Logopenic progressive aphasia

Common Name(s)

Logopenic progressive aphasia

Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule. Click here to view an image of the lobes of the brain. AlzheimerÕs disease is the most common cause. There is a high frequency of apolipoprotein E4 genotype in LPA.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 10 Dec 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 10 Dec 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Logopenic progressive aphasia" returned 15 free, full-text research articles on human participants. First 3 results:

Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
 

Author(s): Kirrie J Ballard, Sharon Savage, Cristian E Leyton, Adam P Vogel, Michael Hornberger, John R Hodges

Journal:

 

Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet remains challenging since it hinges on expert based evaluation of speech and language production. In this study acoustic measures of speech in conjunction ...

Last Updated: 3 Mar 2014

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Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits.
 

Author(s): Michitaka Funayama, Yoshitaka Nakagawa, Yoko Yamaya, Fumihiro Yoshino, Masaru Mimura, Motoichiro Kato

Journal:

 

Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In ...

Last Updated: 17 Jan 2014

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Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation.
 

Author(s): Marc Teichmann, Aurélie Kas, Claire Boutet, Sophie Ferrieux, Marie Nogues, Dalila Samri, Christina Rogan, Didier Dormont, Bruno Dubois, Raffaella Migliaccio

Journal: Brain. 2013 Nov;136(Pt 11):3474-88.

 

Within primary progressive aphasia the logopenic variant remains less understood than the two other main variants, namely semantic and non-fluent progressive aphasia. This may be because of the relatively small number of explored patients and because of the lack of investigations ...

Last Updated: 28 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Logopenic progressive aphasia" returned 2 free, full-text review articles on human participants. First 3 results:

The logopenic variant of primary progressive aphasia.
 

Author(s): Maya L Henry, Maria Luisa Gorno-Tempini

Journal: Curr. Opin. Neurol.. 2010 Dec;23(6):633-7.

 

The aim is to explore the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to outline recent advances that have clarified its clinical characteristics, neural underpinnings, and potential genetic and pathological bases. This is particularly ...

Last Updated: 5 Nov 2010

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The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
 

Author(s): Michael F Bonner, Sharon Ash, Murray Grossman

Journal: Curr Neurol Neurosci Rep. 2010 Nov;10(6):484-90.

 

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants ...

Last Updated: 21 Sep 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tau Imaging in Young Onset Dementia
 

Status: Recruiting

Condition Summary: Alzheimer's Disease, Early Onset; Logopenic Progressive Aphasia; Posterior Cortical Atrophy (PCA)

 

Last Updated: 13 Nov 2014

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Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD
 

Status: Recruiting

Condition Summary: Atypical Alzheimers Disease; Logopenic Variant of Primary Progressive Aphasia (LPA); Posterior Cortical Atrophy (PCA)

 

Last Updated: 25 Nov 2014

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