Superior limbic keratoconjunctivitis

Common Name(s)

Superior limbic keratoconjunctivitis

Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years.  Vision usually remains intact. While the underlying cause of SLK remains unknown, there appears to be an association between the condition and thyroid abnormalities (usually hyperthyroidism), contact lens wear, graft versus host disease, and preservatives from ophthalmologic medications.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Superior limbic keratoconjunctivitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Superior limbic keratoconjunctivitis" returned 4 free, full-text research articles on human participants. First 3 results:

Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis.
 

Author(s): Yi-Chen Sun, Cheng-Hsiang Hsiao, Wei-Li Chen, Fung-Rong Hu

Journal:

 

To explore the presentations of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in superior limbic keratoconjunctivitis (SLK) with typical redundant superior conjunctiva.

Last Updated: 2 Jun 2011

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In vivo evaluation of superior limbic keratoconjunctivitis using laser scanning confocal microscopy and conjunctival impression cytology.
 

Author(s): Takashi Kojima, Yukihiro Matsumoto, Osama M A Ibrahim, Enrique Adan Sato, Murat Dogru, Kazuo Tsubota

Journal: Invest. Ophthalmol. Vis. Sci.. 2010 Aug;51(8):3986-92.

 

To investigate the cytologic findings of superior bulbar conjunctiva in superior limbic keratoconjunctivitis (SLK) using laser scanning confocal microscopy and impression cytology in a prospective controlled study.

Last Updated: 23 Jul 2010

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Treatment of superior limbic keratoconjunctivitis with a unilateral bandage contact lens.
 

Author(s): S Watson, A B Tullo, F Carley

Journal: Br J Ophthalmol. 2002 Apr;86(4):485-6.

 

Last Updated: 26 Mar 2002

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Superior limbic keratoconjunctivitis" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Pathogenesis of Superior Limbic Keratoconjunctivitis
 

Status: Recruiting

Condition Summary: Superior Limbic Keratoconjunctivitis

 

Last Updated: 25 Nov 2005

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