Intravenous leiomyomatosis

Common Name(s)

Intravenous leiomyomatosis

Intravenous leiomyomatosis (IVL) is a benign smooth muscle tumor of the uterus that grows within the veins but does not invade the surrounding tissue. IVL usually starts in the veins of the uterus and can extend into the inferior vena cava and ultimately into the right side of the heart, resulting in death The abnormal smooth muscle cells that cause IVL express estrogen and progesterone receptors and tumor growth thus appears to respond to these hormones. Although this is a benign condition, many affected individuals require surgery to remove the excess tissue in the uterus and heart. The exact cause of IVL remains unknown. IVL is rare, with only about 200 cases reported in the medical literature.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intravenous leiomyomatosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intravenous leiomyomatosis" returned 39 free, full-text research articles on human participants. First 3 results:

The value of (18)F-FDG PET/CT in the diagnosis of uterine intravenous leiomyomatosis extended into the right atrium.
 

Author(s): Jie Xiao, Guobing Liu, Dengfeng Cheng, Haixing Wang, Hongcheng Shi

Journal: Hell J Nucl Med. ;19(2):179-81.

 

Intravenous leiomyomatosis (IVL) of the uterus is a rare neoplasm which usually occurs after hysterectomy. Due to its rarity and non-specific clinical manifestations, IVL is commonly misdiagnosed as malignant thrombus or thrombosis and treated inappropriately. Herein, we report an ...

Last Updated: 2 Aug 2016

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Uterine Intravenous Leiomyomatosis with Intracardiac Extension and Pulmonary Benign Metastases on FDG PET/CT: A Case Report.
 

Author(s): Hui-Chun Wang, Yu-Bin Wang, Xiao-Hong Chen, Lan-Lan Cui

Journal: Korean J Radiol. ;17(2):289-94.

 

A 48-year-old woman presented with a 50-day history of irregular vaginal bleeding and lower abdominal pain. Ultrasound indicated an extremely large occupying lesion in the pelvic cavity that was highly suggestive of malignancy. Fluorodeoxyglucose (FDG) positron emission tomography/computed ...

Last Updated: 9 Mar 2016

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Computerized tomography angiography in preoperative assessment of intravenous leiomyomatosis extending to inferior vena cava and heart.
 

Author(s): Ting Gui, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ping Peng, Keng Shen

Journal:

 

Intravenous leiomyomatosis (IVL) extending to inferior vena cava and heart is one of the most challenging conditions for surgical treatment. We explored the use of computerized tomography angiography (CTA) in preoperative assessment for this disease.

Last Updated: 9 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intravenous leiomyomatosis" returned 4 free, full-text review articles on human participants. First 3 results:

Intravenous leiomyomatosis with intracardiac extension: echocardiographic study and literature review.
 

Author(s): Rongjuan Li, Yanguang Shen, Yan Sun, Chuanchen Zhang, Ya Yang, Jiao Yang, Ruijuan Su, Bo Jiang

Journal:

 

Uterine leiomyomatosis is a common disease in women; however, intravenous leiomyomatosis with intracaval and intracardiac tumor extension is rare. We sought to analyze the clinical and echocardiographic features of intracardiac leiomyomatosis. From January 2003 through July 2012, ...

Last Updated: 26 Nov 2014

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Intravenous leiomyomatosis with extension to the heart: rare or underestimated?
 

Author(s): Mladen J Kocica, Mile R Vranes, Dusan Kostic, Natasa Kovacevic-Kostic, Vesna Lackovic, Vesna Bozic-Mihajlovic, Milos M Velinovic, Aleksandar Dj Mikic, Nevena Dimitrijevic-Kalezic

Journal: J. Thorac. Cardiovasc. Surg.. 2005 Dec;130(6):1724-6.

 

Last Updated: 25 Nov 2005

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Intravenous leiomyomatosis: two cases with different routes of tumor extension.
 

Author(s): Po Mui Lam, Keith W K Lo, Mei Y Yu, Wai S Wong, James Y W Lau, Ahmed A Arifi, Tak H Cheung

Journal: J. Vasc. Surg.. 2004 Feb;39(2):465-9.

 

Intravenous leiomyomatosis is a rare smooth muscle tumor. We report two cases of intravenous leiomyomatosis that grew along different routes of the venous system into the inferior vena cava and the right atrium. The different route of extension makes a difference in the ease of excision ...

Last Updated: 26 Jan 2004

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer
 

Status: Recruiting

Condition Summary: Renal Tumor Histology; Cutaneous Leiomyomatosis; Kidney Cancer

 

Last Updated: 18 Nov 2016

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Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Renal Cell Carcinoma; Hereditary Leiomyomatosis and Renal Cell Cancer; Papillary Renal Cell Carcinoma, Sporadic

 

Last Updated: 18 Nov 2016

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