Non-Hodgkin lymphoma

Common Name(s)

Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) may refer to any lymphoma (cancer of the lymph system) that is not Hodgkin lymphoma. The lymph system is a network of lymph tissue connected by vessels. The lymph system is separate from the blood circulatory system. The main types of cells in lymph tissue are lymphocytes which are white blood cells that fight bacteria, viruses and other foreign cells. Lymph tissue includes lymph nodes as well as knots of lymphocytes found in the intestines, spleen and bone marrow. Lymphoma occurs when lymphocytes begin to multiply uncontrollably or become cancerous. These cancerous cells can invade other parts of the body or metastasize. Non-Hodgkin lymphoma is more common than Hodgkin lymphoma. There are different types of NHL depending on if the cancer began in B-cells or T-cells as well as other characteristics.

Symptoms of NHL may include a swelling of the lymph nodes, unexplained fever, night sweats, weight loss, fatigue, and itching. In general the cause of non-Hodgkin lymphomas is unknown. NHL is more common in males and Caucasians. The risk of developing NHL increases with age, certain viral and bacterial infections and exposure to environmental exposure to certain chemicals and pesticides. NHL more often occurs in persons with an autoimmune disease or weakened immune systems such as those with HIV/AIDS or those who have undergone a transplant.

Lymphomas are generally diagnosed through a biopsy of the lymph nodes and sometimes a biopsy of the bone marrow. Other tests may be performed to determine where the cancer is located and how far it has spread. Treatment is similar to that of other cancers and may include radiation, chemotherapy, targeted therapy or a stem cell transplant. Treatment and prognosis depend upon the type and stage of NHL. If you or a family member has been diagnosed with non-Hodgkin lymphoma, talk with your doctor and specialists about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Non-Hodgkin lymphoma" returned 916 free, full-text research articles on human participants. First 3 results:

Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma.
 

Author(s): Miho Sakumura, Kazuto Tajiri, Shigeharu Miwa, Kohei Nagata, Kengo Kawai, Takayoshi Miyazono, Kotaro Arita, Akinori Wada, Jun Murakami, Toshiro Sugiyama

Journal: Intern. Med.. 2017 ;56(4):395-400.

 

Hepatic sinusoidal obstruction syndrome (SOS), a serious complication that mainly occurs after hematopoietic-stem cell transplantation (HSCT), is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid. Recently, hepatic SOS was reported to occur ...

Last Updated: 16 Feb 2017

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[Eosinophilic pneumonia revealing B-cell non-Hodgkin lymphoma].
 

Author(s): Siham Fikal, Hafsa Sajiai, Hind Serhane, Salma Aitbatahar, Lamyae Amro

Journal:

 

The diagnosis of eosinophilic pneumonia is rare and malignant etiology remains exceptional. Eosinophilic pneumonia etiology varies and is mainly dominated by allergic and drug causes. We report the case of a 61-year-old patient with B-cell non-Hodgkin lymphoma revealed by eosinophilic ...

Last Updated: 3 Feb 2017

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Double-hit lymphomas: clinical, morphological, immunohistochemical and cytogenetic study in a series of Brazilian patients with high-grade non-Hodgkin lymphoma.
 

Author(s): Cristiano Claudino Oliveira, Helena Maciel-Guerra, Luan Kucko, Eric Jun Hirama, Américo Delgado Brilhante, Francisco Carlos Quevedo, Isabela Werneck da Cunha, Fernando Augusto Soares, Ligia Niero-Melo, Patrícia Pintor Dos Reis, Maria Aparecida Custodio Domingues

Journal:

 

Double-hit lymphomas (DHL) are rare high-grade neoplasms characterized by two translocations: one involving the gene MYC and another involving genes BCL2 or BCL6, whose diagnosis depends on cytogenetic examination. This research studied DHL and morphological and/or immunophenotypic ...

Last Updated: 7 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Non-Hodgkin lymphoma" returned 75 free, full-text review articles on human participants. First 3 results:

Lymph Node Fine-Needle Cytology of Non-Hodgkin Lymphoma: Diagnosis and Classification by Flow Cytometry.
 

Author(s): Immacolata Cozzolino, Monia Rocco, Giancarlo Villani, Marco Picardi

Journal: Acta Cytol.. 2016 ;60(4):302-314.

 

In the last decades, lymph node fine-needle cytology (FNC), coupled with flow cytometry (FC), has gained a role in the diagnosis and classification of non-Hodgkin lymphoma (NHL). The combination of FNC/FC allows the diagnosis and classification of NHL in lymph node samples with a ...

Last Updated: 24 Aug 2016

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Dairy Product Consumption and Risk of Non-Hodgkin Lymphoma: A Meta-Analysis.
 

Author(s): Jia Wang, Xutong Li, Dongfeng Zhang

Journal:

 

Many epidemiologic studies have explored the association between dairy product consumption and the risk of non-Hodgkin lymphoma (NHL), but the results remain controversial. A literature search was performed in PubMed, Web of Science and Embase for relevant articles published up to ...

Last Updated: 1 Mar 2016

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Idelalisib for the treatment of non-Hodgkin lymphoma.
 

Author(s): Solomon A Graf, Ajay K Gopal

Journal: Expert Opin Pharmacother. 2016 ;17(2):265-74.

 

B-cell Non-Hodgkin lymphomas (B-NHLs) include a number of disease subtypes, each defined by the tempo of disease progression and the identity of the cancerous cell. Idelalisib is a potent, selective inhibitor of the delta isoform of phosphatidylinositol-3-kinase (PI3K), a lipid kinase ...

Last Updated: 8 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 13 Oct 2016

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Study of Chiauranib in Relapsed/Refractory Non-Hodgkin's Lymphoma
 

Status: Not yet recruiting

Condition Summary: Non-Hodgkin's Lymphoma

 

Last Updated: 5 Mar 2017

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Lenalidomide and Rituximab in Subjects With Previously Untreated Indolent Non-Hodgkin's Lymphoma
 

Status: Recruiting

Condition Summary: Non Hodgkin's Lymphoma

 

Last Updated: 19 Jan 2017

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