Complex regional pain syndrome

Common Name(s)

Complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arm or leg after an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected arm or leg.  Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is not known. Treatment aims to relieve pain and may include topical or oral medications; physical therapy; and/or a sympathetic nerve block.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Complex regional pain syndrome" for support, advocacy or research.

US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Complex regional pain syndrome" returned 190 free, full-text research articles on human participants. First 3 results:

Plasma Exchange Therapy in Patients with Complex Regional Pain Syndrome.
 

Author(s): Enrique Aradillas, Robert J Schwartzman, John R Grothusen, Andreas Goebel, Guillermo M Alexander

Journal: Pain Physician. ;18(4):383-94.

 

Complex regional pain syndrome (CRPS) is a severe chronic pain condition that most often develops following trauma. Some investigators have postulated CRPS to be a post-traumatic neuralgia associated with distal degeneration of small-diameter peripheral axons. Intravenous immunoglobulin ...

Last Updated: 29 Jul 2015

Go To URL
Are pain-related fears mediators for reducing disability and pain in patients with complex regional pain syndrome type 1? An explorative analysis on pain exposure physical therapy.
 

Author(s): Karlijn J Barnhoorn, J Bart Staal, Robert T M van Dongen, Jan Paul M Frölke, Frank P Klomp, Henk van de Meent, Han Samwel, Maria W G Nijhuis-van der Sanden

Journal:

 

To investigate whether pain-related fears are mediators for reducing disability and pain in patients with Complex Regional Pain Syndrome type 1 when treating with Pain Exposure Physical Therapy.

Last Updated: 29 Apr 2015

Go To URL
Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis.
 

Author(s): J Todd Kuenstner, William Chamberlin, Saleh A Naser, Michael T Collins, Coad Thomas Dow, John M Aitken, Stuart Weg, Grzegorz Telega, Kuruvilla John, David Haas, Torsten M Eckstein, Maher Kali, Christine Welch, Thomas Petrie

Journal: World J. Gastroenterol.. 2015 Apr;21(13):4048-62.

 

A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described ...

Last Updated: 8 Apr 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Complex regional pain syndrome" returned 34 free, full-text review articles on human participants. First 3 results:

Complex regional pain syndrome.
 

Author(s): Stephen Bruehl

Journal:

 

Complex regional pain syndrome is a chronic pain condition characterized by autonomic and inflammatory features. It occurs acutely in about 7% of patients who have limb fractures, limb surgery, or other injuries. Many cases resolve within the first year, with a smaller subset progressing ...

Last Updated: 30 Jul 2015

Go To URL
Complex regional pain syndrome and acute carpal tunnel syndrome following radial artery cannulation: a neurological perspective and review of the literature.
 

Author(s): Reynaldo P Lazaro

Journal: Medicine (Baltimore). 2015 Jan;94(3):e422.

 

Complex regional pain syndrome (CRPS) associated with acute carpal tunnel syndrome (aCTS) developed in a 38-year-old right-handed man following radial artery cannulation (RAC) during the course of lumbar spine surgery. Inciting events and risk factors that might have led to these ...

Last Updated: 27 Jan 2015

Go To URL
A systematic review of ketamine for complex regional pain syndrome.
 

Author(s): Sara B Connolly, Joshua P Prager, R Norman Harden

Journal: Pain Med. 2015 May;16(5):943-69.

 

This systematic review aims to examine the available literature and to synthesize published data concerning the treatment of Complex Regional Pain Syndrome (CRPS) with ketamine.

Last Updated: 20 May 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

The Use of Zoledronic Acid to Complex Regional Pain Syndrome
 

Status: Not yet recruiting

Condition Summary: Complex Regional Pain Syndromes

 

Last Updated: 8 Feb 2013

Go to URL
Intravenous Immunoglobulins in Complex-regional Pain Syndrome
 

Status: Not yet recruiting

Condition Summary: Complex Regional Pain Syndrome Type 1

 

Last Updated: 29 Jul 2009

Go to URL
Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome
 

Status: Recruiting

Condition Summary: Complex Regional Pain Syndrome

 

Last Updated: 28 Apr 2016

Go to URL