Acquired Von Willebrand syndrome

Common Name(s)

Acquired Von Willebrand syndrome

Acquired von Willebrand syndrome (AVWS) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a VWF gene mutation. It is most often seen in persons over age 40 years with no prior bleeding history. This condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs. About 300 cases of this condition have been reported in the medical literature thus far. Treatment depends on the underlying cause of the condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acquired Von Willebrand syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acquired Von Willebrand syndrome" returned 28 free, full-text research articles on human participants. First 3 results:

Acquired von Willebrand Syndrome (AVWS) as an important diagnostic category of disease.
 

Author(s): Shinya Goto

Journal: J. Atheroscler. Thromb.. 2015 ;22(3):231-2.

 

Last Updated: 23 Mar 2015

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Acquired von Willebrand syndrome in paediatric patients with congenital heart disease: challenges in the diagnosis and management of this rare condition.
 

Author(s): M L Avila, K-J Lee, V Bouskill, M L Rand, P James, M Carcao

Journal: Haemophilia. 2015 Jan;21(1):e89-92.

 

Last Updated: 30 Dec 2014

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Early diagnosis of acquired von Willebrand Syndrome (AVWS) is elementary for clinical practice in patients treated with ECMO therapy.
 

Author(s): Johannes Kalbhenn, Rene Schmidt, Lea Nakamura, Johannes Schelling, Simone Rosenfelder, Barbara Zieger

Journal: J. Atheroscler. Thromb.. 2015 ;22(3):265-71.

 

Acquired Von Willebrand syndrome (AVWS) is an acquired bleeding disorder that has been reported to aggravate bleeding complications in patients with ventricular assist devices or aortic stenosis. AVWS is characterized by the loss of the high-molecular-weight (HMW) multimers of Von ...

Last Updated: 23 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acquired Von Willebrand syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

Treatment of acquired von Willebrand syndrome in childhood.
 

Author(s): Michael U Callaghan, Trisha E Wong, Augusto B Federici

Journal: Blood. 2013 Sep;122(12):2019-22.

 

A 3-1/2-year-old male with no personal or family history of bleeding disorders presented with abdominal distension, epistaxis, and anemia (hemoglobin 8.2 g/dL). A magnetic resonance imaging scan of the abdomen demonstrated a mass arising from the left kidney. Preoperative laboratory ...

Last Updated: 20 Sep 2013

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How I treat the acquired von Willebrand syndrome.
 

Author(s): Andreas Tiede, Jacob H Rand, Ulrich Budde, Arnold Ganser, Augusto B Federici

Journal: Blood. 2011 Jun;117(25):6777-85.

 

The acquired von Willebrand syndrome (AVWS) is a bleeding disorder that is frequently unrecognized or is misdiagnosed as von Willebrand disease. AVWS is characterized by structural or functional defects of von Willebrand factor (VWF) that are secondary to autoimmune, lymphoproliferative ...

Last Updated: 24 Jun 2011

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Acquired von Willebrand syndrome: an update.
 

Author(s): Massimo Franchini, Giuseppe Lippi

Journal: Am. J. Hematol.. 2007 May;82(5):368-75.

 

Acquired von Willebrand syndrome (aVWS) is a rare bleeding disorder with laboratory findings similar to those for congenital von Willebrand disease (VWD). However, unlike congenital VWD, it arises in individuals with no personal or family history of bleeding. aVWS occurs in association ...

Last Updated: 10 Apr 2007

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.