Cluster headache

Common Name(s)

Cluster headache

Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.   A cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  In some individuals, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. Cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. Males are much more likely than females to develop cluster headaches.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cluster headache" for support, advocacy or research.

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 16 Mar 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cluster headache" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 16 Mar 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cluster headache" returned 135 free, full-text research articles on human participants. First 3 results:

Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
 

Author(s): Martina Curto, Luana Lionetto, Andrea Negro, Matilde Capi, Francesca Perugino, Francesco Fazio, Maria Adele Giamberardino, Maurizio Simmaco, Ferdinando Nicoletti, Paolo Martelletti

Journal: J Headache Pain. 2015 ;17():27.

 

The reported efficacy of memantine in the treatment of patients with cluster headache (CH) suggests that NMDA receptors are involved in mechanisms of nociceptive sensitization within the trigeminal system associated with CH. NMDA receptors are activated or inhibited by neuroactive ...

Last Updated: 22 Mar 2016

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Lack of association between cluster headache and PER3 clock gene polymorphism.
 

Author(s): Hilde K Ofte, Erling Tronvik, Karl B Alstadhaug

Journal: J Headache Pain. 2015 ;17():18.

 

Cluster headache (CH) is regarded as a chronobiological disorder. The hypothalamic biological clock may thus be involved in the pathophysiology, but few studies have actually investigated this in CH patients. A variable number tandem repeat (VNTR) polymorphism of the PER3 clock gene ...

Last Updated: 29 Feb 2016

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Cost-effectiveness of stimulation of the sphenopalatine ganglion (SPG) for the treatment of chronic cluster headache: a model-based analysis based on the Pathway CH-1 study.
 

Author(s): Jan B Pietzsch, Abigail Garner, Charly Gaul, Arne May

Journal: J Headache Pain. 2015 ;16():530.

 

In the recent Pathway CH-1 study, on-demand stimulation of the sphenopalatine ganglion (SPG) by means of an implantable neurostimulation system was proven to be a safe and effective therapy for the treatment of chronic cluster headache. Our objective was to assess the cost-effectiveness ...

Last Updated: 25 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cluster headache" returned 26 free, full-text review articles on human participants. First 3 results:

The Neuropharmacology of Cluster Headache and other Trigeminal Autonomic Cephalalgias.
 

Author(s): Alfredo Costa, Fabio Antonaci, Matteo Cotta Ramusino, Giuseppe Nappi

Journal: Curr Neuropharmacol. 2015 ;13(3):304-23.

 

Trigeminal autonomic cephalalgias (TACs) are a group of primary headaches including cluster headache (CH), paroxysmal hemicrania (PH) and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT). Another form, hemicrania continua (HC), is also ...

Last Updated: 28 Sep 2015

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Cluster headache.
 

Author(s): Karl B Alstadhaug, Hilde Karen Ofte

Journal:

 

Last Updated: 28 Aug 2015

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Neurobiology and sleep disorders in cluster headache.
 

Author(s): Mads Christian Johannes Barloese

Journal: J Headache Pain. 2015 ;16():562.

 

Cluster headache is characterized by unilateral attacks of severe pain accompanied by cranial autonomic features. Apart from these there are also sleep-related complaints and strong chronobiological features. The interaction between sleep and headache is complex at any level and evidence ...

Last Updated: 20 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache
 

Status: Recruiting

Condition Summary: Episodic Cluster Headache; Chronic Cluster Headache

 

Last Updated: 29 Jan 2009

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The Will Erwin Headache Research Center - Cluster Headache Study
 

Status: Recruiting

Condition Summary: Cluster Headache; Cluster Headaches and Other Trigeminal Autonomic Cephalgias; Paroxysmal Hemicrania; SUNCT; Hemicrania Continua; Trigeminal Neuralgia

 

Last Updated: 19 Sep 2016

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The Efficacy of L-cysteine in Prevention of Cluster Headache
 

Status: Recruiting

Condition Summary: Cluster Headache

 

Last Updated: 20 Jan 2016

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