Lyme Disease

Common Name(s)

Lyme Disease

Lyme Disease is a bacterial infection that is solely the result of being bitten by an infected tick and is the most commong tick-borne disease in the Northern Hemisphere. There are at least three bacteria which can cause Lyme Disease, one being common in North America and two different bacteria being more common in Europe. Early symptoms may include fever, headache, fatigue, depression, and a characteric circular skin rash called erythema migrans (EM). Left untreated, later symptoms may involve the joints, heart, and central nervous system. In most cases, the infection and its symptoms are eliminated by antibiotics, especially if the illness is treated early. Delayed or inadequate treatment can lead to more serious symptoms, which can be disabling and difficult to treat.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lyme Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lyme Disease" returned 626 free, full-text research articles on human participants. First 3 results:

Concerns regarding a new culture method for Borrelia burgdorferi not approved for the diagnosis of Lyme disease.
 

Author(s): Christina Nelson, Sally Hojvat, Barbara Johnson, Jeannine Petersen, Marty Schriefer, C Ben Beard, Lyle Petersen, Paul Mead,

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2014 Apr;63(15):333.

 

In 2005, CDC and the Food and Drug Administration (FDA) issued a warning regarding the use of Lyme disease tests whose accuracy and clinical usefulness have not been adequately established. Often these are laboratory-developed tests (also known as "home brew" tests) that are manufactured ...

Last Updated: 17 Apr 2014

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Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes.
 

Author(s): Claudia Hammerschmidt, Arno Koenigs, Corinna Siegel, Teresia Hallström, Christine Skerka, Reinhard Wallich, Peter F Zipfel, Peter Kraiczy

Journal: Infect. Immun.. 2014 Jan;82(1):380-92.

 

CspA of the Lyme disease spirochete Borrelia burgdorferi represents a key molecule in immune evasion, protecting borrelial cells from complement-mediated killing. As previous studies focused almost exclusively on CspA of B. burgdorferi, here we investigate the different binding capacities ...

Last Updated: 19 Dec 2013

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BB0347, from the lyme disease spirochete Borrelia burgdorferi, is surface exposed and interacts with the CS1 heparin-binding domain of human fibronectin.
 

Author(s): Robert A Gaultney, Tammy Gonzalez, Angela M Floden, Catherine A Brissette

Journal:

 

The causative agent of Lyme disease, Borrelia burgdorferi, codes for several known fibronectin-binding proteins. Fibronectin a common the target of diverse bacterial pathogens, and has been shown to be essential in allowing for the development of certain disease states. Another borrelial ...

Last Updated: 2 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lyme Disease" returned 55 free, full-text review articles on human participants. First 3 results:

Metal-dependent gene regulation in the causative agent of Lyme disease.
 

Author(s): Bryan Troxell, X Frank Yang

Journal:

 

Borrelia burgdorferi (Bb) is the causative agent of Lyme disease transmitted to humans by ticks of the Ixodes spp. Bb is a unique bacterial pathogen because it does not require iron (Fe(2+)) for its metabolism. Bb encodes a ferritin-like Dps homolog called NapA (also called BicA), ...

Last Updated: 3 Dec 2013

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Borrelia burgdorferi infection and Lyme disease in children.
 

Author(s): Susanna Esposito, Samantha Bosis, Caterina Sabatini, Laura Tagliaferri, Nicola Principi

Journal: Int. J. Infect. Dis.. 2013 Mar;17(3):e153-8.

 

Lyme disease is a multisystem disease that frequently affects children. It is caused by a group of related spirochetes, Borrelia burgdorferi sensu lato, that are transmitted by ticks belonging to species of the genus Ixodes. The clinical characteristics of Lyme disease in pediatrics ...

Last Updated: 25 Feb 2013

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Diagnosis and management of Lyme disease.
 

Author(s): William F Wright, David J Riedel, Rohit Talwani, Bruce L Gilliam

Journal: Am Fam Physician. 2012 Jun;85(11):1086-93.

 

Lyme disease, caused by the bacterium Borrelia burgdorferi, is the most common tick-borne illness in the United States. Transmission occurs primarily through the bite of an infected deer tick (Ixodes scapularis). Identification of an erythema migrans rash following a tick bite is ...

Last Updated: 11 Sep 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Searching for Persistence of Infection in Lyme Disease
 

Status: Recruiting

Condition Summary: Lyme Disease; Borrelia Burgdorferi

 

Last Updated: 14 Mar 2014

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Evaluation, Treatment, and Follow-up of Patients With Lyme Disease
 

Status: Recruiting

Condition Summary: Lyme Disease

 

Last Updated: 19 Apr 2014

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Evaluation of Lyme Disease: Clinical, Microbiological and Immunological Characteristics
 

Status: Recruiting

Condition Summary: Chronic Disease; Healthy; Lyme Arthritis; Lyme Disease; Multiple Sclerosis

 

Last Updated: 14 Mar 2014

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