Intravascular papillary endothelial hyperplasia

Common Name(s)

Intravascular papillary endothelial hyperplasia

Intravascular papillary endothelial hyperplasia (IPEH) is a benign overgrowth of endothelial cells (the cells lining blood vessels). The most frequent sites for IPEH are the deep vascular inner layers of skin (dermis and subcutis) of the head and neck regions and in the lip, tongue and buccal mucosa.  Rare locations include the thyroid, eye (orbit), parotid gland, muscles involved in chewing (masseter muscle), nose, sinus, mandible, pharynx and central nervous system.  The average age of onset is 34.  Signs and symptoms depend on the location of the IPEH.  A definitive diagnosis is made by biopsy of the tumor and examination of the specimen by a pathologist.   Treatment usually involves removal of the tumor by surgery.  Recurrences are very rare.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intravascular papillary endothelial hyperplasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intravascular papillary endothelial hyperplasia" returned 14 free, full-text research articles on human participants. First 3 results:

HIF-1α and VEGF expression correlates with thrombus remodeling in cases of intravascular papillary endothelial hyperplasia.
 

Author(s): Sunzoo Kim, Jae Hun Jun, Jeongshik Kim, Do Won Kim, Yong Hyun Jang, Weon Ju Lee, Ho Yun Chung, Seok-Jong Lee

Journal:

 

Intravascular papillary endothelial hyperplasia (IPEH) is histopathologically characterized by endothelium-lined papillary structures encircling an acellular fibrin core. The process of IPEH pathogenesis is unclear. The purpose of our study was to identify histopathological and immunohistochemical ...

Last Updated: 2 Dec 2013

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Intravascular papillary endothelial hyperplasia: histomorphological and immunohistochemical features.
 

Author(s): Noyan Can Akdur, Melahat Donmez, Serap Gozel, Huseyin Ustun, Sema Hucumenoglu

Journal:

 

Intravascular papillary endothelial hyperplasia (IPEH) is a benign intravascular process with features mimicking other benign and malignant vascular proliferations. IPEH lesions predominate in the head-neck region and the extremities. The characteristic histomorphological feature ...

Last Updated: 15 Nov 2013

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Intravascular papillary endothelial hyperplasia of the oral cavity.
 

Author(s): Harumi Inoue, Yuji Miyazaki, Kentaro Kikuchi, Masahiro Fujinami, Noriaki Yoshida, Fumio Ide, Hideaki Sakashita, Kaoru Kusama

Journal: J Oral Sci. 2011 Dec;53(4):475-80.

 

To examine the pathogenesis of intravascular papillary endothelial hyperplasia (IPEH), a relatively uncommon benign, non-neoplastic vascular lesion, clinicopathological and immunohistochemical studies were performed. Paraffin-embedded tissue specimens of 78 vascular lesions were examined ...

Last Updated: 14 Dec 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intravascular papillary endothelial hyperplasia" returned 3 free, full-text review articles on human participants. First 3 results:

Cutaneous intravascular papillary endothelial hyperplasia of the hand: a case report and review of the literature.
 

Author(s): Ciğdem Tokyol, Yavuz Demir, Fatma Aktepe

Journal: Turk. J. Pediatr.. ;47(1):71-4.

 

Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign endothelial proliferation that bears a remarkable resemblance to angiosarcoma. We report a case of cutaneous IPEH in the thumb of a seven-year old girl which was successfully treated with excision. The relevant ...

Last Updated: 11 May 2005

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Intravascular papillary endothelial hyperplasia of the central nervous system--four case reports.
 

Author(s): Sedat Cagli, Nezih Oktar, Tayfun Dalbasti, Sertaç Işlekel, Eren Demirtaş, Nurcan Ozdamar

Journal: Neurol. Med. Chir. (Tokyo). 2004 Jun;44(6):302-10.

 

Four rare cases of intracranial intravascular papillary endothelial hyperplasia (IPEH) manifesting as cranial nerve disturbances occurred in 16-, 18-, 24-, and 28-year-old females. Magnetic resonance imaging showed all lesions as isointense with strong enhancement on T1-weighted images, ...

Last Updated: 15 Jul 2004

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Intravascular papillary endothelial hyperplasia arising from the upper lip.
 

Author(s): Kenichi Matsuzaka, Yoshihiko Koike, Takashi Yakushiji, Masaki Shimono, Takashi Inoue

Journal: Bull. Tokyo Dent. Coll.. 2003 May;44(2):55-9.

 

We report a rare case of intravascular papillary endothelial hyperplasia (IPEH) arising from the upper lip. Pathologically, it consisted of a few lobulated masses lined by an incomplete fibrous capsule of variable thickness which was separated from the surrounding tissue and which ...

Last Updated: 5 Sep 2003

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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