Bone marrow necrosis

Common Name(s)

Bone marrow necrosis

In bone marrow necrosis, there is poor circulation of oxygen and nutrients to the bone marrow cells, causing the cells to die. Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. Bone marrow necrosis often causes fever and bone pain, and is associated with blood cancers, in particular acute lymphoblastic leukemia (ALL) although it can be associated with other cancers and non-cancerous conditions (e.g., sickle cell anemia, tuberculosis, infection, and sepsis).
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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bone marrow necrosis" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bone marrow necrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Recommended Apps

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Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

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Relief is when you and the right researcher find each other

Finding the right clinical trial for Bone marrow necrosis can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bone marrow necrosis" returned 51 free, full-text research articles on human participants. First 3 results:

Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages.
 

Author(s): Jean-Yves Tano, Robert H Lee, Guillermo Vazquez

Journal: Biochem. Biophys. Res. Commun.. 2012 Oct;427(1):178-84.

 

We previously showed that survival signaling in TNFα-treated, human THP1-derived macrophages (TDMs) has an obligatory requirement for constitutive Ca(2+) influx through a mechanism involving calmodulin/calmodulin kinase II (CAM/CAMKII). We also demonstrated that such requirement ...

Last Updated: 19 Oct 2012

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Prevalence of bone marrow necrosis in Egyptian cancer patients referring to the National Cancer Institute.
 

Author(s): Basma M Elgamal, Reham A Rashed, Heba N Raslan

Journal: J Egypt Natl Canc Inst. 2011 Sep;23(3):95-9.

 

Bone marrow necrosis is a relatively rare entity which has been associated with a poor prognosis. It is most commonly found in patients with neoplastic disorders and severe infections.

Last Updated: 10 Jul 2012

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Bone marrow necrosis in sickle cell anaemia.
 

Author(s): Panayiotis D Ziakas, Michael Voulgarelis

Journal: Blood Transfus. 2010 Jul;8(3):211.

 

Last Updated: 30 Jul 2010

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To view other free, full-text articles on human participants, please click on the link below.

PubMed Article Results at NCBI: 51 article(s)

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bone marrow necrosis" returned 2 free, full-text review articles on human participants. First 3 results:

[Chronic myeloid leukemia with bone marrow infection and necrosis: a case report and literature review].
 

Author(s): Yong-Yuan Dai, Xi-Mei Hu, Shui-Yang Zhou

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Feb;33(2):145-6.

 

Last Updated: 26 Jun 2012

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The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone.
 

Author(s): P Hernigou, A Poignard, O Manicom, G Mathieu, H Rouard

Journal: J Bone Joint Surg Br. 2005 Jul;87(7):896-902.

 

Last Updated: 23 Jun 2005

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PubMed Review Results at NCBI: 2 review(s)

 
 
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Symptoms, Diagnosis, and Treatment

This information is provided by Genetics Home Reference.
http://ghr.nlm.nih.gov/condition/dyskeratosis-congenita
Full Results at Genetics Home Reference: 4 matches

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mesenchymal Stem Cells in Osteonecrosis of the Femoral Head
 

Status: Recruiting

Condition Summary: Avascular Necrosis of Femur Head

 

Last Updated: 16 Jul 2014

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Evaluation of Mesenchymal Stem Cells to Treat Avascular Necrosis of the Hip
 

Status: Recruiting

Condition Summary: Avascular Necrosis of the Femoral Head

 

Last Updated: 14 Feb 2014

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Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial
 

Status: Recruiting

Condition Summary: Osteonecrosis of the Knee; Bone Marrow Edema of the Knee

 

Last Updated: 9 Jul 2013

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According to ClinicalTrials.gov there are currently 22 additional "open" studies for "Bone marrow necrosis" (open studies are recruiting volunteers) and 68 "Bone marrow necrosis" studies with "all" status. Visit ClinicalTrials.gov now to view them. Or alternatively, consider TrialsFinder for assistance:
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Relief is when you and the right researcher find each other
Finding the right clinical trial for Bone marrow necrosis can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.
Learn More