Non-Hodgkin lymphoma

Common Name(s)

Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) may refer to any lymphoma (cancer of the lymph system) that is not Hodgkin lymphoma. The lymph system is a network of lymph tissue connected by vessels. The lymph system is separate from the blood circulatory system. The main types of cells in lymph tissue are lymphocytes which are white blood cells that fight bacteria, viruses and other foreign cells. Lymph tissue includes lymph nodes as well as knots of lymphocytes found in the intestines, spleen and bone marrow. Lymphoma occurs when lymphocytes begin to multiply uncontrollably or become cancerous. These cancerous cells can invade other parts of the body or metastasize. Non-Hodgkin lymphoma is more common than Hodgkin lymphoma. There are different types of NHL depending on if the cancer began in B-cells or T-cells as well as other characteristics.

Symptoms of NHL may include a swelling of the lymph nodes, unexplained fever, night sweats, weight loss, fatigue, and itching. In general the cause of non-Hodgkin lymphomas is unknown. NHL is more common in males and Caucasians. The risk of developing NHL increases with age, certain viral and bacterial infections and exposure to environmental exposure to certain chemicals and pesticides. NHL more often occurs in persons with an autoimmune disease or weakened immune systems such as those with HIV/AIDS or those who have undergone a transplant.

Lymphomas are generally diagnosed through a biopsy of the lymph nodes and sometimes a biopsy of the bone marrow. Other tests may be performed to determine where the cancer is located and how far it has spread. Treatment is similar to that of other cancers and may include radiation, chemotherapy, targeted therapy or a stem cell transplant. Treatment and prognosis depend upon the type and stage of NHL. If you or a family member has been diagnosed with non-Hodgkin lymphoma, talk with your doctor and specialists about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Non-Hodgkin lymphoma" returned 947 free, full-text research articles on human participants. First 3 results:

Ileocecal Obstruction Due to B-cell Non-Hodgkin Lymphoma.
 

Author(s): Vasile Negrean, Florin Graur, Emil Moiş, Nadim Al-Hajjar,

Journal: Chirurgia (Bucur). ;111(1):71-3.

 

We report a rare case of non-Hodgkin lymphoma presented as an ileocecal mass. The patient was a 77-year-old man with history of symptoms of partial bowel obstruction, intermittent right iliac fossa pain, loss of weight, vomiting and fatigue. Clinical signs included moderate abdominal ...

Last Updated: 18 Mar 2016

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Human Cytokine Genetic Variants Associated With HBsAg Reverse Seroconversion in Rituximab-Treated Non-Hodgkin Lymphoma Patients.
 

Author(s): Liang-Tsai Hsiao, Hao-Yuan Wang, Ching-Fen Yang, Tzeon-Jye Chiou, Jyh-Pyng Gau, Yuan-Bin Yu, Hsiao-Ling Liu, Wen-Chun Chang, Po-Min Chen, Cheng-Hwai Tzeng, Yu-Jiun Chan, Muh-Hwa Yang, Jin-Hwang Liu, Yi-Hsiang Huang

Journal: Medicine (Baltimore). 2016 Mar;95(11):e3064.

 

Hepatitis B virus (HBV) reactivation has been noted in HBV surface antigen (HBsAg)-seronegative patients with CD20 B-cell non-Hodgkin lymphoma (NHL) undergoing rituximab treatment. Clinically, hepatitis flares are usually associated with the reappearance of HBsAg (reverse seroconversion ...

Last Updated: 18 Mar 2016

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Resolving uncertainty in the spatial relationships between passive benzene exposure and risk of non-Hodgkin lymphoma.
 

Author(s): Jeffrey M Switchenko, Catherine Bulka, Kevin Ward, Jean L Koff, A Rana Bayakly, P Barry Ryan, Lance A Waller, Christopher R Flowers

Journal: Cancer Epidemiol. 2016 Apr;41():139-51.

 

Benzene is a known occupational carcinogen associated with increased risk of hematologic cancers, but the relationships between quantity of passive benzene exposure through residential proximity to toxic release sites, duration of exposure, lag time from exposure to cancer development, ...

Last Updated: 19 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Non-Hodgkin lymphoma" returned 73 free, full-text review articles on human participants. First 3 results:

Bilateral hand squamous-cells carcinoma in patient affected with non-Hodgkin lymphoma. Case report and literature review.
 

Author(s): P Fino, A M Spagnoli, M Ruggieri, M Marcasciano, N Scuderi

Journal: G Chir. ;36(4):172-82.

 

Squamous-cell skin cancer is the most frequent tumor in the hand. It occurs on sun-damaged skin, especially in lightskinned individuals with a long history of chronic sun exposure.

Last Updated: 29 Dec 2015

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Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: A PRISMA-Compliant Meta-Analysis of Observational Studies.
 

Author(s): Li Yang, Jianming Dong, Shenghua Jiang, Wenyu Shi, Xiaohong Xu, Hongming Huang, Xuefen You, Hong Liu

Journal: Medicine (Baltimore). 2015 Nov;94(45):e1729.

 

The association between consumption of red and processed meat and non-Hodgkin lymphoma (NHL) remains unclear. We performed a meta-analysis of the published observational studies to explore this relationship.We searched databases in MEDLINE and EMBASE to identify observational studies ...

Last Updated: 12 Nov 2015

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Hepatitis C virus-related mixed cryoglobulinemic endocapillary proliferative glomerulonephritis and B-cell non-Hodgkin lymphoma: a case report and literature review.
 

Author(s): L-J Zhao, F Chen, J-G Li, R Yin, X-H Zhang, S-M Huang, F Liu

Journal: Eur Rev Med Pharmacol Sci. 2015 Aug;19(16):3050-5.

 

Chronic HCV (hepatitis C virus) infection is recognized as the major cause of mixed cryoglobulinemia. Cryoglobulins continually precipitate and form deposits on the vascular endothelium of small to medium-sized blood vessels, which may progress to vasculitic syndrome.

Last Updated: 15 Sep 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 13 Oct 2016

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Lenalidomide and Rituximab in Subjects With Previously Untreated Indolent Non-Hodgkin's Lymphoma
 

Status: Recruiting

Condition Summary: Non Hodgkin's Lymphoma

 

Last Updated: 31 Aug 2016

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A Study Of Blinatumomab For The Treatment Of Relapsed Or Refractory Indolent Non-Hodgkin Lymphoma
 

Status: Not yet recruiting

Condition Summary: Non-Hodgkin Lymphoma

 

Last Updated: 22 Jun 2016

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