Duane syndrome

Common Name(s)

Duane syndrome

Duane syndrome is a disorder of eye movement. This condition prevents outward movement of the eye (toward the ear), and in some cases may also limit inward eye movement (toward the nose). As the eye moves inward, the eyelids partially close and the eyeball pulls back (retracts) into its socket. Usually only one eye is affected. Some people with Duane syndrome develop amblyopia ("lazy eye"), a condition that causes vision loss in the affected eye. Most cases occur without other signs and symptoms. There are three forms of Duane syndrome, designated types 1, 2, and 3. The types vary in which eye movements are most severely restricted (inward, outward, or both). All three types are characterized by retraction of the eyeball as the eye moves inward and are inherited in an autosomal dominant fashion.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Duane syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Duane syndrome" returned 37 free, full-text research articles on human participants. First 3 results:

Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome.
 

Author(s): Alicia A Nugent, Jong G Park, Yan Wei, Alan P Tenney, Nicole M Gilette, Michelle M DeLisle, Wai-Man Chan, Long Cheng, Elizabeth C Engle

Journal: J. Clin. Invest.. 2017 May;127(5):1664-1682.

 

Duane retraction syndrome (DRS) is the most common form of congenital paralytic strabismus in humans and can result from α2-chimaerin (CHN1) missense mutations. We report a knockin α2-chimaerin mouse (Chn1KI/KI) that models DRS. Whole embryo imaging of Chn1KI/KI mice revealed stalled ...

Last Updated: 27 Mar 2017

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Clinical and Genetic Findings in Mexican Patients with Duane Anomaly and Radial Ray Malformations/Okihiro Syndrome.
 

Author(s): Óscar F Chacón-Camacho, Jesús Cabral-Macías, Raúl Ayala-Ramírez, Jazmín Arteaga-Vázquez, Yevgeniya Svyryd, Karla Helmes, Nohemí Pérez-Hernández, Osvaldo M Mutchinick, Juan Carlos Zenteno

Journal: Rev. Invest. Clin.. ;68(5):269-274.

 

Okihiro syndrome is an autosomal-dominant condition characterized by radial ray malformations associated with Duane anomaly and other clinical characteristics. SALL4 mutations have been identified in 80-90% of patients with Duane- Radial ray defects/Okihiro syndrome. We report the ...

Last Updated: 12 Dec 2016

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Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.
 

Author(s): Jong G Park, Max A Tischfield, Alicia A Nugent, Long Cheng, Silvio Alessandro Di Gioia, Wai-Man Chan, Gail Maconachie, Thomas M Bosley, C Gail Summers, David G Hunter, Caroline D Robson, Irene Gottlob, Elizabeth C Engle

Journal: Am. J. Hum. Genet.. 2016 Jun;98(6):1220-1227.

 

Duane retraction syndrome (DRS) is a congenital eye-movement disorder defined by limited outward gaze and retraction of the eye on attempted inward gaze. Here, we report on three heterozygous loss-of-function MAFB mutations causing DRS and a dominant-negative MAFB mutation causing ...

Last Updated: 4 Jun 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Duane syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Review of the major findings about Duane retraction syndrome (DRS) leading to an updated form of classification.
 

Author(s): Demet Yüksel, Jean-Jacques Orban de Xivry, Philippe Lefèvre

Journal: Vision Res.. 2010 Nov;50(23):2334-47.

 

In view of all the reported evidence by electromyography in the 1970s, by histology in the 1980s, and by cerebral imagery since the 2000s, Duane retraction syndrome (DRS) has been described as the consequence of a congenital anomaly of the 6th cranial nerve nuclei with aberrant innervations ...

Last Updated: 8 Nov 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
 

Status: Recruiting

Condition Summary: Congenital Fibrosis of Extraocular Muscles; Duane Retraction Syndrome; Duane Radial Ray Syndrome; Mobius Syndrome; Brown Syndrome; Marcus Gunn Syndrome; Strabismus Congenital; Horizontal Gaze Palsy; Horizontal Gaze Palsy With Progressive Scoliosis; Facial Palsy; Facial Paresis, Hereditary, Congenital; Third Nerve Palsy; Fourth Nerve Palsy; Sixth Nerve Palsy; Synkinesis; Ocular Motility Disorders; Levator-Medial Rectus Synkinesis; Athabaskan Brainstem Dysgenesis; Tongue Paralysis; Ninth Nerve Disorder; Fifth Nerve Palsy; Seventh Nerve Palsy; Eleventh Nerve Disorder; Twelfth Nerve Disorder; Vagus Nerve Paralysis; Moebius Sequence

 

Last Updated: 16 Feb 2017

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