Lyme Disease

Common Name(s)

Lyme Disease

Lyme disease is an infection caused by three types of Borrellia bacteria. One type is most common in the United States, while the other two types are more common in Europe and Asia. These bacteria are carried by certain ticks; in the United States most commonly the deer tick, in Europe the sheep tick and in China the taiga tick. An infected tick can pass the bacteria to humans (and other animals) through its bites although the transfer of the bacteria is believed to only begin after 36-48 hours of the tick being attached.

A characteristic circular rash often develops around the tick bite within 3-30 days and is diagnostic, meaning treatment should begin immediately. Sometimes the rash appears like a bull’s-eye, other times it is a solid red patch, and sometimes the rash does not occur exactly at the site of the tick bite. Other early symptoms include flu like symptoms such as fever, chills, body aches, and fever. Laboratory blood tests are not considered reliable until at least one month after becoming infected through a tick bite. Therefore it is important if you have flu like symptoms with or without a rash to let your doctor know you have been bitten by a tick within a month’s time.

As symptoms progress, an individual may have a stiff neck, severe fatigue, tingling sensation in the hands or feet, or facial paralysis. Left untreated, later symptoms may involve the joints, heart, and central nervous system. In most cases, the infection and its symptoms are eliminated by antibiotics, especially if the illness is treated early. Delayed or inadequate treatment can lead to more serious symptoms, which can be disabling and difficult to treat. If you or a family member has been diagnosed with Lyme disease, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lyme Disease" for support, advocacy or research.

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American Lyme Disease Foundation

The American Lyme Disease Foundation, Inc. is dedicated to the prevention, diagnosis and treatment of Lyme disease. The Foundation plays a key role in providing reliable and scientifically accurate information to the public, medical community and government agencies about Lyme disease and its effects on human health and quality of life.

Last Updated: 7 Jan 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lyme Disease" for support, advocacy or research.

Logo
American Lyme Disease Foundation

The American Lyme Disease Foundation, Inc. is dedicated to the prevention, diagnosis and treatment of Lyme disease. The Foundation plays a key role in providing reliable and scientifically accurate information to the public, medical community and government agencies about Lyme disease and its effects on human health and quality of life.

http://www.aldf.com

Last Updated: 7 Jan 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lyme Disease" returned 643 free, full-text research articles on human participants. First 3 results:

Lyme disease with effusion either in hip or knee in children from Podlaskie region treated in clinic in 2004-2010.
 

Author(s): Anna Moniuszko, Janusz Popko, Tomasz Guszczyn, Tomasz Waliński, Wioletta Zukiewicz-Sobczak, Sławomir Pancewicz

Journal: Przegl Epidemiol. 2014 ;68(3):425-8, 535-7.

 

Lyme disease (LB) relatively commonly causes arthritis among patients, especially in LB endemic area. The aim of the study was to analyze the prevalence of LB in children with hip and knee effusion in the North Eastern region of Poland. Conclusions from our study should justify the ...

Last Updated: 14 Nov 2014

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Bullous Lyme disease.
 

Author(s): Jeffrey B Tiger, Marshall A Guill, M Shane Chapman

Journal: J. Am. Acad. Dermatol.. 2014 Oct;71(4):e133-4.

 

Last Updated: 15 Sep 2014

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Lyme disease in Poland in 2012.
 

Author(s): Iwona Paradowska-Stankiewicz, Irena Chrześcijańska

Journal: Przegl Epidemiol. 2014 ;68(2):275-7, 375-7.

 

In Poland registration of all cases of Lyme disease is conducted by the Epidemiological Unit of National Institute of Public Health - National Institute of Hygiene. Most cases of Lyme disease occur in the North- East region of Poland; however, it is important to note that the disease ...

Last Updated: 19 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lyme Disease" returned 58 free, full-text review articles on human participants. First 3 results:

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi.
 

Author(s): Elizabeth A Novak, Syed Z Sultan, Md A Motaleb

Journal:

 

In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B. burgdorferi must be able to not only detect changes in its environment, but also rapidly ...

Last Updated: 13 May 2014

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Metal-dependent gene regulation in the causative agent of Lyme disease.
 

Author(s): Bryan Troxell, X Frank Yang

Journal:

 

Borrelia burgdorferi (Bb) is the causative agent of Lyme disease transmitted to humans by ticks of the Ixodes spp. Bb is a unique bacterial pathogen because it does not require iron (Fe(2+)) for its metabolism. Bb encodes a ferritin-like Dps homolog called NapA (also called BicA), ...

Last Updated: 3 Dec 2013

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Treatment trials for post-Lyme disease symptoms revisited.
 

Author(s): Mark S Klempner, Phillip J Baker, Eugene D Shapiro, Adriana Marques, Raymond J Dattwyler, John J Halperin, Gary P Wormser

Journal: Am. J. Med.. 2013 Aug;126(8):665-9.

 

The authors of 4 National Institutes of Health-sponsored antibiotic treatment trials of patients with persistent unexplained symptoms despite previous antibiotic treatment of Lyme disease determined that retreatment provides little if any benefit and carries significant risk. Two ...

Last Updated: 26 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation, Treatment, and Follow-up of Patients With Lyme Disease
 

Status: Recruiting

Condition Summary: Lyme Disease

 

Last Updated: 11 Nov 2014

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Meditation and Stretching for Post Treatment Lyme Disease Syndrome
 

Status: Not yet recruiting

Condition Summary: Post Treatment Lyme Disease Syndrome

 

Last Updated: 26 Jan 2015

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Evaluation of Lyme Disease: Clinical, Microbiological and Immunological Characteristics
 

Status: Recruiting

Condition Summary: Lyme Disease

 

Last Updated: 16 Oct 2014

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