Transient Neonatal Diabetes Mellitus

Common Name(s)

Transient Neonatal Diabetes Mellitus

Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited. Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes. Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transient Neonatal Diabetes Mellitus" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transient Neonatal Diabetes Mellitus" returned 10 free, full-text research articles on human participants. First 3 results:

Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene.
 

Author(s): Mehmet Boyraz, Korkut Ulucan, Necati Taşkın, Teoman Akçay, Sarah E Flanagan, Deborah J G Mackay

Journal: J Clin Res Pediatr Endocrinol. 2013 ;5(2):125-8.

 

Neonatal diabetes mellitus (NDM) is a rare form of diabetes that presents within the first six months of life. Nearly 70% of these cases have loss of methylation at the differentially methylated region on chromosome 6q24. To describe the findings in a Turkish male patient with NDM ...

Last Updated: 10 Jun 2013

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Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1.
 

Author(s): Anke Hoffmann, Dietmar Spengler

Journal: Mol. Cell. Biol.. 2012 Jul;32(13):2549-60.

 

The biallelic expression of the imprinted gene ZAC1/PLAGL1 underlies ≈ 60% of all cases of transient neonatal diabetes mellitus (TNDM) that present with low perinatal insulin secretion. Molecular targets of ZAC1 misexpression in pancreatic β cells are unknown. Here, we identified ...

Last Updated: 11 Jun 2012

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Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
 

Author(s): Anna L Gloyn, Deborah J G Mackay, Michael N Weedon, Mark I McCarthy, Mark Walker, Graham Hitman, Bridget A Knight, Katharine R Owen, Andrew T Hattersley, Timothy M Frayling

Journal: Diabetes. 2006 Aug;55(8):2272-6.

 

Recent evidence supports the strong overlap between genes implicated in monogenic diabetes and susceptibility to type 2 diabetes. Transient neonatal diabetes mellitus (TNDM) is a rare disorder associated with overexpression of genes at a paternally expressed imprinted locus on chromosome ...

Last Updated: 28 Jul 2006

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Reviews from the PubMed Database

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The terms "Transient Neonatal Diabetes Mellitus" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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