Intravenous leiomyomatosis

Common Name(s)

Intravenous leiomyomatosis

Intravenous leiomyomatosis (IVL) is a benign smooth muscle tumor of the uterus that grows within the veins but does not invade the surrounding tissue. IVL usually starts in the veins of the uterus and can extend into the inferior vena cava and ultimately into the right side of the heart, resulting in death The abnormal smooth muscle cells that cause IVL express estrogen and progesterone receptors and tumor growth thus appears to respond to these hormones. Although this is a benign condition, many affected individuals require surgery to remove the excess tissue in the uterus and heart. The exact cause of IVL remains unknown. IVL is rare, with only about 200 cases reported in the medical literature.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intravenous leiomyomatosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intravenous leiomyomatosis" returned 41 free, full-text research articles on human participants. First 3 results:

Intravenous leiomyomatosis disguised as a large deep vein thrombosis.
 

Author(s): Camille C Gunderson, Blake Parsons, Shyla Penaroza, Marvin D Peyton, Lisa M Landrum

Journal:

 

Intravenous leiomyomatosis is a benign smooth muscle tumor which despite its histology can have devastating consequences. Furthermore, the clinical manifestations are variable and nonspecific, typically leading to delayed or missed diagnosis. Thus, it is critical for clinicians to ...

Last Updated: 20 Oct 2016

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Different surgical strategies of patients with intravenous leiomyomatosis.
 

Author(s): Guotao Ma, Qi Miao, Xingrong Liu, Chaoji Zhang, Jianzhou Liu, Yuehong Zheng, Jiang Shao, Ninghai Cheng, Shunda Du, Zhan Hu, Zhinan Ren, Luxi Sun

Journal: Medicine (Baltimore). 2016 Sep;95(37):e4902.

 

Intravenous leiomyomatosis (IVL) is a rare benign tumor. The study aimed to assess outcomes of patients treated surgically for IVL.Between November 2002 and January 2015, 76 patients were treated for IVL. The stage of IVL was evaluated preoperatively by echocardiography and enhanced ...

Last Updated: 16 Sep 2016

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Surgical Treatment Strategies of Intravenous Leiomyomatosis withRight Cardiac Cavities Extension.
 

Author(s): Guo-Tao Ma, Qi Miao, Xing-Rong Liu, Chao-Ji Zhang, Yue-Hong Zheng, Jiang Shao, Ning-Hai Cheng, Shun-da DU, Jian-Zhou Liu, Chao Jiang

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Aug;38(4):438-43.

 

Objective To investigate the diagnosis and surgical treatment strategies of intravenous leiomyomatosis(IVL)extending through inferior vena cava into the right cardiac cavities. Methods Thirty patients of IVL extending through inferior vena cava into the right cardiac cavities were ...

Last Updated: 5 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intravenous leiomyomatosis" returned 4 free, full-text review articles on human participants. First 3 results:

Intravenous leiomyomatosis with intracardiac extension: echocardiographic study and literature review.
 

Author(s): Rongjuan Li, Yanguang Shen, Yan Sun, Chuanchen Zhang, Ya Yang, Jiao Yang, Ruijuan Su, Bo Jiang

Journal:

 

Uterine leiomyomatosis is a common disease in women; however, intravenous leiomyomatosis with intracaval and intracardiac tumor extension is rare. We sought to analyze the clinical and echocardiographic features of intracardiac leiomyomatosis. From January 2003 through July 2012, ...

Last Updated: 26 Nov 2014

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Intravenous leiomyomatosis with extension to the heart: rare or underestimated?
 

Author(s): Mladen J Kocica, Mile R Vranes, Dusan Kostic, Natasa Kovacevic-Kostic, Vesna Lackovic, Vesna Bozic-Mihajlovic, Milos M Velinovic, Aleksandar Dj Mikic, Nevena Dimitrijevic-Kalezic

Journal: J. Thorac. Cardiovasc. Surg.. 2005 Dec;130(6):1724-6.

 

Last Updated: 25 Nov 2005

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Intravenous leiomyomatosis: two cases with different routes of tumor extension.
 

Author(s): Po Mui Lam, Keith W K Lo, Mei Y Yu, Wai S Wong, James Y W Lau, Ahmed A Arifi, Tak H Cheung

Journal: J. Vasc. Surg.. 2004 Feb;39(2):465-9.

 

Intravenous leiomyomatosis is a rare smooth muscle tumor. We report two cases of intravenous leiomyomatosis that grew along different routes of the venous system into the inferior vena cava and the right atrium. The different route of extension makes a difference in the ease of excision ...

Last Updated: 26 Jan 2004

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer
 

Status: Recruiting

Condition Summary: Renal Tumor Histology; Cutaneous Leiomyoma; Kidney Cancer

 

Last Updated: 5 Oct 2017

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Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Renal Cell Carcinoma; Hereditary Leiomyomatosis and Renal Cell Cancer; Papillary Renal Cell Carcinoma, Sporadic

 

Last Updated: 18 Oct 2017

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