Logopenic progressive aphasia

Common Name(s)

Logopenic progressive aphasia

Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule. Click here to view an image of the lobes of the brain. AlzheimerÕs disease is the most common cause. There is a high frequency of apolipoprotein E4 genotype in LPA.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Logopenic progressive aphasia" returned 9 free, full-text research articles on human participants. First 3 results:

Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia.
 

Author(s): Jennifer L Whitwell, Val J Lowe, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Kejal Kantarci, Samantha M Wille, Matthew L Senjem, Matthew C Murphy, Jeffrey L Gunter, Clifford R Jack, Keith A Josephs

Journal: J. Neurol. Neurosurg. Psychiatr.. 2013 Dec;84(12):1357-64.

 

Most subjects with logopenic variant of primary progressive aphasia (lvPPA) have β-amyloid (Aβ) deposition on Pittsburgh Compound B positron emission tomography (PiB-PET), usually affecting prefrontal and temporoparietal cortices, with less occipital involvement.

Last Updated: 15 Nov 2013

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FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer's type.
 

Author(s): Ajay Madhavan, Jennifer L Whitwell, Stephen D Weigand, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Nirubol Tosakulwong, Matthew L Senjem, Jeffrey L Gunter, Val J Lowe, Ronald C Petersen, Clifford R Jack, Keith A Josephs

Journal:

 

The logopenic variant of primary progressive aphasia is an atypical clinical variant of Alzheimer's disease which is typically characterized by left temporoparietal atrophy on magnetic resonance imaging and hypometabolism on F-18 fluorodeoxyglucose positron emission tomography. We ...

Last Updated: 29 Apr 2013

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Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia.
 

Author(s): Jonathan D Rohrer, Francesca Caso, Colin Mahoney, Maya Henry, Howard J Rosen, Gil Rabinovici, Martin N Rossor, Bruce Miller, Jason D Warren, Nick C Fox, Gerard R Ridgway, Maria Luisa Gorno-Tempini

Journal: Brain Lang. 2013 Nov;127(2):121-6.

 

The logopenic variant of primary progressive aphasia (PPA) is characterised by impaired sentence repetition and word retrieval difficulties. Post mortem studies, amyloid imaging and CSF tau/Aβ measurements suggest Alzheimer's disease (AD) pathology as the underlying cause. Relatively ...

Last Updated: 25 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Logopenic progressive aphasia" returned 2 free, full-text review articles on human participants. First 3 results:

The logopenic variant of primary progressive aphasia.
 

Author(s): Maya L Henry, Maria Luisa Gorno-Tempini

Journal: Curr. Opin. Neurol.. 2010 Dec;23(6):633-7.

 

The aim is to explore the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to outline recent advances that have clarified its clinical characteristics, neural underpinnings, and potential genetic and pathological bases. This is particularly ...

Last Updated: 5 Nov 2010

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The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
 

Author(s): Michael F Bonner, Sharon Ash, Murray Grossman

Journal: Curr Neurol Neurosci Rep. 2010 Nov;10(6):484-90.

 

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants ...

Last Updated: 21 Sep 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD
 

Status: Recruiting

Condition Summary: Atypical Alzheimers Disease; Logopenic Variant of Primary Progressive Aphasia (LPA); Posterior Cortical Atrophy (PCA)

 

Last Updated: 25 Jun 2014

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