BRCA 2

Common Name(s)

BRCA 2

BRCA2 (breast cancer 2, early onset) is a specific gene found in a person’s DNA, or genetic code. Sometimes there are variations or mutations in a person’s genetic code. While some of these go unnoticed (harmless changes), others may put a person at risk for certain health problems. Harmful mutations in the BRCA2 gene (BRCA2 mutation) lead to an increased risk of certain cancers, especially breast cancer and ovarian cancer in women. On average, a woman with a BRCA2 mutation has up to a 40-85% lifetime risk of developing breast cancer and up to an 11-27% lifetime risk of developing ovarian cancer. The risk varies depending on the exact mutation, family history of cancer, reproductive history, and other genes which may modify the cancer risk. Men with a BRCA2 mutation may be at an increased risk to develop male breast and prostate cancer. Both men and women with a BRCA2 mutation may be at an increased risk to develop cancer of the pancreas or an aggressive form of skin cancer called melanoma. Individuals with a BRCA2 mutation require screening for these cancers more often. Some women may even decide to have prophylactic (risk reducing) surgical removal of the breasts (mastectomy) or ovaries (oophorectomy) before they have cancer, in order to prevent developing these cancers. Management and prevention options for individuals with a BRCA2 mutation are individualized based on other factors such as family history of cancer, personal preference, and other risk factors for cancer. To decide the best care plan, talk with your physician if you or a family member has a mutation in the BRCA2 gene. Talking with a genetic counselor or specialist may be helpful, as well as with other women and men who also have a BRCA2 mutation through support organizations. Genetic testing may be recommended if you have a family history of certain cancers or certain ethnic backgrounds. If you are concerned that you should be tested, speak with a genetic counselor.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "BRCA 2" for support, advocacy or research.

Breast Cancer Options

Our mission is to educate breast cancer patients about effective treatment options, to advocate for and support informed patient choice and to promote public awareness regarding cancer risk reduction.

Last Updated: 28 Oct 2012

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "BRCA 2" for support, advocacy or research.

Breast Cancer Options

Our mission is to educate breast cancer patients about effective treatment options, to advocate for and support informed patient choice and to promote public awareness regarding cancer risk reduction.

http://www.breastcanceroptions.org

Last Updated: 28 Oct 2012

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

View Details
Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

http://www.sharsheret.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "BRCA 2" returned 6 free, full-text research articles on human participants. First 3 results:

Medical mistrust influences black women's level of engagement in BRCA 1/2 genetic counseling and testing.
 

Author(s): Vanessa B Sheppard, Darren Mays, Thomas LaVeist, Kenneth P Tercyak

Journal: J Natl Med Assoc. 2013 ;105(1):17-22.

 

Clinical evidence supports the value of BRCA1/2 genetic counseling and testing for managing hereditary breast and ovarian cancer risk; however, BRCA1/2 genetic counseling and testing are underutilized among black women, and reasons for low use remain elusive. We examined the potential ...

Last Updated: 18 Jul 2013

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BRCA1/2 mutations appear embryo-lethal unless rescued by low (CGG n<26) FMR1 sub-genotypes: explanation for the "BRCA paradox"?
 

Author(s): Andrea Weghofer, Muy-Kheng Tea, David H Barad, Ann Kim, Christian F Singer, Klaus Wagner, Norbert Gleicher

Journal: PLoS ONE. 2012 ;7(9):e44753.

 

BRCA1/2 mutations and recently described constitutional FMR1 genotypes have, independently, been associated with prematurely diminished ovarian reserve. Whether they interrelate in distribution, and whether observed effects of BRCA1/2 and FMR1 on ovaries are independent of each other, ...

Last Updated: 17 Sep 2012

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Reported referral for genetic counseling or BRCA 1/2 testing among United States physicians: a vignette-based study.
 

Author(s): Katrina F Trivers, Laura-Mae Baldwin, Jacqueline W Miller, Barbara Matthews, C Holly A Andrilla, Denise M Lishner, Barbara A Goff

Journal: Cancer. 2011 Dec;117(23):5334-43.

 

Genetic counseling and testing is recommended for women at high but not average risk of ovarian cancer. National estimates of physician adherence to genetic counseling and testing recommendations are lacking.

Last Updated: 21 Nov 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "BRCA 2" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
 

Status: Recruiting

Condition Summary: brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer

 

Last Updated: 22 Mar 2011

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Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer
 

Status: Recruiting

Condition Summary: BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype

 

Last Updated: 17 Jan 2013

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Transformation Potential of E2 Exposed Breast Cancer Susceptibility Gene Mutation Heterozygous Epithelial Breast Cells
 

Status: Not yet recruiting

Condition Summary: BRCA1 Gene Mutation; BRCA2 Gene Mutation

 

Last Updated: 24 Jul 2013

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