Moyamoya disease

Common Name(s)

Moyamoya disease

Moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name "moyamoya" means "puff of smoke" in Japanese and describes the look of the tangled vessels that form to compensate for the blockage. This condition usually affects children, but can affect adults. Affected people are at increased risk for blood clots, strokes, and transient ischemic attacks (TIAs) which are frequently accompanied by seizures and muscular weakness, or paralysis on one side of the body. Affected people may also have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems. Researchers believe that Moyamoya disease is an inherited condition because it tends to run in families.

Moyamoya syndrome is a related term that refers to cases of moyamoya disease that occur in association with other conditions or risk factors, such as neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, Sturge-Weber syndrome, and tuberous sclerosis.

 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Moyamoya disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Moyamoya disease" returned 357 free, full-text research articles on human participants. First 3 results:

Intraoperative dexmedetomidine and postoperative cerebral hyperperfusion syndrome in patients who underwent superficial temporal artery-middle cerebral artery anastomosis for moyamoya disease: A retrospective observational study.
 

Author(s): Hyungseok Seo, Ho-Geol Ryu, Je Do Son, Jeong-Soo Kim, Eun Jin Ha, Jeong-Eun Kim, Hee-Pyoung Park

Journal: Medicine (Baltimore). 2016 Dec;95(52):e5712.

 

Dexmedetomidine, a selective α2-agonist, reduces cerebral blood flow and has neuroprotective effects against cerebral ischemia/reperfusion injury in experimental animals. We examined whether intraoperative dexmedetomidine would reduce the incidence of postoperative cerebral hyperperfusion ...

Last Updated: 29 Dec 2016

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Moyamoya disease: impact on the performance of oral and written language.
 

Author(s): Dionísia Aparecida Cusin Lamônica, Camila da Costa Ribeiro, Plínio Marcos Duarte Pinto Ferraz, Maria de Lourdes Merighi Tabaquim

Journal: Codas. ;28(5):661-665.

 

Moyamoya disease is an unusual form of occlusive, cerebrovascular disorder that affects the arteries of the central nervous system, causing acquired language alterations and learning difficulties. The study aim was to describe the oral/written language and cognitive skills in a seven-year-and-seven-month-old ...

Last Updated: 16 Nov 2016

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Color Doppler ultrasonography in the evaluation of compensatory arteries in patients with moyamoya disease: combined with cerebral angiography.
 

Author(s): H-W Pan, L Chen, H-Q Jiang, Z Ye, Y Wang, Y Wang

Journal: Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):937-45.

 

To evaluate the hemodynamics of maxillary artery (MA), superficial temporal artery (STA) and ophthalmic artery (OA), and evaluate the hemodynamics prediction capability of these arteries formed compensatory arteries into intracranial using Doppler ultrasonography.

Last Updated: 25 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Moyamoya disease" returned 33 free, full-text review articles on human participants. First 3 results:

Moyamoya Disease: A Review of Clinical Research.
 

Author(s): Tomohito Hishikawa, Kenji Sugiu, Isao Date

Journal: Acta Med. Okayama. 2016 Aug;70(4):229-36.

 

About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, ...

Last Updated: 23 Aug 2016

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Research Progresses in Understanding the Pathophysiology of Moyamoya Disease.
 

Author(s): Anna Bersano, Stephanie Guey, Gloria Bedini, Sara Nava, Dominique Hervé, Peter Vajkoczy, Turgut Tatlisumak, Marika Sareela, Albert van der Zwan, Catharina J M Klijn, Kees P J Braun, Annick Kronenburg, Francesco Acerbi, Martin M Brown, Lionel Calviere, Charlotte Cordonnier, Hilde Henon, Laurent Thines, Nadia Khan, M Czabanka, Markus Kraemer, Robert Simister, Paolo Prontera, E Tournier-Lasserve, Eugenio Parati,

Journal: Cerebrovasc. Dis.. 2016 ;41(3-4):105-18.

 

The pathogenesis of moyamoya disease (MMD) is still unknown. The detection of inflammatory molecules such as cytokines, chemokines and growth factors in MMD patients' biological fluids supports the hypothesis that an abnormal angiogenesis is implicated in MMD pathogenesis. However, ...

Last Updated: 12 Mar 2016

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High-resolution Magnetic Resonance Imaging of Moyamoya Disease.
 

Author(s): Le-Bao Yu, Qian Zhang, Zhi-Yong Shi, Ming-Qiu Wang, Dong Zhang

Journal: Chin. Med. J.. 2015 Dec;128(23):3231-7.

 

To introduce the imaging characteristics of moyamoya disease (MMD) using high-resolution magnetic resonance imaging (HR-MRI) and to discuss the role of HR-MRI in differentiating MMD from other intracranial artery diseases, especially intracranial atherosclerotic disease (ICAD).

Last Updated: 27 Nov 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya Disease
 

Status: Recruiting

Condition Summary: Moyamoya Disease

 

Last Updated: 2 Dec 2016

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Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
 

Status: Recruiting

Condition Summary: Moyamoya Disease

 

Last Updated: 16 Mar 2016

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Characteristics and Outcomes of Childhood Moyamoya in the UK
 

Status: Recruiting

Condition Summary: Moyamoya

 

Last Updated: 4 May 2015

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