Moyamoya disease

Common Name(s)

Moyamoya disease

Moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name "moyamoya" means "puff of smoke" in Japanese and describes the look of the tangled vessels that form to compensate for the blockage. This condition usually affects children, but can affect adults. Affected people are at increased risk for blood clots, strokes, and transient ischemic attacks (TIAs) which are frequently accompanied by seizures and muscular weakness, or paralysis on one side of the body. Affected people may also have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems. Researchers believe that Moyamoya disease is an inherited condition because it tends to run in families.

Moyamoya syndrome is a related term that refers to cases of moyamoya disease that occur in association with other conditions or risk factors, such as neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, Sturge-Weber syndrome, and tuberous sclerosis.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Moyamoya disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Moyamoya disease" returned 376 free, full-text research articles on human participants. First 3 results:

Mapping altered brain connectivity and its clinical associations in adult moyamoya disease: A resting-state functional MRI study.
 

Author(s): Ken Kazumata, Khin Khin Tha, Haruto Uchino, Masaki Ito, Naoki Nakayama, Takeo Abumiya

Journal:

 

Detection of subtle ischemic injuries in moyamoya disease may enable optimization of timing of revascularization surgery, and could potentially improve functional outcomes. Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to study functional organization ...

Last Updated: 7 Aug 2017

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Frequency and significance of rare RNF213 variants in patients with adult moyamoya disease.
 

Author(s): Mi-Ae Jang, Jong-Won Chung, Je Young Yeon, Jong-Soo Kim, Seung Chyul Hong, Oh Young Bang, Chang-Seok Ki

Journal:

 

Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by stenosis of the internal carotid arteries with compensatory development of collateral vessels. Although a founder variant of RNF213, p.Arg4810Lys (c.14429G>A, rs112735431), is a major genetic risk factor for ...

Last Updated: 15 Jun 2017

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Impact of aberrant cerebral perfusion on resting-state functional MRI: A preliminary investigation of Moyamoya disease.
 

Author(s): Yituo Wang, Lubin Wang, Penggang Qiao, Fugeng Sheng, Cong Han, Enmao Ye, Yu Lei, Feng Yan, Shanshan Chen, Yuyang Zhu, Guiyun Mi, Gongjie Li, Zheng Yang

Journal:

 

The impact of chronic cerebral hypoperfusion on resting-state blood oxygen level-dependent signal fluctuations remains unknown. We aimed to determine whether chronic ischemia induces changes in amplitude of low-frequency fluctuations (ALFF) and to investigate the correlation between ...

Last Updated: 25 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Moyamoya disease" returned 36 free, full-text review articles on human participants. First 3 results:

Role of Ring Finger Protein 213 in Moyamoya Disease.
 

Author(s): Yong-Gang Ma, Qian Zhang, Le-Bao Yu, Ji-Zong Zhao

Journal: Chin. Med. J.. 2016 10;129(20):2497-2501.

 

The aim of this study was to help people comprehensively understand the research advances related to ring finger protein 213 (RNF213) in moyamoya disease (MMD) and to understand the disease at the molecular level to provide a new perspective of the diagnosis of the disease.

Last Updated: 17 Oct 2016

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Moyamoya Disease: A Review of Clinical Research.
 

Author(s): Tomohito Hishikawa, Kenji Sugiu, Isao Date

Journal: Acta Med. Okayama. 2016 Aug;70(4):229-36.

 

About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, ...

Last Updated: 23 Aug 2016

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Progress on Complications of Direct Bypass for Moyamoya Disease.
 

Author(s): Jinlu Yu, Lei Shi, Yunbao Guo, Baofeng Xu, Kan Xu

Journal:

 

Moyamoya disease (MMD) involves progressive occlusion of the intracranial internal carotid artery resulting in formation of moyamoya-like vessels at the base of the brain. It can be characterized by hemorrhage or ischemia. Direct vascular bypass is the main and most effective treatment ...

Last Updated: 8 Aug 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya Disease
 

Status: Recruiting

Condition Summary: Moyamoya Disease

 

Last Updated: 2 Dec 2016

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Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
 

Status: Recruiting

Condition Summary: Moyamoya Disease

 

Last Updated: 21 Aug 2017

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Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke
 

Status: Recruiting

Condition Summary: Moyamoya Disease; Intracranial Atherosclerotic Stroke; Intracranial Steno-occlusive Disease

 

Last Updated: 24 Apr 2017

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