Hemiplegic migraine

Common Name(s)

Hemiplegic migraine

Hemiplegic migraine refers to migraine with aura accompanied with motor weakness. Signs and symptoms vary but may include visual disturbance, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. Frequency of hemiplegic migraine can vary considerably. It can take time for symptoms to resolve, but permanent motor, sensory, language, or visual symptoms are extremely rare. It can occur as a sporadic or genetic disorder. When inherited, it is passed through families in an autosomal dominant fashion.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemiplegic migraine" for support, advocacy or research.

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemiplegic migraine" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemiplegic migraine" returned 71 free, full-text research articles on human participants. First 3 results:

Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i.
 

Author(s): Mariano N Di Guilmi, Tiantian Wang, Carlota Gonzalez Inchauspe, Ian D Forsythe, Michel D Ferrari, Arn M J M van den Maagdenberg, J Gerard G Borst, Osvaldo D Uchitel

Journal: J. Neurosci.. 2014 May;34(21):7047-58.

 

Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated CaV2.1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of common migraine with aura. We used transgenic knock-in (KI) mice harboring the human ...

Last Updated: 22 May 2014

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Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²⁺ channel due to a familial hemiplegic migraine mutation.
 

Author(s): Akira Inagaki, C Andrew Frank, Yuriy M Usachev, Morris Benveniste, Amy Lee

Journal: Neuron. 2014 Jan;81(1):91-102.

 

Voltage-gated ion channels exhibit complex properties, which can be targeted in pharmacological therapies for disease. Here, we report that the pro-oxidant, tert-butyl dihydroquinone (BHQ), modulates Ca(v)2.1 Ca²⁺ channels in ways that oppose defects in channel gating and synaptic ...

Last Updated: 13 Jan 2014

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Sporadic hemiplegic migraine with permanent neurological deficits.
 

Author(s): Todd J Schwedt, Jiying Zhou, David W Dodick

Journal: Headache. 2014 Jan;54(1):163-6.

 

By definition, the neurologic impairments of hemiplegic migraine are reversible. However, a few cases of permanent neurologic deficits associated with hemiplegic migraine have been reported. Herein, we present the case of a patient with permanent impairments because of hemiplegic ...

Last Updated: 9 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemiplegic migraine" returned 2 free, full-text review articles on human participants. First 3 results:

Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models.
 

Author(s): Stephanie M Gritz, Richard A Radcliffe

Journal:

 

Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha ...

Last Updated: 1 May 2013

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Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine.
 

Author(s): Daniela Pietrobon

Journal: J. Physiol. (Lond.). 2010 Jun;588(Pt 11):1871-8.

 

Migraine is a very common disabling brain disorder with unclear pathogenesis. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in CaV2.1 (P/Q-type) Ca2+ channels. This review describes the functional consequences of FHM1 mutations ...

Last Updated: 2 Jun 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.