Monogenic diabetes

Common Name(s)

Monogenic diabetes

The most common forms of diabetes, type 1 and type 2, are polygenic, meaning the risk of developing these forms of diabetes is related to multiple genes . Environmental factors, such as obesity in the case of type 2 diabetes, also play a part in the development of polygenic forms of diabetes. Polygenic forms of diabetes often run in families. Doctors diagnose polygenic forms of diabetes by testing blood glucose in individuals with risk factors or symptoms of diabetes .

Some rare forms of diabetes result from mutations in a single gene and are called monogenic . Monogenic forms of diabetes may account for about 1 to 5 percent of all cases of diabetes in young people . In some cases of monogenic diabetes, the gene mutation is inherited; but in others, the gene mutation develops spontaneously . Most mutations in monogenic diabetes reduce the body's ability to produce insulin, a protein produced in the pancreas that is essential for the body to use glucose for energy . As a result, monogenic diabetes can easily be mistaken for type 1 diabetes .

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Monogenic diabetes" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Monogenic diabetes" returned 34 free, full-text research articles on human participants. First 3 results:

Genomic screening for monogenic forms of diabetes.
 

Author(s): Leslie G Biesecker

Journal:

 

Adult-onset, or type II diabetes mellitus (T2DM) has a complex genetic architecture, from hundreds of genes with low penetrance, common susceptibility variants (e.g., TCF7L2), to a set of more than ten genes that, when mutated, can cause a single-gene or Mendelian form of T2DM (e.g., ...

Last Updated: 31 Dec 1969

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Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals.
 

Author(s): Vikas Bansal, Johann Gassenhuber, Tierney Phillips, Glenn Oliveira, Rebecca Harbaugh, Nikki Villarasa, Eric J Topol, Thomas Seufferlein, Bernhard O Boehm

Journal:

 

Diagnosis of monogenic as well as atypical forms of diabetes mellitus has important clinical implications for their specific diagnosis, prognosis, and targeted treatment. Single gene mutations that affect beta-cell function represent 1-2% of all cases of diabetes. However, phenotypic ...

Last Updated: 31 Dec 1969

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Precision medicine for monogenic diabetes: from a survey to the development of a next-generation diagnostic panel.
 

Author(s): Sakina Kherra, Jean-Louis Blouin, Federico Santoni, Valerie Schwitzgebel

Journal:

 

Monogenic diabetes (MD) accounts for 1-2% of all diabetes cases. Because of its wide phenotypic spectrum, MD is often misdiagnosed as type 1 or type 2 diabetes. While clinical and biochemical parameters can suggest MD, a definitive diagnosis requires genetic analysis. We conducted ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Monogenic diabetes" returned 7 free, full-text review articles on human participants. First 3 results:

Management of sulfonylurea-treated monogenic diabetes in pregnancy: implications of placental glibenclamide transfer.
 

Author(s): M Shepherd, A J Brook, A J Chakera, A T Hattersley

Journal: Diabet. Med.. 2017 10;34(10):1332-1339.

 

The optimum treatment for HNF1A/HNF4A maturity-onset diabetes of the young and ATP-sensitive potassium (K ) channel neonatal diabetes, outside pregnancy, is sulfonylureas, but there is little evidence regarding the most appropriate treatment during pregnancy. Glibenclamide has been ...

Last Updated: 31 Dec 1969

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Precision diabetes: learning from monogenic diabetes.
 

Author(s): Andrew T Hattersley, Kashyap A Patel

Journal: Diabetologia. 2017 05;60(5):769-777.

 

The precision medicine approach of tailoring treatment to the individual characteristics of each patient or subgroup has been a great success in monogenic diabetes subtypes, MODY and neonatal diabetes. This review examines what has led to the success of a precision medicine approach ...

Last Updated: 31 Dec 1969

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Monogenic diabetes: Implementation of translational genomic research towards precision medicine.
 

Author(s): Martine Vaxillaire, Philippe Froguel

Journal: J Diabetes. 2016 Nov;8(6):782-795.

 

Various forms of early onset non-autoimmune diabetes are recognized as monogenic diseases, each subtype being caused by a single highly penetrant gene defect at the individual level. Monogenic diabetes (MD) is clinically and genetically heterogeneous, including maturity onset diabetes ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes Mellitus
 

Status: Recruiting

Condition Summary: Genetic Variation; Diabetes

 

Last Updated: 7 Aug 2018

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Last Updated: 10 Dec 2017

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