BRCA 1

Common Name(s)

BRCA 1

BRCA 1 is a specific gene found in a person’s DNA, or genetic code. Sometimes there are variations or mutations in a person’s genetic code, and while some of these go unnoticed, others can have negative effects. Mutations in the BRCA 1 gene lead to an increased risk of cancer, particularly breast cancer in women. Between 55 and 65 percent of women who inherit a mutated BRCA1 gene will develop breast cancer by age 70. Women with this gene mutation require more vigilant screening for cancer and some even decide to have an elective mastectomy, where the breasts are surgically removed in order to prevent cancer. Management options for this gene mutation are individualized based on other factors such as family history of cancer, personal preference, and other risk factors for cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "BRCA 1" for support, advocacy or research.

Breast Cancer Options

Our mission is to educate breast cancer patients about effective treatment options, to advocate for and support informed patient choice and to promote public awareness regarding cancer risk reduction.

Last Updated: 28 Oct 2012

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

Last Updated: 5 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "BRCA 1" for support, advocacy or research.

Breast Cancer Options

Our mission is to educate breast cancer patients about effective treatment options, to advocate for and support informed patient choice and to promote public awareness regarding cancer risk reduction.

http://www.breastcanceroptions.org

Last Updated: 28 Oct 2012

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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Sharsheret

Sharsheret is a national not-for-profit organization supporting young Jewish women and their families facing breast cancer. Our mission is to offer a community of support to women, of all Jewish backgrounds, diagnosed with breast cancer or at increased genetic risk, by fostering culturally-relevant individualized connections with networks of peers, health professionals, and related resources.

http://www.sharsheret.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "BRCA 1" returned 19 free, full-text research articles on human participants. First 3 results:

Medical mistrust influences black women's level of engagement in BRCA 1/2 genetic counseling and testing.
 

Author(s): Vanessa B Sheppard, Darren Mays, Thomas LaVeist, Kenneth P Tercyak

Journal: J Natl Med Assoc. 2013 ;105(1):17-22.

 

Clinical evidence supports the value of BRCA1/2 genetic counseling and testing for managing hereditary breast and ovarian cancer risk; however, BRCA1/2 genetic counseling and testing are underutilized among black women, and reasons for low use remain elusive. We examined the potential ...

Last Updated: 18 Jul 2013

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Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer.
 

Author(s): Fang-Fang Bi, Da Li, Qing Yang

Journal:

 

Poly (ADP-ribose) polymerase 1 (PARP1) overexpression plays a critical role in ovarian cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated ovarian cancer has advanced rapidly. However, the mechanism regulating PARP1 expression remains unknown. ...

Last Updated: 18 Mar 2013

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Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke.
 

Author(s): Yi-Chu Liao, Hsiu-Fen Lin, Yuh-Cherng Guo, Chung-Hung Chen, Zhi-Zhang Huang, Suh-Hang Hank Juo, Ruey-Tay Lin

Journal:

 

Atherosclerosis shares common pathogenic features with myocardial infarction (MI) and ischemic stroke. BRCA-1 associated protein (BRAP), a newly identified risk gene for MI, aggravates the inflammatory response in atherosclerosis. The aim of this study was to test the association ...

Last Updated: 6 Feb 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "BRCA 1" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Testing Positive for the BRCA1 or BRCA2 Mutation in Young Women Who Are BRCA1 or BRCA2 Mutation Carriers
 

Status: Recruiting

Condition Summary: brca1 Mutation Carrier; brca2 Mutation Carrier; Sexuality and Reproductive Issues

 

Last Updated: 6 Apr 2010

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Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
 

Status: Recruiting

Condition Summary: brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer

 

Last Updated: 22 Mar 2011

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COsegregation of VARiants in the BRCA1/2 Genes
 

Status: Recruiting

Condition Summary: Genes, BRCA1; Genes, BRCA2; Ovarian Neoplasms; Breast Neoplasms

 

Last Updated: 20 Sep 2012

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