Interstitial cystitis

Common Name(s)

Interstitial cystitis

Interstitial cystitis (IC) is a condition that causes discomfort or pain in the bladder and abdomen. Symptoms may vary, but often include an urgent or frequent need to urinate. Many of the individuals affected by IC are women. Because IC varies so much in symptoms and severity, most researchers believe it is not one, but several diseases. In recent years, scientists have started to use the terms bladder pain syndrome (BPS) or painful bladder syndrome (PBS) to describe cases with painful urinary symptoms that may not meet the strictest definition of IC. While there is no cure for IC/PBS, in many cases, the symptoms can be managed. Treatments include dietary and lifestyle changes; distending, or inflating, the bladder; bathing the inside of the bladder with a medicine solution; oral medicines and in rare cases, surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Interstitial cystitis" for support, advocacy or research.

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Interstitial Cystitis Association

The Interstitial Cystitis Association (ICA) advocates for research dedicated to discovery of a cure and better treatments, raises awareness, and serves as a central hub for the healthcare providers, researchers and millions of patients who suffer with constant urinary urgency and frequency and extreme bladder pain called IC, or interstitial cystitis. Vision Conquering IC. Changing lives. Mission Early diagnosis and optimal care with dignity for people affected by IC

Last Updated: 19 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Interstitial cystitis" for support, advocacy or research.

Logo
Interstitial Cystitis Association

The Interstitial Cystitis Association (ICA) advocates for research dedicated to discovery of a cure and better treatments, raises awareness, and serves as a central hub for the healthcare providers, researchers and millions of patients who suffer with constant urinary urgency and frequency and extreme bladder pain called IC, or interstitial cystitis. Vision Conquering IC. Changing lives. Mission Early diagnosis and optimal care with dignity for people affected by IC

http://www.ichelp.org

Last Updated: 19 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Interstitial cystitis" returned 256 free, full-text research articles on human participants. First 3 results:

Somatoform disorder as a predictor of interstitial cystitis/bladder pain syndrome: Evidence from a nested case-control study and a retrospective cohort study.
 

Author(s): I-Chun Chen, Ming-Huei Lee, Hsuan-Hung Lin, Shang-Liang Wu, Kun-Min Chang, Hsiu-Ying Lin

Journal: Medicine (Baltimore). 2017 May;96(18):e6304.

 

Interstitial cystitis/bladder pain syndrome (IC/BPS) has several well-known comorbid psychiatric manifestations, including insomnia, anxiety, and depression. We hypothesized that somatoform disorder, which is a psychosomatic disease, can be used as a sensitive psychiatric phenotype ...

Last Updated: 4 May 2017

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Fulranumab in patients with interstitial cystitis/bladder pain syndrome: observations from a randomized, double-blind, placebo-controlled study.
 

Author(s): Hao Wang, Lucille J Russell, Kathleen M Kelly, Steven Wang, John Thipphawong

Journal:

 

This study was designed to evaluate the efficacy and safety of fulranumab, a fully human monoclonal antibody directed against nerve growth factor (NGF), for pain relief in patients with interstitial cystitis/bladder pain syndrome (IC/BPS).

Last Updated: 6 Jan 2017

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Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report.
 

Author(s): Jong Hae Kim, Eugene Kim, Bong Il Kim

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5549.

 

A variety of therapeutic modalities are available for the treatment of interstitial cystitis. However, among them, the less invasive therapies are usually ineffective, whereas the invasive ones carry potential risks of serious side effects and complications. Pulsed radiofrequency ...

Last Updated: 8 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Interstitial cystitis" returned 30 free, full-text review articles on human participants. First 3 results:

Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome.
 

Author(s): Jung-Soo Pyo, Won Jin Cho

Journal: Cell. Physiol. Biochem.. 2016 ;39(4):1618-25.

 

To assess the efficacy of intravesical hyaluronic acid (HA) and HA/chondroitin sulfate (CS) instillation in patients with interstitial cystitis/painful bladder syndrome by systematic review and meta-analysis.

Last Updated: 16 Sep 2016

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Intravesical Botulinum Toxin A Injections for Bladder Pain Syndrome/Interstitial Cystitis: A Systematic Review and Meta-Analysis of Controlled Studies.
 

Author(s): Junpeng Wang, Qiang Wang, Qinghui Wu, Yang Chen, Peng Wu

Journal:

 

BACKGROUND The role of intravesical botulinum toxin A (BTX-A) injections in bladder pain syndrome/interstitial cystitis (BPS/IC) has not been clearly defined. The aim of this study was to evaluate high-level evidence regarding the efficacy and safety of BTX-A injections for BPS/IC. ...

Last Updated: 14 Sep 2016

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Beyond a Simple Anesthetic Effect: Lidocaine in the Diagnosis and Treatment of Interstitial Cystitis/bladder Pain Syndrome.
 

Author(s): Richard A Henry, Alvaro Morales, Catherine M Cahill

Journal: Urology. 2015 May;85(5):1025-33.

 

Intravesical local anesthetics, in a wide variety of combinations, are increasingly used to treat patients with interstitial cystitis-bladder pain syndrome (IC/BPS). Lidocaine has demonstrated properties that block the neuroinflammatory cycle associated with IC/BPS at many of the ...

Last Updated: 28 Apr 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome (Pilot Study)
 

Status: Recruiting

Condition Summary: Chronic Interstitial Cystitis

 

Last Updated: 6 Jul 2017

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Intravesicular Onabotulinumtoxin A in Interstitial Cystitis
 

Status: Recruiting

Condition Summary: Interstitial Cystitis

 

Last Updated: 9 Feb 2017

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Evaluation of Intravesical LP08 in Patients With Interstitial Cystitis/Painful Bladder Syndrome
 

Status: Recruiting

Condition Summary: Interstitial Cystitis

 

Last Updated: 24 Apr 2017

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