Complex regional pain syndrome

Common Name(s)

Complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arm or leg after an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected arm or leg.  Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is not known. Treatment aims to relieve pain and may include topical or oral medications; physical therapy; and/or a sympathetic nerve block.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Complex regional pain syndrome" returned 160 free, full-text research articles on human participants. First 3 results:

Ultrasound-guided pulsed radiofrequency treatment of the cervical sympathetic chain for complex regional pain syndrome: A retrospective observational study.
 

Author(s): Eung Don Kim, Woo Joo Yoo, Yoo Na Kim, Hue Jung Park

Journal: Medicine (Baltimore). 2017 Jan;96(1):e5856.

 

The stellate ganglion is a common target to manage neuropathic pain in the upper extremities. However, the effect duration of a single stellate ganglion block is often temporary. To overcome the short-term effects of a single sympathetic block, pulsed radiofrequency (PRF) can be applied. ...

Last Updated: 10 Jan 2017

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Multicenter study on the asymmetry of skin temperature in complex regional pain syndrome: An examination of temperature distribution and symptom duration.
 

Author(s): Chan Woo Cho, Francis Sahngun Nahm, Eunjoo Choi, Pyung-Bok Lee, In-Ki Jang, Chul Joong Lee, Yong Chul Kim, Sang Chul Lee

Journal: Medicine (Baltimore). 2016 Dec;95(52):e5548.

 

According to the International Association for the Study of Pain (IASP) and American Medical Association (AMA), the diagnostic criteria for complex regional pain syndrome (CRPS) require the presence of skin temperature asymmetry. In CRPS, it is generally accepted that the temperature ...

Last Updated: 29 Dec 2016

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A rare complication of total knee arthroplasty: Type l complex regional pain syndrome of the foot and ankle.
 

Author(s): Gözde Özcan Söylev, Hakan Boya

Journal: Acta Orthop Traumatol Turc. 2016 Oct;50(5):592-595.

 

Complex regional pain syndrome (CRPS) is a painful and disabling disorder that usually affects the extremities. This complication may affect the knee joint after total knee arthroplasty (TKA). We report a unique case of CRPS of the foot and ankle, which was an unusual involvement ...

Last Updated: 11 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Complex regional pain syndrome" returned 27 free, full-text review articles on human participants. First 3 results:

New Concepts in Complex Regional Pain Syndrome.
 

Author(s): Maral Tajerian, John David Clark

Journal: Hand Clin. 2016 Feb;32(1):41-9.

 

Despite the severe pain and disability associated with complex regional pain syndrome (CRPS), the lack of understanding of the pathophysiological mechanisms supporting this enigmatic condition prevents the rational design of new therapies, a situation that is frustrating to both the ...

Last Updated: 27 Nov 2015

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Invasive Management for Pediatric Complex Regional Pain Syndrome: Literature Review of Evidence.
 

Author(s): Manuel J Rodriguez, Mariano Fernandez-Baena, Alex Barroso, Jose A Yanez

Journal: Pain Physician. 2015 Nov;18(6):621-30.

 

Complex regional pain syndrome (CRPS) is a multifactorial condition with complex pathogenesis characterized by spontaneous or stimulus-induced pain that is disproportionate to the inciting event. It is also commonly accompanied by a myriad of autonomic and motor disturbances in highly ...

Last Updated: 26 Nov 2015

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Complex regional pain syndrome.
 

Author(s): Stephen Bruehl

Journal:

 

Complex regional pain syndrome is a chronic pain condition characterized by autonomic and inflammatory features. It occurs acutely in about 7% of patients who have limb fractures, limb surgery, or other injuries. Many cases resolve within the first year, with a smaller subset progressing ...

Last Updated: 30 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Body Perception and Complex Regional Pain Syndrome
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndromes

 

Last Updated: 25 Jan 2017

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Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndrome

 

Last Updated: 28 Apr 2016

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Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndrome (CRPS) TYPE I

 

Last Updated: 3 Aug 2016

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