Cluster headache

Common Name(s)

Cluster headache

Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks.   A cluster headache usually begins suddenly with excruciating pain on one side of the head, often behind or around one eye.  In some individuals, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to an hour or two before going away. Cluster headaches generally begin between the ages of 20 and 50, although the syndrome can also start in childhood or late in life. Males are much more likely than females to develop cluster headaches.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cluster headache" for support, advocacy or research.

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National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

Last Updated: 16 Mar 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cluster headache" for support, advocacy or research.

Logo
National Headache Foundation

The National Headache Foundation exists to enhance the healthcare of individuals with headache. It is a source of help to their families, physicians and allied healthcare professionals who treat them, and to the public. The NHF accomplishes its mission by providing educational and informational resources, supporting headache research, and advocating for the understanding of headache as a legitimate neurobiological disease.

http://www.headaches.org

Last Updated: 16 Mar 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cluster headache" returned 171 free, full-text research articles on human participants. First 3 results:

Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry.
 

Author(s): Mads Barloese, Anja Petersen, Philipp Stude, Tim Jürgens, Rigmor Højland Jensen, Arne May

Journal:

 

Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established pharmacological therapy. This study examines outcomes of a cohort of mainly chronic CH patients treated with sphenopalatine ...

Last Updated: 31 Dec 1969

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Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study.
 

Author(s): Zhiliang Fan, Lei Hou, Dongjun Wan, Ran Ao, Dengfa Zhao, Shengyuan Yu

Journal:

 

Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirmed that the HCRTR2 (Hypocretin Receptor 2) SNP rs2653349, and the ADH4 (Alcohol ...

Last Updated: 31 Dec 1969

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Cost-effectiveness of gammaCore (non-invasive vagus nerve stimulation) for acute treatment of episodic cluster headache.
 

Author(s): Mkaya Mwamburi, Eric J Liebler, Andrew T Tenaglia

Journal: Am J Manag Care. 2017 Nov;23(16 Suppl):S300-S306.

 

Cluster headache is a debilitating disease characterized by excruciatingly painful attacks that affects 0.15% to 0.4% of the US population. Episodic cluster headache manifests as circadian and circannual seasonal bouts of attacks, each lasting 15 to 180 minutes, with periods of remission. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cluster headache" returned 30 free, full-text review articles on human participants. First 3 results:

Review of non-invasive vagus nerve stimulation (gammaCore): efficacy, safety, potential impact on comorbidities, and economic burden for episodic and chronic cluster headache.
 

Author(s): Mkaya Mwamburi, Eric J Liebler, Andrew T Tenaglia

Journal: Am J Manag Care. 2017 Nov;23(17 Suppl):S317-S325.

 

The FDA has cleared gammaCore (non-invasive vagus nerve stimulator [nVNS]) for the treatment of episodic cluster headache (eCH). With the exception of subcutaneous sumatriptan, all other treatments are used off label and have many limitations. The FDA approval process for devices ...

Last Updated: 31 Dec 1969

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The development and validation of the Cluster Headache Quality of life scale (CHQ).
 

Author(s): Norazah Abu Bakar, Mariam Torkamani, Surat Tanprawate, Giorgio Lambru, Manjit Matharu, Marjan Jahanshahi

Journal: J Headache Pain. 2016 Dec;17(1):79.

 

Cluster headache (CH) is a rare, excruciating and highly disabling primary headache disorder. Using non cluster headache specific measures, previous studies have shown that CH has a significant negative impact on patients' quality of life (QoL), but a CH-specific QoL scale is currently ...

Last Updated: 31 Dec 1969

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[Cluster headache in pediatric population: four case reports and review of the literature].
 

Author(s): C Alfaro-Iznaola, D Natera-de Benito, R Rodriguez-Diaz, M A Taboas-Pereira, M Cuadrado-Martin, M M Ballesteros-Garcia

Journal: Rev Neurol. 2016 Jul;63(2):65-70.

 

Cluster headache is a rare cause of primary headache in children. We report four cases with a mean age of onset of 8.6, ranged from 2 to 13 years.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 Jul 2018

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The Efficacy of L-cysteine in Prevention of Cluster Headache
 

Status: Recruiting

Condition Summary: Cluster Headache

 

Last Updated: 22 Jun 2017

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Safety and Efficacy Study of SOM230 s.c. in Cluster Headache
 

Status: Recruiting

Condition Summary: Cluster Headache - Episodic and Chronic

 

Last Updated: 5 Feb 2018

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