Brain Stem Cancer

Common Name(s)

Brain Stem Cancer

Brain Stem Cancer is a rare form of cancer characterized by abnormal cell growth in the brain stem. Individuals with this disorder may grow harmful tumors in the brain that can impair brain function and spread to the rest of the body if not diagnosed and treated early. The brain stem is important for maintaining eye movements, muscle movements, and motor coordination. Brain stem cancer can thus cause individuals to be less capable of performing important movements, like walking and running. Some individuals may loss their ability to move certain parts of their body (paralysis). Without early diagnosis and treatment, prognosis for this condition can be severe. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. If an individual's cancer has progressed, doctors may suggest chemotherapy or surgery to combat cancer symptoms.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brain Stem Cancer" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brain Stem Cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brain Stem Cancer" returned 27 free, full-text research articles on human participants. First 3 results:

Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases.
 

Author(s): Deepak Kanojia, Irina V Balyasnikova, Ramin A Morshed, Richard T Frank, Dou Yu, Lingjiao Zhang, Drew A Spencer, Julius W Kim, Yu Han, Dihua Yu, Atique U Ahmed, Karen S Aboody, Maciej S Lesniak

Journal: Stem Cells. 2015 Oct;33(10):2985-94.

 

The treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer has been revolutionized by trastuzumab. However, longer survival of these patients now predisposes them to forming HER2 positive brain metastases, as the therapeutic antibodies cannot cross ...

Last Updated: 21 Sep 2015

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Over Expression of BCL2 and Low Expression of Caspase 8 Related to TRAIL Resistance in Brain Cancer Stem Cells.
 

Author(s): Ling Qi, Kuang Ren, Fang Fang, Dong-Hai Zhao, Ning-Jiang Yang, Yan Li

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(12):4849-52.

 

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been investigated as an effective agent to treat various cancers. Cancer stem cells are resistant to TRAIL treatment, but the mechanism of TRAIL resistance remains unknown. In this study, brain cancer stem cells were ...

Last Updated: 12 Jul 2015

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Pre-exposure of human adipose mesenchymal stem cells to soluble factors enhances their homing to brain cancer.
 

Author(s): Chris L Smith, Kaisorn L Chaichana, Young M Lee, Benjamin Lin, Kevin M Stanko, Thomas O'Donnell, Saksham Gupta, Sagar R Shah, Joanne Wang, Olindi Wijesekera, Michael Delannoy, Andre Levchenko, Alfredo QuiƱones-Hinojosa

Journal: Stem Cells Transl Med. 2015 Mar;4(3):239-51.

 

Recent research advances have established mesenchymal stem cells (MSCs) as a promising vehicle for therapeutic delivery. Their intrinsic tropism for brain injury and brain tumors, their lack of immunogenicity, and their ability to breach the blood-brain barrier make these cells an ...

Last Updated: 25 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brain Stem Cancer" returned 11 free, full-text review articles on human participants. First 3 results:

Effective treatment of glioblastoma requires crossing the blood-brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine.
 

Author(s): Sang-Soo Kim, Joe B Harford, Kathleen F Pirollo, Esther H Chang

Journal: Biochem. Biophys. Res. Commun.. 2015 Dec;468(3):485-9.

 

Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the blood-brain barrier (BBB) play a major role in the poor prognosis of GBM patients. Accumulated evidence suggests that in many ...

Last Updated: 28 Dec 2015

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It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brain.
 

Author(s): Derek H Janssens, Cheng-Yu Lee

Journal: Semin. Cell Dev. Biol.. 2014 Apr;28():63-9.

 

During malignant transformation the cells of origin give rise to cancer stem cells which possess the capacity to undergo limitless rounds of self-renewing division, regenerating themselves while producing more tumor cells. Within normal tissues, a limitless self-renewal capacity is ...

Last Updated: 27 May 2014

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The role of cancer stem cells and miRNAs in defining the complexities of brain metastasis.
 

Author(s): Ashhar S Ali, Aamir Ahmad, Shadan Ali, Bin Bao, Philip A Philip, Fazlul H Sarkar

Journal: J. Cell. Physiol.. 2013 Jan;228(1):36-42.

 

Researchers and clinicians have been challenged with the development of therapies for the treatment of cancer patients whose tumors metastasized to the brain. Among the most lethal weapons known today, current management of brain metastases involves multiple therapeutic modalities ...

Last Updated: 8 Oct 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Nimotuzumab in Combination With Radio-chemotherapy for the Treatment of Brainstem Tumor in Children
 

Status: Recruiting

Condition Summary: Childhood Brain Stem Neoplasm

 

Last Updated: 11 Sep 2016

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Application of Palliative Treatment in Children With Brain Stem Glioma and Recurrent High-grade Tumors in the Central Nervous System With the Nanomaterial NPt-Ca
 

Status: Not yet recruiting

Condition Summary: Brain Tumor, Pediatric, Brainstem Glioma; Brain Tumor, Pediatric, Recurrent

 

Last Updated: 11 Aug 2017

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