Polycystic ovarian syndrome

Common Name(s)

Polycystic ovarian syndrome, Stein-Leventhal syndrome

Polycystic ovarian syndrome (PCOS) is a condition caused by the hormone levels in a woman being unbalanced. The ovaries of women with PCOS produce higher than normal levels of male hormones (androgens). Insulin levels (the hormone which helps our cells use sugar and starches for energy) are also higher and may be linked to PCOS. PCOS is the leading cause of infertility. Between 1 in 10 to 20 women of childbearing age are affected by PCOS. PCOS may develop in girls as young as 10 years old.

Symptoms of PCOS may include the growth of small ovarian cysts (fluid filled sacs), acne, excessive hair growth, weight gain and problems with ovulation. Other symptoms include infrequent or absent periods, infertility, male patterned baldness, pelvic pain, sleep apnea, anxiety or depression. Symptoms and severity vary. Having a female relative with diabetes or PCOS may increase your risk.

Diagnosis of PCOS is made through a medical history, physical exam, blood tests and a vaginal ultrasound. Ovarian cysts and enlarged ovaries may be seen in an ultrasound. The lining of the uterus (endometrium) may be thicker in women with PCOS.

The cause of PCOS is unknown. PCOS may lead to infertility and increased risk of miscarriage, premature labor, preeclampsia, and gestational diabetes. PCOS also increases a woman’s risk for uterine cancer and diabetes later in life. High blood pressure and cholesterol levels can also be a result of PCOS and may lead to heart problems. Treatment for PCOS may include dietary changes, birth control pills, diabetes medication, fertility medications, surgery and androgen-reducing medication. If you have been diagnosed with PCOS, talk to your obstetrician or midwife as well as endocrinologist (a doctor who specializes in treating hormonal conditions) about the most current treatment options. Support groups are a good source of information and can connect you with other women who are living with PCOS.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polycystic ovarian syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polycystic ovarian syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polycystic ovarian syndrome" returned 122 free, full-text research articles on human participants. First 3 results:

A cross-sectional study to assess any possible linkage of C/T polymorphism in CYP17A1 gene with insulin resistance in non-obese women with polycystic ovarian syndrome.
 

Author(s): Ushasi Banerjee, Anindya Dasgupta, Aparna Khan, Mrinal Kanti Ghosh, Pranab Roy, Jayanta Kumar Rout, Priyankar Roy, Suparna Dhara

Journal: Indian J. Med. Res.. 2016 Jun;143(6):739-747.

 

Insulin resistance (IR) is a major confounding factor in polycystic ovarian syndrome (PCOS) irrespective of obesity. Its exact mechanism remains elusive till now. C/T polymorphism in the -34 promoter region of the CYP17 gene is inconsistently attributed to elucidate the mechanism ...

Last Updated: 17 Oct 2016

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Impact of Body Mass Index on Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Among Polycystic Ovarian Syndrome Patients.
 

Author(s): Na Cui, Huixia Wang, Wei Wang, Jie Zhang, Yueming Xu, Lei Jiang, Aimin Yang, Guimin Hao

Journal: Cell. Physiol. Biochem.. 2016 ;39(5):1723-1734.

 

The aim of this study is to assess the effect of body mass index (BMI) on outcomes of in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) among polycystic ovarian syndrome (PCOS) and non-PCOS patients.

Last Updated: 16 Oct 2016

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A huge ovarian mucinous cystadenoma associated with contralateral teratoma and polycystic ovary syndrome in an obese adolescent girl.
 

Author(s): Patcharapa Thaweekul, Yuthadej Thaweekul, Karicha Mairiang

Journal: Asia Pac J Clin Nutr. 2016 Dec;25(4):920-923.

 

A 13-year-old, obese girl presented with acute abdominal pain with abdominal distension for a year. The physical examination revealed marked abdominal distension with a large well-circumscribed mass sized 13×20 cm. Her body mass index (BMI) was 37.8 kg/m2. An abdominal CT scan revealed ...

Last Updated: 5 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polycystic ovarian syndrome" returned 23 free, full-text review articles on human participants. First 3 results:

From Placenta to Polycystic Ovarian Syndrome: The Role of Adipokines.
 

Author(s): Chiara Sartori, Pietro Lazzeroni, Silvia Merli, Viviana Dora Patianna, Francesca Viaroli, Francesca Cirillo, Sergio Amarri, Maria Elisabeth Street

Journal: Mediators Inflamm.. 2016 ;2016():4981916.

 

Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, ...

Last Updated: 17 Oct 2016

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Metformin or Oral Contraceptives for Adolescents With Polycystic Ovarian Syndrome: A Meta-analysis.
 

Author(s): Reem A Al Khalifah, Ivan D Florez, Brittany Dennis, Lehana Thabane, Ereny Bassilious

Journal: Pediatrics. 2016 May;137(5):.

 

Polycystic ovarian syndrome (PCOS) is a common disease. There is limited evidence to support various treatment choices. This leads to variable treatment practices.

Last Updated: 1 Jun 2016

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The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol.
 

Author(s): Reem A Al Khalifah, Iván D Flórez, Brittany Dennis, Binod Neupane, Lehana Thabane, Ereny Bassilious

Journal:

 

Polycystic ovarian syndrome (PCOS) is a common reproductive endocrine disease that is seen among adolescent women. Currently, there is limited evidence to support treatment options leading to considerable variation in practice among healthcare specialists. The objective of this study ...

Last Updated: 30 Sep 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Paleo Versus Healthy ADA Diets for Treatment of Polycystic Ovarian Syndrome (PCOS)
 

Status: Recruiting

Condition Summary: Polycystic Ovarian Syndrome

 

Last Updated: 7 Oct 2016

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Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome
 

Status: Recruiting

Condition Summary: Polycystic Ovarian Syndrome

 

Last Updated: 12 Apr 2017

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The Genetics of Polycystic Ovarian Syndrome
 

Status: Recruiting

Condition Summary: Polycystic Ovary Syndrome

 

Last Updated: 27 Mar 2017

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