Hemiplegic migraine

Common Name(s)

Hemiplegic migraine

Hemiplegic migraine refers to migraine with aura accompanied with motor weakness. Signs and symptoms vary but may include visual disturbance, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. Frequency of hemiplegic migraine can vary considerably. It can take time for symptoms to resolve, but permanent motor, sensory, language, or visual symptoms are extremely rare. It can occur as a sporadic or genetic disorder. When inherited, it is passed through families in an autosomal dominant fashion.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemiplegic migraine" for support, advocacy or research.

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemiplegic migraine" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemiplegic migraine" returned 68 free, full-text research articles on human participants. First 3 results:

Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects.
 

Author(s): Sandrine Cestèle, Emanuele Schiavon, Raffaella Rusconi, Silvana Franceschetti, Massimo Mantegazza

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2013 Oct;110(43):17546-51.

 

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. Mutations causing FHM type 3 have been identified in SCN1A, the gene encoding the Nav1.1 Na(+) channel, which is also a major target of epileptogenic mutations and is particularly important for the excitability ...

Last Updated: 23 Oct 2013

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Monozygotic twin sisters discordant for familial hemiplegic migraine.
 

Author(s): José Barros, Rui Barreto, Ana Filipa Brandão, Joana Domingos, Joana Damásio, Cristina Ramos, Carolina Lemos, Jorge Sequeiros, Isabel Alonso, José Pereira-Monteiro

Journal:

 

The high concordance rate of migraine in monozygotic twin pairs has long been recognised. In the current study, we present a monozygotic twin pair discordant for familial hemiplegic migraine (FHM).

Last Updated: 15 Nov 2013

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Sporadic hemiplegic migraine in a Nigerian woman.
 

Author(s): Owolabi F Lukman

Journal: Ann Afr Med. ;12(3):185-7.

 

Sporadic hemiplegic migraine (SHM) is a rare form of migraine. I report a 23-year-old Nigerian lady with SHM. She had recurrent attacks characterized by visual aura that progressed to headache, dysphasia, and hemiplegia. Her motor symptom was always followed by development of nausea ...

Last Updated: 5 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemiplegic migraine" returned 2 free, full-text review articles on human participants. First 3 results:

Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models.
 

Author(s): Stephanie M Gritz, Richard A Radcliffe

Journal:

 

Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha ...

Last Updated: 1 May 2013

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Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine.
 

Author(s): Daniela Pietrobon

Journal: J. Physiol. (Lond.). 2010 Jun;588(Pt 11):1871-8.

 

Migraine is a very common disabling brain disorder with unclear pathogenesis. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in CaV2.1 (P/Q-type) Ca2+ channels. This review describes the functional consequences of FHM1 mutations ...

Last Updated: 2 Jun 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.