Transient Neonatal Diabetes Mellitus

Common Name(s)

Transient Neonatal Diabetes Mellitus

Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited. Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes. Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transient Neonatal Diabetes Mellitus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transient Neonatal Diabetes Mellitus" returned 14 free, full-text research articles on human participants. First 3 results:

Transient Neonatal Diabetes Mellitus followed by recurrent asymptomatic hypoglycaemia: a case report.
 

Author(s): Archana Priyadarshi, Charles F Verge, Leah Vandervliet, Deborah J G Mackay, Srinivas Bolisetty

Journal:

 

Transient Neonatal Diabetes Mellitus is the commonest cause of diabetes presenting in the first week of life. Majority of infants recover by 3 months of age but are predisposed to developing type 2 diabetes later on in life. This condition is usually due to genetic aberrations at ...

Last Updated: 3 Dec 2015

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Treatment of transient neonatal diabetes mellitus: insulin pump or insulin glargine? Our experience.
 

Author(s): Stefano Passanisi, Tiziana Timpanaro, Donatella Lo Presti, Corrado Mammì, Manuela Caruso-Nicoletti

Journal: Diabetes Technol. Ther.. 2014 Dec;16(12):880-4.

 

Neonatal diabetes mellitus (NDM) results from impaired insulin secretion, occurring within the first 6 months of life. NDM is classified as transient NDM (TNDM) or permanent NDM. To date there are no universal guidelines regarding its management. Intravenous insulin infusion represents ...

Last Updated: 2 Dec 2014

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6q24 transient neonatal diabetes mellitus: the first case report from China.
 

Author(s): Bin Yao, Xinhan Zhang, Hua Liang, Wen Xu, Mengyin Cai, Jinhua Yan, Jianping Weng

Journal: Chin. Med. J.. 2014 ;127(20):3680.

 

Last Updated: 15 Oct 2014

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Reviews from the PubMed Database

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The terms "Transient Neonatal Diabetes Mellitus" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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