BRCA2

Common Name(s)

BRCA2

BRCA2 (breast cancer 2, early onset) is a specific gene found in a person’s DNA, or genetic code. Sometimes there are variations or mutations in a person’s genetic code. While some of these go unnoticed (harmless changes), others may put a person at risk for certain health problems. Harmful mutations in the BRCA2 gene (BRCA2 mutation) lead to an increased risk of certain cancers, especially breast cancer and ovarian cancer in women. On average, a woman with a BRCA2 mutation has up to a 40-85% lifetime risk of developing breast cancer and up to an 11-27% lifetime risk of developing ovarian cancer. The risk varies depending on the exact mutation, family history of cancer, reproductive history, and other genes which may modify the cancer risk. Men with a BRCA2 mutation may be at an increased risk to develop male breast and prostate cancer. Both men and women with a BRCA2 mutation may be at an increased risk to develop cancer of the pancreas or an aggressive form of skin cancer called melanoma. Individuals with a BRCA2 mutation require screening for these cancers more often. Some women may even decide to have prophylactic (risk reducing) surgical removal of the breasts (mastectomy) or ovaries (oophorectomy) before they have cancer, in order to prevent developing these cancers. Management and prevention options for individuals with a BRCA2 mutation are individualized based on other factors such as family history of cancer, personal preference, and other risk factors for cancer. To decide the best care plan, talk with your physician if you or a family member has a mutation in the BRCA2 gene. Talking with a genetic counselor or specialist may be helpful, as well as with other women and men who also have a BRCA2 mutation through support organizations. Genetic testing may be recommended if you have a family history of certain cancers or certain ethnic backgrounds. If you are concerned that you should be tested, speak with a genetic counselor.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "BRCA2" for support, advocacy or research.

Basser Research Center for BRCA

The Basser Research Center for BRCA provides education and support for individuals and families with BRCA1 and BRCA2 mutations. Our mission is to deliver cutting edge research in basic and clinical sciences to advance the care of individuals who carry BRCA mutations. The Basser Center is part of the Abramson Cancer Center at Penn Medicine.

Last Updated: 29 Oct 2014

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Breast Cancer Options

Our mission is to educate breast cancer patients about effective treatment options, to advocate for and support informed patient choice and to promote public awareness regarding cancer risk reduction.

Last Updated: 28 Oct 2012

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "BRCA2" for support, advocacy or research.

Basser Research Center for BRCA

The Basser Research Center for BRCA provides education and support for individuals and families with BRCA1 and BRCA2 mutations. Our mission is to deliver cutting edge research in basic and clinical sciences to advance the care of individuals who carry BRCA mutations. The Basser Center is part of the Abramson Cancer Center at Penn Medicine.

http://www.basser.org

Last Updated: 29 Oct 2014

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Breast Cancer Options

Our mission is to educate breast cancer patients about effective treatment options, to advocate for and support informed patient choice and to promote public awareness regarding cancer risk reduction.

http://www.breastcanceroptions.org

Last Updated: 28 Oct 2012

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

http://www.sharsheret.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "BRCA2" returned 852 free, full-text research articles on human participants. First 3 results:

Rapid evolution of BRCA1 and BRCA2 in humans and other primates.
 

Author(s): Dianne I Lou, Ross M McBee, Uyen Q Le, Anne C Stone, Gregory K Wilkerson, Ann M Demogines, Sara L Sawyer

Journal:

 

The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this process, it is expected that DNA repair proteins would be evolutionarily conserved, exhibiting ...

Last Updated: 23 Jul 2014

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The role of testing for BRCA1 and BRCA2 mutations in cancer prevention.
 

Author(s): Anne Marie McCarthy, Katrina Armstrong

Journal: JAMA Intern Med. 2014 Jul;174(7):1023-4.

 

Last Updated: 9 Jul 2014

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Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.
 

Author(s): Kelly Metcalfe, Shelley Gershman, Parviz Ghadirian, Henry T Lynch, Carrie Snyder, Nadine Tung, Charmaine Kim-Sing, Andrea Eisen, William D Foulkes, Barry Rosen, Ping Sun, Steven A Narod

Journal:

 

To compare the survival rates of women with BRCA associated breast cancer who did and did not undergo mastectomy of the contralateral breast.

Last Updated: 12 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "BRCA2" returned 44 free, full-text review articles on human participants. First 3 results:

BRCA2: one small step for DNA repair, one giant protein purified.
 

Author(s): Ryan B Jensen

Journal:

 

DNA damage, malfunctions in DNA repair, and genomic instability are processes that intersect at the crossroads of carcinogenesis. Underscoring the importance of DNA repair in breast and ovarian tumorigenesis is the familial inherited cancer predisposition gene BRCA2. The role of BRCA2 ...

Last Updated: 18 Dec 2013

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A comprehensive focus on global spectrum of BRCA1 and BRCA2 mutations in breast cancer.
 

Author(s): Fatemeh Karami, Parvin Mehdipour

Journal: Biomed Res Int. 2013 ;2013():928562.

 

Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel ...

Last Updated: 6 Dec 2013

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Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivation.
 

Author(s): Liam D Cassidy, Siong-Seng Liau, Ashok R Venkitaraman

Journal: Mol Oncol. 2014 Mar;8(2):161-8.

 

Chromosomal instability is a hallmark of human cancer cells, but its role in carcinogenesis remains poorly resolved. Insights into this role have emerged from studies on the tumour suppressor BRCA2, whose inactivation in human cancers causes chromosomal instability through the loss ...

Last Updated: 28 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
 

Status: Recruiting

Condition Summary: brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer

 

Last Updated: 22 Mar 2011

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Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer
 

Status: Recruiting

Condition Summary: BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype

 

Last Updated: 17 Jan 2013

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Transformation Potential of E2 Exposed Breast Cancer Susceptibility Gene Mutation Heterozygous Epithelial Breast Cells
 

Status: Not yet recruiting

Condition Summary: BRCA1 Gene Mutation; BRCA2 Gene Mutation

 

Last Updated: 24 Jul 2013

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