Complex regional pain syndrome

Common Name(s)

Complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arm or leg after an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected arm or leg.  Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is not known. Treatment aims to relieve pain and may include topical or oral medications; physical therapy; and/or a sympathetic nerve block.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Complex regional pain syndrome" returned 125 free, full-text research articles on human participants. First 3 results:

Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome.
 

Author(s): Lino Becerra, Simona Sava, Laura E Simons, Athena M Drosos, Navil Sethna, Charles Berde, Alyssa A Lebel, David Borsook

Journal:

 

Pediatric complex regional pain syndrome (P-CRPS) offers a unique model of chronic neuropathic pain as it either resolves spontaneously or through therapeutic interventions in most patients. Here we evaluated brain changes in well-characterized children and adolescents with P-CRPS ...

Last Updated: 7 Nov 2014

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Low-dose intravenous immunoglobulin treatment for complex regional pain syndrome (LIPS): study protocol for a randomized controlled trial.
 

Author(s): Andreas Goebel, Nicholas Shenker, Nick Padfield, Karim Shoukrey, Candida McCabe, Mick Serpell, Mark Sanders, Caroline Murphy, Amaka Ejibe, Holly Milligan, Joanna Kelly, Gareth Ambler

Journal:

 

Longstanding complex regional pain syndrome (CRPS) is refractory to treatment with established analgesic drugs in most cases, and for many patients, alternative pain treatment approaches, such as with neuromodulation devices or rehabilitation methods, also do not work. The development ...

Last Updated: 7 Nov 2014

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Lenalidomide for complex regional pain syndrome type 1: lack of efficacy in a phase II randomized study.
 

Author(s): Donald C Manning, Guillermo Alexander, Joseph C Arezzo, Alyse Cooper, R Norman Harden, Anne Louise Oaklander, Srinivasa N Raja, Richard Rauck, Robert Schwartzman

Journal: J Pain. 2014 Dec;15(12):1366-76.

 

Complex regional pain syndrome (CRPS) is a potentially debilitating chronic pain syndrome with a poorly understood but likely neuroimmune/multifactorial pathophysiology associated with axonal injury. Based on the potential contribution of proinflammatory cytokines to CRPS pathogenesis ...

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Complex regional pain syndrome" returned 24 free, full-text review articles on human participants. First 3 results:

Thermal pain in complex regional pain syndrome type I.
 

Author(s): John R Grothusen, Guillermo Alexander, Kirsten Erwin, Robert Schwartzman

Journal: Pain Physician. ;17(1):71-9.

 

Quantitative sensory testing (QST), with thermal threshold determinations, is a routine part of the comprehensive clinical workup of patients suffering from chronic pain, especially those with Complex Regional Pain Syndrome seen at our outpatient pain clinic. This is done to quantitatively ...

Last Updated: 23 Jan 2014

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Diagnosis of partial complex regional pain syndrome type 1 of the hand: retrospective study of 16 cases and literature review.
 

Author(s): Michel Konzelmann, Olivier Deriaz, François Luthi

Journal:

 

The partial form of the complex regional pain syndrome of the hand type 1 (CRPS 1), involving only 1 to 3 fingers, is a rare condition first described in 1972. The aim of the study is to define more precisely the diagnosis workup and the prognosis of this clinical entity.

Last Updated: 17 Apr 2013

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Prognostic factors in complex regional pain syndrome 1: a systematic review.
 

Author(s): Maria Wertli, Lucas M Bachmann, Shira Schecter Weiner, Florian Brunner

Journal: J Rehabil Med. 2013 Mar;45(3):225-31.

 

The aim of this systematic review was to merge and summarize the current evidence about prognostic factors relevant to the course of complex regional pain syndrome 1.

Last Updated: 6 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Use of Zoledronic Acid to Complex Regional Pain Syndrome
 

Status: Not yet recruiting

Condition Summary: Complex Regional Pain Syndromes

 

Last Updated: 8 Feb 2013

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Intravenous Immunoglobulins in Complex-regional Pain Syndrome
 

Status: Not yet recruiting

Condition Summary: Complex Regional Pain Syndrome Type 1

 

Last Updated: 29 Jul 2009

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Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study)
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndromes; CRPS

 

Last Updated: 26 Jun 2008

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