Complex regional pain syndrome

Common Name(s)

Complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arm or leg after an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected arm or leg.  Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is not known. Treatment aims to relieve pain and may include topical or oral medications; physical therapy; and/or a sympathetic nerve block.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Complex regional pain syndrome" returned 179 free, full-text research articles on human participants. First 3 results:

Different patterns in mental rotation of facial expressions in complex regional pain syndrome patients.
 

Author(s): Won Joon Lee, Soo-Hee Choi, Joon Hwan Jang, Jee Youn Moon, Yong Chul Kim, EunChung Noh, Jung Eun Shin, HyunSoon Shin, Do-Hyung Kang

Journal: Medicine (Baltimore). 2017 Sep;96(39):e7990.

 

Although facial pain expressions are considered to be the most visible pain behaviors, it is known that the association between pain intensity and facial pain expression is weak for chronic pain. The authors hypothesized that the facial pain expressiveness was altered in chronic pain ...

Last Updated: 27 Sep 2017

Go To URL
Pramipexole-induced limb dystonia and its associated complex regional pain syndrome in idiopathic Parkinson's disease: A case report.
 

Author(s): Donghwi Park

Journal: Medicine (Baltimore). 2017 Jul;96(28):e7530.

 

This case may be due to basal ganglia dysfunction, which was probably caused by abnormal activation of dopamine 1-like receptor (D1R) boosted by pramipexole binding on dopamine 3-like receptor (D3R) in a situation where D3R was overexpressed by the chronic treatment of L-dopa.

Last Updated: 12 Jul 2017

Go To URL
Impaired insula functional connectivity associated with persistent pain perception in patients with complex regional pain syndrome.
 

Author(s): Jae-Hun Kim, Soo-Hee Choi, Joon Hwan Jang, Do-Hyeong Lee, Kyung-Jun Lee, Won Joon Lee, Jee Youn Moon, Yong Chul Kim, Do-Hyung Kang

Journal:

 

Given that the insula plays a contributory role in the perception of chronic pain, we examined the resting-state functional connectivity between the insular cortex and other brain regions to investigate neural underpinnings of persisting perception of background pain in patients with ...

Last Updated: 10 Jul 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Complex regional pain syndrome" returned 29 free, full-text review articles on human participants. First 3 results:

Usefulness of bone scintigraphy for the diagnosis of Complex Regional Pain Syndrome 1: A systematic review and Bayesian meta-analysis.
 

Author(s): Maria M Wertli, Florian Brunner, Johann Steurer, Ulrike Held

Journal:

 

Since 2007, the Budapest criteria are recommended for the diagnosis of Complex Regional Pain Syndrome (CRPS) 1. The usefulness of bone scintigraphy (BS, index test) for the diagnosis of CRPS 1 remains controversial. Imperfect reference tests (RT) result in underestimation of the diagnostic ...

Last Updated: 16 Mar 2017

Go To URL
Pediatric complex regional pain syndrome: a review.
 

Author(s): Rotem Weissmann, Yosef Uziel

Journal:

 

Complex regional pain syndrome (CRPS) is a chronic, intensified localized pain condition that can affect children and adolescents as well as adults, but is more common among adolescent girls. Symptoms include limb pain; allodynia; hyperalgesia; swelling and/or changes in skin color ...

Last Updated: 30 Apr 2016

Go To URL
New Concepts in Complex Regional Pain Syndrome.
 

Author(s): Maral Tajerian, John David Clark

Journal: Hand Clin. 2016 Feb;32(1):41-9.

 

Despite the severe pain and disability associated with complex regional pain syndrome (CRPS), the lack of understanding of the pathophysiological mechanisms supporting this enigmatic condition prevents the rational design of new therapies, a situation that is frustrating to both the ...

Last Updated: 27 Nov 2015

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Body Perception and Complex Regional Pain Syndrome
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndromes

 

Last Updated: 25 Jan 2017

Go to URL
TMS for Complex Regional Pain Syndrome
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndromes

 

Last Updated: 7 Nov 2017

Go to URL
Complex Regional Pain Syndrome in Children: Impact of Bergès Relaxation on the Autonomic Balance
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndrome Type I

 

Last Updated: 18 Oct 2017

Go to URL