Monogenic diabetes

Common Name(s)

Monogenic diabetes

The most common forms of diabetes, type 1 and type 2, are polygenic, meaning the risk of developing these forms of diabetes is related to multiple genes . Environmental factors, such as obesity in the case of type 2 diabetes, also play a part in the development of polygenic forms of diabetes. Polygenic forms of diabetes often run in families. Doctors diagnose polygenic forms of diabetes by testing blood glucose in individuals with risk factors or symptoms of diabetes .

Some rare forms of diabetes result from mutations in a single gene and are called monogenic . Monogenic forms of diabetes may account for about 1 to 5 percent of all cases of diabetes in young people . In some cases of monogenic diabetes, the gene mutation is inherited; but in others, the gene mutation develops spontaneously . Most mutations in monogenic diabetes reduce the body's ability to produce insulin, a protein produced in the pancreas that is essential for the body to use glucose for energy . As a result, monogenic diabetes can easily be mistaken for type 1 diabetes .

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Monogenic diabetes" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Monogenic diabetes" returned 19 free, full-text research articles on human participants. First 3 results:

Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model.
 

Author(s): Rui Gao, Yanxia Liu, Anette Prior Gjesing, Mette Hollensted, Xianzi Wan, Shuwen He, Oluf Pedersen, Xin Yi, Jun Wang, Torben Hansen

Journal:

 

Monogenic diabetes is a genetic disease often caused by mutations in genes involved in beta-cell function. Correct sub-categorization of the disease is a prerequisite for appropriate treatment and genetic counseling. Target-region capture sequencing is a combination of genomic region ...

Last Updated: 6 Mar 2014

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Improved genetic testing for monogenic diabetes using targeted next-generation sequencing.
 

Author(s): S Ellard, H Lango Allen, E De Franco, S E Flanagan, G Hysenaj, K Colclough, J A L Houghton, M Shepherd, A T Hattersley, M N Weedon, R Caswell

Journal: Diabetologia. 2013 Sep;56(9):1958-63.

 

Current genetic tests for diagnosing monogenic diabetes rely on selection of the appropriate gene for analysis according to the patient's phenotype. Next-generation sequencing enables the simultaneous analysis of multiple genes in a single test. Our aim was to develop a targeted next-generation ...

Last Updated: 8 Aug 2013

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Prevalence of monogenic diabetes amongst Polish children after a nationwide genetic screening campaign.
 

Author(s): W Fendler, M Borowiec, A Baranowska-Jazwiecka, A Szadkowska, E Skala-Zamorowska, G Deja, P Jarosz-Chobot, I Techmanska, J Bautembach-Minkowska, M Mysliwiec, A Zmyslowska, I Pietrzak, M T Malecki, W Mlynarski

Journal: Diabetologia. 2012 Oct;55(10):2631-5.

 

The aim of this study was to study dynamic changes in the prevalence of different types of diabetes in paediatric populations in Poland, with a specific focus on monogenic diabetes (MD).

Last Updated: 5 Sep 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Monogenic diabetes" returned 3 free, full-text review articles on human participants. First 3 results:

Monogenic diabetes mellitus due to defects in insulin secretion.
 

Author(s): Christoph Henzen

Journal:

 

Monogenic forms of diabetes mellitus cover a heterogeneous group of diabetes which are uniformly caused by a single gene mutation and are characterised by impaired insulin secretion of the pancreatic beta cell. It is estimated that they account for up to 5% of all cases of diabetes ...

Last Updated: 5 Oct 2012

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[The rare syndromic forms of monogenic diabetes in childhood].
 

Author(s): Agnieszka Zmysłowska, Jerzy Bodalski, Wojciech Młynarski

Journal: Pediatr Endocrinol Diabetes Metab. 2008 ;14(1):41-3.

 

The most frequent form of diabetes in the childhood is type 1 diabetes. Moreover, the rare forms of diabetes have been also identified in children. Besides of neonatal diabetes caused by the mutations in KCNJ11, SUR1 and GCK genes, other forms of monogenic diabetes are associated ...

Last Updated: 25 Jun 2008

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Monogenic diabetes in children and young adults: Challenges for researcher, clinician and patient.
 

Author(s): Annabelle S Slingerland

Journal: Rev Endocr Metab Disord. 2006 Sep;7(3):171-85.

 

Monogenic diabetes results from one or more mutations in a single gene which might hence be rare but has great impact leading to diabetes at a very young age. It has resulted in great challenges for researchers elucidating the aetiology of diabetes and related features in other organ ...

Last Updated: 11 Jan 2007

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Incretin Regulation of Insulin Secretion in Monogenic Diabetes
 

Status: Recruiting

Condition Summary: Monogenic Diabetes

 

Last Updated: 26 Mar 2014

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Identification and Characterization of Monogenic Diabetes
 

Status: Recruiting

Condition Summary: Diabetes

 

Last Updated: 11 Apr 2014

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