Inflammatory myofibroblastic tumor

Common Name(s)

Inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumor is made up of specific cells called myofibroblastic spindle cells. This tumor can occur in many different parts of the body, but it occurs most frequently in the lungs, soft tisues, or internal organs. Inflammatory myofibroblastic tumor usually develops in children or young adults, although it can affect people of any age. This type of tumor tends to recur in the same location, but it rarely spreads (metastasizes) to other parts of the body. Approximately 50% of inflammatory myofibroblastic tumors have rearrangements of the ALK gene on chromosome 2. Treatment typically involves surgery to remove the tumor.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory myofibroblastic tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory myofibroblastic tumor" returned 77 free, full-text research articles on human participants. First 3 results:

Recurrent laryngeal inflammatory myofibroblastic tumor with positive anaplastic lymphoma kinase mimicking recurrent respiratory papillomatosis: a case report.
 

Author(s): Chun-yan He, Ge-hong Dong, Hong-gang Liu

Journal:

 

Inflammatory myofibroblastic tumor (IMT) of the larynx is an unusual lesion, particularly in the pediatric age group. Laryngeal IMTs in children follow a benign clinical course with reports of only rare recurrences and no metastases. Although anaplastic lymphoma kinase (ALK) has been ...

Last Updated: 19 Mar 2014

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Inflammatory myofibroblastic tumor occurs in the mediastinum.
 

Author(s): Xiangjiao Meng, Renben Wang

Journal: J Cancer Res Ther. ;9(4):721-3.

 

Inflammatory myofibroblastic tumor (IMT) is a rare disease. We report a rare case of inflammatory myofibroblastic tumor occurs in the mediastinum. Chest contrast-enhanced computed tomography (CT) showed a heterogeneously enhanced irregular mass in the anterior mediastinum; a small ...

Last Updated: 12 Feb 2014

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Inflammatory myofibroblastic tumor of the heart. Overlap with IgG4-related disease?
 

Author(s): Hidemichi Kouzu, Takayuki Miki, Masashi Mizuno, Yukishige Kimura, Atsuko Muranaka, Satoshi Yuda, Yoshiko Keira, Tadashi Hasegawa, Yasuko Miyaki, Nobuyuki Takagi, Tetsuya Higami, Tetsuji Miura

Journal: Circ. J.. 2014 ;78(4):1006-8.

 

Last Updated: 27 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory myofibroblastic tumor" returned 12 free, full-text review articles on human participants. First 3 results:

Recurrent meningeal inflammatory myofibroblastic tumor: a case report and literature review.
 

Author(s): Maria Pascual-Gallego, Miguel Yus-Fuertes, Manuela Jorquera, Alfredo Gonzalez-Mat, Luis Ortega, Armando Martinez-Martinez, Horacio Zimman

Journal: Neurol India. ;61(6):644-9.

 

An inflammatory myofibroblastic tumor (IMT) is a rare lesion with an uncertain prognosis and a disorder difficult to classify. IMTs are a heterogeneous group of lesions, sometimes indistinguishable from meningiomas and other expanding or inflammatory lesions of the central nervous ...

Last Updated: 20 Jan 2014

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Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review.
 

Author(s): Jian Li, Wei-hua Yin, Kengo Takeuchi, Hong Guan, Yu-hua Huang, John K C Chan

Journal:

 

Inflammatory myofibroblastic tumors (IMTs) are categorized as intermediate biologic neoplasms, whereas IMTs with genetic features of ran-binding protein 2 (RANBP2) and anaplastic lymphoma kinase (ALK) rearrangement (IMT-RAs) are possibly related to a more aggressive clinical course. ...

Last Updated: 15 Nov 2013

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Successful treatment of an unresectable inflammatory myofibroblastic tumor of the frontal bone using a cyclooxygenase-2 inhibitor and methotrexate.
 

Author(s): Fumiko Kusunoki-Nakamoto, Takashi Matsukawa, Masaki Tanaka, Toji Miyagawa, Tomotaka Yamamoto, Jun Shimizu, Masako Ikemura, Junji Shibahara, Shoji Tsuji

Journal: Intern. Med.. 2013 ;52(5):623-8.

 

Inflammatory myofibroblastic tumor (IMT) is a disease characterized by tumorous lesions consisting of myofibroblastic spindle cells and inflammatory cells that occur primarily in the soft tissues and viscera of children and young adults. Total excision is the most effective therapy. ...

Last Updated: 1 Mar 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CREATE: Cross-tumoral Phase 2 With Crizotinib
 

Status: Recruiting

Condition Summary: Locally Advanced and/or Metastatic Anaplastic Large Cell Lymphoma; Locally Advanced and/or Metastatic Inflammatory Myofibroblastic Tumor; Locally Advanced and/or Metastatic Papillary Renal Cell Carcinoma Type 1; Locally Advanced and/or Metastatic Alveolar Soft Part Sarcoma; Locally Advanced and/or Metastatic Clear Cell Sarcoma; Locally Advanced and/or Metastatic Alveolar Rhabdomyosarcoma

 

Last Updated: 2 Jun 2014

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Phase 1 Safety Study of X-396, an Oral ALK Inhibitor, in Patients With Advanced Solid Tumors
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors

 

Last Updated: 21 Aug 2014

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Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)
 

Status: Recruiting

Condition Summary: Anaplastic Lymphoma Kinase (ALK)

 

Last Updated: 2 Dec 2014

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