Non-Hodgkin lymphoma

Common Name(s)

Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) may refer to any lymphoma (cancer of the lymph system) that is not Hodgkin lymphoma. The lymph system is a network of lymph tissue connected by vessels. The lymph system is separate from the blood circulatory system. The main types of cells in lymph tissue are lymphocytes which are white blood cells that fight bacteria, viruses and other foreign cells. Lymph tissue includes lymph nodes as well as knots of lymphocytes found in the intestines, spleen and bone marrow. Lymphoma occurs when lymphocytes begin to multiply uncontrollably or become cancerous. These cancerous cells can invade other parts of the body or metastasize. Non-Hodgkin lymphoma is more common than Hodgkin lymphoma. There are different types of NHL depending on if the cancer began in B-cells or T-cells as well as other characteristics.

Symptoms of NHL may include a swelling of the lymph nodes, unexplained fever, night sweats, weight loss, fatigue, and itching. In general the cause of non-Hodgkin lymphomas is unknown. NHL is more common in males and Caucasians. The risk of developing NHL increases with age, certain viral and bacterial infections and exposure to environmental exposure to certain chemicals and pesticides. NHL more often occurs in persons with an autoimmune disease or weakened immune systems such as those with HIV/AIDS or those who have undergone a transplant.

Lymphomas are generally diagnosed through a biopsy of the lymph nodes and sometimes a biopsy of the bone marrow. Other tests may be performed to determine where the cancer is located and how far it has spread. Treatment is similar to that of other cancers and may include radiation, chemotherapy, targeted therapy or a stem cell transplant. Treatment and prognosis depend upon the type and stage of NHL. If you or a family member has been diagnosed with non-Hodgkin lymphoma, talk with your doctor and specialists about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Non-Hodgkin lymphoma" returned 995 free, full-text research articles on human participants. First 3 results:

Neurolymphomatosis in non-Hodgkin lymphoma with cranial multineuritis: A case report.
 

Author(s): Handan Haydaroglu Sahin, Ahmet Mete, Mustafa Pehlivan

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0303.

 

Neurolymphomatosis (NL) is a rare syndrome of lymphoma and leukemic infiltration of cranial or peripheral nerves.

Last Updated: 31 Dec 1969

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Lack of usefulness of computed tomography for surveillance in patients with aggressive non-Hodgkin lymphoma.
 

Author(s): Ka-Won Kang, Se Ryeon Lee, Dae Sik Kim, Eun Sang Yu, Hwa Jung Sung, Seok Jin Kim, Chul Won Choi, Yong Park, Byung Soo Kim

Journal:

 

Surveillance computed tomography (CT) is usual practice for patients with aggressive non-Hodgkin lymphoma (aNHL) in complete remission (CR). However, evidence to support this strategy is lacking. We retrospectively analyzed our institutional lymphoma registry, including patients with ...

Last Updated: 31 Dec 1969

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Synchronous papillary thyroid cancer and non-Hodgkin lymphoma: Case report.
 

Author(s): Georgi I Popivanov, Pavel Bochev, Radka Hristoskova, Ventsislav M Mutafchiyski, Mihail Tabakov, Anthony Philipov, Roberto Cirocchi

Journal: Medicine (Baltimore). 2018 Feb;97(6):e9831.

 

Differentiated thyroid cancer is the most common endocrine malignancy with concomitant hematological malignancy in 7%.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Non-Hodgkin lymphoma" returned 86 free, full-text review articles on human participants. First 3 results:

Non-Hodgkin lymphoma, diagnostic, and prognostic particularities in children - a series of case reports and a review of the literature (CARE compliant).
 

Author(s): Cristina Oana Mărginean, Lorena Elena Meliţ, Emoke Horvath, Horea Gozar, Mihaela Ioana Chinceşan

Journal: Medicine (Baltimore). 2018 Feb;97(8):e9802.

 

Non-Hodgkin lymphoma remains an unpredictable condition in pediatric patients.

Last Updated: 31 Dec 1969

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PI3Kδ-selective and PI3Kα/δ-combinatorial inhibitors in clinical development for B-cell non-Hodgkin lymphoma.
 

Author(s): Benjamin L Lampson, Jennifer R Brown

Journal: Expert Opin Investig Drugs. 2017 Nov;26(11):1267-1279.

 

The efficacy of the prototypical phosphatidylinositol-3-kinase (PI3K) inhibitor idelalisib for the treatment of chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma (iNHL) has led to development of multiple compounds targeting this pathway. Areas Covered: We review ...

Last Updated: 31 Dec 1969

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Model-based meta-analysis of progression-free survival in non-Hodgkin lymphoma patients.
 

Author(s): Mengyao Li, Nimita Dave, Ahmed Hamed Salem, Kevin J Freise

Journal: Medicine (Baltimore). 2017 Sep;96(35):e7988.

 

Non-Hodgkin lymphoma (NHL) is a group of lymphoproliferative malignancies with varying treatment responses and progression-free survival (PFS) times. The objective of this study was to quantify the effect of treatment and patient-population characteristics on PFS in patients with NHL.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Chiauranib in Relapsed/Refractory Non-Hodgkin's Lymphoma
 

Status: Recruiting

Condition Summary: Non-Hodgkin's Lymphoma

 

Last Updated: 2 Apr 2018

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Last Updated: 22 Nov 2017

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Last Updated: 15 Nov 2017

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