Moyamoya disease

Common Name(s)

Moyamoya disease

Moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name "moyamoya" means "puff of smoke" in Japanese and describes the look of the tangle of tiny vessels formed to compensate for the blockage. This condition primarily affects children, but can affect adults. In moyamoya disease the carotid arteries are thickened, slowing blood flow to the brain and increasing the risk for blood clots, strokes, and transient ischemic attacks (TIA), frequently accompanied by seizures and muscular weakness or paralysis on one side of the body. Individuals with this disorder may have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems.  Because it tends to run in families, researchers think that Moyamoya disease is the result of inherited genetic abnormalities.  

Moyamoya syndrome is a related term that refers to cases of moyamoya disease that occurs in association with other conditions or risk factors (e.g., neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, Sturge-Weber syndrome, tuberous sclerosis).  

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Moyamoya disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Moyamoya disease" returned 285 free, full-text research articles on human participants. First 3 results:

Moyamoya disease presenting with acute subdural hemorrhage.
 

Author(s): Amit Kumar Ghosh

Journal: Neurol India. ;62(2):202-3.

 

Last Updated: 14 May 2014

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Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state.
 

Author(s): Daisuke Morito, Kouki Nishikawa, Jun Hoseki, Akira Kitamura, Yuri Kotani, Kazumi Kiso, Masataka Kinjo, Yoshinori Fujiyoshi, Kazuhiro Nagata

Journal:

 

Moyamoya disease is an idiopathic human cerebrovascular disorder that is characterized by progressive stenosis and abnormal collateral vessels. We recently identified mysterin/RNF213 as its first susceptibility gene, which encodes a 591-kDa protein containing enzymatically active ...

Last Updated: 24 Mar 2014

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Multi-delay arterial spin labeling perfusion MRI in moyamoya disease--comparison with CT perfusion imaging.
 

Author(s): Rui Wang, Songlin Yu, Jeffry R Alger, Zhentao Zuo, Juan Chen, Rong Wang, Jing An, Bo Wang, Jizong Zhao, Rong Xue, Danny J J Wang

Journal: Eur Radiol. 2014 May;24(5):1135-44.

 

To present a multi-delay pseudo-continuous ASL (pCASL) protocol that offers simultaneous measurements of cerebral blood flow (CBF) and arterial transit time (ATT), and to study correlations between multi-delay pCASL and CT perfusion in moyamoya disease.

Last Updated: 4 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Moyamoya disease" returned 25 free, full-text review articles on human participants. First 3 results:

Management of distal choroidal artery aneurysms in patients with moyamoya disease: report of three cases and review of the literature.
 

Author(s): Kangmin He, Wei Zhu, Liang Chen, Ying Mao

Journal:

 

Prevention of rebleeding plays an important role in the treatment of hemorrhagic moyamoya disease, because rebleeding results in high mortality and morbidity. We discuss possible treatment for patients with moyamoya disease accompanied with distal choroidal artery aneurysms and review ...

Last Updated: 26 Aug 2013

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Bypass surgery for moyamoya disease: concept and essence of sugical techniques.
 

Author(s): Satoshi Kuroda, Kiyohiro Houkin

Journal: Neurol. Med. Chir. (Tokyo). 2012 ;52(5):287-94.

 

This review describes the basic concepts of surgical revascularization for moyamoya disease, including direct and indirect bypass surgery. Direct bypass surgery can improve cerebral hemodynamics and reduce further ischemic events immediately after surgery, but may be technically challenging ...

Last Updated: 12 Jun 2012

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Review of past research and current concepts on the etiology of moyamoya disease.
 

Author(s): Kiyohiro Houkin, Masaki Ito, Taku Sugiyama, Hideo Shichinohe, Naoki Nakayama, Ken Kazumata, Satoshi Kuroda

Journal: Neurol. Med. Chir. (Tokyo). 2012 ;52(5):267-77.

 

Research on moyamoya disease has progressed remarkably in the past several decades. Indeed, many new facts concerning the epidemiology of the disease have been revealed and surgical treatments have been drastically improved. However, despite extensive research, the mechanism of moyamoya ...

Last Updated: 12 Jun 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke
 

Status: Recruiting

Condition Summary: Moyamoya Disease; Intracranial Atherosclerotic Stroke; Intracranial Steno-occlusive Disease

 

Last Updated: 26 Feb 2014

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Subclavian Vein catheterization_Seldinger Vs Modified Seldinger
 

Status: Recruiting

Condition Summary: Brain Neoplasm; Intracranial Aneurysm; Cerebrovascular Moyamoya Disease

 

Last Updated: 11 May 2014

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