Logopenic progressive aphasia

Common Name(s)

Logopenic progressive aphasia

Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule. Click here to view an image of the lobes of the brain. AlzheimerÕs disease is the most common cause. There is a high frequency of apolipoprotein E4 genotype in LPA.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Logopenic progressive aphasia" returned 11 free, full-text research articles on human participants. First 3 results:

Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits.
 

Author(s): Michitaka Funayama, Yoshitaka Nakagawa, Yoko Yamaya, Fumihiro Yoshino, Masaru Mimura, Motoichiro Kato

Journal:

 

Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In ...

Last Updated: 17 Jan 2014

Go To URL
Phonological facilitation of object naming in agrammatic and logopenic primary progressive aphasia (PPA).
 

Author(s): Jennifer E Mack, Soojin Cho-Reyes, James D Kloet, Sandra Weintraub, M-Marsel Mesulam, Cynthia K Thompson

Journal: Cogn Neuropsychol. 2013 ;30(3):172-93.

 

Phonological processing deficits are characteristic of both the agrammatic and logopenic subtypes of primary progressive aphasia (PPA-G and PPA-L). However, it is an open question which substages of phonological processing (i.e., phonological word form retrieval, phonological encoding) ...

Last Updated: 8 Oct 2013

Go To URL
Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia.
 

Author(s): Jennifer L Whitwell, Val J Lowe, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Kejal Kantarci, Samantha M Wille, Matthew L Senjem, Matthew C Murphy, Jeffrey L Gunter, Clifford R Jack, Keith A Josephs

Journal: J. Neurol. Neurosurg. Psychiatr.. 2013 Dec;84(12):1357-64.

 

Most subjects with logopenic variant of primary progressive aphasia (lvPPA) have β-amyloid (Aβ) deposition on Pittsburgh Compound B positron emission tomography (PiB-PET), usually affecting prefrontal and temporoparietal cortices, with less occipital involvement.

Last Updated: 15 Nov 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Logopenic progressive aphasia" returned 2 free, full-text review articles on human participants. First 3 results:

The logopenic variant of primary progressive aphasia.
 

Author(s): Maya L Henry, Maria Luisa Gorno-Tempini

Journal: Curr. Opin. Neurol.. 2010 Dec;23(6):633-7.

 

The aim is to explore the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to outline recent advances that have clarified its clinical characteristics, neural underpinnings, and potential genetic and pathological bases. This is particularly ...

Last Updated: 5 Nov 2010

Go To URL
The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
 

Author(s): Michael F Bonner, Sharon Ash, Murray Grossman

Journal: Curr Neurol Neurosci Rep. 2010 Nov;10(6):484-90.

 

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants ...

Last Updated: 21 Sep 2010

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD
 

Status: Recruiting

Condition Summary: Atypical Alzheimers Disease; Logopenic Variant of Primary Progressive Aphasia (LPA); Posterior Cortical Atrophy (PCA)

 

Last Updated: 25 Jun 2014

Go to URL