 2016

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Last Updated: 28 Sep 2016

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