Systemic capillary leak syndrome

Common Name(s)

Systemic capillary leak syndrome

Systemic capillary leak syndrome is a condition in which fluid and proteins leak out of tiny blood vessels and flow into surrounding tissues, resulting in dangerously low blood pressure. Attacks frequently last for several days and require emergency care.  Most cases of capillary leak occur randomly in previously healthy adults.  Treatment involves preventing attacks using medications which may decrease capillary leakage and interfere with hormones that may cause future leakage. Once an attack is underway, treatment is aimed at controlling blood pressure to maintain blood flow to vital organs and prevention of swelling due to fluid accumulation.  Capillary leak syndrome may lead to multiple organ failure, shock and even death.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic capillary leak syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic capillary leak syndrome" returned 24 free, full-text research articles on human participants. First 3 results:

[Issues about systemic capillary leak syndrome].
 

Author(s): B Besteiro Grandío, A Vázquez González, M Madruga Garrido, M Mourelo Fariña

Journal: Med Intensiva. 2012 Nov;36(8):597-8.

 

Last Updated: 17 Oct 2012

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Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome).
 

Author(s): Zhihui Xie, Chandra C Ghosh, Roshni Patel, Shoko Iwaki, Donna Gaskins, Celeste Nelson, Nina Jones, Philip R Greipp, Samir M Parikh, Kirk M Druey

Journal: Blood. 2012 May;119(18):4321-32.

 

The systemic capillary leak syndrome (SCLS) is a rare disorder characterized by transient episodes of hypotensive shock and anasarca thought to arise from reversible microvascular barrier dysfunction. Although the high prevalence of a monoclonal gammopathy of unknown significance ...

Last Updated: 4 May 2012

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Systemic capillary leak syndrome caused by granulocyte colony-stimulating factor.
 

Author(s): Kenji Shinohara

Journal: Intern. Med.. 2011 ;50(19):2259; author reply 2261.

 

Last Updated: 3 Oct 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic capillary leak syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Narrative review: the systemic capillary leak syndrome.
 

Author(s): Kirk M Druey, Philip R Greipp

Journal: Ann. Intern. Med.. 2010 Jul;153(2):90-8.

 

The systemic capillary leak syndrome (SCLS) is a rare disease of reversible plasma extravasation and vascular collapse accompanied by hemoconcentration and hypoalbuminemia. Its cause is unknown, although it is believed to be a manifestation of transient endothelial dysfunction due ...

Last Updated: 20 Jul 2010

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Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years.
 

Author(s): Varun Dhir, Vivek Arya, Ishwar Chandra Malav, B S Suryanarayanan, Rajiva Gupta, A B Dey

Journal: Intern. Med.. 2007 ;46(12):899-904.

 

'Idiopathic systemic capillary leak syndrome (SCLS), or Clarkson's disease is an unusual entity first described 45 years ago. It presents with recurrent episodes of shock due to leakage of the plasma, which is reflected by accompanying hemo-concentration, hypo-albuminemia and edema. ...

Last Updated: 18 Jun 2007

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Systemic capillary leak syndrome.
 

Author(s): Shotetsu Kawabe, Takako Saeki, Hajime Yamazaki, Masaaki Nagai, Ryuji Aoyagi, Shoji Miyamura

Journal: Intern. Med.. 2002 Mar;41(3):211-5.

 

A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-lambda. She had had a similar episode of generalized edema ...

Last Updated: 3 Apr 2002

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
 

Status: Recruiting

Condition Summary: Systemic Capillary Leak Syndrome

 

Last Updated: 3 Sep 2014

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