Cluster headache

Common Name(s)

Cluster headache

Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.   A cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  In some individuals, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. Cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. Males are much more likely than females to develop cluster headaches.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cluster headache" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 16 Mar 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cluster headache" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 16 Mar 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cluster headache" returned 142 free, full-text research articles on human participants. First 3 results:

What is cluster headache? Fact sheet for patients and their families. A publication to mark Cluster Headache Day 2016.
 

Author(s): Paolo Rossi, J Whelan, A Craven, E Ruiz De La Torre

Journal: Funct. Neurol.. ;31(3):181-3.

 

Last Updated: 28 Sep 2016

Go To URL
Cluster headache in Greece: an observational clinical and demographic study of 302 patients.
 

Author(s): Michail Vikelis, Alan M Rapoport

Journal: J Headache Pain. 2016 Dec;17(1):88.

 

Cluster headache (CH) is considered the most excruciating primary headache syndrome; although much less prevalent than migraine, it is not rare as it affects more than 1/1000 people. While its clinical presentation is considered stereotypic, atypical features are often encountered. ...

Last Updated: 30 Sep 2016

Go To URL
Release of PACAP-38 in episodic cluster headache patients - an exploratory study.
 

Author(s): Bernadett Tuka, Nikoletta Szabó, Eszter Tóth, Zsigmond Tamás Kincses, Árpád Párdutz, Délia Szok, Tamás Körtési, Teréz Bagoly, Zsuzsanna Helyes, Lars Edvinsson, László Vécsei, János Tajti

Journal: J Headache Pain. 2016 Dec;17(1):69.

 

Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) ...

Last Updated: 1 Aug 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cluster headache" returned 27 free, full-text review articles on human participants. First 3 results:

The development and validation of the Cluster Headache Quality of life scale (CHQ).
 

Author(s): Norazah Abu Bakar, Mariam Torkamani, Surat Tanprawate, Giorgio Lambru, Manjit Matharu, Marjan Jahanshahi

Journal: J Headache Pain. 2016 Dec;17(1):79.

 

Cluster headache (CH) is a rare, excruciating and highly disabling primary headache disorder. Using non cluster headache specific measures, previous studies have shown that CH has a significant negative impact on patients' quality of life (QoL), but a CH-specific QoL scale is currently ...

Last Updated: 6 Sep 2016

Go To URL
The Neuropharmacology of Cluster Headache and other Trigeminal Autonomic Cephalalgias.
 

Author(s): Alfredo Costa, Fabio Antonaci, Matteo Cotta Ramusino, Giuseppe Nappi

Journal: Curr Neuropharmacol. 2015 ;13(3):304-23.

 

Trigeminal autonomic cephalalgias (TACs) are a group of primary headaches including cluster headache (CH), paroxysmal hemicrania (PH) and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT). Another form, hemicrania continua (HC), is also ...

Last Updated: 28 Sep 2015

Go To URL
Cluster headache.
 

Author(s): Karl B Alstadhaug, Hilde Karen Ofte

Journal:

 

Last Updated: 28 Aug 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 2 Aug 2016

Go to URL
Sleep, Circadian Rhythms and Cluster Headache
 

Status: Recruiting

Condition Summary: Cluster Headache

 

Last Updated: 1 Dec 2015

Go to URL
The Efficacy of L-cysteine in Prevention of Cluster Headache
 

Status: Recruiting

Condition Summary: Cluster Headache

 

Last Updated: 20 Jan 2016

Go to URL