Warfarin response

Common Name(s)

Warfarin response

Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement ({27:Yuan et al., 2005}). The dose requirement is highly variable, both interindividually and interethnically. Variation in the VKORC1 gene is believed to be the most important individual predictor of warfarin dose, accounting for about 30% of the variance observed in dosing ({17:Ross et al., 2010}).
 

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Condition Specific Organizations

Following organizations serve the condition "Warfarin response" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Warfarin response" returned 31 free, full-text research articles on human participants. First 3 results:

Last Updated: 25 Feb 2015

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Warfarin dosage response related pharmacogenetics in Chinese population.
 

Author(s): Siyue Li, Yuangao Zou, Xia Wang, Xunbei Huang, Yong Sun, Yuqing Wang, Li Dong, Hong Jiang

Journal:

 

As the most frequently prescribed anticoagulant, warfarin has large inter-individual variability in dosage. Genetic polymorphisms could largely explain the differences in dosage requirement. rs9923231 (VKORC1), rs7294 (VKORC1), rs1057910 (CYP2C9), rs2108622 (CYP4F2), and rs699664 ...

Last Updated: 17 Jan 2015

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Response to letter regarding article, "Warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis".
 

Author(s): Mitesh Shah, Meytal Avgil Tsadok, Cynthia A Jackevicius, Vidal Essebag, Mark J Eisenberg, Elham Rahme, Karin H Humphries, Jack V Tu, Hassan Behlouli, Helen Guo, Louise Pilote

Journal: Circulation. 2014 Dec;130(25):e428-9.

 

Last Updated: 25 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Warfarin response" returned 2 free, full-text review articles on human participants. First 3 results:

Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.
 

Author(s): Andrea L Jorgensen, Richard J FitzGerald, James Oyee, Munir Pirmohamed, Paula R Williamson

Journal: PLoS ONE. 2012 ;7(8):e44064.

 

Warfarin is a highly effective anticoagulant however its effectiveness relies on maintaining INR in therapeutic range. Finding the correct dose is difficult due to large inter-individual variability. Two genes, CYP2C9 and VKORC1, have been associated with this variability, leading ...

Last Updated: 6 Sep 2012

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The pharmacogenetics of the response to warfarin in Chinese.
 

Author(s): May P S Lam, Bernard M Y Cheung

Journal: Br J Clin Pharmacol. 2012 Mar;73(3):340-7.

 

Warfarin is a commonly used oral anticoagulant with a narrow therapeutic range and large interindividual variability in daily dose. Compared with Caucasians, Chinese are known to require lower doses of warfarin. Differences between Caucasians and Chinese in the allelic frequencies ...

Last Updated: 14 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pharmacogenetic Study of Warfarin Dose-Response: a Prospective Trial
 

Status: Not yet recruiting

Condition Summary: Cardiovascular Diseases

 

Last Updated: 4 Apr 2008

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Genotype-guided Warfarin Individualized Treatment
 

Status: Recruiting

Condition Summary: Atrial Fibrillation; Deep Venous Thrombosis

 

Last Updated: 6 Apr 2016

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Genetic Variability in the Response to Warfarin at Baseline and During Induction of CYP2C9
 

Status: Not yet recruiting

Condition Summary: Healthy Subjects

 

Last Updated: 5 Jul 2011

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