Progressive myoclonic epilepsy

Common Name(s)

Progressive myoclonic epilepsy

Progressive myoclonus epilepsy (PME) refers to a group of inherited conditions involving the central nervous system and representing more than a dozen different diseases. These diseases share certain features, including a worsening of symptoms over time and the presence of both muscle contractions (myoclonus) and seizures (epilepsy). PME is different from myoclonic epilepsy.  Other features include dementia, dystonia, and trouble walking or speaking. These rare disorders often get worse over time and sometimes are fatal. Many of these PME diseases begin in childhood or adolescence.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive myoclonic epilepsy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive myoclonic epilepsy" returned 9 free, full-text research articles on human participants. First 3 results:

3D texture analysis reveals imperceptible MRI textural alterations in the thalamus and putamen in progressive myoclonic epilepsy type 1, EPM1.
 

Author(s): Sanna Suoranta, Kirsi Holli-Helenius, Päivi Koskenkorva, Eini Niskanen, Mervi Könönen, Marja Äikiä, Hannu Eskola, Reetta Kälviäinen, Ritva Vanninen

Journal:

 

Progressive myoclonic epilepsy type 1 (EPM1) is an autosomal recessively inherited neurodegenerative disorder characterized by young onset age, myoclonus and tonic-clonic epileptic seizures. At the time of diagnosis, the visual assessment of the brain MRI is usually normal, with no ...

Last Updated: 7 Aug 2013

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Efficacy of topiramate as add-on therapy in two different types of progressive myoclonic epilepsy.
 

Author(s): Caner Feyzi Demir, Hasan Hüseyin Ozdemir, Bülent Müngen

Journal: Acta Medica (Hradec Kralove). 2013 ;56(1):36-8.

 

The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora's disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded ...

Last Updated: 5 Aug 2013

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Horizontal gaze palsy with progressive myoclonic epilepsy: rare presentation of Gaucher's disease.
 

Author(s): Sudhir Sharma, Vivek Lal, Reena Das

Journal: Neurol India. ;61(2):177-8.

 

Last Updated: 6 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive myoclonic epilepsy" returned 1 free, full-text review articles on human participants. First 3 results:

Progressive myoclonic epilepsy.
 

Author(s): P Satishchandra, S Sinha

Journal: Neurol India. ;58(4):514-22.

 

Progressive myoclonic epilepsy (PME) is a disease complex and is characterized by the development of relentlessly progressive myoclonus, cognitive impairment, ataxia, and other neurologic deficits. It encompasses different diagnostic entities and the common causes include Lafora body ...

Last Updated: 26 Aug 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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