Familial Hemiplegic Migraine

Common Name(s)

Familial Hemiplegic Migraine

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Hemiplegic Migraine" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial Hemiplegic Migraine" returned 55 free, full-text research articles on human participants. First 3 results:

Repeated encephalopathy and hemicerebral atrophy in a patient with familial hemiplegic migraine type 1.
 

Author(s): Yuichi Tashiro, Tsuneo Yamazaki, Shun Nagamine, Yuji Mizuno, Adachi Yoshiki, Koichi Okamoto

Journal: Intern. Med.. 2014 ;53(19):2245-50.

 

We herein describe a case of a 38-year-old man with familial hemiplegic migraine with a T666M mutation in the electrical potential-dependent calcium ion channel (CACNA1A) gene. His migraine was accompanied by hemiparesis and impaired consciousness. Brain magnetic resonance imaging ...

Last Updated: 2 Oct 2014

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Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i.
 

Author(s): Mariano N Di Guilmi, Tiantian Wang, Carlota Gonzalez Inchauspe, Ian D Forsythe, Michel D Ferrari, Arn M J M van den Maagdenberg, J Gerard G Borst, Osvaldo D Uchitel

Journal: J. Neurosci.. 2014 May;34(21):7047-58.

 

Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated CaV2.1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of common migraine with aura. We used transgenic knock-in (KI) mice harboring the human ...

Last Updated: 22 May 2014

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Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²⁺ channel due to a familial hemiplegic migraine mutation.
 

Author(s): Akira Inagaki, C Andrew Frank, Yuriy M Usachev, Morris Benveniste, Amy Lee

Journal: Neuron. 2014 Jan;81(1):91-102.

 

Voltage-gated ion channels exhibit complex properties, which can be targeted in pharmacological therapies for disease. Here, we report that the pro-oxidant, tert-butyl dihydroquinone (BHQ), modulates Ca(v)2.1 Ca²⁺ channels in ways that oppose defects in channel gating and synaptic ...

Last Updated: 13 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial Hemiplegic Migraine" returned 2 free, full-text review articles on human participants. First 3 results:

Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models.
 

Author(s): Stephanie M Gritz, Richard A Radcliffe

Journal:

 

Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha ...

Last Updated: 1 May 2013

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Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine.
 

Author(s): Daniela Pietrobon

Journal: J. Physiol. (Lond.). 2010 Jun;588(Pt 11):1871-8.

 

Migraine is a very common disabling brain disorder with unclear pathogenesis. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in CaV2.1 (P/Q-type) Ca2+ channels. This review describes the functional consequences of FHM1 mutations ...

Last Updated: 2 Jun 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.