Systemic capillary leak syndrome

Common Name(s)

Systemic capillary leak syndrome

Systemic capillary leak syndrome is a condition in which fluid and proteins leak out of tiny blood vessels and flow into surrounding tissues, resulting in dangerously low blood pressure. Attacks frequently last for several days and require emergency care.  Most cases of capillary leak occur randomly in previously healthy adults.  Treatment involves preventing attacks using medications which may decrease capillary leakage and interfere with hormones that may cause future leakage. Once an attack is underway, treatment is aimed at controlling blood pressure to maintain blood flow to vital organs and prevention of swelling due to fluid accumulation.  Capillary leak syndrome may lead to multiple organ failure, shock and even death.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic capillary leak syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic capillary leak syndrome" returned 38 free, full-text research articles on human participants. First 3 results:

Antiphospholipids Syndrome Complicated by a Systemic Capillary Leak-Like Syndrome Treated With Steroids and Intravenous Immunoglobulins: A Case Report.
 

Author(s): Marcella Prete, Livio Urso, Maria Celeste Fatone, Vincenzo Pinto, Federico Perosa

Journal: Medicine (Baltimore). 2016 Feb;95(5):e2648.

 

This report describes the onset of systemic capillary leak (SCL)-like syndrome in a 30-year-old woman with antiphospholipids syndrome (APS) during puerperium.Twelve hours after a cesarean section, she presented a sudden fever and abdominal pains followed by dyspnea, severe edema of ...

Last Updated: 5 Feb 2016

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Increased myocardial extracellular volume in active idiopathic systemic capillary leak syndrome.
 

Author(s): Andrew Ertel, Drew Pratt, Peter Kellman, Steve Leung, Patricia Bandettini, Lauren M Long, Michael Young, Celeste Nelson, Andrew E Arai, Kirk M Druey

Journal:

 

The Systemic Capillary Leak Syndrome (SCLS) is a rare disorder of unknown etiology presenting as recurrent episodes of shock and peripheral edema due to leakage of fluid into soft tissues. Insights into SCLS pathogenesis are few due to the scarcity of cases, and the etiology of vascular ...

Last Updated: 28 Aug 2015

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Endothelial Expression of Endothelin Receptor A in the Systemic Capillary Leak Syndrome.
 

Author(s): Albert C Sek, Zhihui Xie, Kaoru Terai, Lauren M Long, Celeste Nelson, Arkadiusz Z Dudek, Kirk M Druey

Journal:

 

Idiopathic systemic capillary leak syndrome (SCLS) is a rare and potentially fatal vascular disorder characterized by reversible bouts of hypotension and edema resulting from fluid and solute escape into soft tissues. Although spikes in permeability-inducing factors have been linked ...

Last Updated: 16 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic capillary leak syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

Narrative review: the systemic capillary leak syndrome.
 

Author(s): Kirk M Druey, Philip R Greipp

Journal: Ann. Intern. Med.. 2010 Jul;153(2):90-8.

 

The systemic capillary leak syndrome (SCLS) is a rare disease of reversible plasma extravasation and vascular collapse accompanied by hemoconcentration and hypoalbuminemia. Its cause is unknown, although it is believed to be a manifestation of transient endothelial dysfunction due ...

Last Updated: 20 Jul 2010

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Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years.
 

Author(s): Varun Dhir, Vivek Arya, Ishwar Chandra Malav, B S Suryanarayanan, Rajiva Gupta, A B Dey

Journal: Intern. Med.. 2007 ;46(12):899-904.

 

'Idiopathic systemic capillary leak syndrome (SCLS), or Clarkson's disease is an unusual entity first described 45 years ago. It presents with recurrent episodes of shock due to leakage of the plasma, which is reflected by accompanying hemo-concentration, hypo-albuminemia and edema. ...

Last Updated: 18 Jun 2007

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Systemic capillary leak syndrome.
 

Author(s): Shotetsu Kawabe, Takako Saeki, Hajime Yamazaki, Masaaki Nagai, Ryuji Aoyagi, Shoji Miyamura

Journal: Intern. Med.. 2002 Mar;41(3):211-5.

 

A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-lambda. She had had a similar episode of generalized edema ...

Last Updated: 3 Apr 2002

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
 

Status: Recruiting

Condition Summary: Systemic Capillary Leak Syndrome

 

Last Updated: 29 Nov 2016

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Last Updated: 9 Sep 2016

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