Acquired Von Willebrand syndrome

Common Name(s)

Acquired Von Willebrand syndrome

Acquired von Willebrand syndrome (AVWS) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a VWF gene mutation. It is most often seen in persons over age 40 years with no prior bleeding history. This condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs. About 300 cases of this condition have been reported in the medical literature thus far. Treatment depends on the underlying cause of the condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acquired Von Willebrand syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acquired Von Willebrand syndrome" returned 34 free, full-text research articles on human participants. First 3 results:

Acquired von Willebrand Syndrome During the Course of Myelofibrosis: Analysis of 32 Cases.
 

Author(s): Andrzej Mital, Witold Prejzner, Andrzej Hellmann

Journal: Adv Clin Exp Med. ;24(6):1001-6.

 

Identification of patients with myelofibrosis being at increased risk of acquired von Willebrand syndrome (avWS) would likely facilitate individualization of treatment and improve its outcomes.

Last Updated: 16 Jan 2016

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Impact of Acquired von Willebrand Syndrome in Severe Aortic Stenosis.
 

Author(s): Yoshihiro Fukumoto

Journal: J. Atheroscler. Thromb.. 2015 ;22(11):1113-4.

 

Last Updated: 2 Nov 2015

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Unexpectedly High Prevalence of Acquired von Willebrand Syndrome in Patients with Severe Aortic Stenosis as Evaluated with a Novel Large Multimer Index.
 

Author(s): Toshihiro Tamura, Hisanori Horiuchi, Masao Imai, Tomohisa Tada, Hiroki Shiomi, Maiko Kuroda, Shunsuke Nishimura, Yusuke Takahashi, Yusuke Yoshikawa, Akira Tsujimura, Masashi Amano, Yukiko Hayama, Sari Imamura, Naoaki Onishi, Yodo Tamaki, Soichiro Enomoto, Makoto Miyake, Hirokazu Kondo, Kazuaki Kaitani, Chisato Izumi, Takeshi Kimura, Yoshihisa Nakagawa

Journal: J. Atheroscler. Thromb.. 2015 ;22(11):1115-23.

 

Severe gastrointestinal bleeding sometimes occurs in patients with aortic stenosis (AS), known as Heyde's syndrome. This syndrome is thought to be caused by acquired von Willebrand syndrome and is characterized by reduced large von Willebrand factor (vWF) multimers. However, the relationship ...

Last Updated: 2 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acquired Von Willebrand syndrome" returned 5 free, full-text review articles on human participants. First 3 results:

Treatment of acquired von Willebrand syndrome in childhood.
 

Author(s): Michael U Callaghan, Trisha E Wong, Augusto B Federici

Journal: Blood. 2013 Sep;122(12):2019-22.

 

A 3-1/2-year-old male with no personal or family history of bleeding disorders presented with abdominal distension, epistaxis, and anemia (hemoglobin 8.2 g/dL). A magnetic resonance imaging scan of the abdomen demonstrated a mass arising from the left kidney. Preoperative laboratory ...

Last Updated: 20 Sep 2013

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How I treat the acquired von Willebrand syndrome.
 

Author(s): Andreas Tiede, Jacob H Rand, Ulrich Budde, Arnold Ganser, Augusto B Federici

Journal: Blood. 2011 Jun;117(25):6777-85.

 

The acquired von Willebrand syndrome (AVWS) is a bleeding disorder that is frequently unrecognized or is misdiagnosed as von Willebrand disease. AVWS is characterized by structural or functional defects of von Willebrand factor (VWF) that are secondary to autoimmune, lymphoproliferative ...

Last Updated: 24 Jun 2011

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Acquired von Willebrand syndrome: is it an extremely rare disorder or do we see only the tip of the iceberg?
 

Author(s): A B Federici

Journal: J. Thromb. Haemost.. 2008 Apr;6(4):565-8.

 

Last Updated: 14 Mar 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.