Systemic capillary leak syndrome

Common Name(s)

Systemic capillary leak syndrome

Systemic capillary leak syndrome is a condition in which fluid and proteins leak out of tiny blood vessels and flow into surrounding tissues, resulting in dangerously low blood pressure. Attacks frequently last for several days and require emergency care.  Most cases of capillary leak occur randomly in previously healthy adults.  Treatment involves preventing attacks using medications which may decrease capillary leakage and interfere with hormones that may cause future leakage. Once an attack is underway, treatment is aimed at controlling blood pressure to maintain blood flow to vital organs and prevention of swelling due to fluid accumulation.  Capillary leak syndrome may lead to multiple organ failure, shock and even death.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic capillary leak syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic capillary leak syndrome" returned 27 free, full-text research articles on human participants. First 3 results:

Systemic capillary leak syndrome associated with a rare abdominal and four-limb compartment syndrome: a case report.
 

Author(s): Hayat Lamou, Jan-Peter Grassmann, Marcel Betsch, Michael Wild, Mohssen Hakimi, Joachim Windolf, Pascal Jungbluth

Journal:

 

Systemic capillary leak syndrome is a rare and life threatening disease characterized by periodic episodes of hypovolemic shock due to leakage of plasma from the intravascular to the extravascular space. It is associated with hemoconcentration, hypoalbuminemia, and generalized edema. ...

Last Updated: 15 Aug 2014

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10-year-old girl with life-threatening idiopathic systemic capillary leak syndrome: a case report.
 

Author(s): Tadashi Iwasa, Hiroyuki Ohashi, Kentaro Kihira, Yuhki Koike, Kohei Otake, Mikihiro Inoue, Hirofumi Sawada, Hidemi Toyoda, Yoshihiro Komada

Journal:

 

Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder, characterized by episodic life-threatening hypotension, hypoalbuminemia, and hemoconcentration.

Last Updated: 16 Jun 2014

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Mechanistic classification of the systemic capillary leak syndrome: Clarkson disease.
 

Author(s): Zhihui Xie, Chandra C Ghosh, Samir M Parikh, Kirk M Druey

Journal: Am. J. Respir. Crit. Care Med.. 2014 May;189(9):1145-7.

 

Last Updated: 5 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic capillary leak syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Narrative review: the systemic capillary leak syndrome.
 

Author(s): Kirk M Druey, Philip R Greipp

Journal: Ann. Intern. Med.. 2010 Jul;153(2):90-8.

 

The systemic capillary leak syndrome (SCLS) is a rare disease of reversible plasma extravasation and vascular collapse accompanied by hemoconcentration and hypoalbuminemia. Its cause is unknown, although it is believed to be a manifestation of transient endothelial dysfunction due ...

Last Updated: 20 Jul 2010

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Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years.
 

Author(s): Varun Dhir, Vivek Arya, Ishwar Chandra Malav, B S Suryanarayanan, Rajiva Gupta, A B Dey

Journal: Intern. Med.. 2007 ;46(12):899-904.

 

'Idiopathic systemic capillary leak syndrome (SCLS), or Clarkson's disease is an unusual entity first described 45 years ago. It presents with recurrent episodes of shock due to leakage of the plasma, which is reflected by accompanying hemo-concentration, hypo-albuminemia and edema. ...

Last Updated: 18 Jun 2007

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Systemic capillary leak syndrome.
 

Author(s): Shotetsu Kawabe, Takako Saeki, Hajime Yamazaki, Masaaki Nagai, Ryuji Aoyagi, Shoji Miyamura

Journal: Intern. Med.. 2002 Mar;41(3):211-5.

 

A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-lambda. She had had a similar episode of generalized edema ...

Last Updated: 3 Apr 2002

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
 

Status: Recruiting

Condition Summary: Systemic Capillary Leak Syndrome

 

Last Updated: 28 Jul 2015

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