Cutaneous mastocytosis

Common Name(s)

Cutaneous mastocytosis, Urticaria pigmentosa

Cutaneous mastocytosis is a condition caused by the accumulation of mast cells in the skin. Mast cells contain substances such as histamine that regulate allergic reactions. This condition is usually diagnosed in children and typically resolves by puberty. Treatment is generally based on a person's symptoms, but it may include antihistamines to prevent the effect of mast cell histamine.

There are several different types of cutaneous mastocytosis. Urticaria pigmentosa is the most common form and is characterized by brown patches on the skin where mast cells have accumulated. Diffuse cutaneous mastocytosis is a very rare form of the condition that presents at birth with skin that is thickened and easily blistered. A mastocytoma is raised nodule that is also usually seen in infancy. Another rare form that occurs in adults is called telangiectasia macularis eruptiva perstans (TMEP).
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous mastocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous mastocytosis" returned 21 free, full-text research articles on human participants. First 3 results:

Bullous cutaneous mastocytosis, a rarely reported disease in Asian children.
 

Author(s): Hyun Jun Lee, Mi Jin Jang, E Young Bae, Seung Beom Han, Dae Chul Jeong, Jin Han Kang, Young Min Park

Journal: Asian Pac. J. Allergy Immunol.. 2014 Dec;32(4):354-7.

 

Diffuse cutaneous mastocytosis, the most rare form of cutaneous mastocytosis, often manifests as bullous lesions. Although cutaneous mastocytosis should be included in a differential diagnosis for pruritic skin lesions in children, early diagnosis of the disease is not easy due to ...

Last Updated: 28 Dec 2014

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Expression of the basophil-specific antibodies 2D7 and BB1 in patients with cutaneous Mastocytosis.
 

Author(s): M A Idoate, J Echeveste, P Gil, M L Sanz, M Ferrer

Journal: J Investig Allergol Clin Immunol. 2013 ;23(6):392-7.

 

2D7 and BB1 are thought to be basophil-specific markers. In this study, we tested both antibodies in different skin and mast cell disorders with the aim of determining whether it was possible to differentiate between benign and aggressive presentations of mastocytosis.

Last Updated: 27 Jan 2014

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[Cutaneous mastocytosis: baby leopard appearance].
 

Author(s): Najwa Guerouaz, Badredine Hassam

Journal:

 

Last Updated: 30 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous mastocytosis" returned 4 free, full-text review articles on human participants. First 3 results:

Cutaneous mastocytosis with abundant eosinophilic infiltration: a case report with review of the literature.
 

Author(s): Mitsuaki Ishida, Muneo Iwai, Akiko Kagotani, Nozomi Iwamoto, Hidetoshi Okabe

Journal:

 

Last Updated: 26 Jun 2014

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Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations.
 

Author(s): Mariana Castells, Dean D Metcalfe, Luis Escribano

Journal: Am J Clin Dermatol. 2011 Aug;12(4):259-70.

 

Cutaneous mastocytosis in children is a generally benign disease that can present at birth and is often associated with mast cell mediator-related symptoms including pruritus, flushing, and abdominal pain with diarrhea. The most common form of presentation is urticaria pigmentosa, ...

Last Updated: 14 Jun 2011

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Pediatric cutaneous mastocytosis: a review of 180 patients.
 

Author(s): Dan Ben-Amitai, Aryeh Metzker, Herman A Cohen

Journal: Isr. Med. Assoc. J.. 2005 May;7(5):320-2.

 

Mastocytosis is a heterogeneous group of diseases characterized by the abnormal infiltration of mast cells in the skin and, sometimes, other organs. Some patients may experience symptoms related to mast cell mediator release.

Last Updated: 24 May 2005

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase 3 Study to Compare Efficacy and Safety of Masitinib to Placebo in the Treatment of Patients With Smouldering Systemic, Indolent Systemic or Cutaneous Mastocytosis With Handicap
 

Status: Recruiting

Condition Summary: Smouldering Systemic Mastocytosis; Indolent Systemic Mastocytosis; Cutaneous Mastocytosis With Handicap; Mastocytosis

 

Last Updated: 25 Sep 2012

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Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia
 

Status: Recruiting

Condition Summary: Aggressive Systemic Mastocytosis; Mast Cell Leukemia; Systemic Mastocytosis

 

Last Updated: 20 Jan 2015

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Cladribine Plus Pegylated Interpheron Alfa-2a in Systemic Mastocytosis
 

Status: Recruiting

Condition Summary: Advanced Systemic Mastocytosis

 

Last Updated: 19 May 2012

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