X-linked Hyper IgM Syndrome

Common Name(s)

X-linked Hyper IgM Syndrome

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "X-linked Hyper IgM Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "X-linked Hyper IgM Syndrome" returned 34 free, full-text research articles on human participants. First 3 results:

A novel mutation in the CD40 ligand gene in a Chinese boy with X-linked hyper-IgM syndrome.
 

Author(s): Po-Ning Liu, Hong Li, Qiang Li, Zhong-Wei Yin, Chen-Yan Zhou, Ming-Yan Jiang, Xia Guo

Journal: Asian Pac. J. Allergy Immunol.. 2014 Sep;32(3):270-4.

 

X-linked hyper-IgM Syndrome (XHIGM) is caused by a mutation of CD40 ligand (CD40L), which is normally expressed on activated CD4+ T cells and is responsible for immunoglobulin class switching. A 7-year-old boy with recurrent sino-pulmonary infections since the age of 3 months had ...

Last Updated: 1 Oct 2014

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CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome.
 

Author(s): Xiying Fan, Bhaskar Upadhyaya, Liming Wu, Christopher Koh, Mónica Santín-Durán, Stefania Pittaluga, Gulbu Uzel, David Kleiner, Ester Williams, Chi A Ma, Aaron Bodansky, Joao B Oliveira, Pamela Edmonds, Ronald Hornung, Duane W Wong, Ronald Fayer, Tom Fleisher, Theo Heller, Calman Prussin, Ashish Jain

Journal: Clin. Immunol.. 2012 May;143(2):152-61.

 

X-linked hyper-IgM syndrome (XHM) is a combined immune deficiency disorder caused by mutations in CD40 ligand. We tested CP-870,893, a human CD40 agonist monoclonal antibody, in the treatment of two XHM patients with biliary Cryptosporidiosis. CP-870,893 activated B cells and APCs ...

Last Updated: 16 Apr 2012

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Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand.
 

Author(s): Ashish Jain, Joseph A Kovacs, David L Nelson, Stephen A Migueles, Stefania Pittaluga, William Fanslow, Xiying Fan, Duane W Wong, Justin Massey, Ronald Hornung, Margaret R Brown, Jacob J Spinner, Shuying Liu, Victoria Davey, Harry A Hill, Hans Ochs, Thomas A Fleisher

Journal: Blood. 2011 Oct;118(14):3811-7.

 

X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease. Three children were administered ...

Last Updated: 7 Oct 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "X-linked Hyper IgM Syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies
 

Status: Recruiting

Condition Summary: SCID; Omenn's Syndrome; Reticular Dysgenesis; Wiskott-Aldrich Syndrome; Bare Lymphocyte Syndrome; Common Variable Immunodeficiency; Chronic Granulomatous Disease; CD40 Ligand Deficiency; Hyper IgM Syndrome; X-linked Lymphoproliferative Disease; Hemophagocytic Lymphohistiocytosis; Griscelli Syndrome; Chediak-Higashi Syndrome; Langerhan's Cell Histiocytosis

 

Last Updated: 15 May 2014

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Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases
 

Status: Recruiting

Condition Summary: Primary Immune Deficiency Disorders; Common Variable Immunodeficiency; X-linked Agammaglobulinaemia; Hyper-IgM Syndrome

 

Last Updated: 1 Dec 2014

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Reduced Intensity Conditioning for Children and Adults With Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (PIDs) (BMT Clinical Trials Network 1204)
 

Status: Not yet recruiting

Condition Summary: Hemophagocytic Lymphohistiocytosis; CAEBV; Chronic Granulomatous Disease; HIGM-1; Leukocyte Adhesion Deficiency; IPEX

 

Last Updated: 25 Nov 2013

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