Acquired Von Willebrand syndrome

Common Name(s)

Acquired Von Willebrand syndrome

Acquired von Willebrand syndrome (AVWS) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a VWF gene mutation. It is most often seen in persons over age 40 years with no prior bleeding history. This condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs. About 300 cases of this condition have been reported in the medical literature thus far. Treatment depends on the underlying cause of the condition.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acquired Von Willebrand syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acquired Von Willebrand syndrome" returned 16 free, full-text research articles on human participants. First 3 results:

Acquired von Willebrand syndrome: a rare disorder of heterogeneous etiology.
 

Author(s): P Kasatkar, K Ghosh, S Shetty

Journal: J Postgrad Med. ;59(2):98-101.

 

Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that mimics the inherited form of von Willebrand disease (VWD) in terms of laboratory findings and clinical presentation.

Last Updated: 24 Jun 2013

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Are intravenous immunoglobulins really inappropriate in acquired von Willebrand syndrome?
 

Author(s): Augusto B Federici, Valentina Rossi, Elisabetta Sacchi, Massimo Franchini

Journal: Blood Transfus. 2012 Jul;10(3):402-3; author reply 404-5.

 

Last Updated: 14 Aug 2012

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Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired von Willebrand syndrome: response to septal myectomy.
 

Author(s): Joseph L Blackshear, Hartzell V Schaff, Steve R Ommen, Dong Chen, William L Nichols

Journal: Mayo Clin. Proc.. 2011 Mar;86(3):219-24.

 

Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with ...

Last Updated: 2 Mar 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acquired Von Willebrand syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

How I treat the acquired von Willebrand syndrome.
 

Author(s): Andreas Tiede, Jacob H Rand, Ulrich Budde, Arnold Ganser, Augusto B Federici

Journal: Blood. 2011 Jun;117(25):6777-85.

 

The acquired von Willebrand syndrome (AVWS) is a bleeding disorder that is frequently unrecognized or is misdiagnosed as von Willebrand disease. AVWS is characterized by structural or functional defects of von Willebrand factor (VWF) that are secondary to autoimmune, lymphoproliferative ...

Last Updated: 24 Jun 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.