Inflammatory myofibroblastic tumor

Common Name(s)

Inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumor is made up of specific cells called myofibroblastic spindle cells. This tumor can occur in many different parts of the body, but it occurs most frequently in the lungs, soft tisues, or internal organs. Inflammatory myofibroblastic tumor usually develops in children or young adults, although it can affect people of any age. This type of tumor tends to recur in the same location, but it rarely spreads (metastasizes) to other parts of the body. Approximately 50% of inflammatory myofibroblastic tumors have rearrangements of the ALK gene on chromosome 2. Treatment typically involves surgery to remove the tumor.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory myofibroblastic tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory myofibroblastic tumor" returned 84 free, full-text research articles on human participants. First 3 results:

[Inflammatory myofibroblastic tumor in the brain].
 

Author(s): L Salgado-Lopez, C de Quintana-Schmidt, B Gomez-Anson, S Bague-Rosell, J Molet-Teixido

Journal: Rev Neurol. 2014 Sep;59(6):281-2.

 

Last Updated: 5 Sep 2014

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Inflammatory myofibroblastic tumor of the bladder - an unexpected case coexisting with an ovarian teratoma.
 

Author(s): Zuzanna Dobrosz, Janusz Ryś, Piotr Paleń, Paweł Właszczuk, Marek Ciepiela

Journal:

 

Inflammatory myofibroblastic tumors (IMTs) mainly occur in children and young adults, usually in the first two decades of life. IMT-type tumors belong to neoplasms of an intermediate biologic potential with considerable rate of local recurrence and in some cases that able to create ...

Last Updated: 30 Jul 2014

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Inflammatory myofibroblastic tumor of the thigh without bone involvement: a case report.
 

Author(s): Jun Lin, Hao Liu, Yin Zhuang, Peng Yang, Yifei Zheng, Yan Yang, Huilin Yang

Journal:

 

Inflammatory myofibroblastic tumors are rare, and those located in the extremities without bone involvement are even rarer. We present the case of a 61-year-old Chinese male patient with an inflammatory myofibroblastic tumor of the right thigh. It was excised and a histopathologic ...

Last Updated: 30 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory myofibroblastic tumor" returned 12 free, full-text review articles on human participants. First 3 results:

Recurrent meningeal inflammatory myofibroblastic tumor: a case report and literature review.
 

Author(s): Maria Pascual-Gallego, Miguel Yus-Fuertes, Manuela Jorquera, Alfredo Gonzalez-Mat, Luis Ortega, Armando Martinez-Martinez, Horacio Zimman

Journal: Neurol India. ;61(6):644-9.

 

An inflammatory myofibroblastic tumor (IMT) is a rare lesion with an uncertain prognosis and a disorder difficult to classify. IMTs are a heterogeneous group of lesions, sometimes indistinguishable from meningiomas and other expanding or inflammatory lesions of the central nervous ...

Last Updated: 20 Jan 2014

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Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review.
 

Author(s): Jian Li, Wei-hua Yin, Kengo Takeuchi, Hong Guan, Yu-hua Huang, John K C Chan

Journal:

 

Inflammatory myofibroblastic tumors (IMTs) are categorized as intermediate biologic neoplasms, whereas IMTs with genetic features of ran-binding protein 2 (RANBP2) and anaplastic lymphoma kinase (ALK) rearrangement (IMT-RAs) are possibly related to a more aggressive clinical course. ...

Last Updated: 15 Nov 2013

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Successful treatment of an unresectable inflammatory myofibroblastic tumor of the frontal bone using a cyclooxygenase-2 inhibitor and methotrexate.
 

Author(s): Fumiko Kusunoki-Nakamoto, Takashi Matsukawa, Masaki Tanaka, Toji Miyagawa, Tomotaka Yamamoto, Jun Shimizu, Masako Ikemura, Junji Shibahara, Shoji Tsuji

Journal: Intern. Med.. 2013 ;52(5):623-8.

 

Inflammatory myofibroblastic tumor (IMT) is a disease characterized by tumorous lesions consisting of myofibroblastic spindle cells and inflammatory cells that occur primarily in the soft tissues and viscera of children and young adults. Total excision is the most effective therapy. ...

Last Updated: 1 Mar 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CREATE: Cross-tumoral Phase 2 With Crizotinib
 

Status: Recruiting

Condition Summary: Locally Advanced and/or Metastatic Anaplastic Large Cell Lymphoma; Locally Advanced and/or Metastatic Inflammatory Myofibroblastic Tumor; Locally Advanced and/or Metastatic Papillary Renal Cell Carcinoma Type 1; Locally Advanced and/or Metastatic Alveolar Soft Part Sarcoma; Locally Advanced and/or Metastatic Clear Cell Sarcoma; Locally Advanced and/or Metastatic Alveolar Rhabdomyosarcoma

 

Last Updated: 2 Jun 2014

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Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Neoplasm With Perivascular Epithelioid Cell Differentiation; Nerve Sheath Neoplasm; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Unclassified Pleomorphic Sarcoma of Bone; Undifferentiated (Embryonal) Sarcoma

 

Last Updated: 21 May 2015

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Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors; Non-small Cell Lung Cancer

 

Last Updated: 29 Apr 2015

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