Logopenic progressive aphasia

Common Name(s)

Logopenic progressive aphasia

Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule. Click here to view an image of the lobes of the brain. AlzheimerÕs disease is the most common cause. There is a high frequency of apolipoprotein E4 genotype in LPA.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Logopenic progressive aphasia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Logopenic progressive aphasia" returned 22 free, full-text research articles on human participants. First 3 results:

Phonological short-term memory in logopenic variant primary progressive aphasia and mild Alzheimer's disease.
 

Author(s): Aaron M Meyer, Sarah F Snider, Rachael E Campbell, Rhonda B Friedman

Journal: Cortex. 2015 Oct;71():183-9.

 

It has been argued that individuals with logopenic variant primary progressive aphasia (lvPPA) have an impairment of the phonological loop, which is a component of the short-term memory (STM) system. In contrast, this type of impairment is not thought to be present in mild typical ...

Last Updated: 19 Sep 2015

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Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia.
 

Author(s): Jennifer L Whitwell, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Matthew L Senjem, Christopher G Schwarz, Robert Reid, Matthew C Baker, Ralph B Perkerson, Val J Lowe, Rosa Rademakers, Clifford R Jack, Keith A Josephs

Journal: Brain Lang. 2015 Mar;142():45-53.

 

Logopenic primary progressive aphasia (lvPPA) is a progressive language disorder characterized by anomia, difficulty repeating complex sentences, and phonological errors. The majority, although not all, lvPPA patients have underlying Alzheimer's disease. We aimed to determine whether ...

Last Updated: 21 Feb 2015

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Logopenic progressive aphasia associated with idiopathic Parkinson's disease.
 

Author(s): J A Matías-Guiu, R García-Ramos, M N Cabrera-Martín, T Moreno-Ramos

Journal: Neurologia. 2015 Oct;30(8):521-4.

 

Last Updated: 28 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Logopenic progressive aphasia" returned 2 free, full-text review articles on human participants. First 3 results:

The logopenic variant of primary progressive aphasia.
 

Author(s): Maya L Henry, Maria Luisa Gorno-Tempini

Journal: Curr. Opin. Neurol.. 2010 Dec;23(6):633-7.

 

The aim is to explore the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to outline recent advances that have clarified its clinical characteristics, neural underpinnings, and potential genetic and pathological bases. This is particularly ...

Last Updated: 5 Nov 2010

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The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
 

Author(s): Michael F Bonner, Sharon Ash, Murray Grossman

Journal: Curr Neurol Neurosci Rep. 2010 Nov;10(6):484-90.

 

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants ...

Last Updated: 21 Sep 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular and Structural Imaging in Atypical Alzheimer's Disease: A Longitudinal Study
 

Status: Not yet recruiting

Condition Summary: Atypical Alzheimer's Disease; Logopenic Progressive Aphasia (LPA); Posterior Cortical Atrophy (PCA)

 

Last Updated: 22 Apr 2016

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