Bone marrow necrosis

Common Name(s)

In bone marrow necrosis, there is poor circulation of oxygen and nutrients to the bone marrow cells, causing the cells to die. Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. Bone marrow necrosis often causes fever and bone pain, and is associated with blood cancers, in particular acute lymphoblastic leukemia (ALL) although it can be associated with other cancers and non-cancerous conditions (e.g., sickle cell anemia, tuberculosis, infection, and sepsis).

Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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Advocacy and Support Organizations

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Advocacy and Support Organizations

Condition Specific Organizations

Following organizations serve the condition "Bone marrow necrosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bone marrow necrosis" returned 78 free, full-text research articles on human participants. First 3 results:

From Bone Marrow Necrosis to Gaucher Disease; A Long Way to Run.

Author(s): Neslihan Erdem, Ahmet Çizmecioğlu, İsmet Aydoğdu

Journal: Turk J Haematol. 2015 Dec;32(4):373-4.

Last Updated: 19 Jan 2016

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Bone marrow necrosis in acute leukemia: Clinical characteristic and outcome.

Author(s): Talha Badar, Aditya Shetty, Carlos Bueso-Ramos, Jorge Cortes, Marina Konopleva, Gautam Borthakur, Sherry Pierce, Xuelin Huang, Hsiang-Chun Chen, Tapan Kadia, Naval Daver, Courtney Dinardo, Susan O'Brien, Guillermo Garcia-Manero, Hagop Kantarjian, Farhad Ravandi

Journal: Am. J. Hematol.. 2015 Sep;90(9):769-73.

Bone marrow necrosis (BMN) is characterized by infarction of the medullary stroma, leading to marrow necrosis with preserved cortical bone. In reported small series, BMN in hematological malignancies is associated with poor prognosis. We sought to find the impact of BMN on clinical ...

Last Updated: 21 Aug 2015

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Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells.

Author(s): Tzung-Hai Yen, Malcolm R Alison, Robert A Goodlad, William R Otto, Rosemary Jeffery, H Terence Cook, Nicholas A Wright, Richard Poulsom

Journal: J. Cell. Mol. Med.. 2015 Feb;19(2):463-73.

To assess effects of epidermal growth factor (EGF) and pegylated granulocyte colony-stimulating factor (P-GCSF; pegfilgrastim) administration on the cellular origin of renal tubular epithelium regenerating after acute kidney injury initiated by mercuric chloride (HgCl2 ). Female mice ...

Last Updated: 29 Jan 2015

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PubMed Article Results at NCBI: 78 article(s)

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bone marrow necrosis" returned 1 free, full-text review articles on human participants. First 3 results:

The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone.

Author(s): P Hernigou, A Poignard, O Manicom, G Mathieu, H Rouard

Journal: J Bone Joint Surg Br. 2005 Jul;87(7):896-902.

Last Updated: 23 Jun 2005

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PubMed Review Results at NCBI: 1 review(s)

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Symptoms, Diagnosis, and Treatment

This information is provided by Genetics Home Reference.

Full Results at Genetics Home Reference: 686 matches

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation(BM-MSC) for Kienbock's Disease

Status: Recruiting

Condition Summary: Kienböck's Disease

Last Updated: 18 Jul 2016

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Effect of BM-MSCs on Early Graft Function Recovery After DCD Kidney Transplant.

Status: Not yet recruiting

Condition Summary: Kidney Transplantation; Acute Kidney Tubular Necrosis

Last Updated: 28 Sep 2015

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Effect of BM-MSCs in DCD Kidney Transplantation

Status: Not yet recruiting

Condition Summary: Kidney Transplantation; Acute Kidney Tubular Necrosis

Last Updated: 25 Sep 2015

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According to ClinicalTrials.gov there are currently 10 additional "open" studies for "Bone marrow necrosis" (open studies are recruiting volunteers) and 78 "Bone marrow necrosis" studies with "all" status. Visit ClinicalTrials.gov now to view them. Or alternatively, consider TrialsFinder for assistance:

Relief is when you and the right researcher find each other
Finding the right clinical trial for Bone marrow necrosis can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.

Learn More