Inflammatory myofibroblastic tumor

Common Name(s)

Inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumor is made up of specific cells called myofibroblastic spindle cells. This tumor can occur in many different parts of the body, but it occurs most frequently in the lungs, soft tisues, or internal organs. Inflammatory myofibroblastic tumor usually develops in children or young adults, although it can affect people of any age. This type of tumor tends to recur in the same location, but it rarely spreads (metastasizes) to other parts of the body. Approximately 50% of inflammatory myofibroblastic tumors have rearrangements of the ALK gene on chromosome 2. Treatment typically involves surgery to remove the tumor.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory myofibroblastic tumor" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory myofibroblastic tumor" returned 110 free, full-text research articles on human participants. First 3 results:

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior.
 

Author(s): Bhawna Sethi, Trupti Pai, Abhishek Allam, Sridhar Epari

Journal: Indian J Pathol Microbiol. ;58(4):509-12.

 

Inflammatory myofibroblastic tumor (IMT), an intermediate-grade neoplasm of myofibroblastic/fibroblastic differentiation, occurs commonly in children and young adults. It is characterized by anaplastic lymphoma kinase (ALK) gene rearrangement and overexpression of ALK-protein. However, ...

Last Updated: 9 Nov 2015

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Inflammatory myofibroblastic tumor of inguinal lymph nodes, simulating lymphoma.
 

Author(s): Akansha Gandhi, Kiran Preet Malhotra, Sonal Sharma

Journal: J Cancer Res Ther. ;11(3):645.

 

Multiple enlarged lymph nodes in an elderly female patient can have varied etiologies as well as histologic pictures. We are presenting the case of a 53-year-old female who presented with inguinal lymphadenopathy with fever, which was clinically misconstrued as lymphoma. Cytology ...

Last Updated: 13 Oct 2015

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One case of inflammatory myofibroblastic tumor--a case report.
 

Author(s): Chunze Zhang, Chun-Jie Li, Wen-Kang Zong, Mei-Lin Xu, Guan-Wei Fan

Journal: J Cancer Res Ther. 2015 Aug;11 Suppl 1():C131-3.

 

Inflammatory myofibroblastic tumor is a rare mesenchymal tumor, it can also be found on the trunk, head and neck, internal organs, and soft tissue. It has been named as inflammatory pseudotumor, plasma cell granuloma, solitary mast cell tumor, pseudotumor pneumonia and tissue cells, ...

Last Updated: 1 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory myofibroblastic tumor" returned 18 free, full-text review articles on human participants. First 3 results:

Inflammatory Myofibroblastic Tumor of Genitourinary Tract Beyond Collecting System: A Rare Case Report With Literature Review.
 

Author(s): Ling-Fan Xu, Jun Zhou, Chao-Zhao Liang

Journal: Medicine (Baltimore). 2015 Oct;94(42):e1706.

 

Inflammatory myofibroblastic tumor (IMT) rarely arises in genitourinary tract especially beyond collecting system, which determines the unspecific clinic symptoms and sometimes can mimic malignancy. Therefore, IMT's diagnosis may usually be a pitfall. This case report characterizes ...

Last Updated: 27 Oct 2015

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Coexistence of gastrointestinal stromal tumor and inflammatory myofibroblastic tumor of the stomach presenting as a collision tumor: first case report and literature review.
 

Author(s): Hyeong Chan Shin, Mi Jin Gu, Se Won Kim, Jae Woon Kim, Joon Hyuk Choi

Journal:

 

Collision tumors of the stomach are rare. We report on a case of a collision tumor consisting of a gastrointestinal stromal tumor (GIST) and an inflammatory myofibroblastic tumor (IMT) of the stomach in a 16-year-old female. A polypoid mass located in the distal body of the stomach ...

Last Updated: 8 Oct 2015

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Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
 

Author(s): Jun-Jie Zhao, Jia-Qian Ling, Yong Fang, Xiao-Dong Gao, Ping Shu, Kun-Tang Shen, Jing Qin, Yi-Hong Sun, Xin-Yu Qin

Journal: World J. Gastroenterol.. 2014 Oct;20(37):13625-31.

 

Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regression without any treatment. Our case report and literature review ...

Last Updated: 13 Oct 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CREATE: Cross-tumoral Phase 2 With Crizotinib
 

Status: Recruiting

Condition Summary: Locally Advanced and/or Metastatic Anaplastic Large Cell Lymphoma; Locally Advanced and/or Metastatic Inflammatory Myofibroblastic Tumor; Locally Advanced and/or Metastatic Papillary Renal Cell Carcinoma Type 1; Locally Advanced and/or Metastatic Alveolar Soft Part Sarcoma; Locally Advanced and/or Metastatic Clear Cell Sarcoma; Locally Advanced and/or Metastatic Alveolar Rhabdomyosarcoma

 

Last Updated: 6 Jul 2016

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Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Undifferentiated (Embryonal) Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone

 

Last Updated: 25 Aug 2016

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Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors; Non-small Cell Lung Cancer

 

Last Updated: 9 Aug 2016

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